Clinical trials: Bone and Bones
Immediate Dental Implant, Implant Osseointegration
Clinical and Radiographic Evaluation of Topical Vitamin D on Immediate Dental Implants
This study evaluates the clinical and radiographic outcomes of topical vitamin D application on immediate dental implants in patients undergoing single-rooted tooth extraction in the anterior mandibular region.
- Conditions
- Immediate Dental Implant, Implant Osseointegration, Vitamin D, Tooth Extraction
- Trial name
- NCT06806423
- Testing
- Immediate Dental Implant Placement without Adjunctive Treatments, Immediate Dental Implant Placement with Topical Vitamin D Gel Application
- Where
- Egypt
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Osteogenesis Imperfecta, Rare Bone Disorders
Morphology in Oral Rare Syndromes & Artificial Intelligence for Clinical Diagnosis
MOSAIC aims to determine whether oro-dental morphological anomalies, particularly palatal morphology, associated with rare bone and cartilage diseases can be precisely characterized using 3D digital models analysed through…
- Conditions
- Osteogenesis Imperfecta, Rare Bone Disorders, Hypophosphatemia, X-Linked
- Trial name
- MOSAIC (NCT07666269)
- Testing
- intra-oral 3D optical impression
- Where
- France
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- University Hospital, Bordeaux
Cancer
Hematotoxic Effects of Particulate Exposure
Hematotoxicity is caused by a number of agents such as a benzene by-product called hydroquinone and the antitumor agent doxorubicin.
- Trial name
- NCT00015483
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute of Environmental Health Sciences (NIEHS)
Patients Diagnosed With Persistent Apical Periodontitis in Maxillary Anterior Regions Require Endodontic Microsurgery
Bone-Bioactive Liquid as an Adjunct in Endodontic Surgery
This randomized controlled clinical trial will include patients indicated for endodontic microsurgery due to persistent periapical lesions. Participants will be randomly allocated into two groups.
- Trial name
- NCT07879482
- Testing
- Bone Bioactive Liquid in endosurgery, conventional endodontic surgery
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Postoperative Pain, Anesthesia, Regional
Mid-Transverse Process to Pleural (MTP) Block and Erector Spinal Plan (ESP) Block in Spinal Surgery
Ethics committee approval was taken on October 22, 2019, numbered 19/342. 120 adult patients who will undergo spine stabilization surgery between October 2019 and January 2020 in "Gülhane Training and Research Hospital" were…
- Conditions
- Postoperative Pain, Anesthesia, Regional, Spinal Stenosis
- Trial name
- NCT04193488
- Testing
- MTP block, ESP block, No Block group
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Gulhane School of Medicine
Osteoporosis
The Added Value of Bone Microstructure Assessment in the Management of Osteoporotic Bone
1. To assess the clinical utility of trabecular bone score (TBS) on fracture risk prediction including the new version (TBS V4) and future TBS versions at the spine and hip. 2.
- Trial name
- ADVANTAGE BONE (NCT06513442)
- Testing
- Trabecular bone score software
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Robert Jones and Agnes Hunt Orthopaedic and District NHS Trust
Family Member
Vitamin D's Effect on Physical Performance in the Elderly
The purpose of this study is to compare vitamin D deficient and vitamin D sufficient elderly individuals and examine the effect of a vitamin D dietary supplement on serum vitamin D level, bone formation, resorption, and mineral…
- Trial name
- NCT02066441
- Testing
- Bio-D-Mulsion Forte®
- Where
- United States
- Volunteers
- 101 people, healthy volunteers welcome
- Sponsor
- University of Miami
Weight Loss, Vitamin D or Placebo
The Effect of Vitamin D Supplementation During Caloric Restriction on Intestinal Calcium Absorption
The purpose of this study is to learn how the amount of vitamin D supplementation influences intestinal fractional calcium absorption (a measure of the amount of calcium absorbed).
- Trial name
- NCT00472654
- Testing
- Weight Loss, Vitamin D 2500 IU, Weight Maintenance
- Where
- United States
- Volunteers
- 83 people, healthy volunteers welcome
- Sponsor
- Rutgers University
Postmenopausal Osteoporosis
The Deferasirox-calcium-vitamin D3 Therapy for Postmenopausal Osteoporosis (PMOP)
In 2006, Weinberg proposed a hypothesis that iron accumulation was a risk factor for osteoporosis. Osteoporosis is a common complication in various diseases, such as hemochromatosis, African hemosiderosis, thalassemia, and sickle…
- Trial name
- PMOP (NCT02854722)
- Testing
- Deferasirox and calcium-vitamin D3, Calcium-vitamin D3
- Where
- China
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Second Affiliated Hospital of Soochow University
Vitamin D Deficiency
The Effect of Vitamin D Supplements on Vitamin D Status, Cardiometabolic Health and Immune Defense in Danish Children
The main purpose of this study is to investigate whether and in which doses vitamin D intake is needed in order to maintain an adequate vitamin D status in 4-8 year-old Danish children during wintertime.
- Trial name
- ODIN Junior (NCT02145195)
- Testing
- Vitamin D3 (cholecalciferol)
- Where
- Denmark
- Volunteers
- 130 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
SAPHO Syndrome
Immune Response in the SAPHO Syndrome
The aetiology of SAPHO syndrome seems to involve genetic, infectious and immunological components. The investigators examined innate and adaptative immune responses in SAPHO syndrome as compared with psoriatic arthritis and…
- Trial name
- NCT01688219
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Scoliosis, Scoliosis Idiopathic
Yoga in the Treatment of Adolescent Idiopathic and Degenerative Scoliosis
The effect of two isometric exercises is measured on Cobb angles from films taken 4-10 months apart.
- Trial name
- NCT03110965
- Testing
- Yoga poses
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Manhattan Physical Medicine and Rehabilitation, LLP
Tooth, Impacted
Dental Stem Cells and Bone Tissue Engineering (CELSORDINO)
The main limitation in bone regeneration is the lack of vascularization of the newly shaped tissue. The main objective of this project is to check if the simultaneous differentiation of dental mesenchymal stem cells toward…
- Trial name
- CELSORDINO (NCT03194451)
- Testing
- non-interventional study
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Central Hospital, Nancy, France
Graft-Versus-Host Disease, Graft-versus-leukemia
Improved Methods of Cell Selection for Bone Marrow Transplant Alternatives
Bone marrow transplants (BMT) are one form of treatment for disorders of the blood, including leukemia. However, because the procedure is often associated with potentially life-threatening reactions, it is usually reserved for…
- Conditions
- Graft-Versus-Host Disease, Graft-versus-leukemia, Donor Apheresis
- Trial name
- NCT00001529
- Testing
- G-CSF
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Implant Site Reaction
Assessment of Heat Generation From Low Speed Drilling Without Irrigation
ASSESSMENT OF LOW SPEED DRILLING WITHOUT IRRIGATION VERSUS CONVENTIONAL DRILLING WITH IRRIGATION REGARDING HEAT GENERATION AND PERI-IMPLANT MARGINAL BONE LOSS
- Trial name
- NCT03743545
- Testing
- low speed drilling without irrigation
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Cairo University
Paroxysmal Nocturnal Hemoglobinuria, PNH
To Evaluate Safety, Tolerability, PK/PD & Food Effect of Single/Multiple Oral TUL321 Capsules in Healthy Participants.
Phase I Study Evaluating Safety, Tolerability, PK and PD of Single and Multiple Doses of TUL321 Capsule in Healthy Participants and Food Effect on PK
- Trial name
- NCT07760467
- Testing
- Part1: TUL321, Part2: TUL321
- Where
- China
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zhuhai United Laboratories Co., Ltd.
Relative Energy Deficiency in Sport
Impact Loading Effect on Bone Biomarkers in Female Runners
This study is a randomized, cross-over intervention study that will evaluate the effect of brief, high-impact loading exercises on biomarkers of bone metabolism in energy-restricted female runners.
- Trial name
- NCT05341700
- Testing
- Impact Load Exercises, No Impact Load Exercises
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Virginia Polytechnic Institute and State University
Cleft Palate, Trauma
Cell Therapy for Craniofacial Bone Defects
The purpose of this research is to determine if a patient's own bone marrow tissue can help regenerate bone in the area of the jaw where an implant will be placed. The name of the process is called Bone Repair Cell (BRC) Therapy.
- Trial name
- NCT01616953
- Testing
- Ixmyelocel-T, Autogenous Bone Grafting
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Atrophied Anterior Maxillary Ridges
GBR With Ptfe With Bovine Bone With and Without Autogenous
Ridge Augmentation in Atrophic Anterior Maxillary Ridges with a Titanium Reinforced Polytetraflouroethelene Membrane and Anorganic Bovine Bone-Derived Mineral in intervention group and Anorganic Bovine Bone-Derived Mineralwith…
- Trial name
- NCT03628157
- Testing
- Geistlich Bio-Oss® bovine bone alone
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Horizontal Atrophy of Edentulous Alveolar Ridge
Cortical Bone Plate Versus Cortico-cancellous Block Graft
Horizontal ridge augmentation using either cortical bone plate technique or cortico-cancellous block graft was the aim of the study.
- Trial name
- NCT04567966
- Testing
- Split-block technique, Cortico-cancellous block graft
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
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