Clinical trials: Bone Volume
Blow-Out Fractures, Orbital Fractures
Accuracy& Orbital Volume Using Patient Specific Titanium Implant Vs Zirconia for Orbital Floor Reconstruction
Comparative study used to assess if the patient specific zirconia implant will provide better accuracy, intraoperative adaptability, precise orbital volume and soft tissue reaction with more cost effectiveness than the patient…
- Conditions
- Blow-Out Fractures, Orbital Fractures, Orbital Floor Fracture, Orbital Trauma
- Trial name
- NCT06369129
- Testing
- Orbital floor reconstruction with Patient Specific Zirconia Implant, Orbital floor reconstruction with Patient Specific Titanium Implant
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Myelofibrosis (MF)
Study of Oral Navitoclax Tablet In Combination With Oral Ruxolitinib Tablet When Compared With Oral Ruxolitinib Tablet To Assess Change In Spleen Volume In Adult Participants With Myelofibrosis
Myelofibrosis is a type of bone marrow cancer that usually develops slowly and disrupts body's normal production of blood cells. It causes bone marrow scarring, leading to severe anemia that can cause weakness and fatigue.
- Trial name
- TRANSFORM-1 (NCT04472598)
- Testing
- Ruxolitinib, Navitoclax
- Where
- 194 sites in United States, Australia and 23 more
- Volunteers
- 252 people
- Sponsor
- AbbVie
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
A Phase 3 Study of Pacritinib in Patients With Primary Myelofibrosis, Post Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocythemia Myelofibrosis
This study (study ID PAC203 North America; PAC303 ex-North America) is evaluating 200 mg BID of pacritinib compared to physician's choice (P/C) therapy in patients with MF and severe thrombocytopenia (platelet count <50,000/μL).
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- PACIFICA (NCT03165734)
- Testing
- Pacritinib, Physician's Choice medications
- Where
- 207 sites in United States, Australia and 22 more
- Volunteers
- 407 people
- Sponsor
- Swedish Orphan Biovitrum
Bone Injuries, Muscle Injuries
Impact of Volume Imaging Using Diagnostic Ultrasound
Determine if volume imaging can diagnose bone, ligament, muscle injuries.
- Conditions
- Bone Injuries, Muscle Injuries, Tendon Injuries
- Trial name
- NCT01601782
- Testing
- Ultrasound Scan, Ultrasound Scan using a General Electric Ultrasound Scanner Model Logiq E9 (model name).
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of Michigan
Myelofibrosis
A Study to Evaluate Single Agent Selinexor Versus Physician's Choice in Participants With Previously Treated Myelofibrosis
This is a Phase 2, multicenter, two-arm, open-label study to evaluate the safety and efficacy of selinexor versus treatment per physician's choice (PC) in participants with myelofibrosis (MF) who had at least 6 months of…
- Trial name
- NCT04562870
- Testing
- Selinexor, Physician's Choice Treatment
- Where
- 21 sites in United States, China and 5 more
- Volunteers
- 112 people
- Sponsor
- Karyopharm Therapeutics Inc
Implant Geometry, Osseointegration, Soft Tissue Volume, Marginal Bone Levels, Soft Tissue Recession, Volumetric Analysis
The Influence of a New Implant Neck Configuration on Hard and Soft Tissue Healing
Title: Randomized Controlled Clinical Trial comparing two dental implants with different neck configurations. Objective: To evaluate the changes in peri-implant soft tissues and marginal bone level when using a one-piece implant…
- Trial name
- NCT04308083
- Testing
- dental implant placement
- Where
- Spain
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- PerioCentrum Research
Lumbar Spondylolisthesis, Arthrosis; Spine
Analysis of the Clinical Efficacy of Intravenous Application of Hemostatic Drugs in Improving the Clarity of Vision Under Endoscope, Perioperative Bleeding Volume and Anti-inflammatory Effect of Spinal Endoscopic Lumbar Fusion
To study the clinical efficacy of carosodiumsulfonate and desmopressin in improving the clarity of vision under endoscope, perioperative bleeding volume and anti-inflammatory effect in endoscopic lumbar fusion
- Trial name
- NCT06255366
- Testing
- Caroxime sodium sulfonate, Desmopressin, 0.9% Sodium Chloride Injection
- Volunteers
- 126 people
- Sponsor
- Chengdu University of Traditional Chinese Medicine
Dental Implant, Tooth Extraction
Soft Tissue Volume Changes After Immediate Implants With Two Different Techniques
The aim is to comparatively evaluate the soft tissue volume changes that occur after tooth extraction and immediate dental implant placement using two different surgical techniques.
- Conditions
- Dental Implant, Tooth Extraction, Bone Resorption
- Trial name
- NCT04803110
- Testing
- Dental implant placement after tooth extraction
- Where
- Spain
- Volunteers
- 20 people
- Sponsor
- Aula Dental Avanzada
Alveolar Bone Loss
Autologous Fat Grafting Versus Subepithelial Connective Tissue Graft for Volume Augmentation
The aim of this study was to evaluate the effectiveness of autologous fat as a grafting material for soft tissue volume augmentation of localized horizontal ridge defects in humans.
- Trial name
- NCT04214041
- Testing
- Autologous fat grafting, Sub-epithelial connective tissue graft
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Nourhan M.Aly
Type 2 Diabetes Mellitus, Bone Fractures
Microarchitecture, Bone Strength and Fracture Risk in Type 2 Diabetes
This multicenter, prospective, observational cohort study will assess bone differences in women and men with type 2 diabetes mellitus (T2DM) with and without fragility fractures.
- Trial name
- DiabOS (NCT02551315)
- Where
- 5 sites in Switzerland
- Volunteers
- 274 people, healthy volunteers welcome
- Sponsor
- University Hospital, Basel, Switzerland
Emphysema
Safety and Feasibility Study of Administration of Mesenchymal Stemcells for Treatment of Emphysema
The purpose of this study is to show safety and feasibility to administer patients own mesenchymal stem cells to show signs of repair of emphysematous lung tissue
- Trial name
- NCT01306513
- Testing
- autologous bone marrow derived mesenchymal stromal cells
- Where
- Netherlands
- Volunteers
- 10 people
- Sponsor
- Leiden University Medical Center
Left Ventricular Dysfunction
Use of Adult Autologous Stem Cells in Treating People 2 to 3 Weeks After Having a Heart Attack (The Late TIME Study)
More than 1 million Americans suffer heart attacks each year. Although current treatments are able to stabilize the condition of the heart, none is able to restore heart function as it was prior to the heart attack.
- Trial name
- NCT00684060
- Testing
- Adult stem cells
- Where
- 5 sites in United States
- Volunteers
- 87 people
- Sponsor
- The University of Texas Health Science Center, Houston
Hip Fractures
Stroke Volume Optimisation in Patients With Hip Fracture
The aim of this study is to assess whether intra-operative fluid supplementation (to improve tissue perfusion) can reduce the incidence of postoperative complications in elderly patients with hip fracture.
- Trial name
- FRACTALE (NCT00444262)
- Testing
- hemodynamic optimisation guided using esophageal Doppler, VOLUVEN and others solute
- Where
- 19 sites in France
- Volunteers
- 215 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Augmentation, Alveolar Ridge
Evaluation of the Bone Volume in Horizontal Atrophic Ridges Augmentation Using Tenting Grafting Technique Versus Khoury Technique in Mandibular Molar and Premolar Region: Randomized Clinical Trial
The aim of this study is to compare the effectiveness of the Tenting Grafting Technique and the Khoury Technique for horizontal augmentation of atrophic alveolar ridges in mandibular molar and premolar regions in dental implant…
- Trial name
- NCT06889558
- Testing
- tenting titanium technique, tenting titanium screw
- Volunteers
- 20 people
- Sponsor
- Cairo University
Myeloid Malignancy
Therapeutic RSK1 Targeting in Myeloid Malignancies
This study hypothesizes that PMD-026, an oral inhibitor of ribosomal protein S6 kinase A1 (RSK1), is safe and well tolerated in participants with myelofibrosis (MF) and myelodysplastic syndromes/myeloproliferative neoplasms…
- Trial name
- NCT07379125
- Testing
- PMD-026
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington University School of Medicine
Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis
Pacritinib Versus Best Available Therapy to Treat Myelofibrosis
Phase 3, randomized, controlled study to evaluate the safety and efficacy of oral pacritinib compared to Best Available Therapy (BAT) in patients with primary or secondary myelofibrosis.
- Conditions
- Primary Myelofibrosis, Post-polycythemia Vera Myelofibrosis, Post-essential Thrombocythemia Myelofibrosis
- Trial name
- NCT01773187
- Testing
- Pacritinib, Best Available Therapy
- Where
- 81 sites in United States, Australia and 10 more
- Volunteers
- 327 people
- Sponsor
- CTI BioPharma
Metastases to Bone
Pilot Randomized Study for Treatment Volume De-Escalation for Spinal Metastases With Stereotactic Body Radiation Therapy
A single centre, non-profit, randomised, unblinded pilot study on volume definition for spinal stereotactic body radiation therapy treatment. Randomization will be 1:1 between two types of SBRT treatment for spinal metastases.
- Trial name
- REVOL-SPINE (NCT07538024)
- Testing
- Stereotactic Body Radiation Therapy (SBRT) in control arm, Stereotactic Body Radiation Therapy (SBRT) in experimental arm
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- IRCCS Sacro Cuore Don Calabria di Negrar
Bone Volume
Vegetable Ivory Bone Material in Bone Healing Compared to Current Standard Methods of Bone Healing
The purpose of this research study is to evaluate whether a biobased natural vegetable ivory formulation can produce similar or better results compared to the current standard bone healing treatment.
- Trial name
- NCT06548685
- Testing
- Bone Grafting, Vegetable Derived
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Mark Stanczyk
Jaw Cysts
Radiographic Bone Volume Alteration After Jaw Cyst Enucleation With Different Bone Grafts
For decades, implantology has attracted extensive interest for restoration in patients with the defect of dentition. It has emerged as a very established prosthetic with a 5-year survival rate of 96% .
- Trial name
- NCT05478421
- Testing
- Collagen sponge, GBR, CS/GBR
- Where
- China
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- The Dental Hospital of Zhejiang University School of Medicine
Tooth Extraction Site Healing, Alveolar Ridge Preservation
Assessment of the Impact of Neobone® (Biphasic Calcium Phosphate) on Bone Volume in Alveolar Ridge Preservation After Tooth Extraction
The goal of this randomized clinical trial is to assess whether BCP (Biphasic Calcium Phosphate) improves alveolar ridge preservation (ARP) in patients who need tooth extraction.
- Trial name
- BCPARPBV (NCT07638358)
- Testing
- Neobone® (Biphasic Calcium Phosphate)
- Where
- Portugal
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Egas Moniz - Cooperativa de Ensino Superior, CRL