Clinical trials: Bone Microarchitecture
Liver Diseases, Transplant-Related Disorder
Liver Transplantation: Skeletal Effects
Fifty patients awaiting liver transplantation and 50 age and gender matched control subjects with normal liver function will be included in the study.
- Conditions
- Liver Diseases, Transplant-Related Disorder, Osteoporosis
- Trial name
- NCT03399227
- Volunteers
- healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes, Osteoporosis
Bone Health in Youth With Type 1 Diabetes
This is an observational study of children and young adults ages 6-20 years with type 1 diabetes and age- and race-matched controls.
- Trial name
- NCT02140424
- Where
- United States
- Volunteers
- 242 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Cystic Fibrosis
Bone Microarchitecture in Young Cystic Fibrosis Patients
Patients with cystic fibrosis are at risk of developing low bone mineral density (BMD) potentially leading to pathological fractures at adult age.
- Trial name
- NCT01788267
- Testing
- scan examination HR-pQCT
- Where
- France
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Hospices Civils de Lyon
Primary Hyperparathyroidism, Bone Disease
Bone Architectural Parameters in Postmenopausal Women Affected With Primary Hyperparathyroidism
Bone lesions are frequent in primary hyperparathyroidism (PHPT). Conventional measurement by Dual-Energy X-ray Absorptiometry does not provide enough information about the bone impact of excessive parathyroid hormone (PTH)…
- Trial name
- MicrOs (NCT02539498)
- Testing
- HR-pQCT
- Where
- 3 sites in France
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Osteopenia
Effects of Whole Body Vibration (WBV) on Musculoskeletal System of Aged Women
A controlled, non-randomized trial will be carried out in 240 postmenopausal women, aged 55-75 years, over a 18-month period. The group 1 received a physical intervention, consisting of whole body vibration (WBV) over 12 months…
- Trial name
- VIBROS (NCT01982214)
- Testing
- sedentary, Vibration
- Where
- France
- Volunteers
- 225 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne
Osteoporosis, Fracture
Bone Microarchitecture in Women With and Without Fracture
Osteoporosis is a common disorder of compromised bone strength causing 40-50% of women and ~25% of men to sustain fragility fractures during their lifetime.
- Trial name
- mMRI (NCT01049191)
- Where
- 2 sites in United States
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Prostate Cancer
Assessment of Bone Loss in Men Receiving Treatment for Prostate Cancer
The ANTELOPE trial is a longitudinal observational clinical study of changes in bone density, structure and strength over 12 months in men receiving treatment for prostate cancer.
- Trial name
- ANTELOPE (NCT02785627)
- Testing
- Comprehensive bone health assessment
- Where
- United Kingdom
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Prof Janet Brown
Bone Demineralization, Hypoestrogenism
The Kampala Women's Bone Study
The primary objective of this study is to address critical safety questions with concurrent TDF-based PrEP and DMPA use. We hypothesize that young women using TDF-based PrEP and DMPA will have lower bone acquisition and altered…
- Conditions
- Bone Demineralization, Hypoestrogenism, Subclinical Kidney Injury, Bone Microarchitecture
- Trial name
- NCT03464266
- Testing
- FTC/TDF and DMPA, FTC/TDF, DMPA
- Where
- Uganda
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- University of Washington
Primary Hyperparathyroidism, Bone Diseases, Metabolic
Radius Loading in Primary Hyperparathyroidism
The purpose of the study is to determine the effect of forearm exercise on forearm bone density in post-menopausal women with or without primary hyperparathyroidism.
- Conditions
- Primary Hyperparathyroidism, Bone Diseases, Metabolic, Osteoporosis, Postmenopausal, Bone Loss, Postmenopausal
- Trial name
- NCT01571843
- Testing
- Forearm exercise program, Walking program
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Columbia University
Postmenopause
Bone Microstructure in Nasal Salmon Calcitonin Treated Postmenopausal Women
Calcitonin has been used for many years for treating osteoporosis in postmenopausal women. Recent data from the 2 years placebo-controlled QUEST study have shown a preservation of microarchitecture as measured by high resolution…
- Trial name
- NCT00372099
- Testing
- Salmon calcitonin
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Rene Rizzoli
Bone Alteration, Dietary Modification
Efficacy of a Once Daily Calcium and Vitamin D Fortified Food Product to Improve Bone Microarchitecture
The primary objective of this randomized, double-blind, placebo controlled trial is to determine the efficacy of a once per day calcium (1000mg) and vitamin D (1000IU) fortified food product on bone turnover markers, including…
- Trial name
- NCT02375503
- Testing
- Calcium/Vitamin D
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- United States Army Research Institute of Environmental Medicine
Cystic Fibrosis
Bone Microarchitecture at the Radius: a Pilot Comparison Between Children With Cystic Fibrosis and Healthy Controls
Cystic fibrosis (CF) affects an estimated 30,000 people in the United States and is caused by a mutation in the gene encoding a protein called CF transmembrane regulator (CFTR).
- Trial name
- NCT01331980
- Testing
- Peripheral quantitative computed tomography (pQCT), Dual X-ray absorptiometry (DXA)
- Where
- United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Arkansas
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Exercise, Healthy
Bone and Body Composition Adaptations to Physical Training
The goal of this clinical trial is to evaluate how different exercise programs alter bone density, structure, and strength in adults.
- Trial name
- BoBCAT (NCT06972862)
- Testing
- Osteogenic Index Optimized Exercise Training Program
- Where
- 2 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Bone Regeneration
Teriparatide on Maxillary Sinus Floor Osseointegration
The aim of this triple blind randomized controlled trial will be to analyze the effect of a dose of teriparatide combined with a xenograft on bone augmentation of the maxillary sinus, to observe the microarchitecture of the newly…
- Trial name
- NCT06061354
- Testing
- Teriparatide, Maxillary Sinus Augmentation, Dental Implant Installation
- Where
- Chile
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Type 1 Diabetes Mellitus
Microarchitecture, Bone Strength and Fracture Risk in Long-term Type 1 Diabetes
This single center case control study will assess differences in bone structure between women and men with longstanding type 1 diabetes (diabetes duration>/= 25 years) and healthy controls.
- Trial name
- BOLD-1 (NCT03751839)
- Testing
- Biochemical Tests, Osteodensitometry, Clinical Tests
- Where
- Switzerland
- Volunteers
- 136 people, healthy volunteers welcome
- Sponsor
- Christian Meier
Cone Beam Computed Tomography, Periodontitis
Evaluation of the Effects of Smoking on Trabecular Bone Microarchitecture Using CBCT in Periodontal Disease
The purpose of this cross-sectional study is to evaluate the morphometric properties of trabecular bone quality using Cone-beam computed tomography in periodontal disease at different stages, comparing smokers and non-smokers.
- Conditions
- Cone Beam Computed Tomography, Periodontitis, Diagnosis of Bone Quality, Diagnosis, Oral
- Trial name
- NCT06676358
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Okan University
Osteoporosis, Postmenopause
The Effect of Mechanical Loading on Bone Material Strength and Microarchitecture in Postmenopausal Women
Osteoporosis is a large public health disease, characterized by low bone mass and micro architectural deterioration of bone tissue, resulting in enhanced bone fragility and consequent increase in fracture risk.
- Trial name
- NCT02339051
- Testing
- Jumping on one leg
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mattias Lorentzon
Bone Microarchitecture
Bone Microarchitecture in Women Practicing Golf
After the age of 50, one in three women and one in eight men will experience at least one fragility fracture during the rest of their lives.
- Trial name
- NCT02544399
- Testing
- 3D CT scan
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Saint Etienne