Clinical trials: Bone Substitute
Degenerative Disc Disease
Outcomes of Degenerative Disc Disease Patients Treated With an Anterior-Only Fusion Using InQu Bone Graft
The purpose of this study is to report the radiographic, clinical, and functional outcomes of a consecutive series of patients diagnosed with single or bilateral degenerative disc disease between L4 and S1, that have been treated…
- Trial name
- InQu (NCT01746212)
- Testing
- One-level or two-level anterior lumbar interbody fusion, InQu Bone Graft Extender and Substitute mixed with BMAC, Synthes Spinal Instrumentation
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Kansas Joint and Spine Institute
Sinus Implant Reconstruction
Performance and Safety of Bone Substitute MBCP-FS in Maxillary Sinus Lift Procedures
The purpose of this study is to evaluate the performance and to monitor the safety of the bone substitute Macroporous Biphasic Calcium Phosphate-Fibrin Sealant Vapor Heated Solvent/Detergent Treated 4 IU/ML Thrombin (MBCP-FS) in…
- Trial name
- NCT00163605
- Testing
- Macroporous Biphasic Calcium Phosphate-Fibrin Sealant Vapor Heated Solvent/Detergent Treated 4 IU/ML Thrombin (MBCP-FS)
- Where
- 3 sites in Germany
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Baxter Healthcare Corporation
Nasal Septum
Bone Substitute in the Multi Traumatized Nasal Septum Reconstruction
The aim of this project is to evaluate the safety and efficacy of the biomaterial made of HAP/TCP (BCP, Kasios®), in septoplasties of multi traumatized human nose.
- Trial name
- NASEPT (NCT01234415)
- Testing
- Rhinoplasty
- Where
- 3 sites in France
- Volunteers
- 26 people
- Sponsor
- University Hospital, Bordeaux
Bone Resorption
Bone Substitutes Outcomes - Post Market Follow-up
A Post-Market Clinical Follow-Up (PMCF) Study to collect clinical data on safety and performance of all TEKNIMED Bone Substitute range of products: CERAFORM, TRIHA+, NANOGEL, and all their private labels.
- Trial name
- NCT06374342
- Testing
- Bone defect, Spine fusion, Cage filling
- Where
- 6 sites in France, Germany
- Volunteers
- 425 people
- Sponsor
- Teknimed
Periodontitis
Evaluation of Advanced PRF Combined With Nano-crystalline Hydroxyapatite for Management of Grade II Furcation Defects
this study is to evaluate the use of advanced platelet rich fibrin (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement (OPD) versus open flap debridement alone in the management of…
- Trial name
- NCT03804086
- Testing
- Advanced PRF (A-PRF) + nano-crystalline hydroxyapatite bone substitute combined with open flap debridement, Open flap debridement
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Hadeer Ashraf Hassan Roushdy
Cancellous Bone Autograft, Bone Substitute
Cancellous Bone Autograft, Bone Substitute, Local Antibiotic, and Fresh Blood for Ununited Fixed Femoral and Tibial Fractures
This study aimed to assess the clinical and radiological outcomes of the usage of autogenous bone graft mixed with bone substitute, fresh blood of patient and local antibiotic used as an onlay graft in treatment of nonunion or…
- Conditions
- Cancellous Bone Autograft, Bone Substitute, Local Antibiotic, Fresh Blood
- Trial name
- NCT07561788
- Testing
- Revision using a composite graft
- Where
- Egypt
- Volunteers
- 25 people
- Sponsor
- Tanta University
Insufficiency Fractures, Stress Fracture
A Longitudinal Outcomes Study of the Subchondroplasty® Procedure in the Foot/Ankle
Post Market clinical outcomes study to collect data on the short - and long-term outcomes for subjects who are undergoing or who have undergone the Subchondroplasty Procedure in the foot and/or ankle in a standard clinical…
- Conditions
- Insufficiency Fractures, Stress Fracture, Stress Fracture, Ankle, Foot and Toes
- Trial name
- NCT03087396
- Testing
- Treatment of insufficiency fractures
- Where
- 12 sites in United States, Canada
- Volunteers
- 148 people
- Sponsor
- Zimmer Biomet
Marginal Bone Loss in Socket Shield Technique
Evaluate Marginal B. Loss in Immediate Implant Placement in Maxillary Esthetic Zone Using Socket Shield Versus Xenograft
Anterior maxilla (Esthetic zone) is very challenging area because of thin buccal plate of bone. After tooth extraction physiological process occur causing alteration of bone and soft tissue so, delayed placement of implant lead…
- Trial name
- NCT03394625
- Testing
- Socket shield technique, using Xenograft material
- Where
- Egypt
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cairo University
Jaw, Edentulous, Jaw, Edentulous, Partially
Comparison of Synthetic Bone Substitute and a Bovine-derived Xenograft in Horizontal Bone Augmentation
The objective of the study is to test the efficacy on bone formation of Straumann Bone Ceramic as a grafting material applied in buccal bone dehiscences on simultaneously placed oral implants.
- Trial name
- NCT00901017
- Testing
- Straumann BoneCeramic, Bio-Oss
- Where
- Belgium
- Volunteers
- 14 people
- Sponsor
- Institut Straumann AG
Cervical Disc Disorder With Radiculopathy, Spinal Stenosis
Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion
The goal of this clinical trial is to evaluate the safety and efficacy of the combination product "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene, in spinal fusion…
- Conditions
- Cervical Disc Disorder With Radiculopathy, Spinal Stenosis, Lumbar and Other Intervertebral Disc Disorders With Radiculopathy, Biomechanical Lesion, Unspecified
- Trial name
- NCT06365307
- Testing
- Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft"), Synthetic osteoplastic material based on β-TCP or bone autograft
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Histograft Co., Ltd.
Bone Augmentation
Evaluation of the Safety and Performance of the Neocement® Inject P: A Prospective Observational Study in Dental Area
This study aims to collect real-world clinical data to gather information on the performance and safety of the Neocement® Inject P when used according to its intended purpose and current clinical applications.
- Trial name
- NeoInjDent01 (NCT07179510)
- Where
- Portugal
- Volunteers
- 66 people
- Sponsor
- Bioceramed
Survival, Prosthesis, Bone Loss
Osteotome-mediated Sinus Floor Elevation With or Without Grafting Material
Implant placement in the posterior part of the maxilla is frequently compromised or impossible due to atrophy of the alveolar process and pneumatisation of the maxillary sinus.
- Conditions
- Survival, Prosthesis, Bone Loss, Patient Satisfaction
- Trial name
- NCT04618900
- Testing
- Sinus floor elevation with a grafting material
- Where
- Denmark
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Aalborg University Hospital
Bone Loss
Freeze-dried Bovine Hydroxyapatite/Secretome Composite for Bone Defects
This clinical trial aims to investigate the efficacy of freeze-dried bovine hydroxyapatite/secretome composite application for the management of long bone defects and other bone healing disorders in the lower extremities.
- Trial name
- NCT04980261
- Testing
- ORIF + autograft, ORIF + FD BHA/Secretome
- Where
- Indonesia
- Volunteers
- 32 people
- Sponsor
- Dr. Soetomo General Hospital
Periodontitis, Bone Defects
The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.
The main aim will be to evaluate the difference in PD changes at 12-month follow-up, measured from the gingival margin to the base of the pocket, comparing periodontal regeneration using two different bone substitutes, that is…
- Trial name
- OSSIXPERIO (NCT07546279)
- Testing
- EMD + collagenated DBBM, EMD + hydroxyapatite collagen matrix
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Osteomyelitis Chronic
Evaluation of the Efficiency of the Bone Substitute Cerament-G Locally Delivering Gentamicin in the Treatment of Chronic Osteomyelitis of Long Bones
Chronic osteomyelitis is a serious osteoarticular infection that most often occurs in the long bones (tibia, femur, humerus), responsible for significant morbidity with risk of fracture and amputation.
- Trial name
- CONVICTION (NCT04805164)
- Testing
- Corticotomy and use of the bone substitute : Cerament-G device., Corticotomy
- Where
- 15 sites in France
- Volunteers
- 220 people
- Sponsor
- Hospices Civils de Lyon
Bone Cysts, Bone Atrophy
Gene-activated Bone Substitute for Maxillofacial Bone Regeneration
The purpose of this study is to evaluate the safety and efficacy of the gene-activated bone substitute consisting of octacalcium phosphate and plasmid DNA encoding vascular endothelial growth factor (VEGF) for maxillofacial bone…
- Conditions
- Bone Cysts, Bone Atrophy, Bone Deformity, Bone Fracture
- Trial name
- NCT03076138
- Testing
- Gene-activated matrix (OCP + plasmid DNA with VEGF gene)
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- Histograft Co., Ltd.
Alveolar Process
Evaluation of a Synthetic Bone Substitute for Ridge Preservation
Fifteen patients were selected, each presenting at least two jaw front teeth indicated for extraction: in the Test Group (TG), post-extraction sockets was filled by synthetic bone substitute ReproBone, and in the Control Group…
- Trial name
- NCT02894528
- Testing
- BioMend and ReproBone, BioMend without ReproBone
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Intrabony Periodontal Defect
The Influence of Citric Acid Bone Surface Etching and Bone Defect Fill on GCF BMP-2 Release Profile
This study evaluates the effect of citric acid on bone surface of infrabony defects when used for 30 seconds at ph 1 and 50% concentration before the application of bovine derived xenograft to fill the defect, Bone Morphogenic…
- Trial name
- NCT03769402
- Testing
- Citric acid, Control Test
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Alveolar Ridge Enlargement
Leukocyte-platelet Rich Fibrin for Alveolar Ridge Preservation
After tooth extraction, there is a subsequent bone loss as a part of the natural healing of the tissue. Up to 50% of bone loss occurs during the first three months after extraction, jeopardizing a possible implant treatment.
- Trial name
- L-PRF (NCT05572242)
- Testing
- Premolar extraction and socked preservation with L-PRF, Premolar extraction and socked preservation with Xenogenic bone and collagen membrane.
- Where
- Chile
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Bone Regeneration, Safety Issues
Evaluation of Performance, Safety and Benefit of the Wishbone HA as Bone Graft Substitute, a Pre-market Clinical Investigation
This investigation is a pre-market, prospective, multi-center, randomized, single blinded, parallel controlled clinical investigation performed in at least 5 clinical centers for confirmatory purposes of the use of WHA as…
- Trial name
- NCT06383377
- Testing
- Tooth extraction and bone graft procedure
- Where
- 5 sites in Belgium
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Wishbone SA