Clinical trials: Bone Remodeling
Healthy, Females
The Combined Effect of Dairy and Exercise on Bone and Inflammation
This study analyzes whether dairy supplementation positively impacts loading exercise-induced bone cell activity and inflammation in healthy young females.
- Conditions
- Healthy, Females, Bone, Inflammation
- Trial name
- Cre-Ex-Inf (NCT03615989)
- Testing
- Resistance and Plyometric Exercise, Carbohydrate (Maltodextrin powder mixed with water), Skim Milk
- Where
- Canada
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- York University
Osteoarthritis, Hip
Femoral Remodeling Following Total Hip Arthroplasty With OMNI Apex Modular™ and OMNI Apex ARC™ Stem Compared to Competitive Designs
This study compares the change in bone density which occurs after hip replacement with different femoral stem devices.
- Trial name
- NCT01359540
- Testing
- OMNI Apex Modular™ Hip Device, OMNI Apex ARC™ Hip Device
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Healthy Adults
The Impact of Meal Frequency on Bone Remodeling in Healthy Adults
The study aimed to investigate the effect of meal frequency on bone remodeling using the marker Procollagen Type 1 N-terminal propeptide (P1NP).
- Trial name
- NCT06359483
- Testing
- Meal Frequency Manipulation
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Age-Related Osteoporosis
Training in a Local Community Aimed Upon Musculoskeletal Health Promotion for Postmenopausal Women
To minimize fracture risk, diverse and varied training of high intensity (multimodal training) is recommended to increase bone strength.
- Trial name
- NCT05164679
- Testing
- multimodal training (MMT)
- Where
- Denmark
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
Relapse, Bite Force
''Comparative Evaluation of Change in Bite Force and Levels of Bone Turnover Markers CTX and BALP in Hyperdivergent and Hypodivergent Cases During Retention Phases-A Prospective Clinical Trial ''
Long-term studies have shown that various occlusal changes occur after the active phase of orthodontic treatment. some of these changes are unwanted changes and are considered as relapse The retention appliances are used to…
- Conditions
- Relapse, Bite Force, Biomarker
- Trial name
- NCT06456827
- Testing
- Bite force and Gcf
- Where
- India
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Growth and Development
To Investigate the Impact of a Nutritional Supplement on Bone Turnover Markers in Indian Healthy Premenopausal Women (25- 45 Years) After 6 Months of Intervention
To investigate the effect of nutritional supplement on bone turnover markers (which are sensitive and respond quickly to nutrition or drug intervention) in Indian healthy premenopausal women after 6 months of intervention.
- Trial name
- NCT03155269
- Testing
- Fortified Beverage Powder, Non fortified beverage Powder
- Where
- India
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Peri-implant Bone Loss, Peri-implant Marginal Bone Loss
Evaluation of Fluid Biomarkers Around Implants Exhibiting Early Stage Periimplant Bone Loss
This study aimed to compare biological mediators known to be important in peri-implant diseases in implants with and without early stage marginal bone loss.
- Conditions
- Peri-implant Bone Loss, Peri-implant Marginal Bone Loss, Marginal Bone Loss, Peri-Implant Health
- Trial name
- NCT07584759
- Testing
- Collecting of peri-implant sulcus fluid, Periapical radiography
- Where
- Turkey (Türkiye)
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Pamukkale University
Alveolar Ridge Augmentation
Allograft Ridge Augmentation: 3D Analysis of CAD/CAM Custom Milled and Prefabricated Conventional Allogeneic Bone Blocks and Dental Implant Follow-up
To rehabilitate patients after the loss of their own teeth, dental implants are nowadays the therapy of choice if the indication is suitable.
- Trial name
- NCT06027710
- Testing
- Extensive alveolar ridge augmentation with allogeneic bone blocks; dental implant insertion in allogeneic bone graft
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Chronic Renal Insufficiency, Renal Osteodystrophy
Clinical Observation on Bone Metabolism Induced by Chronic Renal Insufficiency
Patients with chronic renal insufficiency usually develop secondary osteoporosis or bone loss, which is called renal osteodystrophy.
- Trial name
- NCT02147782
- Where
- 4 sites in China
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Shanghai University of Traditional Chinese Medicine
Healthy
The Safety and Efficacy of Recombinant Human Prolactin
Medications used to increase breast milk production increase prolactin secretion, the main hormone of lactation. There are no FDA approved medications used to improve breast feeding, but metoclopramide is used off-label and can…
- Trial name
- NCT00438490
- Testing
- Recombinant Human Prolactin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Osteoporosis Risk, Menopause
Rhythmic Estradiol and Bone Health
The goal of this randomized-controlled trial is to compare the effect of rhythmic estrogen treatment to continuous estrogen treatment on bone turnover in healthy postmenopausal women.
- Trial name
- REBEL (NCT05903820)
- Testing
- Estradiol patch, Progesterone
- Where
- Netherlands
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Postmenopausal Osteoporosis, Iron Metabolism Disorders
Association of Serum Ferritin and Bone Mineral Density With Bone Metabolism in Chinese Healthy Postmenopausal Women
Large amounts of experimental and animal evidence have confirmed that iron accumulation is associated with bone loss. However, it is still lack of the clinical studies relating iron accumulation to bone loss, especially in the…
- Trial name
- NCT03512743
- Where
- China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Healthy
Bioavailability of Vitamin D in Cod Liver Oil and Multivitamin Tablets in Healthy Subjects in Norway
The main aim of the present study is to compare the bioavailability of vitamin D from cod liver oil and multivitamin tablets given to healthy individuals under the same conditions, as well as to study the influence of gender and…
- Trial name
- NCT01482689
- Testing
- Fish oil capsule (specially manufactured for the study), Multivitamin tablet of type: Vitaplex ABCD
- Where
- Norway
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Oslo
To Assess the Changes in Markers of Bone Turnover Over a Six Month Period After Epidural Steroid Inject, To Assess the Changes in Bone Mineral Density
Effect of Epidural Steroid Injection on Bone Mineral Density in Postmenopausal Women
To evaluate for the effect of corticosteroid epidural injections on bone mineral density in postmenopausal women. Candidates for the study: Post menopausal women between the ages of 55 and 80. No history of bone disease.
- Trial name
- NCT00941473
- Testing
- Triamcinilone (kenalog)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Obesity, Inflammation
Long-term Investigation of Resveratrol in Obesity
The aim of this study is to investigate potential metabolic effects of resveratrol in men with metabolic syndrome(otherwise healthy).
- Conditions
- Obesity, Inflammation, Insulin Sensitivity, Osteoporosis
- Trial name
- LIRMOI (NCT01412645)
- Testing
- Resveratrol
- Where
- Denmark
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Osteoporosis, Frailty
Effects of DHEA/Exercise on Bone, Muscle and Balance
The purpose of this study is to examine whether muscle strength and balance will improve in women with frailty selected for dehydroepiandrosterone sulfate (DHEAS) levels below 550 ng/dl treated with DHEAS supplementation and…
- Trial name
- NCT00664053
- Testing
- DHEA, Yoga, Aerobics
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National Aeronautics and Space Administration (NASA)
Lactation
Bone Accrual and Hormones in Response to Lactation
This is a prospective observational trial of healthy postpartum women to investigate changes in bone density and markers of bone turnover during lactation.
- Trial name
- NCT01563094
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Dietary Proteins, Acute Exercise
Protein Ingestion on BMM Response in Endurance Runners
The goal of this clinical trial is to investigate the effects of protein ingestion post-exercise on bone turnover markers. The main questions it aims to answer is: Does protein ingestion independently influence the bone metabolic…
- Conditions
- Dietary Proteins, Acute Exercise, Bone Diseases, Metabolic
- Trial name
- BonePRO (NCT06645119)
- Testing
- Whey Protein Supplement
- Where
- Canada
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- McGill University
Intrabony Periodontal Defect
Comparison of the GTR Procedure Alone and in Combination With Immediate OTM
The aim is to evaluate in a prospective, randomized, controlled clinical study the healing of a GTR procedure, when it is combined with an immediate orthodontic tooth movement or used alone.
- Trial name
- NCT04896450
- Testing
- Guided tissue regeneration (GTR), Orthodontic tooth movement (OTM)
- Where
- Hungary
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Osteoporosis, Postmenopausal Bone Loss
Mediterranean Diet for Post-menopausal Women: Effects on Bone Turnover
The investigators propose a 24 week clinical research trial (12 week observational period followed by 12 week MedSD intervention) with feasibility of diet adoption and markers of bone turnover as the primary outcomes.
- Trial name
- MedSD (NCT01653275)
- Testing
- Mediterranean Diet
- Where
- United States
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- UConn Health