Clinical trials: Bone Pain
Non-radiographic Axial Spondyloarthritis
A Study of Secukinumab to Evaluate Maintenance of Response in Participants With Non-radiographic Axial Spondyloarthritis Who Achieved Remission
This study will establish whether prolonged chronic dosing with secukinumab is needed in participants with Non-radiographic axial spondyloarthritis, (nr-axSpA) who have achieved remission.
- Trial name
- NCT05622708
- Testing
- Secukinumab
- Where
- 61 sites in Belgium, Brazil and 16 more
- Volunteers
- 240 people
- Sponsor
- Novartis Pharmaceuticals
Lumbar Spinal Stenosis, Lumbar Disc Herniation
Liposomal Bupivacaine in One-level Instrumented Posterior Spinal Fusion
This study will describe postoperative pain management for spine surgery patients receiving liposomal bupivacaine (Exparel®) compared to patients not receiving the drug.
- Conditions
- Lumbar Spinal Stenosis, Lumbar Disc Herniation, Lumbar Disc Disease, Lumbar Spondylolisthesis
- Trial name
- NCT03745040
- Testing
- Liposomal bupivacaine
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Allina Health System
Femoral Neck Fractures
Hemiarthroplasty or Internal Fixation for Displaced Femoral Neck Fractures
An estimated 1.6 million patients sustain a hip fracture every year, about half of these are intracapsular femoral neck fractures.
- Trial name
- NCT00464230
- Testing
- Bipolar hemiarthroplasty (Charnley/Hastings), Internal fixation with two parallel screws (Olmed)
- Where
- Norway
- Volunteers
- 220 people
- Sponsor
- Ullevaal University Hospital
Fracture of Distal Radius, Bone Fractures
Effectiveness of Pulsed Electromagnetic Fields and Nutraceutical Supplementation in Women With Distal Radius Fracture
This single-center randomized controlled trial tests whether adding a daily nutraceutical supplement to standard pulsed electromagnetic field (PEMF) therapy improves recovery after a recent distal radius (wrist) fracture in…
- Conditions
- Fracture of Distal Radius, Bone Fractures, Wrist Injuries
- Trial name
- NCT07352501
- Testing
- Pulsed Electromagnetic Field Therapy, Nutraceutical Supplement
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- University of Palermo
Degenerative Disc Disease
Trial for Treating Painful Degenerative Disc Disease
To evaluate and compare two platelet-based treatments of the functional spinal unit spaced 4 weeks apart to sham procedures for the treatment of degenerative disc disease.
- Trial name
- NCT05287867
- Testing
- Platelet-rich plasma (PRP), Platelet lysate (PL), and Platelet Poor Plasma (PPP)
- Where
- 2 sites in United States
- Volunteers
- 42 people
- Sponsor
- Regenexx, LLC
Postoperative Pain, Fracture Femur
Preoperative and Postoperative Comparison of Two Nerve Blocks in Intertrochanteric Fracture Surgery
Patients with intertrochanteric femur fractures experience significant perioperative and postoperative pain. Perioperative pain can complicate and prolong the anesthesia process for patients undergoing spinal anesthesia, leading…
- Trial name
- NCT07075432
- Where
- Turkey (Türkiye)
- Volunteers
- 84 people
- Sponsor
- Erzincan University
Lumbar Disc Herniation, Pain, Postoperative
mTLIP vs. ITP Blocks in Lumbar Disc Surgery
to compare ultrasonography (USG)-guided intertransverse process block and modified thoracolumbar interfascial plan (mTLIP) block in the treatment of postoperative pain in patients undergoing lumbar disc herniation surgery under…
- Conditions
- Lumbar Disc Herniation, Pain, Postoperative, Regional Aneshesia
- Trial name
- NCT06391541
- Testing
- modified thoracolumbar interfacial plan block (mTLIP), Intertransverse process block (ITP)
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Zonguldak Bulent Ecevit University
Degenerative Disc Disease, Low Back Pain
Effectiveness and Safety of Mesenchymal Stem Cell (MSC) Implantation on Degenerative Discus Disease Patients
This study evaluates the effectivity and safety of MSC implantation on Degenerative Disc Disease Patients by assessing visual analog scale, ROM improvement and MRI examination.
- Conditions
- Degenerative Disc Disease, Low Back Pain, Disc Degeneration
- Trial name
- MSC (NCT04499105)
- Testing
- Mesenchymal Stem Cell + NaCl 0,9% 2ml
- Where
- Indonesia
- Volunteers
- 10 people
- Sponsor
- Ahmad Jabir Rahyussalim
Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy
Evaluating The Use of CGF Made Gel in Mandibular Extraction Sites of Lower Impacted 3rd Molars.
The goal of this clinical trial is to learn if Concentrated Growth Factor (CGF) Gel help improve bone healing and reduce pain after the surgical removal of impacted lower third molars.
- Conditions
- Impacted Lower Third Molar, Alveolar Bone Regeneration Following Odontectomy, Postoperative Pain Management in Oral Surgery, Concentrated Growth Factor for Extraction Socket Healing
- Trial name
- CGF (NCT07520097)
- Testing
- Concentrated Growth Factor (CGF) Gel
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Leukemia, Aplastic Anemia
Methadone as an Alternative Treatment for Children Underdoing HSCT
Mucositis is a normal side effect of stem cell transplant which happens as a result of chemotherapy being given prior to a new donor cell infusion (bone marrow transplant).
- Conditions
- Leukemia, Aplastic Anemia, Bone Marrow Failure Syndromes, SCID
- Trial name
- MATCH (NCT06940570)
- Testing
- PCA plus methadone (Experimental), PCA Alone (SOC)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Texas Southwestern Medical Center
Low Back Pain
Serum Cytokine Levels in Patients with Lumbal Disc Herniation and Effectiveness of Exercise
The aim of the study is to investigate serum cytokine levels and the efficacy of lumbar stabilization exercises in patients with lumbar disc herniation with and without neurological deficits.
- Trial name
- NCT04912388
- Testing
- Lumbal stabilization excercises, Conventional exercises
- Where
- Turkey (Türkiye)
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Axial Spondyloarthritis, Back Pain
Spondyloarthritis Inception Cohort of Southern Denmark
People with axial spondyloarthritis (axSpA) experience a diagnostic delay of 6.5 years in men and up to 8.8 years in women. One of the reasons for the diagnostic delay seems to be limited awareness of the disease characteristics…
- Trial name
- SPINCODE (NCT06337513)
- Testing
- Rehabilitation intervention, Usual care
- Where
- Denmark
- Volunteers
- 250 people
- Sponsor
- The Danish Center for Expertise in Rheumatology
Bone Metastasis
Pain Management With Pecfent in the Prevention of Pain Induced by Position in Radiotherapy
The clinical trial is a stage 3 study to determine the role of fentanyl transmucosal in the prevention of pain induced by mobilization in patients receiving a bone metastasis radiation for bone metastasis irradiations
- Trial name
- PARABONE (NCT02426697)
- Testing
- fentanyl transmucosal
- Where
- France
- Volunteers
- 39 people
- Sponsor
- Centre Henri Becquerel
Ankle Fracture
Ankle Fracture Tourniquet Utilization
Lower extremity tourniquet utilization remains a controversial practice during the operative fixation of rotational ankle fractures and is often left to surgeon discretion.
- Trial name
- NCT06863688
- Testing
- Tourniquet, No Tourniquet
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Alex Demers
Pain, Bone Neoplasm
A Study of Loading Doses of Intravenous Bondronat (Ibandronate) in Patients With Breast Cancer and Metastatic Bone Disease.
This single arm study will assess the efficacy of loading doses of intravenous Bondronat in reducing pain in patients with breast cancer and metastatic bone disease experiencing moderate to severe bone pain.
- Conditions
- Pain, Bone Neoplasm, Neoplasm Metastasis
- Trial name
- NCT00478270
- Testing
- ibandronate [Bondronat]
- Where
- 6 sites in Greece
- Sponsor
- Hoffmann-La Roche
Breast Cancer, Metastatic Cancer
Radiation Therapy in Treating Patients With Bone Metastases From Breast or Prostate Cancer
RATIONALE: Radiation therapy uses high-energy x-rays to damage tumor cells. It is not yet known which radiation therapy regimen is more effective for bone metastases.
- Conditions
- Breast Cancer, Metastatic Cancer, Pain, Prostate Cancer
- Trial name
- NCT00003162
- Testing
- pain therapy, radiation therapy
- Where
- 253 sites in United States, Canada
- Volunteers
- 949 people
- Sponsor
- Radiation Therapy Oncology Group
Metastatic Malignant Neoplasm in the Bone, Metastatic Malignant Solid Neoplasm
Comparing Radiation Therapy to Usual Treatment for Patients With High-Risk Bone Metastases That Are Not Causing Pain, PREEMPT Trial
This phase III trial compares the effect of adding radiation therapy to usual treatment on the occurrence of bone-related complications in cancer patients with high-risk bone metastases that are not causing symptoms, such as pain…
- Trial name
- NCT06745024
- Testing
- Best Practice, Biospecimen Collection, Bone Metastases Treatment
- Where
- 626 sites in United States, Canada
- Volunteers
- 280 people
- Sponsor
- NRG Oncology
Plasma Cell Myeloma
Loratadine for the Reduction of G-CSF Induced Bone Pain in Patients With Multiple Myeloma Undergoing Stem Cell Mobilization
This early phase I trial studies how well loratadine works in reducing granulocyte-colony stimulating factor (G-CSF) induced bone pain in patients with multiple myeloma who are undergoing stem cell mobilization.
- Trial name
- NCT04211259
- Testing
- Loratadine, Questionnaire Administration
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Rutgers, The State University of New Jersey
Sacroiliac Joint Somatic Dysfunction, Sacroiliac; Spondylitis
Sacroiliac Joint Fusion Comparison Study
Patients diagnosed with chronic SIJ pain that can be treated by sacroiliac joint fusion or radiofrequency ablation. The radio frequency ablation is performed using either conventional or "cooled" techniques aimed at the S1-S3…
- Trial name
- NCT03230279
- Testing
- Sacroiliac joint fusion, Sacroiliac joint radiofrequency ablation
- Sponsor
- Ochsner Health System
Hip Fracture Surgery, Postoperative Pain Management
Comparison of Sacral Erector Spinae Plane Block and Supra-Inguinal Fascia Iliaca Block for Analgesia After Hip Fracture Surgery
This study compares the postoperative analgesic effectiveness of Sacral Erector Spinae Plane Block (SESPB) and Supra-Inguinal Fascia Iliaca Block (SIFIB) in patients undergoing hip fracture surgery.
- Conditions
- Hip Fracture Surgery, Postoperative Pain Management, Regional Anesthesia, Elderly Patients
- Trial name
- NCT07081867
- Testing
- Supra-inguinal Fascia Iliaca Block (SIFIB), Sacral Erector Spinae Plane Block (SESPB)
- Where
- Turkey (Türkiye)
- Volunteers
- 77 people
- Sponsor
- Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
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