Clinical trials: Bone Fragility
Osteoporosis
Opportunistic Fragility Fracture Risk Estimates From Radiographs
The proposed study will predict a patients' risk of having osteoporosis by using a combination of the IBEX BH (Bone Health) software outputs and other clinical risk factors such as age, gender, medical history and lifestyle.
- Trial name
- OFFER2 (NCT06110442)
- Testing
- IbexBH Software
- Where
- United Kingdom
- Volunteers
- 497 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Hip Fractures
The Effects of Fragility Fracture Integrated Rehabilitation Management
To determine the effects of Fragility Fracture Integrated Rehabilitation Management approach in geriatric hip fracture patients (post surgical)
- Trial name
- NCT04760756
- Testing
- Fragility Fracture Integrated Rehabilitation Management
- Where
- Pakistan
- Volunteers
- 20 people
- Sponsor
- Zohra Institute of Health Sciences
Osteoporosis, Fracture
Fragility Fracture Liaison Service Project
Aims: to Establish the FLS services at the National Taiwan University Hospital (NTUH) and its Beihu Branch (BB). Method: From Jan., 2014, two related fracture liaison services (FLSs) following the 13 'Capture the Fracture Best…
- Trial name
- NCT02194660
- Where
- Taiwan
- Volunteers
- 600 people
- Sponsor
- National Taiwan University Hospital
Fragility Fracture
PRevention of OsTEoporotiC FracTure 2 Pilot Study
With the aging of the world population, osteoporosis and fragility fractures have become global public health concerns. It has been estimated the population of people ≥60 years of age will increase from 229 million (16.2%) in…
- Trial name
- PROTECT-2 (NCT06134908)
- Testing
- Multifaceted Intervention
- Where
- 7 sites in China
- Volunteers
- 50 people
- Sponsor
- Third Affiliated Hospital, Sun Yat-Sen University
Osteoporosis, Fracture
Fragility Fracture Liaison Service and Anti-osteoporosis Medication Monitoring Service Study
Aims: (1) to Establish the FLS services at the National Taiwan University Hospital Jinshan Branch. (2) To establish a anti-osteoporosis medication management service at Jinshan Branch.
- Trial name
- NCT02635022
- Where
- Taiwan
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Hip Fractures
Fragility Fracture Integrated Rehabilitation Management (FIRM)
A number of studies for clinical pathway (CP) after hip fracture have been suggested to improve post-fracture outcome. However, CP is not carried out properly in most countries due to inadequate system and awareness, and lack of…
- Trial name
- FIRM (NCT03430193)
- Testing
- FIRM, Conventional rehabilitation
- Where
- South Korea
- Volunteers
- 288 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Pelvic Trauma, Pelvic Fracture
A Snapshot Audit of Traumatic Pelvic Ring Injuries
Multicenter, snapshot cohort studies or audits have the ability to gather large patient numbers in short time periods from many healthcare systems with different resources or practices of care concerning one specific surgical…
- Conditions
- Pelvic Trauma, Pelvic Fracture, Fragility Fractures of the Pelvis (FFP)
- Trial name
- NCT06540339
- Testing
- Snapshot-audit studies do not necessitate any intervention in the defined cohorts.
- Volunteers
- 500 people
- Sponsor
- University Hospital, Aachen
Vertebral Fracture, Osteoporotic Fractures
CCEF in the Treatment of Acute VFFs: Randomized Controlled Trial
in recent years the search for therapeutic protocols that could enhance the VFFs healing, thus reducing bed rest-related complications and improving the quality of life of osteoporotic patients.
- Trial name
- NCT05803681
- Testing
- Capacitive Coupled Electric Fields (CCEF), Calssic clinical protocol
- Volunteers
- 70 people
- Sponsor
- University of Bari Aldo Moro
Breast Cancer, Osteoporosis
Fingernails in Evaluating Bone Health in Postmenopausal Women With Breast Cancer Undergoing Hormone Therapy on Clinical Trial IBCSG-1-98
RATIONALE: Studying samples of fingernails in the laboratory from patients with breast cancer may help in evaluating bone health in postmenopausal women undergoing hormone therapy for breast cancer.
- Trial name
- NCT00899288
- Testing
- spectroscopy
- Volunteers
- 60 people
- Sponsor
- ETOP IBCSG Partners Foundation
Osteoporosis, Postmenopausal Osteoporosis
Can Serum Lumican Level Identify a Hidden Fragility Phenotype Beyond Bone Mineral Density in Postmenopausal Women?
Osteoporosis is a major cause of morbidity and fragility fractures in postmenopausal women. Bone mineral density (BMD) alone may not fully reflect fracture risk and skeletal fragility.
- Conditions
- Osteoporosis, Postmenopausal Osteoporosis, Frailty, Fragility Fractures
- Trial name
- LUMINOS (NCT07677072)
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people
- Sponsor
- Kanuni Sultan Suleyman Training and Research Hospital
Multiple Myeloma, Vertebral Fracture
Vertebral Fat Quantitative MRI as a Marker of Bone Fragility in Multiple Myeloma (MYELOMEFRAGIQUANTI)
Multiple myeloma is a disease that causes increased bone fragility which is often revealed or complicated by vertebral fractures. Invasion of bone marrow by tumor plasma cells leads to bone destruction and reduced fat fraction.
- Trial name
- NCT04609150
- Testing
- Bone marrow fat quantification by MRI
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Fragility Fractures of the Pelvis (FFP), Osteoporotic Fractures
Functional Outcomes in Older Adults With Fragility Fractures of the Pelvis: The FFP-France Study
Fragility fractures of the pelvis (FFP) are an increasingly common complication of osteoporosis in older adults and are associated with substantial morbidity, loss of independence, and mortality.
- Trial name
- NCT07871084
- Testing
- Observational Assessment of Fragility Fractures of the Pelvis
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Osteoporosis, Arthroplasty Complications
Surgeon-Initiated Bone Health Referral Pathway in Patients Undergoing Lower Extremity Arthroplasty
The goal of this clinical trial is to observe the impact of a surgeon-driven bone health referral pathway following lower extremity arthroplasty.
- Conditions
- Osteoporosis, Arthroplasty Complications, Fragility Fracture
- Trial name
- NCT05845021
- Testing
- Surgeon-Initiated Bone Health Referral Pathway
- Where
- United States
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Osteoporosis, Osteoporotic Fractures
RESTORE: REducing Future fractureS and Improving ouTcOmes of fRagility fracturE
RESTORE tests whether Augmented-FLS, where patients are contacted by a patient navigator (serving as the liaison) and referred to a bone health provider, is better than Enhanced Usual Care, which includes patient and PCP…
- Conditions
- Osteoporosis, Osteoporotic Fractures, Fragility Fracture
- Trial name
- RESTORE (NCT06455085)
- Testing
- Augmented-Fracture Liaison Service Arm, Enhanced Usual Care Arm
- Where
- 23 sites in United States
- Volunteers
- 2,634 people
- Sponsor
- University of Alabama at Birmingham
Inherited BMF Syndrome
Mutations and Phenotypes of Unclassifiable Inherited Bone Marrow Failure Syndromes
Inherited bone marrow failure syndromes (IBMFSs) are a diverse collection of genetic illnesses characterized by various degrees of peripheral cytopenias due to defective single-lineage or multi-lineage hematopoiesis, it can…
- Trial name
- NCT05436587
- Testing
- The whole-exome sequencing
- Where
- Egypt
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sohag University
Osteoporosis With Current Fragility Fracture
Evaluation of an Osteoporosis Prevention Strategy in Women With Osteoporotic Fracture of the Upper Limb
Osteoporosis is a disease characterized by reduced bone mass and increased skeletal fragility, predisposing to an increased fracture risk.
- Trial name
- PREVOST (NCT01780012)
- Testing
- Osteoporosis prevention program
- Where
- France
- Volunteers
- 436 people
- Sponsor
- Hospices Civils de Lyon
Fragility Fracture
MyNOURISH: Hydrolysed Collagen Supplementation in Older Adults With Fragility Fractures
The goal of this clinical trial is to learn whether hydrolysed collagen supplementation (PROTÉGEN Plus) within multidisciplinary care can improve nutrition and recovery in older adults with fragility fractures.
- Trial name
- MyNOURISH (NCT07347236)
- Testing
- Hydrolysed Collagen (PROTÉGEN Plus), Standard Multidisciplinary Care
- Where
- Malaysia
- Volunteers
- 76 people
- Sponsor
- Hospital Pengajar Universiti Putra Malaysia
Accidental Falls, Fractures
Falls With Fracture : Role of Cognitive Disorders and Comparison With Bone Fragility
The purpose of this study is to determine whether cognitive disorders are a risk factor for a fracture after a fall independently of a bone fragility.
- Trial name
- CFC (NCT02292316)
- Testing
- gait and cognitive assessments, blood sample, osteodensitometry
- Where
- 2 sites in France
- Volunteers
- 218 people, healthy volunteers welcome
- Sponsor
- University Hospital, Caen
Fragility Fracture, Femur; Fracture, Pertrochanteric
Role of Strontium Ranelate in Proximal Femur Fragility Fractures.
This study is being conducted with the aim of comparing the time to bone healing after surgery for fragility fractures of proximal femur between patients receiving strontium ranelate and placebo.
- Conditions
- Fragility Fracture, Femur; Fracture, Pertrochanteric, Clinical Trial
- Trial name
- STRONG (NCT05712616)
- Testing
- Strontium Ranelate, Lacto-N-Hexaose
- Where
- Pakistan
- Volunteers
- 100 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Odontoid Fracture, Osteoporosis
Characteristics and Outcomes of Odontoid Fragility Fractures in Elderly
Usually, cervical spine fractures are not considered as osteoporotic fractures. However, recent studies show that odontoid fractures are the most common fractures of the cervical spine in elderly and may occur in a context of low…
- Conditions
- Odontoid Fracture, Osteoporosis, Surgery
- Trial name
- FOOP (NCT02800278)
- Testing
- observational
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nice