Clinical trials: Bone Fracture
Bone Metastases
Study of Denosumab vs. Zoledronic Acid to Treat Bone Metastases in Subjects With Advanced Cancer or Multiple Myeloma.
The purpose of this study is to determine if denosumab is non-inferior to zoledronic acid (Zometa®) in the treatment of bone metastases (lytic bone lesions from multiple myeloma) in subjects with advanced cancer and multiple…
- Trial name
- NCT00330759
- Testing
- Denosumab, Zoledronic Acid
- Volunteers
- 1,779 people
- Sponsor
- Amgen
Proximal Humeral Fracture
Orthopaedic Treatment Proximal Humeral Fractures
Prospective non-randomized, open, unicentric observational study to compare two different treatments for Three-four parts fractures of proximal humerus (Neer's Classification) in elderly patients (over 75 years old).
- Trial name
- NCT03339570
- Testing
- Orthopedic treatment for a proximal humeral fracture
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Mikel Aburto
Pelvic Fracture
Use of Teriparatide to Accelerate Fracture Healing
The purpose of this study is to compare the effect of the drug teriparatide to the effect of placebo on pelvic fracture healing.
- Trial name
- NCT00594906
- Testing
- Teriparatide
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Osteopenia
A Study of Oral Recombinant Salmon Calcitonin (rsCT) to Prevent Postmenopausal Osteoporosis
The primary purpose of this study was to evaluate the efficacy of oral calcitonin (rsCT)tablets in the prevention of bone loss in postmenopausal women with lower bone mineral density at increased risk of fracture.
- Trial name
- NCT01292187
- Testing
- Oral calcitonin at dinnertime, Oral calcitonin at bedtime
- Where
- 10 sites in United States
- Volunteers
- 129 people
- Sponsor
- Tarsa Therapeutics, Inc.
Femoral Fractures, Pain, Postoperative
Efficacy Study of Femoral Nerve Block in Children With a Femur Fracture
The purpose of this study is to examine the efficacy of the use of Marcaine in femoral nerve blocks and hematoma blocks for post operative pain relief for femoral shaft fractures in a pediatric population.
- Trial name
- NCT01294098
- Testing
- Marcaine
- Where
- 2 sites in United States
- Volunteers
- 2 people
- Sponsor
- Washington University School of Medicine
Fracture of Calcaneus, Pilon or Tibial Plateau
Vacuum Assisted Closure as a Treatment for Soft Tissue Injuries
This project is designed as a prospective, randomized, comparative study evaluating the use of a negative pressure vacuum device in treating soft tissue injuries and the surgical incision following open reduction and internal…
- Trial name
- VAC-ST (NCT00582998)
- Testing
- Standard Wound Dressing, Vacuum Assisted Closure Device
- Where
- United States
- Volunteers
- 249 people
- Sponsor
- University of Alabama at Birmingham
Venous Thromboembolism
ODEN Trial: Option vs. Denali IVC Filters
This research study is a prospective randomized trial evaluating the relative safety of two inferior vena cava (IVC) filters used to prevent the migration of potentially dangerous deadly blood clots from the legs to the lung in…
- Trial name
- ODEN (NCT02201277)
- Testing
- Filter Placed
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- University of California, San Francisco
Pathological Fracture of Vertebra Due to Secondary Osteoporosis (Disorder), Pathological Fracture of Vertebra Due to Neoplastic Disease (Disorder)
Xpede Clinical Study
The purpose of this clinical study is to confirm the efficacy and safety of the Kyphon®Xpede™ Bone Cement in human use in China.
- Trial name
- NCT03730207
- Testing
- Xpede™ Bone Cement, Mendec Spine Bone Cement
- Where
- 3 sites in China
- Volunteers
- 180 people
- Sponsor
- Medtronic Spinal and Biologics
Hip Fractures
Computer-Assisted Fixation of Trochanteric Femur Fractures
The purpose of this study is to assess whether the Stryker© ADAPT™ augmented-reality platform can assist surgeons in optimizing placement of the lag screw component of the Stryker© Gamma™ cephalomedullary nail.
- Trial name
- NCT04528459
- Testing
- Stryker© ADAPT™ platform, Traditional fluoroscopy
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Columbia University
Delirium
Supporting the Health of Adults Undergoing Orthopedic Surgery During the Recovery Period
Delirium (acute confusion) is a highly prevalent condition among hospitalized elders with substantial morbidity within the hospital and beyond.
- Trial name
- SHARP (NCT00586196)
- Testing
- donepezil
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Beth Israel Deaconess Medical Center
Osteoporosis, Vertebral Fracture
Study of Effect of Exercise With Osteoporosis and Vertebral Fracture
The aim of this randomized controlled trial is to evaluate the effectiveness for health-related quality of life (HRQOL) of a 3-month course of exercises for a group of postmenopausal women with osteoporosis who has at least one…
- Trial name
- NCT01120197
- Testing
- Exercise group, Control Group
- Where
- Norway
- Volunteers
- 89 people
- Sponsor
- Ostfold Hospital Trust
Patellar (or Kneecap) Instability and Mal-alignment
CT Analysis of the Patellofemoral Joint in Patients Having Knee Surgery
The primary hypothesis is that measures of patellofemoral alignment obtained from the investigational cone beam CT scanner will be reduced, but still correlated to those obtained from the conventional CT scan.
- Trial name
- PF (NCT02257099)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- State University of New York at Buffalo
Open Tibia Fracture
Pilot RCT Local Gentamicin for Open Tibial Fractures in Tanzania
Local application of antibiotics directly to the traumatic wound is a promising strategy for the prevention of infection after open tibia fractures, which are a significant source of disease burden globally, particularly in…
- Trial name
- pGO-Tibia (NCT03559400)
- Testing
- local gentamicin injection
- Where
- Tanzania
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Osteoporosis, Postmenopausal, Osteoporosis
Preventing Osteoporosis Using Denosumab
The purpose of this research study is to find out if denosumab (Prolia®), an injection given in the arm under the skin every 6 months, works to treat bone loss and prevent it from worsening in older men and women (ages 65 and…
- Conditions
- Osteoporosis, Postmenopausal, Osteoporosis, Osteoporotic Fractures
- Trial name
- PROUD (NCT02753283)
- Testing
- denosumab, Calcium and Vitamin D
- Where
- United States
- Volunteers
- 201 people
- Sponsor
- Susan L. Greenspan
Elbow Fracture
The Post-Operative Pain Management of Pediatric Supracondylar Elbow Fractures
The goal of this study is to compare different ways of treating pain after surgery. This research study involves subjects who have a supracondylar elbow fracture and need surgery.
- Trial name
- NCT01328782
- Testing
- Oxycodone with Acetaminophen, Bupivacaine 0.25%, Ropivacaine 0.20%
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- University of Colorado, Denver
Dental Restoration Failure of Marginal Integrity, Dental Caries
Clinical Investigation of a New Bulk Fill Composite Resin in the Restoration of Posterior Teeth
Polymerization shrinkage remains one of the primary disadvantages of composite resin restorative materials (tooth-colored fillings).
- Conditions
- Dental Restoration Failure of Marginal Integrity, Dental Caries, Unrepairable Overhanging of Dental Restorative Materials, Poor Aesthetics of Existing Restoration
- Trial name
- NCT02572570
- Testing
- Filtek Bulk Fill Posterior, Filtek Supreme Ultra
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Distal Radius Fracture
Postsurgical Bupivacaine Extended-release Liposome Injection for Open-reduction Internal Distal Radius Fixation.
For patients undergoing open-reduction internal-fixaton (ORIF) of isolated distal radius fractures, administration of 66.5 mg of liposomal bupivacaine to operative field may decrease the need for post-operative narcotic pain…
- Trial name
- NCT02515851
- Testing
- Exparel
- Volunteers
- 30 people
- Sponsor
- University of Louisville
Anemia, Hematologic Diseases
Safety and Effectiveness of Two Blood Transfusion Strategies in Surgical Patients With Cardiovascular Disease
The purpose of this study is to compare liberal red blood cell transfusion therapy with restrictive red blood cell transfusion therapy in surgical patients with cardiovascular disease or risk factors.
- Conditions
- Anemia, Hematologic Diseases, Cardiovascular Diseases, Heart Diseases
- Trial name
- FOCUS (NCT00071032)
- Testing
- Liberal (10 g/dL) Transfusion Strategy, Restrictive (Symptomatic) Transfusion Strategy
- Where
- United States
- Volunteers
- 2,016 people
- Sponsor
- Rutgers, The State University of New Jersey
Vitamin D Receptor Defect
Association Between Vitamin D Receptor Polymorphism and Serum Vitamin D Levels in Children With Low-Energy Fractures
This study was designed to determine the impact of vitamin D serum levels and vitamin D receptor (VDR) polymorphisms on the occurrence of low energy fractures in children.
- Trial name
- NCT02805647
- Where
- Poland
- Volunteers
- 222 people, healthy volunteers welcome
- Sponsor
- Medical University of Bialystok
Spinal Fractures, Fractures, Compression
The Kiva® System as a Vertebral Augmentation Treatment
The purpose of this study is to evaluate the safety and effectiveness of the Kiva VCF Treatment system in comparison to balloon kyphoplasty for the treatment of osteoporotic vertebral compression fractures of the thoracic or…
- Conditions
- Spinal Fractures, Fractures, Compression, Back Injuries
- Trial name
- KAST (NCT01123512)
- Testing
- Vertebral augmentation
- Where
- 21 sites in United States, Belgium and 3 more
- Volunteers
- 300 people
- Sponsor
- Benvenue Medical, Inc.