Clinical trials: Bone Marrow Transplantation
Thrombotic Microangiopathy, Disorder Related to Bone Marrow Transplantation
Identification and Treatment of Thrombotic Microangiopathies in Allogeneic Stem Cell Transplants
Mortality in the major thrombotic microangiopathies (TMAs), TTP and aHUS, exceeds 90% unless rapidly diagnosed and appropriately treated.
- Trial name
- NCT02604420
- Testing
- eculizumab
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Weill Medical College of Cornell University
Bone Marrow Transplantation
Fecal Microbiota Transplantation After HSCT
This research study is studying an intervention called fecal microbiota transplantation (FMT). Patients who are scheduled to undergo Hematopoietic Stem Cell Transplantation are invited to take part in this clinical trial to…
- Trial name
- NCT02733744
- Testing
- Fecal Microbiota Transplantation (FMT)
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Massachusetts General Hospital
Cancer, Allogeneic Peripheral Blood Stem Cell Transplant
An Exploratory Study of the Characteristics of and Challenges for International Families Seeking Medical Care in the United States
Background: State-of-the art care for children with cancer or rare diseases is not available in all countries. Owing to the proximity of Latin America and the growing numbers of Latinos already in the United States, many…
- Conditions
- Cancer, Allogeneic Peripheral Blood Stem Cell Transplant, Bone Marrow Transplantation
- Trial name
- NCT01211990
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Bone Marrow Transplantation, Sickle Cell Disease
Sickle Cell Disease Conditioning for Bone Marrow Transplant
Most bone marrow transplants for children with sickle cell disease are performed using high doses of two chemotherapy agents: busulfan and cyclophosphamide for the pre-transplant conditioning.
- Trial name
- NCT00968162
- Testing
- fludarabine
- Where
- 10 sites in United States
- Volunteers
- 8 people
- Sponsor
- Emory University
Family Caregivers, Bone Marrow Transplantation
Education Program to Manage Emotional Stress of Stem Cell Transplant Recipients and Their Caregivers
his study will evaluate a series of problem-solving education sessions for patients undergoing a stem cell transplant and their family caregivers.
- Trial name
- NCT00423774
- Testing
- Problem-Solving Education
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Bone Marrow Transplantation
An Adaptive Phase I Study to Evaluate the Safety, Efficacy and Dose Responses of Ronacaleret in Healthy Human Volunteers
Ronacaleret is an orally administered CaSR antagonist which has previously been demonstrated to transiently increase PTH in both animals and humans.
- Trial name
- NCT01466335
- Testing
- Ronacaleret (100mg tablet)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Acute Myeloid Leukemia, Disorder Related to Bone Marrow Transplantation
Early Tapering of Immunosuppressive Agents to Immunomodulation to Improve Survival of AML Patients
Early reduction of immunosuppressive agents after HLA matched donor transplantation can improve the survival of advanced stage acute myeloid leukemia. single-center, open clinical study
- Trial name
- NCT03150134
- Testing
- Cyclosporine, routine reduction of immunosuppressive drugs(cyclosporine)
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Blood And Marrow Transplantation, Leukemia
Cord Blood Fucosylation to Enhance Homing and Engraftment in Patients With Hematologic Malignancies
The goal of this clinical research study is to learn if it is safe and feasible to transplant changed cord blood for patients with leukemia or lymphoma. Researchers also want to learn if this can help to control the disease.
- Conditions
- Blood And Marrow Transplantation, Leukemia, Lymphoma, Transplantation Infection
- Trial name
- NCT01471067
- Testing
- Melphalan, Fludarabine, Mycophenolate mofetil
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- M.D. Anderson Cancer Center
Bone Marrow Transplantation
Early Versus Late Bronchoscopy in Bone Marrow Transplantation (BMT) Patients
This study will evaluate the outcomes of bronchoscopy in Bome Marrow Transplant (BMT) patients who develop lung infiltrates suspicious for infections of the lungs.
- Trial name
- NCT00846352
- Testing
- Variation in the time for performing bronchoscopy
- Where
- 3 sites in United States
- Volunteers
- 22 people
- Sponsor
- Wake Forest University Health Sciences
Stem Cell Transplantation, Bone Marrow Transplantation
Related Hematopoietic Stem Cell Transplantation (HSCT) for Genetic Diseases of Blood Cells
Many genetic diseases of lymphohematopoietic cells (such as sickle cell anemia, thalassemia, Diamond-Blackfan anemia, Combined Immune Deficiency (CID), Wiskott-Aldrich syndrome, chronic granulomatous disease, X-linked…
- Conditions
- Stem Cell Transplantation, Bone Marrow Transplantation, Peripheral Blood Stem Cell Transplantation, Allogeneic Transplantation
- Trial name
- NCT02512679
- Testing
- Cyclophosphamide Dose Level 1, Cyclophosphamide Dose Level 2, Cyclophosphamide Dose Level 3
- Volunteers
- 20 people
- Sponsor
- Children's Hospital Los Angeles
Graft Versus Host Disease, Bone Marrow Transplantation
Alemtuzumab and Cyclosporine for the Prevention of Graft vs Host Disease After Stem Cell Transplants
Graft versus host disease (GVHD) is one of the common complications after stem cell transplant. This is a complication, which happens when the new stem cells from the donor attack other cells in the body of the transplant…
- Trial name
- NCT00775632
- Testing
- Alemtuzumab, mycophenolate or cyclosporine and methotrexate
- Where
- Canada
- Volunteers
- 78 people
- Sponsor
- University Health Network, Toronto
Bone Marrow Transplantation, Blood Disease
Retention of Bone Marrow Donors in a National Registry
To identify factors that affected the National Marrow Donor Program's (NMDP) success in retention of bone marrow volunteers.
- Trial name
- NCT00005556
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bone Marrow Transplantation, Graft vs Host Disease
T-Cell Depletion in Unrelated Donor Marrow Transplantation
To determine if a reduction in morbidity and mortality from acute and chronic graft versus host disease (GvHD) can be achieved through use of T-cell depletion techniques without a counterbalancing increase in relapse of leukemia…
- Conditions
- Bone Marrow Transplantation, Graft vs Host Disease, Immunologic Diseases, Leukemia
- Trial name
- NCT00000591
- Testing
- lymphocyte depletion
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bone Marrow Transplantation, Blood Disease
Blood and Marrow Transplant Clinical Research Network
The purpose of this network is to accelerate research in hematopoietic stem cell transplantation by comparing novel therapies to existing ones.
- Conditions
- Bone Marrow Transplantation, Blood Disease, Hematopoietic Stem Cell Transplantation, Leukemia
- Trial name
- NCT00023530
- Testing
- fluconazole, voriconazole, bone marrow transplant
- Where
- 16 sites in United States
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Bone Marrow Transplantation
Assessment of CMV-specific ELISPOT Assay for Predicting CMV Infection in Bone Marrow Transplant Recipients (ACE-BMT)
CMV is one of the most important opportunistic infection in transplant recipients. In South Korea, more than 95% of adults reveal sero-positivity for CMV IgG.
- Trial name
- NCT02081716
- Where
- South Korea
- Volunteers
- 88 people
- Sponsor
- Asan Medical Center
Psychological Distress, Haematopoietic Stem Cell Transplantation
Psychological Intervention for Distress During HSCT
This Phase II trial aims to evaluate a new psychological intervention to alleviate distress during haematopoietic stem cell transplantation (HSCT) together with examining feasibility.
- Conditions
- Psychological Distress, Haematopoietic Stem Cell Transplantation, Bone Marrow Transplantation
- Trial name
- NCT02212236
- Testing
- Psychological preparation
- Where
- 2 sites in United Kingdom
- Volunteers
- 45 people
- Sponsor
- University of Nottingham
Bone Marrow Transplantation, Hematopoietic Stem Cell Transplantion
Glutamine Popsicles in Bone Marrow Transplant (BMT)/Hematopoietic Stem Cell Transplant (HSCT) Patients
Nutrition is an important part of the recovery process after having a head injury so that subjects can gain strength and fight off infection.
- Trial name
- NCT00204958
- Testing
- nutritional supplement, glutamine popsicle
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Wisconsin, Madison
Bone Marrow Transplantation, Cytomegalovirus
Valganciclovir in Prevention of Cytomegalovirus (CMV) Reactivation Following Allogeneic-Stem Cell Transplantation (SCT)
The rationale for this protocol is based on the need to assess if the current post stem cell transplantation CMV prophylaxis strategies (e.g.
- Trial name
- NCT00330018
- Testing
- Valganciclovir, Acyclovir
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Hadassah Medical Organization
Hematologic Malignancy, Bone Marrow Transplantation
Mindfulness Meditation in Bone Marrow Transplantation
The main purpose of this study is to examine techniques to help patients cope better with the stem cell/bone marrow transplant procedure.
- Conditions
- Hematologic Malignancy, Bone Marrow Transplantation, Stem Cell Transplantation
- Trial name
- NCT00165282
- Testing
- Mindfulness training, Nurse education
- Where
- 3 sites in United States
- Volunteers
- 241 people
- Sponsor
- Emory University
Malignancy, Bone Marrow Transplantation
Rifaximin for Preventing Acute Graft Versus Host Disease (AGVHD)
Acute graft versus host disease is a frequent and often life threatening complication of allogeneic blood and marrow transplantation. The bacteria that normally reside in the intestine play a critical role in its development.
- Trial name
- NCT00967096
- Testing
- Rifaximin
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Emory University