Clinical trials: Bone Mass
Muscle Wasting (Atrophy) After Hip Fracture Surgery
Study of Efficacy and Safety of Bimagrumab in Patients After Hip Fracture Surgery
The purpose of this study was to assess if bimagrumab is safe and effective in patients with muscle wasting (atrophy) after hip fracture surgery.
- Trial name
- NCT02152761
- Testing
- bimagrumab
- Where
- 53 sites in United States, Argentina and 17 more
- Volunteers
- 251 people
- Sponsor
- Novartis Pharmaceuticals
Systemic Sclerosis
Klotho and Mineral Bone Density in Systemic Sclerosis
The present study recruits female patients aged 45-65 years with a diagnosis of Systemic Sclerosis according to the EULAR/ACR 2013 criteria and age and gender-matched healthy control subjects.
- Trial name
- NCT05777954
- Testing
- Possible Klotho effects on SSc clinical conditions, namely skeletal, fibrotic and microangiopathic damage, Evalution in healthy patients of bone mineral density, Klotho level and key bone-related cytokines
- Where
- Italy
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Osteopenic Women
Effects of Turkish Traditional Dances on Postmenopausal Osteopenic Women
The aim of this study is to evaluate the effects of regular Turkish regional dances, in addition to conventional exercises given with a home program, on the quality of life, balance, aerobic capacity, bone mineral density…
- Trial name
- NCT07068113
- Testing
- DANCE GROUP, EXERCISE GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 81 people
- Sponsor
- Ankara Etlik City Hospital
Sarcopenia;, Osteoporosis
Effects of Whole-body Vibration in the Frail Elderly
Objective: To study the acute and chronic effects of whole-body vibration (WBV) exercises on the lower extremity blood flow, mobility function, balance, muscle strength, bone density, and general health status, and its…
- Trial name
- NCT02090192
- Testing
- WBV training, PRT training
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Li Zhang
Pain, Pain Postoperative
The Effects of Body Mass Index on Erector Spinae Plane Block Analgesia
In recent years, obesity has become one of the leading health problems worldwide. It is known that obesity can cause various diseases and negatively impact the quality of life.
- Conditions
- Pain, Pain Postoperative, Pain Acute, Erector Spinae Plane Block
- Trial name
- NCT06257953
- Testing
- Erector spinae plane block
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people
- Sponsor
- Atatürk Chest Diseases and Chest Surgery Training and Research Hospital
Bone Health
An Intervention Study to Investigate the Effect of B-vitamin Supplementation for 2-years on Bone Health
An intervention study to investigate the effect of B-vitamin supplementation for 2-years on bone health. This is a dual centre (UCD and University of Ulster) 2-year randomised, placebo controlled, double blind intervention.
- Trial name
- Opti-Age (NCT03892395)
- Testing
- B-vitamin supplementation on bone health, Control group; Vitamin D, a daily capsule containing 10 µg/day vitamin D
- Where
- Ireland
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University College Dublin
Osteopenia, Osteoporosis
Low-Dose Hormone Replacement Therapy and Alendronate for Osteoporosis
Osteoporosis, a condition in which bones are fragile and break easily, is a major health problem for postmenopausal women. Research studies have shown that both estrogen/progestin replacement therapy (hormone replacement therapy…
- Trial name
- NCT00000430
- Testing
- Alendronate, Estrogen/progestin therapy
- Where
- United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Marfan Syndrome, Aortic Dissection
Nutritional Ketosis Marfan
In this pilot clinical trial, the investigators will test whether a carefully supervised ketogenic diet can safely help people with Marfan syndrome who already have a chronic or residual aortic dissection.
- Trial name
- NCT07495267
- Testing
- Ketogenic diet
- Volunteers
- 15 people
- Sponsor
- Washington University School of Medicine
Weight Loss
A Comparative Effectiveness Study Evaluating the Effects of Thermogenic Supplements on Body Composition
The purpose of this study is to determine whether subjects taking a supplement designed to increase metabolic rate will have a positive effect on body composition (fat mass, muscle mass, and bone density.)
- Trial name
- NCT01423019
- Testing
- Advantra Z, Advantra Z + Naringin + Hesperiden, Sugar pill
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Integrative Health Technologies, Inc.
Osteoporosis, Postmenopausal
A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab
The purpose of this study is to determine if denosumab is effective in increasing bone mineral density at the lumbar spine in Indian postmenopausal women with osteoporosis.
- Trial name
- NCT01495000
- Testing
- denosumab
- Where
- 11 sites in India
- Volunteers
- 250 people
- Sponsor
- GlaxoSmithKline
Hip Fracture
Effects of Bisphosphonates and Nutritional Supplementation After a Hip Fracture
The study hypothesis is that nutritional supplementation together with bisphosphonates have a better preserving effect on bone mineral density (BMD) after hip fracture than bisphosphonates alone and that nutritional…
- Trial name
- NCT01950169
- Testing
- Risedronate, Nutritional supplement, Calcium and vitamin D3
- Where
- Sweden
- Volunteers
- 79 people
- Sponsor
- Karolinska Institutet
Lactation, Other Disorders of Bone Density and Structure
Longitudinal Lactation Bone Density Study
Changes in maternal calcium metabolism are necessary during lactation to provide adequate calcium in breast milk for development of the newborn skeleton.
- Conditions
- Lactation, Other Disorders of Bone Density and Structure, Endocrine; Complications
- Trial name
- NCT01630629
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Osteoporosis, Osteopenia
Effects of SHR-1222 on Vascular Inflammatory Factors in Patients With Low Bone Mass
This study aims to investigate the effects of SHR-1222 on vascular inflammatory factors in patients with low bone mass.
- Trial name
- NCT03898024
- Testing
- SHR-1222
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Second Xiangya Hospital of Central South University
Osteoporosis, Osteopenia
A Randomized, Double-Blind Study to Compare the Efficacy of Treatment With Denosumab Versus Alendronate Sodium in Postmenopausal Women With Low Bone Mineral Density.
The purpose of this study is to determine whether in postmenopausal women with low bone mineral density, the mean percent change in total hip BMD in subjects receiving denosumab is not less than that observed in subjects…
- Trial name
- NCT00330460
- Testing
- Alendronate, Denosumab
- Volunteers
- 1,189 people
- Sponsor
- Amgen
Overweight and Obesity, Body Composition
Aerobic Exercise and Body Composition in Overweight and Obese Boys.
Overweight and obesity are unhealthy fat accumulations. children aged 2-18 are deemed overweight if their body mass index (BMI)/Age is ≥ 85th - <95th percentile and obese if >95th percentile.
- Conditions
- Overweight and Obesity, Body Composition, Body Fat, Lean Body Mass
- Trial name
- NCT07586579
- Testing
- aerobic exercise
- Where
- Indonesia
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Universitas Sriwijaya
Psychiatry
Comparison of Bone Mineral Density Changes During Tx With Risperidone or Aripiprazole in Adolescents
This study examines if the use of antipsychotic medications might contribute to an interruption in bone mineral development and/or a reduction in bone mineral content in adolescents.
- Trial name
- NCT00573716
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Creighton University
Osteoporosis, Postmenopausal
Switching From Oral Bisphosphonates to Bazedoxifene to Evaluate Effects on Bone Mineral Density in Postmenopausal Women
The aim of this study is see the changes in bone mineral density after discontinuation or stop the use of bisphosphonates and make the switch to bazedoxifene).
- Trial name
- NCT02090400
- Testing
- Bazedoxifene, Calcium/Vit D
- Where
- 3 sites in Spain
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Instituto Palacios
Scoliosis, Vitamin D
6 Years Study on Changes in Bone Quality, Bone Turnover and Curve Severity in AIS With and Without Calcium and Vit-D Supplementation
The study aimed to: 1. To investigate and compare the changes in bone mineral density (BMD), trabecular bone micro-architecture, bone strength, and curve severity at a mean of 6 years longitudinal follow up in AIS girls with low…
- Conditions
- Scoliosis, Vitamin D, Bone
- Trial name
- NCT02904421
- Where
- China
- Volunteers
- 330 people
- Sponsor
- Chinese University of Hong Kong
Rothmund-Thomson Syndrome
Calcium Absorption in Patients With Rothmund-Thomson Syndrome
Osteosarcoma is the most common malignant bone tumor in children and adolescents. Because cure rates for osteosarcoma have remained stagnant for the past several decades despite numerous trials of chemotherapy agents, novel…
- Trial name
- NCT01304407
- Testing
- Calcium stable isotope
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- Baylor College of Medicine
Sarcopenic Obesity
Feasibility of At-Home Chair-Based Resistance Band Training to Improve Balance, Strength, and Bone Density in Older Adults
The purpose of this study is to determine the feasibility of implementing a 24-week at-home chair-based resistance band training intervention, to determine effectiveness of a the a 24-week at-home chair-based resistance band…
- Trial name
- ChaREx (NCT06671847)
- Testing
- THERABand resistance exercise bands
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- The University of Texas Health Science Center, Houston
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