Clinical trials: Bone Mass
Osteoporosis, Spinal Cord Injuries
Treatment With Romosozumab Versus Denosumab to Improve Bone Mineral Density and Architecture in Subacute SCI
The objective of the proposed work is to determine whether administration for 12 months of romosozumab followed by 12 months of denosumab will maintain bone mass at the knee in subjects with subacute SCI compared to 24 months of…
- Trial name
- NCT05101018
- Testing
- Romosozumab, Denosumab
- Where
- 2 sites in United States
- Volunteers
- 40 people
- Sponsor
- James J. Peters Veterans Affairs Medical Center
Healthy, Indicated for EOSedge Imaging
Bone Mineral Density Agreement Study Between EOSedge™ Versus Traditional DXA
The purpose of this research is to collect medical imaging data to allow for the comparison of bone mineral density measurements from two different types of low-dose x-ray exams, EOSedge and conventional DXA.
- Trial name
- NCT06659055
- Testing
- DXA Imaging, EOSedge imaging
- Where
- 4 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- Alphatec Spine, Inc.
Osteoarthritis
Bone Mineral Density (BMD) in Cemented Versus Cementless Hip Resurfacing
The purpose of this study is to compare the bone mineral density of patients who have undergone either cemented or cementless hip resurfacing.
- Trial name
- NCT01353326
- Testing
- Cormet, Conserve
- Where
- Canada
- Volunteers
- 120 people
- Sponsor
- Ottawa Hospital Research Institute
Osteoporosis
A Study of Prevention and Treatment of Postmenopausal Osteoporosis in Chinese Women
The purpose of this trial is to study the efficacy and safety of low dose of estradiol valerate in the prevention and treatment of postmenopausal osteoporosis.
- Trial name
- NCT00860964
- Testing
- estradiol valerate
- Volunteers
- 221 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College
Bone Loss, Osteoporosis
Effect of Bisphosphonate on Bone Loss in Postmenopausal Women With Breast Cancer Initiating Aromatase Inhibitor Therapy
Elderly, postmenopausal women with breast cancer on aromatase inhibitors are at increased risk of developing bone loss and osteoporosis.
- Conditions
- Bone Loss, Osteoporosis, Breast Cancer
- Trial name
- REBBeCA II (NCT00485953)
- Testing
- risedronate
- Where
- United States
- Volunteers
- 109 people
- Sponsor
- Susan L. Greenspan
Osteoporosis, Postmenopausal
A Comparison Study With Alendronate and Raloxifene in Postmenopausal Women With Osteoporosis (0217-189)
The purpose of this study is to compare how well alendronate and raloxifene increase the bone density in women who have osteoporosis and have experienced menopause.
- Trial name
- NCT00389740
- Testing
- MK0217, /Duration of Treatment : 12 Months, Comparator : raloxifene hydrochloride /Duration of Treatment : 12 Months
- Volunteers
- 400 people
- Sponsor
- Organon and Co
Low Bone Mineral Density
An Open-label, Single-arm Extension Study to Evaluate the Long-term Safety of Denosumab Administration in Postmenopausal Women With Low Bone Mineral Density
An Open-label, Single-arm Extension Study to Evaluate the Long-term Safety of Denosumab Administration in Postmenopausal Women with Low Bone Mineral Density
- Trial name
- NCT00325468
- Testing
- AMG 162
- Volunteers
- 200 people
- Sponsor
- Amgen
Total Hip Arthroplasty
A Clinical Trial of a Metal on Poly Component Versus CORAIL Stem: A Bone Mineral Density Study
The main goal is to prospectively evaluate bone mineral density adjacent to the femoral component and femoral bone remodeling of two different designs: CORAIL impaction broach titanium stem compared to a modular titanium femoral…
- Trial name
- NCT01558752
- Testing
- Total hip replacement with titanium shell and CORAIL stem, Total hip replacement with Modular Titanium Femoral Stem
- Where
- Canada
- Volunteers
- 88 people
- Sponsor
- Ottawa Hospital Research Institute
Anterior Cruciate Ligament Reconstruction (ACLR)
The Effect of Lateral Extra-Articular Tenodesis on Lower-Extremity Lean Mass Recovery Following Anterior Cruciate Ligament Reconstruction
The purpose of this study is to determine whether the addition of Lateral Extra-Articular Tenodesis (LET) influences postoperative lower-extremity LM recovery following bone-patellar tendon-bone (BTB) Anterior Cruciate Ligament…
- Trial name
- NCT07777458
- Testing
- Bone-patellar Tendon-bone (BTB), Bone-patellar Tendon-bone (BTB) and Lateral Extra-Articular Tenodesis (LET)
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Alabama at Birmingham
Cerebral Palsy
Functional Progressive Resistive Training and Cerebral Palsy
Functional Progressive Resistive Exercise (FPRE) is a strengthening approach that combines functional movement activities with progressively increased resistance.
- Trial name
- NCT07675343
- Testing
- functional progressive resistive exercise and designed physical therapy program, designed physical therapy program
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Rheumatoid Arthritis, Bone Density
Effect of Baricitinib Treatment on Peripheral Bone in RA
Patients with Rheumatoid Arthritis (RA) suffer systemic and peripheral bone loss. In this study we aim to test the efficacy of in-label treatment with Baricitinib on the volumetric bone mineral density in patients with RA over 52…
- Conditions
- Rheumatoid Arthritis, Bone Density, Finger Joints
- Trial name
- BAREBONE (NCT03701789)
- Testing
- Baricitinib
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University of Erlangen-Nürnberg Medical School
Osteoporosis
TST002 Intervenous Injection in Postmenopausal Women and Men With Reduced Bone Mineral Density
This is a placebo-controlled, single-ascending dose, multicenter Phase I clinical study to evaluate the safety, tolerability, PK and PD characteristics of a single intravenous infusion of TST002 in subjects with reduced bone…
- Trial name
- NCT05391776
- Testing
- TST002 Injection
- Where
- 5 sites in China
- Volunteers
- 32 people
- Sponsor
- HJB (Hangzhou) Co., Ltd.
Crohn's Enteritis, Crohn Disease
Impact of a Physical Activity Program on Bone Mineral Density in Children and Adolescents With Chronic Inflammatory Bowel Disease
Muscle and physical activity play an important role in in growth, development and bone health in healthy children, especially during puberty.
- Conditions
- Crohn's Enteritis, Crohn Disease, Ulcerative Colitis, Chronic; Colitis (Noninfective)
- Trial name
- PROPHYSICOS (NCT03774329)
- Testing
- Usual care, adapted physical activity
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Lille
Diabetes, Myocardial Infarction
Look AHEAD: Action for Health in Diabetes
The Look AHEAD study is a multi-center, randomized clinical trial to examine the long-term effects of a lifestyle intervention designed to achieve and maintain weight loss.
- Conditions
- Diabetes, Myocardial Infarction, Stroke, Kidney Diseases
- Trial name
- LookAHEAD (NCT00017953)
- Testing
- Lifestyle Intervention, Diabetes Support and Education
- Where
- 18 sites in United States
- Volunteers
- 5,145 people
- Sponsor
- Wake Forest University Health Sciences
Osteopenia
To Assess the Efficacy of Over-the-counter Analgesics in the Prevention/Treatment of Transient Post-dose Symptoms Following Zoledronate Infusion in Post-menopausal Women
Zoledronic acid is a medicine being studied in people with low bone mass. Side effects such as headache, fever, muscle aches, and pains, may occur following the infusion.
- Trial name
- NCT00145275
- Testing
- zoledronic acid
- Where
- 10 sites in United States, Australia and 3 more
- Volunteers
- 455 people
- Sponsor
- Novartis
Osteoporosis, Fracture Risk Assessment
Five-Year CT Follow-Up of Vertebral Fracture Risk Using Opportunistic Osteoporosis Screening
This study evaluates whether opportunistic osteoporosis screening using routinely acquired computed tomography (CT) scans improves fracture risk prediction compared with guideline-recommended FRAX-based screening from age 50.
- Conditions
- Osteoporosis, Fracture Risk Assessment, Osteoporotic Fracture of Vertebra
- Trial name
- NCT07487688
- Testing
- Opportunistic osteoporosis screening
- Where
- Germany
- Volunteers
- 2,799 people
- Sponsor
- Technical University of Munich
Osteoporosis, Electrical Stimulation
Increasing Bone Density by Application of Surface Electrical Stimulation
Bonestim system for osteoporosis treatment uses surface electrical stimulation of neuromuscular and skeletal tissue by multipad stimulation electrodes for inducing contractions of the spinal column muscles.
- Conditions
- Osteoporosis, Electrical Stimulation, Posture
- Trial name
- NCT02734719
- Testing
- Bonestim
- Where
- Serbia
- Volunteers
- 3 people
- Sponsor
- University of Belgrade
Breast Cancer
Tamoxifen Versus Anastrozole, Alone or in Combination With Zoledronic Acid
The primary objective is, first, the comparison of tamoxifen and anastrozole and, second, the comparison of zoledronate added to standard adjuvant therapy with controls according to disease-free survival (DFS) in premenopausal…
- Trial name
- NCT00295646
- Testing
- tamoxifen, anastrozole, zoledronic acid
- Where
- 72 sites in Austria, Germany
- Volunteers
- 1,803 people
- Sponsor
- Austrian Breast & Colorectal Cancer Study Group
Osteoporosis
GRACE II (General Retrospective Analysis of Commercial Experience With AGN1 LOEP)
The study is designed as a retrospective, multicenter study for subjects previously treated with the AGN1 LOEP Kit in the proximal femur as part of standard hospital practice. This will be a non-randomized and non-blinded study.
- Trial name
- NCT07594639
- Testing
- AGN1 LOEP
- Where
- Belgium
- Volunteers
- 305 people
- Sponsor
- AgNovos Healthcare, LLC
Osteogenesis Imperfecta
Effect of High-Dose Vitamin D on Bone Density in Osteogenesis Imperfecta
Overall Objective: To test the hypothesis that oral vitamin D supplementation at higher than currently prescribed doses has a beneficial effect on the skeleton of young patients with osteogenesis imperfecta (OI).
- Trial name
- NCT01713231
- Testing
- standard-dose vitamin D (400IU per day), high-dose vitamin D (2000 IU per day)
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Louis-Nicolas Veilleux Ph.D.
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