Clinical trials: Bone Remodeling
Skeletal Muscle, Extracellular Matrix
Effects of Essential and Non-Essential Amino Acids on Post-Exercise Muscle Collagen Synthesis in Young Men
The purpose of this study is to assess which amino acids are affecting acute muscle collagen synthesis in response to supplementation and exercise.
- Conditions
- Skeletal Muscle, Extracellular Matrix, Amino Acids Metabolism, Exercise
- Trial name
- PECS (NCT04596553)
- Testing
- Essential Amino Acid, Collagen Peptide
- Where
- Canada
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Bone Remodeling, Energy Metabolism
Retrospective Monocentric Evaluation of Biomarkers Associated With Bone, Muscle and Energy Metabolism
Bone is a metabolically active tissue undergoing continuous remodeling through the coordinated actions of osteoclasts (resorption), osteoblasts (formation), and osteocytes (regulation).
- Trial name
- OVAD (NCT07454252)
- Where
- Italy
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- IRCCS San Raffaele
Patient Adherence
Effect of Vitamin D Supplementation on Bone Turnover Markers During PrEP in MSM
CCTG 595 is an open-label clinical trial of the effect of a text messaging intervention vs. standard of care on adherence to Truvada as PrEP in MSM at increased risk for HIV infection (ClinicalTrials.gov Identifier: NCT01761643).
- Trial name
- CCTG595VitD (NCT02367599)
- Testing
- Vitamin D Supplement
- Where
- 3 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- University of California, San Diego
Osteoporotic Fractures, Osteoporosis, Postmenopausal
A 5-Year Follow-up Study Investigating Factors Associated With Osteoporotic Fracture in Chinese Postmenopausal Women
This proposed study was designed to investigate the prevalence of a 5-year incident osteoporotic fracture and evaluate the association of a 5-year change of 25-hydroxyvitamin D (25[OH]D)/bone turnover makers/bone mineral density…
- Trial name
- PK-VF (NCT02247011)
- Testing
- Questionaire survey, Bone mineral density examination, Vertebral fracture assessment
- Where
- China
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Laser Therapy, Orthodontic Tooth Movement
Laser Therapy on Orthodontic Tooth Movement
The aims of this study will be to evaluate if a Lower Level Laser Therapy (LLLT): (1) enhances the levels of important pro-inflammatory chemokines involved in the bone remodeling process; (2) increases the rate of orthodontic…
- Conditions
- Laser Therapy, Orthodontic Tooth Movement, Bone Remodeling
- Trial name
- NCT04070170
- Testing
- Low-level Laser Therapy, Orthodontic force
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ildeu Andrade Jr.
Dimensional Alterations
Dimensional Soft and Hard Tissue Alterations Following Single Tooth Extraction in the Anterior Maxilla - A Prospective Clinical Study
Bone modeling after tooth extraction has a major consequence on implant therapy, in particular in the esthetic zone. In esthetic sites, no tissue loss should occur if an optimal esthetic outcome is expected.
- Trial name
- Alterations (NCT02403700)
- Testing
- Cone beam computed tomography (CBCT)
- Where
- Switzerland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Bern
Health Adults
Acute Effects of High Impact Exercise on Bone Metabolism
The goal of this study is to investigate the acute effects of drop-landing exercise on the bone metabolism biomarkers and extracellular vesicles in healthy young males, in order to gain a deeper understanding of the…
- Trial name
- NCT07245225
- Testing
- Exercise
- Where
- United Kingdom
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Osteoporosis
Effects of Phytoestrogen-rich Diets on Bone Turnover in Postmenopausal Women
Osteoporosis is a major health problem. It was hypothesized that isoflavone-containing products may be a potential alternative to HRT for preventing bone loss during the menopausal transition.
- Trial name
- NCT00301353
- Testing
- Isoflavones-enriched foods
- Where
- 3 sites in France, Italy and 1 more
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- TNO
Hypercholesterolemia
The Effect Of Simvastatin On Bone Remodeling In Socket Of Mandibular Teeth
Simvastatin has been reported to promote osteoblastic activity and inhibit osteoclastic activity by enhancing the expression of BMP2.
- Trial name
- NCT01085149
- Testing
- Simvastatin
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Osteoporosis, Postmenopausal
Quercetin's Effect on Bone Health and Inflammatory Markers
Quercetin is a plant-based flavonoid that is naturally found in many fruits and vegetables, and is considered to be a potent antioxidant with several expected health benefits such as anti-inflammatory effects and bone-conserving…
- Trial name
- NCT05371340
- Testing
- Quercetin (500 mg)
- Where
- United States
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Kennesaw State University
Bone Health, Osteoporosis
Effects of Yoga on Bone Metabolism in Premenopausal Women
This study examined the effects of 8 months of Yoga training on bone density and bone turnover markers in premenopausal women, ages 35-50 years.
- Trial name
- NCT02163668
- Testing
- Yoga Group
- Where
- United States
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Fatigue, Inflammation
Effects of Post-exercise Protein Supplementation in Young Athletes
This randomised double blind, placebo-controlled study examined the effects of post-exercise consumption of whey protein (PRO) or carbohydrate (CHO) on performance recovery, muscle damage and inflammatory cytokine responses…
- Conditions
- Fatigue, Inflammation, Bone Resorption
- Trial name
- NCT04114045
- Testing
- Experimental:Whey protein, Active Comparator: Isoenergetic control - Carbohydrate
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Brock University
Other Disorders of Bone Development and Growth
Assessing the Impact of Contraceptives on Bone Health Using 41Ca
This preclinical randomized crossover study will examine the effects of oral versus non-oral contraceptive therapy on bone turnover in young exercising women.
- Trial name
- NCT02367846
- Testing
- Combined Oral Contraceptive (COC), Contraceptive Vaginal Ring (CVR)
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- Penn State University
Healthy Adults
The Impact of Meal Frequency on Bone Remodeling in Healthy Adults
The study aimed to investigate the effect of meal frequency on bone remodeling using the marker Procollagen Type 1 N-terminal propeptide (P1NP).
- Trial name
- NCT06359483
- Testing
- Meal Frequency Manipulation
- Where
- Jordan
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Jordan
Healthy
The Safety and Efficacy of Recombinant Human Prolactin
Medications used to increase breast milk production increase prolactin secretion, the main hormone of lactation. There are no FDA approved medications used to improve breast feeding, but metoclopramide is used off-label and can…
- Trial name
- NCT00438490
- Testing
- Recombinant Human Prolactin
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Vitamin D Deficiency
Vitamin D Intervention Trial in Healthy Chinese, Phase II
This is a double-blind, randomized, placebo-controlled trial. Based on inclusion and exclusion criteria, 400 eligible volunteers, who were 20-45 years, with 25-hydroxyvitamin D between 12.5-50 nmol/L and BMI between 18.5-28…
- Trial name
- NCT01998763
- Testing
- Vitamin D3
- Where
- China
- Volunteers
- 448 people, healthy volunteers welcome
- Sponsor
- Chinese Academy of Sciences
Missing Tooth, Osseointegration Failure of Dental Implant
X-space Implants in Post-extraction Sites.
Several recent systematic reviews have highlighted how the macrodesign of dental implants can influence stress distribution and biomechanical and biological behavior in implants immediately inserted in post-extraction sites.
- Trial name
- NCT04492111
- Testing
- post-extraction dental implant
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Bari
Osteopenia or Osteoporosis
The Effect of Pre-exercise Feeding on Bone Turnover Biomarkers
Osteoporosis is a major contributor to loss of independence due to bone fractures and resulting hospital treatments lead to significant morbidity.
- Trial name
- NCT06550466
- Testing
- Breakfast only, FAST, FED
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Dental Diseases, Dental Trauma
Using Digital Technology Versus Conventional Relining Procedure for Correction of Loose Maxillary Complete Denture
This study aimed to evaluate the use of computer added designning / computer added manufacturing (CAD/ CAM ) technology versus conventional relining procedure for treating ill-fitted loose maxillary complete denture and its…
- Conditions
- Dental Diseases, Dental Trauma, Bone Remodeling Disorder
- Trial name
- NCT06366321
- Testing
- relining technique, CAD/CAM milling technique
- Where
- Egypt
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- British University In Egypt
Dental Implant Bone Loss
A Randomized Controlled Clinical Trial to Assess Crestal Bone Remodeling of Four Different Implant Designs
This randomized controlled trial aimed to assess the effect of the implant neck design (microthreaded vs. non-microthreaded) as well as the type of abutment connection (internal conical vs.
- Trial name
- NCT06821308
- Testing
- Implant placement
- Where
- Belgium
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University Ghent