Clinical trials: Bone Loss, Postmenopausal
Postmenopausal Osteoporosis
Acute Effect of Teriparatide With Bisphosphonate or Denosumab on Bone Resorption
The aim of the study is to assess the relative antiresorptive properties of 2 osteoporosis medications when combined with teriparatide.
- Trial name
- NCT01750086
- Testing
- Teriparatide 40-mcg subcutaneous injection, Denosumab Injection, Alendronate Oral Tablet
- Where
- United States
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Postmenopausal Women
Vitamin D Deficiency: Bone Loss and Vascular Dysfunction
To learn if there is a connection between low vitamin D level and hardening of the arteries.
- Trial name
- NCT00235586
- Testing
- 10 vit. D deficient subjects take vit. D for 3 months.
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Kansas
Postmenopausal Osteoporosis
Molecular Mechanism of POP Kidney Yin Deficiency Syndrome From the Interventional Effects of CLCF1
This study use RT-PCR and Western Blot technique to detect the expression of CLCF1 mRNA and protein in POP Kidney Yin deficiency group and healthy group to verify the relevance between CLCF1 and POP the kidney Yin deficiency…
- Trial name
- pop (NCT01834105)
- Testing
- Liuwei Dihuang Pills
- Where
- China
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
Postmenopausal Osteoporosis, Postmenopause
Study Comparing Bioequivalence of Two New Formulations of Premarin/MPA With Premarin/MPA Reference Formulation.
This study will compare the bioequivalence of two new investigational combination formulations of Premarin and medroxyprogesterone acetate (MPA) with a currently marketed formulation of Premarin and medroxyprogesterone, Prempro™.
- Trial name
- NCT00381251
- Testing
- Formulations A and B of Premarin/MPA 0.45 mg/0.5 mg and PREMPRO0.45 mg/0.5 mg
- Volunteers
- healthy volunteers welcome
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteoporosis, Postmenopausal
Comparing of the Pharmacokinetic, Pharmacodynamic, Safety and Immunogenicity of MW031 and Prolia® in Healthy Adults
A randomized, double-blind and parallel group study to compare the pharmacokinetic, safety and pharmacodynamic of MW031 and Prolia® in healthy adults.
- Trial name
- MW031 (NCT04798313)
- Testing
- MW031, Prolia®
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Mabwell (Shanghai) Bioscience Co., Ltd.
Chronic Periodontitis
Changes of GCF Levels of RANKL and Osteoprotegerin in Postmenopausal Osteoporosis
The investigators evaluated the effect of initial periodontal treatment on clinical findings and receptor activator of Nuclear Factor-kappa B ligand (RANKL) and osteoprotegerin (OPG) in gingival crevicular fluid (GCF) of patients…
- Trial name
- NCT02808988
- Testing
- periodontal phase 1 therapy, gingival crevicular fluid collection, zoledronic acid
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Osteoporosis, Osteoporosis, Postmenopausal
Patient- and Physician-Based Osteoporosis Education
Osteoporosis is an important public health problem. Osteoporosis can cause serious health complications and death and leads to increased medical costs.
- Trial name
- NCT00073190
- Testing
- Osteoporosis Education
- Where
- United States
- Volunteers
- 30,000 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Muscle Weakness, Osteoporosis, Postmenopausal
Assessing the Effect of Shatavari Supplementation on Bone and Skeletal Muscle Health in Healthy Postmenopausal Women
Shatavari is a plant that grows in Nepal, Sri Lanka, India and the Himalayas and its root has long been used in Ayurvedic medicine.
- Trial name
- NCT05025917
- Testing
- Shatavari, Magnesium stearate
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Exeter
Osteoporosis
A Study of Prevention and Treatment of Postmenopausal Osteoporosis in Chinese Women
The purpose of this trial is to study the efficacy and safety of low dose of estradiol valerate in the prevention and treatment of postmenopausal osteoporosis.
- Trial name
- NCT00860964
- Testing
- estradiol valerate
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Postmenopausal Osteoporosis
Open-label Study to Evaluate the Effect of MBP-80 on Bone Remodelling
This study will determine if daily oral intake of 200g of a marketed yogurt with fortified calcium content and a milk basic protein (MBP)80 mg benefits on bone cells activity in postmenopausal women.
- Trial name
- YogA (NCT01501344)
- Testing
- 200 g yogurt with fortified calcium content and MBP 80 mg
- Where
- Canada
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Groupe De Recherche En Rhumatologie Et Maladies Osseuses Inc.
Osteoporosis, Postmenopausal
Efficacy of OsteoBor in Postmenopausal Osteoporosis
This study aims to evaluate the impact of boron supplementation (OsteoBor) on bone health in postmenopausal women. The trial is a phase 2, randomised, double-blind, placebo-controlled study lasting one year
- Trial name
- NCT06809816
- Testing
- Sodium pentaborate pentahydrate
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tabriz University of Medical Sciences
Postmenopausal Osteoporosis
Study on the microRNA Expression Level in Postmenopausal Osteoporosis
The miRNA plays an important regulation role in gene expression, and also closely related to bone metabolism. Previous research found that postmenopausal osteoporosis with kidney Yin deficiency syndrome (POP) is associated with…
- Trial name
- microRNA (NCT02128009)
- Testing
- osteoporosis
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Fujian Academy of Traditional Chinese Medicine
Post-menopausal Osteoporosis
Bone Healing in Healthy and Post-menopausal Osteoporotic Women
Both the pathogenesis and the treatment of osteoporosis may potentially interfere at different levels on the multi-stage complex cascade of events involved in bone healing/regeneration.
- Trial name
- NCT01826656
- Testing
- tooth extraction, CBCT scan, DXA scan
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- University College, London
Osteoporosis, Postmenopausal, Periodontitis
Alterations of GCF Levels of Sclerostin and DKK-1 in Postmenopausal Osteoporosis
Symptoms of periodontal disease are tissue destruction and destruction of the alveolar bone which supports the tooth. Wnt way (wingless-type MMTV integration site family) plays a role in the regulation of bone homeostasis in…
- Trial name
- NCT04149405
- Testing
- Phase 1 periodontal therapy, Bisphosphonate therapy
- Volunteers
- 43 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Postmenopausal Bone Loss
Effects of Arzoxifene on Bone Mass and the Uterus
The purposes of this study are to determine: The effects of arzoxifene on bone mineral density (bone mass) at the spine and hip in postmenopausal women. The effects of arzoxifene on the uterus (womb) in postmenopausal women.
- Trial name
- NCT00085956
- Testing
- Arzoxifene
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Eli Lilly and Company
Osteoporosis, Postmenopausal, Bone Loss, Age-related
Effect of Blueberries on Bone Turnover
This study uses a bone labeling calcium tracer methodology to compare the dose-response effect of blueberry consumption on calcium retention and bone loss.
- Trial name
- NCT02630797
- Testing
- Blueberry Baseline, Blueberry Low, Blueberry Medium
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Purdue University
Postmenopausal Osteoporosis
Clinical Pharmacokinetics and Pharmacodynamics Study of Different Doses of Zoledronic Acid
The recommended dosing regimen of zoledronic acid in Chinese osteoporosis patients is completely in accordance with the one of 5 mg per year abroad that based on the dosing regimen in Paget's disease.
- Trial name
- NCT04719650
- Testing
- Zoledronic Acid Injection
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Osteoporosis, Postmenopausal
Effect of Mechanical Loading With PTH on Cortical Bone
Clinical trial to investigate effect of voluntary upper extremity loading in combination with anabolic osteoporosis therapy.
- Trial name
- NCT03232476
- Testing
- Upper extremity voluntary loading
- Volunteers
- healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Bone Density, Osteopenia
The Influence of Vibration on Bone Mineral Density in Women Who Have Weak Bones After Menopause
This study will examine whether whole-body vibration slows down bone loss in healthy postmenopausal women with osteopenia. Whole-body vibration is a promising novel therapy that involves standing on a platform which produces…
- Conditions
- Bone Density, Osteopenia, Osteoporosis, Post-Menopause
- Trial name
- NCT00420940
- Testing
- Juvent 1000 Dynamic Motion Therapy (DMT) Platform
- Where
- Canada
- Volunteers
- 202 people, healthy volunteers welcome
- Sponsor
- University Health Network, Toronto
Bone Loss, Osteoporosis
Single Ascending-Dose Study to Characterize the Safety, Pharmacokinetics, and Pharmacodynamics of CEP-37251 in Healthy Postmenopausal Women
Study to Characterize the Safety, Pharmacokinetics, and Pharmacodynamics of CEP-37251 in Healthy Postmenopausal Women.
- Trial name
- NCT01159873
- Testing
- CEP-37251
- Where
- Australia
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Cephalon