Clinical trials: Bone Nonunion
Long Bone Nonunion
Use of Adult Bone Marrow Mononuclear Cells in Patients With Long Bone Nonunion
The aim of the study is to determine the safety and feasibility of autologous mononuclear stem cells in long bone nonunion; and moreover, to evaluate the efficacy of the treatment.
- Trial name
- NCT01581892
- Testing
- Osteosynthesis
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Hospital Universitario Central de Asturias
Fracture Non Union, Infection
Antibiotic Loaded Calcium Sulfate RCT
This is a multi-centered, prospective, randomized controlled trial comparing current standard of care for defect management to placement of antibiotic loaded Stimulan as a bone void filler in patients undergoing treatment of…
- Trial name
- NCT03875963
- Testing
- Antibiotic loaded bone filler
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee, Fractures, Ununited
Modern Methods of Treatment and Diagnosis of Patients With Injuries and Diseases of the Musculoskeletal System
Brief Summary This clinical study investigates the safety and effectiveness of combining advanced regenerative therapies with personalized surgical technology for patients with delayed fracture healing (non-unions), knee…
- Conditions
- Osteoarthritis, Knee, Fractures, Ununited, Arthroplasty, Replacement, Knee
- Trial name
- MTDMS (NCT07628010)
- Testing
- Autologous Mesenchymal Stromal Cells Combined with Platelet-Rich Plasma, Patient-Specific 3D-Printed Surgical Instruments
- Where
- Ukraine
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Zaporizhzhiya State Medical University
Defective Composite Restorations, Bone Cysts
Bone Reconstruction With Autologous Bone Marrow Mesenchymal Stem Cells in Vitro to Repair Long Tubular Bone Defects
Commercial decalcified bone scaffolds were combined with autologous bone marrow mesenchymal stem cells to form tissue engineered bone in vitro to explore the effect of this tissue engineered bone in the clinical repair of long…
- Conditions
- Defective Composite Restorations, Bone Cysts, Bone Defect, Bone Nonunion
- Trial name
- NCT07066228
- Testing
- tissue-engineered bone
- Where
- China
- Volunteers
- 30 people
- Sponsor
- The First Affiliated Hospital of Xinxiang Medical College
Recalcitrant Lower Limb Nonunion
Prospective Study in Adults Evaluating Safety & Efficacy of NVD003 for Bone Reconstruction to Treat Lower Limb Nonunion
The goal of this clinical trial is to evaluate the safety and preliminary efficacy of the autologous 3D osteogenic implant NVD-003 for bone reconstruction for the treatment of recalcitrant lower limb nonunion.
- Trial name
- NCT06335394
- Testing
- NVD003
- Where
- 10 sites in Belgium, Luxembourg and 1 more
- Volunteers
- 11 people
- Sponsor
- Novadip Biosciences
Rheumatoid Arthritis, Osteoarthritis
A Single Centre Study to Assess the Long-term Performance of the Pinnacle™ Cup With a Ceramic-on-ceramic Bearing in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of the Pinnacle™ Cup with a ceramic-on-ceramic bearing combination in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872222
- Testing
- Pinnacle™ Acetabular System
- Where
- Czechia
- Volunteers
- 98 people
- Sponsor
- DePuy International
Infections, Infected Wound
PO vs IV Antibiotics for the Treatment of Infected Nonunion of Fractures After Fixation
This is a Phase III clinical randomized control trial to investigate differences between patient with an infected nonunion treated by PO vs. IV antibiotics.
- Conditions
- Infections, Infected Wound, Nonunion of Fracture, Injury Leg
- Trial name
- POvIV2 (NCT05699174)
- Testing
- Standard of Care PO (oral) antibiotics, Standard of Care Intravenous (IV) antibiotics
- Where
- 13 sites in United States
- Volunteers
- 250 people
- Sponsor
- Major Extremity Trauma Research Consortium
Fracture, Bone Nonunion
Safety and Exploratory Efficacy Study of UCMSCs in Patients With Fracture and Bone Nonunion
The purpose of the present study is to evaluate the safety and exploratory efficacy of the umbilical cord mesenchymal stem cells for patients with fracture and bone nonunion.
- Trial name
- NCT02815423
- Testing
- UCMSCs, Percutaneous
- Volunteers
- 40 people
- Sponsor
- South China Research Center for Stem Cell and Regenerative Medicine
Rheumatoid Arthritis, Osteoarthritis
A Study to Assess the Long-term Performance of SmartSet® HV and SmartSet® GHV Bone Cements in Primary Total Hip Replacement
The purpose of this study is to monitor the performance of artificial hip joints implanted with two different bone cements, SmartSet® HV and SmartSet® GHV, in the treatment of patients with hip joint disease requiring a total hip…
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872066
- Testing
- SmartSet® HV bone cement, SmartSet® GHV bone cement
- Where
- Slovakia
- Volunteers
- 243 people
- Sponsor
- DePuy International
Atrophic Nonunion of Fracture
Mesenchymal Stromal Cells for the Treatment of Non-union Fractures of Long Bones
The present study evaluates the effect of XCEL-MT-OSTEO-ALPHA in non-union fractures (pseudoarthrosis) of long bones in comparison to the standard treatment of autologous iliac crest.
- Trial name
- NCT02230514
- Testing
- XCEL-MT-OSTEO-ALPHA, autologous iliac crest, Surgery
- Where
- Spain
- Volunteers
- 19 people
- Sponsor
- Banc de Sang i Teixits
Tibial Fractures, Nonunion of Fracture
Intramedullary Bone Grafting for Open Tibial Shaft Fractures
This study will examine if there is a difference between the time to full union between the control group and the study group. Each group will be composed of patients who have an open fracture in the mid tibia.
- Conditions
- Tibial Fractures, Nonunion of Fracture, Delayed Union of Fracture
- Trial name
- NCT03891888
- Testing
- Intramedullary Bone Graft
- Where
- 2 sites in United States
- Volunteers
- 130 people
- Sponsor
- University of Louisville
Fractures, Bone, Fractures, Closed
Post Market Evaluation of Clinical Safety and Performance of the Fitbone Transport and Lengthening System
This is an open-label, prospective, observational, post-market, uncontrolled, multi-center study intended to evaluate the safety and clinical performance of the FITBONE Transport and Lengthening Nail when used according to the…
- Conditions
- Fractures, Bone, Fractures, Closed, Fractures, Open, Fracture of Femur
- Trial name
- NCT06400732
- Testing
- Fitbone Transport and Lengthening System
- Where
- 9 sites in United States
- Volunteers
- 1 people
- Sponsor
- Orthofix Inc.
Humerus Fractures
Serum-Protein-Based Indices for the Progression of Fracture Healing and Nonunion
To define a serum protein-based diagnostic for the progression and failure of fracture healing, through the identification of a set of serum proteins that appear at early times of biological healing and show a specific…
- Trial name
- UNION (NCT05143476)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Major Extremity Trauma Research Consortium
Nonunion of Fracture
Platelet-rich Plasma Combined With Conventional Surgery in the Treatment of Atrophic Nonunion of Femoral Shaft Fractures
To objectively analyze the effectiveness of platelet-rich plasma (PRP) combined with conventional surgery in the treatment of atrophic nonunion of femoral shaft fractures.
- Trial name
- NCT03129971
- Testing
- conventional surgery, autologous platelet-rich plasma
- Volunteers
- 92 people
- Sponsor
- Qinghai University
Bone Defect, Bone Nonunion
The Clinical Therapeutic Effects and Safety of Tissue-engineered Bone
The purpose of this study is to compare use of a tissue-engineered bone to use of a standard allograft bone to treat bone defect in patients.
- Trial name
- NCT02748343
- Testing
- allograft bone, tissue-engineered bone
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Nonunion Fractures
Treatment of Non Union of Long Bone Fractures by Autologous Mesenchymal Stem Cell
Treatment of nonunion, delayed union and malunion fractures of long bones remains problematic. The definition of nonunion is a failure of the fracture to heal in six months in a patient in whom progressive repair had not been…
- Trial name
- NCT01206179
- Testing
- cell injection
- Where
- Iran
- Volunteers
- 6 people
- Sponsor
- Royan Institute
Rheumatoid Arthritis, Osteoarthritis
A Two Centre Study to Assess the Stability and Long-term Performance of the C-Stem™ AMT in a Total Primary Hip Replacement
The purpose of this study is to monitor the stability of the C-Stem™ AMT hip within the thigh bone when used in the treatment of patients with hip joint disease requiring a total hip replacement.
- Conditions
- Rheumatoid Arthritis, Osteoarthritis, Post-traumatic Arthritis, Collagen Disorders
- Trial name
- NCT00872573
- Testing
- C-Stem™ AMT Femoral Component (standard and high off-set variants)
- Where
- United Kingdom
- Volunteers
- 5 people
- Sponsor
- DePuy International
Nonunion of Fracture
Evaluation the Treatment of Nonunion of Long Bone Fracture of Lower Extremities (Femur and Tibia) Using Mononuclear Stem Cells From the Iliac Wing Within a 3-D Tissue Engineered Scaffold
Because the rate of non union of long bone in lower extremities specially in tibia in this two last decade due to malnutrition and smoking and other risk factors was increased, so many patient in our country suffer from non…
- Trial name
- NCT01958502
- Testing
- surgical treatment of non union with mesenchymal stem cells with BMP2 within a 3-D tissue engineered scaffold
- Where
- Iran
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Emdadi Kamyab Hospital
Scaphoid Fracture
Vascularized Bone Grafts for Treatment of Scaphoid Nonunion
To assess the effect of vascularized bone grafting on the functional, clinical and radiological outcomes of the scaphoid nonunion
- Trial name
- NCT05358015
- Testing
- vascularized bone graft for scaphois nonunion
- Volunteers
- 25 people
- Sponsor
- Assiut University
Diaphyses
The Study of the Nonunion of Long Tubular Bone
The purpose of the study to supplied the diagnostic and treatment criteria of the nonunion of the long tubular bone after treatment of Intramedallery nailing
- Trial name
- NCT02338258
- Testing
- Anti-rotational plate, Exchanged Intramedullary nailing
- Where
- China
- Volunteers
- 82 people, healthy volunteers welcome
- Sponsor
- Beijing Jishuitan Hospital