Clinical trials: Bone Loss in Jaw
Alveolar Bone Atrophy
Efficacy in Alveolar Bone Regeneration With Autologous MSCs and Biomaterial in Comparison to Autologous Bone Grafting
A randomized controlled clinical multi center trial to assess the efficacy of a combination of autologous mesenchymal stem cells and biomaterial in jaw bone regeneration prior to dental implant placement in comparison to standard…
- Trial name
- Maxibone (NCT04297813)
- Testing
- Advanced medicinal Therapy (MSC combined with biomaterial), Autologous bone graft
- Where
- 6 sites in Denmark, France and 2 more
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of Bergen
Bone Loss in Jaw
Demineralized Bone Allograft Fibers Versus Particulate In Sinus Augmentation
The purpose of this clinical trial is to assess if the addition of DFDBA fibers to DBBM results in greater vital bone formation than the addition of DFDBA particles to DBBM.
- Trial name
- NCT06173791
- Testing
- DFDBA fibers, DFDBA particles, DBBM
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center at San Antonio
Infection, Bone Loss
Evaluation of the Osteoinductivity of Atorvastatin Combined With β-TCP
This case series study aims to evaluate the local effects of Atorvastatin (which belongs to the family of lipid-lowering drugs, known as statins) combined with β-TCP (which is a synthetic osteoconductive bone graft), on the…
- Trial name
- NCT06382974
- Testing
- Cyst enucleation and bone grafting
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Alveolar Bone Loss, Edentulous Maxilla, Atrophic
Guided Bone Regeneration Combined With PRGF for Atrophic Edentulous Maxilla
This prospective interventional clinical study evaluated guided bone regeneration combined with plasma rich in growth factors for vertical and horizontal augmentation of the atrophic edentulous maxilla.
- Conditions
- Alveolar Bone Loss, Edentulous Maxilla, Atrophic, Alveolar Ridge Deficiency, Jaw Atrophy
- Trial name
- GBR-PRGF-Maxil (NCT07654218)
- Testing
- Guided Bone Regeneration Combined With Plasma Rich in Growth Factors
- Where
- Portugal
- Volunteers
- 11 people
- Sponsor
- Universidade do Porto
Women, Osteoporosis
Temporomandibular Disorders and Osteoporosis
Increased life expectancy has attracted research attention, interested in provide a quality and healthy aging. According to the latest census conducted in 2010 by IBGE, Brazilian population consists of 97,342,162 women, whom…
- Conditions
- Women, Osteoporosis, Osteopenia, Temporomandibular Disorder
- Trial name
- TMDOST (NCT01029210)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Pocket Depth, Attachment Loss
Clinical and Microbiological Outcomes of Dental Implants After 10-22 Years of Function
Aim: the aim of this retrospective study is to present long-term data (10+ years of functional loading) on the success and survival of ZimVie (3i) implants.
- Conditions
- Pocket Depth, Attachment Loss, Bone Loss in Jaw
- Trial name
- NCT06803576
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- Aristotle University Of Thessaloniki
Tooth-loss
The Use of Platelet-rich Fibrin (PRF) Membranes in Lateral Alveolar Ridge Augmentation When Jaw Bone is Missing Before Dental Implant Installation. A Study Comparing an Autogenous Bone Block Graft Covered Either by a (PRF) Membrane (Test) or Bone Substitute and a Barrier Membrane (Control)
Tooth loss can in many cases be treated with an artificial titanium root (dental implant) and subsequent manufacture of a porcelain crown.
- Trial name
- NCT04350749
- Testing
- PRF is added in the test group.
- Where
- Denmark
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Peri-Implantitis, Bone Loss in Jaw
An Evaluation of Salivary Oxidant and Antioxidant Levels in Peri-implant Health and Disease
Objectives: Inflammatory lesions develop in the tissues surrounding implants are referred to as peri-implant diseases. Oxidants, play a role in inflammatory lesions.
- Conditions
- Peri-Implantitis, Bone Loss in Jaw, Dental Implant Failed, Dental Implant Failure Nos
- Trial name
- NCT05724706
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Biruni University
Edentulous Maxilla, Maxillary Bone Loss
NobelZygoma TiUltra Implant System Study
The goal of this prospective study is to assess short term (12-months) clinical outcomes of NobelZygoma TiUltra implants and Multi-unit Abutment Xeal in the rehabilitation of participants with severely atrophic maxilla treated…
- Conditions
- Edentulous Maxilla, Maxillary Bone Loss, Atrophic Maxilla
- Trial name
- NCT07258940
- Testing
- NobelZygoma™ 0° CC TiUltra™implant ; NobelZygoma™ 45° Ext Hex TiUltra™ implant, Multi-Unit Abutment Xeal Zygoma Ext Hex RP; 17° Multi-Unit Abutment Xeal Zygoma Ext Hex RP; 45° Multi.Unit Abutment Xeal Zygoma CC RP; 60° Multi-Unit Abutment Xeal Zygoma CC RP
- Where
- 2 sites in Italy, Switzerland
- Volunteers
- 85 people
- Sponsor
- Nobel Biocare
Bone Loss in Jaw
Radiographic Evaluation of Bone Level Evaluation Around Implants in All on Four Hybrid OT Restorations With Different Number of Screws
This research aims to compare between using OT Equator abutments for constructing implant supported fixed mandibular prosthesis with different number of screws (3 screws vs 4 screws) regarding the marginal bone height alteration…
- Trial name
- NCT07360015
- Testing
- OT Equator abutments with 3 screws., OT Equator abutments with 4 screws.
- Where
- Egypt
- Volunteers
- 14 people
- Sponsor
- Ain Shams University
Bone Loss in Jaw
Evaluation of Melatonin and Metformin Loaded Nanoparticles in the Treatment of Periodontal Intra-bony Defects
The goal of this clinical trial is to assess the effectiveness of local delivery of melatonin and metformin loaded nanoparticle gel as adjunct to scaling and root planning (SRP) in the treatment of periodontal intra bony defect.
- Trial name
- NCT05906563
- Testing
- Melatonin gel, Metformin and melatonin gel, scaling and root planning
- Where
- Egypt
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Amira ragab
Laser Therapy, Periodontal Diseases
Odontogenic Graft Obtained From Human Tooth and Low Level Laser Therapy
This clinical trial aims to evaluate the effectiveness of an odontogenic graft obtained from extracted human teeth, with and without adjunctive low-level laser therapy (LLLT), on bone regeneration following posterior tooth…
- Conditions
- Laser Therapy, Periodontal Diseases, Bone Loss in Jaw, Alveolar Bone Loss
- Trial name
- NCT07615361
- Testing
- Autogenous Tooth-Derived Bone Graft, Low-Level Laser Therapy (LLLT)
- Where
- Turkey (Türkiye)
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University
Postmenopausal Osteoporosis, Osteopenia
Study Evaluating ASTRA TECH Implant System, OsseoSpeed™ Implants in the Upper Jaw in Women With Osteoporosis
The overall objective of the study is to compare treatment with the ASTRA TECH Implant System, OsseoSpeed™ implant in the maxilla of postmenopausal women with and without systemic osteoporosis.
- Conditions
- Postmenopausal Osteoporosis, Osteopenia, Jaw, Edentulous, Partially
- Trial name
- NCT00745121
- Testing
- OsseoSpeed™
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 103 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Jaw, Edentulous, Partially
Study on OsseoSpeed™ Implants in Patients Missing 2-5 Teeth in the Posterior Lower Jaw, Restored With Permanent Teeth Attached 6-7 Weeks Later
The purpose of the study is to evaluate Astra Tech Dental Implant System, Fixture Osseospeed™, in patients with tooth loss in the posterior mandible in an early loading protocol.
- Trial name
- NCT00711425
- Testing
- OsseoSpeed™
- Where
- 3 sites in United States, Germany
- Volunteers
- 45 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Jaw, Edentulous, Partially
Bacterial Microleakage and Bone Loss in Internal Connection Dental Implants Based on the Type of Abutment Used in Zirconia Partial Fixed Prosthesis: in Vivo Study
This clinical trial aims to observe if there are differences in bacterial micro-filtration on interfaces and to evaluate if there are differences in the occurrence of peri-implant diseases and bone loss in fixed partial…
- Trial name
- NCT06156111
- Testing
- Transepithelial abutment group, Direct to implant group
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Universidad Complutense de Madrid
Bone Loss in Jaw
Evaluation of Efficacy and Safety of Wishbone HA as Bone Graft Substitute, a Pre-market Clinical Investigation
Evaluation of efficacy and safety of Wishbone HA as bone graft substitute, a pre-market clinical investigation. Group1: Extraction Socket management Group 2: Sinus lift
- Trial name
- NCT04054219
- Testing
- Bone graft substitute
- Where
- Belgium
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wishbone SA
Bone Loss in Jaw
Immediate Loading With Provisional Prosthetic Restoration by Means of One Abutment at One Time and Temporary Abutment
This will be a prospective, randomized, controlled, single center clinical trial with 1 year enrollment period, surgical and prosthetic rehabilitation with 1-year post-loading follow-up.
- Trial name
- NCT05668494
- Testing
- immediate loading of implants
- Where
- Serbia
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Belgrade
Bone Loss in Jaw, Dental Implant Failure Nos
Marginal Bone Loss Around Mandibular Implant-retaining Overdentures and Implant Supported Fixed Hybrid Prosthesis
Few if any studies have compared marginal bone loss (MBL) around implant-retaining overdentures (2 implants with locators) versus implant supported fixed hybrid prosthesis (over 4 implants) in the mandible.
- Conditions
- Bone Loss in Jaw, Dental Implant Failure Nos, Dental Implant Failed
- Trial name
- NCT06488599
- Testing
- Peri-apical radiographs on the implants
- Where
- Lebanon
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Saint-Joseph University
Edentulous Jaw
Comparing Marginal Bone Loss for Immediately Loaded Implants in Maxillary Full Arch Interim Prosthesis Using Welded Titanium Bar Versus Polyetheretherketone Bar
Fourteen completely edentulous patients will be randomly allocated into two parallel arm groups. For both groups virtual implant planning will be done and surgical guide will be planned and printed.
- Trial name
- NCT06127017
- Testing
- splinting dental implants with titanium bar, splinting dental implants with PEEK bar
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Recession, Gingival, Bone Loss in Jaw
L-PRF vs Connective Tissue With Customized Healing Abutment in Immediate Implant Placement
comparison between L-prf and connective tissue with dental implant
- Trial name
- NCT07102758
- Testing
- L-PRF with dental implant and customized healing abutment, Connective tissue with dental implant and customized healing abutment
- Where
- Egypt
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Kafrelsheikh University