Clinical trials: Bone Loss
Dental Crowding, Alveolar Bone Loss
Bone Level Changes Using Clear Aligners Compared to Fixed Appliances in Non-Extraction Treatment of Adults
This study compares two common ways of straightening teeth in adults who have mild-to-moderate crowding of the lower front teeth and do not need any teeth removed: clear aligners and traditional fixed braces.
- Conditions
- Dental Crowding, Alveolar Bone Loss, Malocclusion
- Trial name
- NCT07716007
- Testing
- Fixed orthodontic appliance, Clear aligners
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Future University in Egypt
Osteoporosis, Inflammation
Synbiotic to Attenuate Resorption of the Skeleton
This randomized, double blind, placebo controlled clinical trial will test the efficacy of a probiotic/prebiotic combination ("synbiotic") on the skeleton in older women.
- Conditions
- Osteoporosis, Inflammation, Aging
- Trial name
- STARS (NCT06389539)
- Testing
- SBD111 medical food
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Hebrew SeniorLife
Tooth Loss, Dental Implant Failed
Investigation of the Effect of Horizontal Platelet Rich Fibrin Placed in Tooth Extraction Sockets on Bone Formation
Dental implants, the treatment of complete and partial edentulous cases involving the restoration of lost teeth, have become a registered and widely used treatment option.
- Conditions
- Tooth Loss, Dental Implant Failed, Alveolar Bone Loss
- Trial name
- NCT07011303
- Testing
- H-PRF, L-PRF
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Alveolar Bone Loss, Periodontal Diseases
Evaluation of the Effectiveness of Odontogenic Grafts Obtained From Human Teeth on Bone Formation
Tooth extraction triggers a cascade of biological events mediated by the local inflammatory response following surgical intervention and by the loss of masticatory stimulation to the periodontium.
- Conditions
- Alveolar Bone Loss, Periodontal Diseases, Periodontal Bone Loss, Periodontal Atrophy
- Trial name
- NCT07573761
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Osteoporosis
Denosumab Adherence Preference Satisfaction Study
The primary objective is to evaluate the adherence of subjects to subcutaneous (SC) 60 mg denosumab every 6 months (Q6M) treatment compared to oral 70 mg alendronate once a week (QW) treatment at the end of treatment period 1 (12…
- Trial name
- NCT00518531
- Testing
- alendronate, denosumab
- Volunteers
- 250 people
- Sponsor
- Amgen
Breast Cancer, Osteoporosis
Tamoxifen to Prevent Bone Loss and Heart Disease in Premenopausal Women Receiving Chemotherapy for Stage I or Stage II Breast Cancer
RATIONALE: Tamoxifen may be able to increase bone density and decrease cholesterol in women who are undergoing chemotherapy for breast cancer.
- Trial name
- NCT00005605
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Northwestern University
Sarcopenia, Osteopenia
Effect of a Ghrelin Receptor Agonist on Muscle and Bone
Adults with low muscle mass also usually have low bone mass, making them vulnerable to falls, fractures and other injuries. This project will determine the effectiveness of treatment with a ghrelin receptor agonist in improving…
- Trial name
- NCT04021706
- Testing
- Anamorelin Hydrochloride
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Tufts University
Arthrosis, Ankle Arthritis
Outcomes of Surgical Treatment Using a Custom-made Device for Total Ankle and Talar Replacement in the Management of Severe Cases of Bone Loss or Bone Compromise: a Pilot Study.
On February 17th, 2021, the FDA officially approved the use of the first patient-specific 3D-printed talar implant for compassionate use.
- Conditions
- Arthrosis, Ankle Arthritis, Ankle Replacement
- Trial name
- NCT07569848
- Where
- Italy
- Volunteers
- 26 people
- Sponsor
- Istituto Ortopedico Rizzoli
Obesity, Psoriatic Arthritis
Effects of Weight-loss Treatment in Obese Patients With Psoriatic Arthritis
The study is an open intervention study with the aim to determine the effects of weight-loss treatment with Low-Energy liquid Diet (LED) on disease activity, quality of life and markers of the metabolic syndrome in patients with…
- Conditions
- Obesity, Psoriatic Arthritis, Metabolic Syndrome, Psoriasis
- Trial name
- VIPsA (NCT02917434)
- Testing
- Very Low Energy Diet (VLED)
- Where
- 4 sites in Sweden
- Volunteers
- 90 people
- Sponsor
- Vastra Gotaland Region
Breast Cancer, Osteoporosis
Bone Density and Bone Loss in Postmenopausal Women With Breast Cancer Receiving Treatment in Clinical Trial IBCSG-1-98
RATIONALE: Diagnostic procedures, such as bone mineral density testing and x-ray, help measure bone loss in women receiving treatment for breast cancer. The test results may help doctors plan better treatment.
- Trial name
- NCT00369850
- Testing
- laboratory biomarker analysis, Dual energy X-ray absorptiometry (DEXA), Spine X-ray
- Where
- 16 sites in Australia, France and 6 more
- Volunteers
- 458 people
- Sponsor
- ETOP IBCSG Partners Foundation
Stress Reaction, Sleep Disturbance
Functional Assessment of Ashwagandaha Root Extract During Weight Loss
Patients who are involved in a clinical protocol driven 12 week medical weight loss intervention will be randomized to receive either a placebo or 600 mg of an ashwagandha root extract.
- Conditions
- Stress Reaction, Sleep Disturbance, Craving, Obesity
- Trial name
- NCT03112824
- Testing
- Ashwagandha Root Extract Capsule
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Osteopenia
Efficacy of a Probiotic Product on Bone Mineral Density (BMD) in Healthy Women in Early Post-menopausal Phase
The aim of the current study is to evaluate the efficacy of a probiotic product on bone mineral density (BMD) in healthy early post-menopausal women, compared to placebo.
- Trial name
- ProBone16 (NCT02722980)
- Testing
- : Probiotic capsules
- Where
- 2 sites in Sweden
- Volunteers
- 249 people, healthy volunteers welcome
- Sponsor
- Probi AB
Osteopenia, Osteoporosis
Feasibility of a Novel Resistance Exercise in Individuals With Osteoporosis
The aim of the 2 month randomized controlled trial is to investigate the feasibility of a novel progressive muscle resistance exercise in individuals with low bone mass.
- Conditions
- Osteopenia, Osteoporosis, Postmenopausal Osteoporosis, Sarcopenia
- Trial name
- NCT05060380
- Testing
- Exercise training
- Sponsor
- University of Alabama at Birmingham
Alveolar Bone Loss
Alveolar Ridge Augmentation Using Minimally Invasive Subperiosteal Tunneling With Xenogenic Bone Graft and PRF
surgical horizontal augmentation for maxillary alveolar ridge using minimally invasive subperiosteal tunneling in comparison to conventional surgical technique
- Trial name
- MISTT (NCT07079917)
- Testing
- subperiosteal tunneling for horizontal alveolar ridge augmentation, conventional alveolar ridge augmentation
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Fayoum University
Alveolar Ridge Preservation, Post Extraction Alveolar Bone Resorption
Comparison of Demineralized and Mineralized Dentin Grafts in Ridge Preservation
This clinical investigation aims to assess how two different allogeneic dentin graft materials - one de-mineralized and the other mineralized - influence bone preservation following extraction of a single upper posterior tooth.
- Trial name
- DDG-ARP (NCT07242313)
- Testing
- Demineralized Allogeneic Dentin Graft, Mineralized Allogeneic Dentin Graft
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Kafrelsheikh University
Osteopenia
Study to Evaluate the Safety and Efficacy of Seasonale for Treatment of Low Bone Mineral Density
This is a randomized, multicenter, placebo-controlled study to evaluate the effects of Seasonale, an extended-regimen oral contraceptive, on bone mineral density in adolescent females who have had their menstrual period but now…
- Trial name
- NCT00117260
- Testing
- Seasonale (levonorgestrel and ethinyl estradiol)
- Sponsor
- Duramed Research
Alveolar Bone Loss
Alveolar Ridge Preservation Techniques After Tooth Extraction
The aim of the present randomized controlled trial (RCT) was to evaluate the efficacy of different alveolar ridge preservation (ARP) techniques on hard tissue dimensional alterations after tooth extraction, based on clinical…
- Trial name
- NCT04934813
- Testing
- Alveolar ridge preservation
- Where
- Greece
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- National and Kapodistrian University of Athens
Periodontitis, Chronic, Periodontal Diseases
Effects of Antimicrobial Photodynamic Therapy on Regeneration of Class II Furcation Lesions
The aim of this study is to evaluate the additional effect of antimicrobial photodynamic therapy regeneration treatment of mandibular furcation lesions when associated to bovine bone and porcine collagen membrane.
- Conditions
- Periodontitis, Chronic, Periodontal Diseases, Periodontal Bone Loss
- Trial name
- NCT03264118
- Testing
- Scaling and root planing, Toluidine Blue O
- Where
- 2 sites in Brazil
- Volunteers
- 25 people
- Sponsor
- University of Sao Paulo
Osteopenia of Prematurity
Comparison of Two Different Doses of Vitamin D in Preterm Infants
randomized clinical trial comparing two different doses of vitamin d supplementation in preterm infants
- Trial name
- NCT03889717
- Testing
- vitamin D
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Cairo University
Bone Loss, Dental Implant
Immediate Versus Delayed Loading for Implants Retaining Mandibular Complete Overdenture
The aim of this study will be to compare the amount of marginal bone height changes between immediate and delayed loading for immediately inserted implants used as abutments of mandibular overdenture.
- Trial name
- NCT05620797
- Testing
- Immediate loading of the implants, Delayed loading of the implant
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Hams Hamed Abdelrahman