Clinical trials: Bone Mass
Spinal Cord Injury, Acute Spinal Cord Injury
Prevention of Bone Loss After Acute SCI by Zoledronic Acid
The overall objective of this study is to define an effective therapeutic approach, using currently available medication, to prevent or mitigate the loss of bone mass and bone strength that occurs after acute spinal cord injury.
- Conditions
- Spinal Cord Injury, Acute Spinal Cord Injury, Bone Loss, Osteoporosis
- Trial name
- NCT02325414
- Testing
- Zoledronic acid
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Northwestern University
Impacted Mandibular Third Molar
The Effect of Topical Application of Hyaluronic Acid and Melatonin Mixture Following Surgical Extraction of Impacted Mandibular Third Molars .
This randomized controlled clinical trial aims to evaluate the clinical and radiographical effects of the application of a mixture of hyaluronic acid and melatonin after surgical extraction of impacted mandibular third molars.
- Trial name
- NCT07735806
- Testing
- Hyaluronic acid and Melatonin mixture, Gel foam
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Kafrelsheikh University
Postmenopausal Osteoporosis, Postmenopausal Osteopenia
High Intensity Multi-Modal Exercise Training in Postmenopausal Women
in Pakistan 9.9 million people are osteoporotic and 7.2 million amongst them are women. Globally after every 3 seconds there is occurrence of fragility fracture.In Pakistan females carries different risk factors based on distinct…
- Trial name
- HIT-MMEX (NCT04653350)
- Testing
- High Intensity Exercises, General Exercises
- Where
- 2 sites in Pakistan
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Non-Small Cell Lung Cancer, Metastatic Melanoma
A Study to Investigate 14C-bemcentinib in Healthy Male Subjects
The aims of this Study were to determine: How much of the Study Drug (bemcentinib) ends up in urine and faeces How much of the Study Drug and its breakdown products get into the bloodstream The breakdown products (metabolites) of…
- Conditions
- Non-Small Cell Lung Cancer, Metastatic Melanoma, Acute Myeloid Leukemia, Myelodysplastic Syndromes
- Trial name
- 8479217 (NCT06469138)
- Testing
- Bemcentinib
- Where
- United Kingdom
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- BerGenBio ASA
Bone Resorption, Bone Regeneration
COMPARATIVE STUDY OF BONE IMPLANT CONTACT (BIC) ON NEW BONE REGENERATED WITH AUTOGENOUS DENTIN AND NATIVE BONE
The healing process after tooth removal involves bone remodelling which implies some loss of alveolar bone volume.Among materials proposed for minimising this remodelling and preserving the bone, autologous dental tissue is a…
- Trial name
- BIC (NCT06226116)
- Testing
- socket preservation, placement of experimental implants, histological sample collection
- Where
- Spain
- Volunteers
- 27 people
- Sponsor
- Universidad de León
Muscle Atrophy
Milk Versus a Pea-based Beverage for Bone and Muscle Health in Young Athletes
Canada's Food Guide places an increased emphasis on plant-based proteins; however, Canadians who consume a plant-based diet may be compromised because of intake of lower-quality protein.
- Trial name
- NCT05382026
- Testing
- Nutritional supplementation during a 6 month resistance training program
- Where
- Canada
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Osteoporosis, Nutrition
Validation of a Revised Food Frequency Questionnaire
The purpose of this study is to validate a revised food frequency questionnaire that is designed to capture vitamin D, calcium and protein intake in a population of elderly men and women with fragility fractures.
- Trial name
- FFQ (NCT02693184)
- Testing
- Full length Block 2014 Food Frequency Questionnaire, Revised Calcium, Vitamin D and Protein Screener
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- University of Nebraska
Rheumatoid Arthritis
Impact of Bone Mineral Density on Fracture Risk Assessment in RA
This study investigates whether incorporating bone mineral density (BMD) into FRAX calculations changes fracture risk assessment and influences treatment decisions in rheumatoid arthritis (RA) patients.
- Trial name
- NCT06718985
- Testing
- No intervention
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Multiple Sclerosis, Low Bone Density
Comparison of Bone Effects With Copaxone and Interferon in Multiple Sclerosis
The purpose of this study is to determine if certain drugs commonly used to treat multiple sclerosis have an effect on bone health.
- Trial name
- NCT00490906
- Testing
- Copaxone, Interferon-beta 1a, Interferon-beta 1b
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Nancy Hammond, MD
Bone Density, Gut Microbiomes
Linking Dietary Nutrition, Dietary Patterns, Gut Microbiota, and Bone Density: A Cross-Sectional Study
The study aims to understand the current situation of bone health in the Gannan Tibetan primary school student population, to explore the relationship between nutrition, intestinal microorganisms and bone health, to analyze the…
- Trial name
- NCT07256314
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 431 people, healthy volunteers welcome
- Sponsor
- Jianhua Ma
THA
Five-year Migration Pattern and Bone Mineral Density for the Tri-Lock and Summit Femoral Stems.
The incidence of primary hip joint prosthesis is 180 per. 100,000 inhabitants. In male patients younger than 50 years the 10-years survival of the prosthesis is 89 % and 82 % over 15 years.
- Trial name
- NCT06019026
- Testing
- Tri-Lock, Summit
- Volunteers
- 52 people
- Sponsor
- Regional Hospital Holstebro
Bone Health, Osteoporosis
Mediterranean Diet and Progressive Resistance Training Effects on BMD and Bone Turnover in the Elderly
This randomized controlled trial was designed to investigate the effects of progressive resistance training (PRT) combined with a Mediterranean diet on bone mineral density (BMD) and bone turnover markers (BTMs) in older adults.
- Trial name
- MED-RES-BONE (NCT07584785)
- Testing
- Mediterranean Diet combined with Resistance Training
- Where
- Italy
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Sfax
Impacted Third Molar Tooth
Assessment of Bone Density in Impacted Mandibular Third Molar
Preoperative radiograph will be taken to assess the type of impaction either mesioangular, horizontal, distoangular and check mouth opening. Two groups involve in my study.
- Trial name
- NCT05944939
- Testing
- Surgical extraction of impacted third molar
- Where
- 2 sites in Pakistan
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences
Osteogenesis Imperfecta
Whole Body Vibration Training in Children With Osteogenesis Imperfecta and Limited Mobility
Children with osteogenesis imperfecta (OI) have impaired bone strength, fractures, weak muscles and limited mobility. Mild to moderate forms of OI (type 1 and 4) may benefit from muscle training that leads to secondary…
- Trial name
- NCT03029312
- Testing
- Galileo M
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- Birmingham Women's and Children's NHS Foundation Trust
Spinal Cord Injury
Exoskeletal-assisted Walking Combined With Transcutaneous Spinal Cord Stimulation: Effect on Imaging and Serum Biomarkers of Skeletal Muscle Mass and Bone Strength.
Immobilization following spinal cord injury (SCI) results in muscle and bone loss below the level of injury, which ultimately predisposes to fracture at several sites throughout the legs and can lead to several medical…
- Trial name
- NCT07418398
- Testing
- Exoskeleton-Assisted Walking (EAW), Active Transcutaneous Spinal Cord Stimulation (tSCS)
- Where
- 2 sites in United States
- Volunteers
- 24 people
- Sponsor
- VA Office of Research and Development
Vertebral Fractures
Prevalence of Vertebral Fractures in HIV Infected Patients Older Than 50 Years
Prospective cohort study to determine the prevalence of vertebral fractures in HIV infected patients older than 50 years.
- Trial name
- FractaVIH (NCT02131571)
- Where
- Spain
- Volunteers
- 130 people
- Sponsor
- Fundacion para la Investigacion Biomedica del Hospital Universitario Ramon y Cajal
Hypovitaminosis D
Cholecalciferol and Calcifediol Are Both Useful to Improve Vitamin D Serum Levels
Patients with hypovitaminosis D are randomized into three arms of treatment: Group A: Calcifediol 0,266mg each month Group B: Cholecalciferol 25000UI each 15 days Group C: Calcifediol 4 drops per day.
- Trial name
- VITD (NCT06138249)
- Testing
- Vitamin D
- Where
- Italy
- Volunteers
- 90 people
- Sponsor
- Azienda Ospedaliero-Universitaria Consorziale Policlinico di Bari
Alagille Syndrome, Cholestasis
Study of Magnesium Sulfate in Children With Reduced Bone Density Secondary to Chronic Cholestatic Liver Disease
OBJECTIVES: I. Determine the role of magnesium deficiency in the pathogenesis of decreased serum vitamin D and reduced bone density in children with chronic cholestatic liver disease.
- Conditions
- Alagille Syndrome, Cholestasis, Biliary Atresia
- Trial name
- NCT00007033
- Testing
- magnesium gluconate, magnesium sulfate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Center for Research Resources (NCRR)
Osteoporosis
Association Between Isokinetic Lower Extremity Muscle Strength and Bone Mineral Density in Elderly Women With and Without Osteoporosis
bone density and muscle strength appear to be more related to each other. Examining the association between muscle strength and bone health is very important in recognizing risk factors for lower extremity muscle weakness.
- Trial name
- NCT07084857
- Testing
- correlational analysis between BMD and isokinetic lower extremity strength
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Bone Loss
A Prospective, Multicentre, Open-label Randomised Controlled Study to Investigate the Effectiveness of Pamidronate in the Prevention of Bone Loss in de Novo Renal Transplant Patients.
The purpose of the study was to evaluate the effect of Pamidronate on bone mineral density loss and fracture rates up to 2 years, in post renal-transplant subjects on a Ciclosporin A and glucocorticoid based immunosuppressive…
- Trial name
- SMART (NCT00738257)
- Testing
- Pamidronate
- Where
- United Kingdom
- Volunteers
- 126 people
- Sponsor
- Novartis Pharmaceuticals
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