Clinical trials: Bone Substitute
Bone Marrow Edema, Knee Pain Chronic
Subchondroplasty® Knee RCT
This is a multi-center, prospective, single-blinded, two-arm study, randomized to include approximately 134 subjects treated with Subchondroplasty (SCP) + Arthroscopy and 67 subjects with arthroscopy alone.
- Conditions
- Bone Marrow Edema, Knee Pain Chronic, Knee Osteoarthritis, Osteoarthritis, Knee
- Trial name
- PRESERVE Knee (NCT03112200)
- Testing
- Subchondroplasty with Arthroscopy, Arthroscopy Alone
- Where
- 13 sites in United States, Canada
- Volunteers
- 131 people
- Sponsor
- Zimmer Biomet
Cervical Disc Disorder With Radiculopathy, Spinal Stenosis
Comparative Study of Gene-Activated Bone Substitute "Histograft" for Lumbar and Cervical Spinal Fusion
The goal of this clinical trial is to evaluate the safety and efficacy of the combination product "Histograft", a bone substitute based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA gene, in spinal fusion…
- Conditions
- Cervical Disc Disorder With Radiculopathy, Spinal Stenosis, Lumbar and Other Intervertebral Disc Disorders With Radiculopathy, Biomechanical Lesion, Unspecified
- Trial name
- NCT06365307
- Testing
- Osteoplastic material based on octacalcium phosphate and biologically active nucleic acids for bone tissue regeneration Nucleostim-VEGF ("Histograft"), Synthetic osteoplastic material based on β-TCP or bone autograft
- Where
- Russia
- Volunteers
- 300 people
- Sponsor
- Histograft Co., Ltd.
Alveolar Bone Loss, Periodontal Diseases
GUIDOR® Growth Factor Enhanced Bone Graft Substitute for the Treatment of Periodontal Defects 6-months Post-Surgery
GUIDOR Growth Factor Enchanted Bone Graft Substitute (GFeBGS) when used in periodontal surgery will shown greater gum and bone regeneration when compare to bone graft substitute alone. Also, to find the optimal dose.
- Trial name
- NCT01728844
- Testing
- beta-tricalcium phosphate alone, GFeBGS 0.1%, GFeBGS 0.3%
- Where
- 6 sites in United States
- Volunteers
- 88 people
- Sponsor
- Sunstar Americas
Maxillary Sinus Floor Augmentation, Dental Implant
Evaluation of Sinus Augmentation Bone Healing Using Autograft and Xenograft Compared to Xenograft Alone
To evaluate bone healing at 4 months after lateral sinus augmentation with a 4:1 ratio of autologous bone and xenograft or xenograft alone. A radiographic volumetric, histomorphometric, and histologic analysis.
- Conditions
- Maxillary Sinus Floor Augmentation, Dental Implant, Bone Substitute, Autogenous Bone Graft
- Trial name
- NCT06247098
- Testing
- Sinus Lift augmentation, Cone-beam computed tomography systems (CBCT)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tufts University
Alveolar Ridge Preservation
Novel Porous Bioceramic Material as a Bone Substitute
The aim of this study is to demonstrate that new synthetic bone graft bioceramic composites (Adaptos®-Si and Adaptos®, Biomendex Oy) are able to support the preservation of the alveolar ridge and to promote bone regeneration…
- Trial name
- NCT04719624
- Testing
- Adaptos®-Si [0.5-1 mm] (bone grafting surgery), Adaptos®-Si [1-2 mm] (bone grafting surgery), Geistlich Bio-Oss (bone grafting surgery)
- Where
- Finland
- Volunteers
- 76 people
- Sponsor
- Orton Orthopaedic Hospital
Osteoarthritis, Knee
Outcome Comparison of Allograft and Synthetic Bone Substitute in High Tibial Osteotomy
This study is conducted to determine whether a new synthetic bone substitute is better than allogenic bone graft for addressing bone defect in medial open wedge high tibial osteotomy in terms of postoperative pain, postoperative…
- Trial name
- NCT02000297
- Testing
- Allogenic bone graft, Synthetic bone substitute (geneX®)
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Seoul National University Hospital
Periodontitis, Bone Defects
The Use of Two Bone Substitutes in Adjunct to EMD for the Treatment of One- and Two-wall Intrabony Defects.
The main aim will be to evaluate the difference in PD changes at 12-month follow-up, measured from the gingival margin to the base of the pocket, comparing periodontal regeneration using two different bone substitutes, that is…
- Trial name
- OSSIXPERIO (NCT07546279)
- Testing
- EMD + collagenated DBBM, EMD + hydroxyapatite collagen matrix
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- I.R.C.C.S Ospedale Galeazzi-Sant'Ambrogio
Periodontitis
Clinical and Biochemical Assessment of Ozonated Olive Oil Mixed Bone Substitute in Treating Intra Bony Periodontal Defect
The goal of this study is to investigate the effect of ozonated olive oil in treating intra bony defect by means of clinical and radiographic parameters, and gingival cervicular fluid BMP2 level.
- Trial name
- NCT05655923
- Testing
- ozonized olive oil, xenograft bone substitute
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Lumbar Spine Disease, Lumbar Spondylolisthesis
OSTEOAMP Lumbar Fusion Intra-Patient Controlled Study
The objective of this clinical study is to compare OSTEOAMP SELECT Fibers to Infuse Bone Graft, in terms of effectiveness and safety, when used as a bone graft substitute in in skeletally mature patients qualified for 2-lumbar…
- Conditions
- Lumbar Spine Disease, Lumbar Spondylolisthesis, Lumbar Spine Instability, Lumbar Spondylosis
- Trial name
- SELECT (NCT05405374)
- Testing
- OSTEOAMP, Infuse
- Where
- 9 sites in United States
- Volunteers
- 101 people
- Sponsor
- Bioventus LLC
Alveolar Ridge Augmentation
Comparison of the Use of Natural and Synthetic Bone Substitutes in Dental Implants
The goal of this clinical trial is to compare the effectiveness of a natural and synthetic bone substitute in preserving the alveolar ridge (bone) of a single- rooted tooth after an extraction.
- Trial name
- BSNS (NCT05938114)
- Testing
- Bonalive, Bio-Oss®
- Where
- 6 sites in United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Central Lancashire
Patients with Posterior Maxillary Atrophy and Need for Sinus Lift Surgery to Allow Implant Placement
Efficacy of L-PRF Against Deproteinized Bovine Mineralized Bone (DBBM)
Objective: The main objective of this study is to evaluate whether the use of L-PRF combined with deproteinized bovine mineralized bone (DBBM; BioOss, Geistlich Pharma®) reduces healing time, through histomorphometric analysis…
- Trial name
- NCT06686836
- Testing
- Sinus lift augmentation with bone substitute (Bio-Oss), Open sinus lift surgery lift using Platelet- and leukocyte-rich fibrin (L-PRF) mixed with a bone substitute (Bio-Oss®(Geistlich AG, Wolhusen, Switzerland)) - L-PRF Block
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Santiago de Compostela
Intrabony Periodontal Defect
Effect of Alendronate With β - TCP Bone Substitute in Surgical Therapy of Periodontal Intra-osseous Defects.
The aim of the present study was to evaluate the bone formation potential of 400µg alendronate delivered in β-TCP in the treatment of periodontal intra-osseous defects.
- Trial name
- NCT02795546
- Testing
- Alendronate sodium, beta-tricalcium phosphate bone substitute
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Panineeya Mahavidyalaya Institute of Dental Sciences & Research Centre
Sinus Floor Elevation
Histomorphometric and Radiographic Evaluation of Bone Following Maxillary Sinus Augmentation
Two groups of patients with posterior vertical deficient maxillary alveolar ridge with pneumatized sinus and needing dental implant .
- Trial name
- NCT06700772
- Testing
- mixing bone marrow aspirate concentrate from maxillary tuberosity with bovine bone, mixing autogenous bone with bovine bone
- Where
- 2 sites in Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Bone Substitutes, Calcium Phosphates
Biphasic Calcium Phosphate vs. Hydroxyapatite in Sinus Floor Elevation
Twenty patients scheduled for lateral-window sinus floor Elevation (SFE) are randomized into two groups: use of SYMBIOS® Biphasic Bone Graft Material (Group 1) or of Algipore® Bone Substitution Material (Group 2).
- Conditions
- Bone Substitutes, Calcium Phosphates, Hydroxyapatite, Rhodophyta
- Trial name
- NCT04331314
- Testing
- Use of Symbios Bone Graft Material, Algipore Bone Substitution Material
- Volunteers
- 20 people
- Sponsor
- Medical University of Graz
Residual Bone Height, Marginal Bone Loss
Influence of Residual Bone Height on Marginal Bone Loss Around Implants Following Lateral Sinus Floor Augmentation With Deproteinized Bovine Bone Mineral
Data collection will be done on all patients who underwent a lateral maxillary sinus floor augmentation in the Faculty of Dental Medicine, both in the Periodontology Department and in the Oral Surgery Department.
- Conditions
- Residual Bone Height, Marginal Bone Loss, Implant Type, Smoking
- Trial name
- NCT07550491
- Testing
- sinus lift using DBBM
- Where
- Lebanon
- Volunteers
- 142 people
- Sponsor
- Saint-Joseph University
Alveolar Process
Evaluation of a Synthetic Bone Substitute for Ridge Preservation
Fifteen patients were selected, each presenting at least two jaw front teeth indicated for extraction: in the Test Group (TG), post-extraction sockets was filled by synthetic bone substitute ReproBone, and in the Control Group…
- Trial name
- NCT02894528
- Testing
- BioMend and ReproBone, BioMend without ReproBone
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Bone Regeneration, Bone Transplantation
Horizontal Ridge Augmentation With or Without Autogenous Block Grafts
To evaluate dimensional bone alterations following horizontal ridge augmentation using guided bone regeneration (GBR) with or without autogenous block graft (ABG) for the rehabilitation of atrophic jaws with dental implants.
- Conditions
- Bone Regeneration, Bone Transplantation, Bone Substitutes, Cone-beam Computed Tomography
- Trial name
- NCT03432702
- Testing
- Horizontal ridge augmentation
- Where
- Peru
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Universidad Científica del Sur
Dental Implant
Socket Reconstruction Technique and Immediate Implant Placement With Two Different Bone Substitute Materials.
The present research is a national multicentric prospective parallel double-blinded (both the patient and the examiner are blind) randomized controlled clinical trial.
- Trial name
- NCT06517030
- Testing
- Tooth Extraction, Immediate Implant Placement, Socket reconstruction with DBBB+HA
- Where
- Italy
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Università Vita-Salute San Raffaele
Peri Implantitis
BonyPid-500TM Bone Graft Substitute Study
This study is designed to assess the safety and effectiveness of BonyPid-500TM implantation for intrabony peri-implantitis defects.
- Trial name
- NCT02531100
- Testing
- BonyPid 500TM implantation concomitantly to SOC treatment, SOC treatment only
- Where
- 2 sites in Israel
- Volunteers
- 27 people
- Sponsor
- PolyPid Ltd.
Osteomyelitis, Infections
Surgical Treatment of Osteoarticular Infections Using Bioactive Bone Substitute
This prospective research project aims to evaluate the effectiveness and clinical outcomes of utilizing antibiotic-impregnated bioactive bone substitute (PerOssal®) in the surgical management of osteoarticular infections.
- Conditions
- Osteomyelitis, Infections, Fracture, Antibiotics
- Trial name
- NCT06402292
- Testing
- OSTEOMYELITIS SURGICAL TREATMENT WITH LOCAL ANTIBIOTICS AND PEROSSAL
- Volunteers
- 25 people
- Sponsor
- Federal University of São Paulo