Clinical trials: Bone Infection
Obesity
Antibiotic-related Serious Adverse Events in Obese Patients Treated for Bone and Joint Infection
It exists recommendations to get an optimal antibiotic treatment for bone and joint infection and prescription of antibiotics in the bone and joint infections on material meets certain obligations: the micro-organism must be…
- Trial name
- NCT02861092
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Hospices Civils de Lyon
Chronic Myeloproliferative Disorders, Leukemia
Busulfan, Fludarabine, and Total-Body Irradiation in Treating Patients Who Are Undergoing a Donor Stem Cell Transplant for Hematologic Cancer
RATIONALE: Giving low doses of chemotherapy, such as fludarabine and busulfan, before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- Bu Flu TBI (NCT00245037)
- Testing
- therapeutic allogeneic lymphocytes, busulfan, cyclosporine
- Where
- United States
- Volunteers
- 147 people
- Sponsor
- OHSU Knight Cancer Institute
Ankylosing Spondylitis
Dose-Ranging Study Of Tofacitinib In Adults With Active Ankylosing Spondylitis
This is the first study of oral tofacitinib in adults with active ankylosing spondylitis. It is designed to obtain information on the efficacy and safety of 3 different doses of tofacitinib.
- Trial name
- NCT01786668
- Testing
- Tofacitinib 2 mg, Tofacitinib 5 mg, Tofacitinib 10 mg
- Where
- 67 sites in United States, Canada and 8 more
- Volunteers
- 208 people
- Sponsor
- Pfizer
Leukemia, Lymphoma
Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or Secondary Myelodysplasia Previously Treated With High-Dose Chemotherapy and Autologous Stem Cell Transplant
RATIONALE: Giving chemotherapy, such as busulfan and fludarabine phosphate, before a peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Leukemia, Lymphoma, Lymphoproliferative Disorder, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT01118013
- Testing
- anti-thymocyte globulin, donor lymphocytes, filgrastim
- Where
- 10 sites in United States
- Volunteers
- 6 people
- Sponsor
- Alliance for Clinical Trials in Oncology
Staphylococcus Aureus Infection, Bone and Joint Infection
Recurrent S. Aureus Infections in Osteoarticular Infections
Staphylococcus aureus osteoarticular infections, in particular those associated with the presence of implant, relapse in 20% of cases.
- Trial name
- RELAPSTAPH (NCT04712123)
- Testing
- relapse due to S. aureus
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Axial Spondyloarthritis
Continuing Versus Withdrawing Adalimumab in Maintaining Remission in Non-Radiographic Axial Spondyloarthritis
The objective of this multicenter, randomized, double-blind study was to evaluate the efficacy and safety of continuing versus withdrawing therapy with adalimumab 40 mg given every other week SC in maintaining remission in…
- Trial name
- NCT01808118
- Testing
- adalimumab
- Volunteers
- 673 people
- Sponsor
- AbbVie
Rheumatoid Arthritis
Prospective Study of Patients With Rheumatoid Arthritis After the Age of 65
Rheumatoid arthritis (RA) is associated with a higher prevalence of infections, malignancies, osteoporotic fractures and cardiovascular diseases.
- Trial name
- PRESAGE (NCT02686320)
- Where
- France
- Volunteers
- 176 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
HIV
Optimized Antiretroviral Therapy During Allogeneic Hematopoietic Stem Cell Transplantation in HIV-1 Individuals
To find out if it is possible for HIV-1 patients to maintain antiretroviral medications during allogeneic bone marrow transplant
- Trial name
- NCT01836068
- Testing
- Enfuvirtide
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins
Diabetic Foot Ulcer
Pathogenicity Factors of Staphylococcus Pettenkoferi in Foot Wounds and Osteitis in Diabetic Patients
Gram-positive cocci, particularly Staphylococcus aureus and coagulase-negative staphylococci (SCoN), are the bacteria most frequently isolated from diabetic foot ulcers. Although studies have been carried out on the role of S.
- Trial name
- PETTENK-OS (NCT06688084)
- Testing
- Molecular epidemiology of the collection, Study of the resistome of the S. pettenkoferi population, Study of the virulome of the S. pettenkoferi population
- Where
- France
- Volunteers
- 230 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Surgical Site Infection, Unplanned Fracture-Related Reoperation
Pre-operative Aqueous Antiseptic Skin Solutions in Open Fractures
The prevention of infection is the single most important goal influencing peri-operative care of patients with open fractures. Standard practice in the management of open fractures includes sterile technique and pre-operative…
- Conditions
- Surgical Site Infection, Unplanned Fracture-Related Reoperation, Open Appendicular Fracture
- Trial name
- Aqueous-PREP (NCT03385304)
- Testing
- 10% povidone-iodine (1% free iodine) in purified water, 4% chlorhexidine gluconate (CHG) in purified water
- Where
- 15 sites in United States, Canada and 1 more
- Volunteers
- 1,638 people
- Sponsor
- University of Maryland, Baltimore
Spondylarthritis, Spondylarthropathies; Spondylitis, Ankylosing
Effects of a Digital Exercise Intervention on Sleep and Physical Activity in Patients With Spondyloarthritis
The goal of this clinical trial is to assess whether a tailored digital Adapted Physical Activity (APA) program can improve physical activity levels and sleep quality in adults diagnosed with spondyloarthritis (SpA).
- Trial name
- ASPIRE (NCT07034404)
- Testing
- Digital Adapted Physical Activity, Control (Standard treatment)
- Where
- 3 sites in France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Grenoble
Trauma, Infection
Use of 5-Aminolevulinic Acid to Assess Bone and Tissue Profusion in Orthopaedic Infection Patients
The focus of this study is to explore the variability distribution of 5-Aminolevulinic Acid (ALA)associated with bone and soft tissue perfusion in infection patients, using 5-ALA fluorescence imaging.
- Conditions
- Trauma, Infection, Bone Fracture
- Trial name
- NCT04976049
- Testing
- Imaging using 5-Aminolevulinic Acid (5-ALA) during surgery
- Where
- United States
- Sponsor
- Dartmouth-Hitchcock Medical Center
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Osteomyelitis
Study on the Safety and Efficacy of Dalbavancin Versus Active Comparator in Adult Participants With Osteomyelitis
This clinical study will be a single-center, randomized, open-label, active-controlled, parallel-group study comparing dalbavancin to standard of care (SOC) therapy in osteomyelitis.
- Trial name
- NCT02685033
- Testing
- Dalbavancin, Comparator
- Where
- Ukraine
- Volunteers
- 80 people
- Sponsor
- Durata Therapeutics Inc., an affiliate of Allergan plc
Melanoma, Merkel Cell Carcinoma
Videoscopic Versus Open Inguinal Lymphadenectomy for Cancer
Patients with melanoma, some other rare skin cancers, and some cancers of the penis and scrotum can have their cancer spread to the lymph nodes in the upper part of the leg, called the groin.
- Conditions
- Melanoma, Merkel Cell Carcinoma, Squamous Cell Carcinoma, Penile Carcinoma
- Trial name
- NCT01526486
- Testing
- Videoscopic procedure, Open, traditional approach
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Emory University
Osteoporosis, Fractures
Determination of Optimum Age for DXA Screening for Osteoporosis in HIV - The Probono 1 Study
The purpose of this study is to determine the bone mineral density in male and female patients with HIV infection according to age groups.
- Conditions
- Osteoporosis, Fractures, HIV Infection
- Trial name
- Probono1 (NCT01669954)
- Where
- United Kingdom
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- King's College London
Bone or Joint Infection
Study to Assess Safety, Tolerability and Efficacy of Afabicin in The Treatment of Participants With Bone or Joint Infection Due to Staphylococcus
This is a randomized, active-controlled, open-label study to assess the safety, tolerability and efficacy of Afabicin in the treatment of participants with bone or joint infection due to Staphylococcus aureus [both…
- Trial name
- NCT03723551
- Testing
- Afabicin, Cefazolin, Vancomycin
- Where
- 19 sites in Georgia, South Africa and 1 more
- Volunteers
- 67 people
- Sponsor
- Debiopharm International SA
Spondyloarthritis
Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh
Treatment failure of Spondyloarthropathies (SpA) leads to marked functional disability, higher rates of morbidity, mortality and poor quality of life.
- Trial name
- NCT03504072
- Testing
- Tofacitinib 5 mg,, Etanercept
- Where
- Bangladesh
- Volunteers
- 174 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Chronic Myeloproliferative Disorders, Leukemia
Ultraviolet-B Light Therapy and Allogeneic Stem Cell Transplantation in Treating Patients With Hematologic Malignancies
RATIONALE: Peripheral stem cell transplantation may be able to replace immune cells that were destroyed by chemotherapy. Sometimes the transplanted cells from a donor are rejected by the body's normal cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00068523
- Testing
- anti-thymocyte globulin, cyclophosphamide, cyclosporine
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Case Comprehensive Cancer Center
Cancer
Ribavirin With or Without Monoclonal Antibody Therapy in Treating Patients Who Develop RSV Pneumonia Following Peripheral Stem Cell Transplantation
RATIONALE: Antivirals such as ribavirin are used to treat infections caused by viruses. It is not yet known if ribavirin is more effective with or without monoclonal antibody therapy in treating patients who develop RSV pneumonia…
- Trial name
- NCT00014391
- Testing
- palivizumab, ribavirin
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center