Clinical trials: Bone Mass
Obesity, Adolescent
Myokines Role During Obesity
We showed, for the first time, that Z-score increase during obesity was dependent on sex, severity of obesity and age but also on the bone site.
- Trial name
- Bonamy (NCT02973867)
- Volunteers
- 150 people
- Sponsor
- University Hospital, Montpellier
Osteoporosis, Osteopenia, Hypercholesterolemia
Effect of Pitavastatin on Bone
This clinical trial investigates the effects of pitavastatin on bone health in postmenopausal women with osteopenia or osteoporosis and hypercholesterolemia.
- Conditions
- Osteoporosis, Osteopenia, Hypercholesterolemia, Menopausal Osteoporosis
- Trial name
- NCT06359353
- Testing
- Pitavastatin
- Where
- South Korea
- Volunteers
- 70 people
- Sponsor
- Seoul National University Bundang Hospital
Marfan Syndrome, Marfan Syndrome Cardiovascular Manifestations
Mortality and Morbidity Outcomes in Marfans
Marfan Syndrome (MFS) is a genetic disease affecting the eyes, skeleton, heart and arteries. Despite MFS affecting multiple organ systems, cardiovascular manifestations are the most serious and life threatening.
- Trial name
- NCT04774172
- Where
- United Kingdom
- Volunteers
- 6,700 people
- Sponsor
- Barts & The London NHS Trust
Age-Related Osteoporosis
Training in a Local Community Aimed Upon Musculoskeletal Health Promotion for Postmenopausal Women
To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength.
- Trial name
- NCT05164679
- Testing
- multimodal training (MMT)
- Where
- Denmark
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Osteoporosis
Cohort Study on Associations Between Purinergic Receptor SNPs and Osteoporosis Risk
Background: Osteoporosis is a high-prevalence disease with a strong genetic component. Nucleotides, including ATP (adenosine 5'-triphosphate) and its purinergic receptors, play a role in bone physiology.
- Trial name
- ATPBone (NCT00697983)
- Where
- Netherlands
- Volunteers
- 1,000 people
- Sponsor
- Maastricht University Medical Center
Osteoporosis
The Relationship Between Vitamin D, Fingernail Thickness and Bone Density
Vitamin D deficiency is common in the elderly and contributes to the increased incidence of falls, hip fracture and depression in this population.
- Trial name
- NCT00006196
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Center for Research Resources (NCRR)
HIV Infection, Osteopenia
Bone Mineral Density Changes in HIV-positive Females With Osteopenia Switching to Raltegravir
Given the high prevalence of bone alteration in the course of HIV infection or antiretroviral treatment and the favourable properties of raltegravir the investigators designed this pilot randomized and controlled study.
- Trial name
- RALBAT (NCT01902186)
- Testing
- raltegravir and atazanavir and ritonavir, tenofovir/emtricitabine and atazanavir and ritonavir
- Where
- 2 sites in Italy
- Volunteers
- 4 people
- Sponsor
- Giovanni Di Perri
Rare Diseases, Thoracic Aortic Aneurysm (TAA)
Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases
The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate…
- Conditions
- Rare Diseases, Thoracic Aortic Aneurysm (TAA), Marfan Syndrome
- Trial name
- FIBRA (NCT06786754)
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Osteoporosis
Building Better Bones in Children
Calcium is important for healthy bone growth in children. Poor bone growth and development during childhood can lead to osteoporosis later in life.
- Trial name
- NCT00063037
- Testing
- Behavioral modification - nutrition education
- Where
- United States
- Volunteers
- 139 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Osteoporosis
A Study of LY2541546 in Women With Low Bone Mineral Density
The primary objectives of this study include evaluating the dose response of LY2541546 using bone mineral density (BMD) change from baseline as compared to placebo and evaluating the overall safety and tolerability of LY2541546…
- Trial name
- NCT01144377
- Testing
- LY2541546
- Where
- 8 sites in United States, Denmark and 3 more
- Volunteers
- 154 people
- Sponsor
- Eli Lilly and Company
Vascular Calcification, Atherosclerosis
Association of Bone Quality and Quantity With Vascular Calcification
The purpose of this study is to determine if there is a link between calcium build up in the veins or arteries (including the veins/arteries of the heart) and deterioration of the bone.
- Conditions
- Vascular Calcification, Atherosclerosis, Bone Density
- Trial name
- NCT00892853
- Testing
- CT of the bones
- Where
- United States
- Sponsor
- University of Michigan
Postmenopausal Osteoporosis
Study Evaluating Bazedoxifene Dose-Response in Japanese Patients With Postmenopausal Osteoporosis.
Dose-response in Japanese patients with postmenopausal osteoporosis.
- Trial name
- NCT00238745
- Testing
- Bazedoxifene
- Volunteers
- 375 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Osteopenia Of Prematurity
A Preliminary Study of Bone Density in Neonates
The study is to measure how dense or solid the infant's bones are using a new ultrasound machine and how that density changes over time.
- Trial name
- NCT00631397
- Testing
- Ultrasound machine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Chronic Kidney Disease Requiring Chronic Dialysis, Osteoporosis
Association Between DXA Results and the Complications, Clinical Courses and Outcomes in Chronic Dialysis Patients
Aims: 1. To determine whether BMD and muscle mass were associated with fractures and other adverse events in dialysis patients. 2.
- Trial name
- NCT02616627
- Where
- Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Hepatitis C, Chronic, Liver Diseases
Influence of Antiviral Therapy on Bone Mineral Density and Metabolism in Patients With Chronic Hepatitis C
One single study has suggested that bone mineral density (BMD) is reduced in patients with non-cirrhotic chronic viral hepatitis C. Antiviral combination therapy with standard interferon and ribavirin may further decrease BMD.
- Conditions
- Hepatitis C, Chronic, Liver Diseases, Virus Diseases
- Trial name
- NCT00948220
- Testing
- peginterferon alfa-2a and ribavirin
- Where
- Germany
- Volunteers
- 26 people
- Sponsor
- University of Ulm
Postmenopausal Osteoporosis
Pharmacodynamics, Pharmacokinetics, Safety and Tolerability of PTH Analog Tablets in Postmenopausal Women
This study is designed to provide information about the bone anabolic properties and absorption profile of Unigene's PTH Analog when administered as oral tablets over a period of 24 weeks to postmenopausal women with osteoporosis.
- Trial name
- NCT01321723
- Testing
- PTH analog, Forsteo (Teriparatide)
- Where
- 4 sites in Denmark, Estonia
- Volunteers
- 97 people
- Sponsor
- Unigene Laboratories Inc.
Endometrial Cancer, Breast Cancer
Bone Mineral Density and Subsequent Cancer Risk
Recent cohort studies demonstrated reduced breast cancer risks among women with a history of fractures or low bone mineral density (BMD).
- Trial name
- NCT00340262
- Where
- United States
- Volunteers
- 15,595 people
- Sponsor
- National Cancer Institute (NCI)
Breast Cancer, Other Disorders of Bone Density and Structure
Impact of Chemotherapy Followed by Aromatase Inhibitors on Bone Health of Women With ER-positive Early Breast Cancer
The purpose of this study is to identify the combined impact on bone loss as well as the incidence of bone fractures in women with estrogen receptor (ER)-positive, early breast cancer treated with an aromatase inhibitor (AI)…
- Trial name
- POCHARBI (NCT01298362)
- Testing
- Aromatase Inhibitors, Chemotherapy
- Where
- Greece
- Volunteers
- 290 people
- Sponsor
- Hellenic Breast Surgeons Society
Effect of Treatment on Bone Mineral Density
Assessment of the Effects of Enclomiphene Citrate on Bone Mineral Density in Men With Secondary Hypogonadism
To determine the effects of 12 months of treatment with Androxal on bone mineral density in men with secondary hypogonadism.
- Trial name
- NCT01619683
- Testing
- enclomiphene citrate
- Where
- 17 sites in United States
- Volunteers
- 300 people
- Sponsor
- Repros Therapeutics Inc.
Prostate Cancer, Osteoporosis
Prevention of Osteoporosis in Men With Prostate Cancer
The purpose of this two year study is to examine the safety and effectiveness of alendronate (Fosamax) for the prevention of bone loss in men with prostate cancer who are on therapy to lower their testosterone levels.
- Conditions
- Prostate Cancer, Osteoporosis, Hypogonadism
- Trial name
- NCT00048841
- Testing
- alendronate
- Where
- United States
- Volunteers
- 112 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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