Clinical trials: Bone and Bones
Maxillary Cyst
Deproteinized Bovine Bone in Alveolar Bone Critical Size Defect (>2cm) Secondary to Cyst Removal
The aim of this study was to evaluate the effect of the use of deproteinized bovine bone as a filler material of critical-sized (diameter >=20 mm) bony defects derived from the excision of maxillary and mandibular cysts.
- Trial name
- NCT02612740
- Testing
- Deproteinized bovine bone, granules of deproteinized bovine bone (Bio-Oss)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Padova, School of Dental Medicine
Fracture of Femur
mHealth to Improve the Experience, Adherence to Drug Treatment and Positive Mental Health
The present study aims to evaluate the effectiveness of a pharmacological nursing educational intervention (EFE) with "Myplan Aplication" about the patient's experience, adherence to pharmacological treatment, and positive mental…
- Trial name
- NCT05669040
- Testing
- Pharmacological education, Training in the use of MyPlan Aplication, Patient Experience
- Where
- Spain
- Volunteers
- 278 people
- Sponsor
- Hospital Clinic of Barcelona
Shoulder Fractures, Shoulder Arthritis
Zimmer Biomet Shoulder Arthroplasty PMCF
The objectives of this study are to confirm the safety, performance, and clinical benefits of Zimmer Biomet Shoulder Arthroplasty Systems and its instrumentation in primary or revision shoulder arthroplasty.
- Conditions
- Shoulder Fractures, Shoulder Arthritis, Shoulder Osteoarthritis, Shoulder Deformity
- Trial name
- NCT04984291
- Testing
- Alliance Glenoid, Identity Stem
- Where
- 17 sites in United States, Japan and 1 more
- Volunteers
- 584 people
- Sponsor
- Zimmer Biomet
Osteosarcoma
Monocyte Phenotypic and Functional Differences
The purpose of this study is to identify phenotypic (cell surface receptor expression) and functional differences in monocyte populations in humans with osteosarcoma as compared to published historical data on normal human…
- Trial name
- NCT02132182
- Testing
- Blood draw
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Duke University
Children With Fracture Femur
Dexmedetomidine Addition to Fascia Iliaca Compartment Block
Fractures of the shaft of femur (FSF) are common in children, especially isolated fractures of the mid-third of the femur which are intensely painful.
- Trial name
- NCT01600027
- Testing
- Fascia iliaca compartment block, Fascia iliaca block
- Where
- Egypt
- Volunteers
- 28 people
- Sponsor
- Mansoura University
Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase, Primary Myelofibrosis
LCL161 in Treating Patients With Primary Myelofibrosis, Post-Polycythemia Vera Myelofibrosis, or Post-Essential Thrombocytosis Myelofibrosis
This phase II trial studies how well second mitochondrial-derived activator of caspases (SMAC) mimetic LCL161 (LCL161) works in treating patients with primary myelofibrosis, post-polycythemia vera myelofibrosis, or post-essential…
- Conditions
- Polycythemia Vera, Post-Polycythemic Myelofibrosis Phase, Primary Myelofibrosis, Secondary Myelofibrosis
- Trial name
- NCT02098161
- Testing
- Laboratory Biomarker Analysis, Questionnaire Administration, Smac Mimetic LCL161
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- M.D. Anderson Cancer Center
Lumbar Disc Herniation
Impact of Transforaminal Epidural Steroid Injection in Lumbar Disc Prolpse on Micro RNA-155 Serum Level
Chronic pain could be considered a brain disease as it can affect multiple aspects of brain function, chemistry, neural networks and structure. Pain is associated with impaired cognitive function (1).
- Trial name
- NCT05626283
- Testing
- transforaminal epidural injection., micro RNA-155 serum level
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Beni-Suef University
Osteoporotic Fractures
Impact of Osteoporotic Fractures on Work: Data From a Fracture Liaisons Service
Osteoporosis is a bone disease characterized by a decrease in bone density with deterioration of the micro-architecture and the appearance of bone fragility, responsible for an increased risk of fractures.
- Trial name
- OPTIWORK (NCT04781556)
- Testing
- No intervention
- Where
- France
- Volunteers
- 121 people
- Sponsor
- Fondation Hôpital Saint-Joseph
Fractures, Closed
Volar Plate vs. Conventus DRS Fixation
Open reduction and internal fixation (ORIF) of unstable distal radius fractures is performed using a variety of fixation techniques. The most common method is fixed angle volar plate application.
- Trial name
- NCT02390856
- Testing
- Conventus DRS, Volar Plate
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Hospital for Special Surgery, New York
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Idarubicin, Cytarabine, and Tipifarnib in Treating Patients With Newly Diagnosed Myelodysplastic Syndromes or Acute Myeloid Leukemia
This phase I/II trial is studying the side effects and best dose of tipifarnib when given with idarubicin and cytarabine and to see how well it works in treating patients with newly diagnosed myelodysplastic syndromes or acute…
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00096122
- Testing
- cytarabine, idarubicin, tipifarnib
- Where
- United States
- Volunteers
- 95 people
- Sponsor
- National Cancer Institute (NCI)
Hepatitis B, Osteoporosis
Awareness of Osteoporosis in Patients With Hepatitis B Infection
Osteoporosis is a condition that describes compromised skeletal microarchitecture in general, with clinical signs of decreased bone mineral density.
- Conditions
- Hepatitis B, Osteoporosis, Osteoporosis Risk
- Trial name
- NCT05768737
- Testing
- Patient Participation Form
- Volunteers
- 400 people
- Sponsor
- Uskudar State Hospital
Neoplasms, Hematologic Neoplasms
Collection of Tissue Specimens From Patients With Solid Tumors or Blood Disorders and Their HLA-Compatible Family Members
This study will collect biological samples for use in research experiments aimed at better understanding the clinical features of certain diseases.
- Conditions
- Neoplasms, Hematologic Neoplasms, Healthy Volunteers
- Trial name
- NCT00071045
- Where
- United States
- Volunteers
- 6,000 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Rib Fractures
Long-term Outcome After Removal of Rib Stabilization Hardware in Patients With Blunt Chest Trauma
The main study objective is to evaluate the long-term outcome in a prospective follow-up visit of patients who underwent hardware removal after surgical stabilization of rib fractures (SSRF) after a blunt chest trauma .
- Trial name
- REMOVE (NCT06003595)
- Testing
- Data collection on patient reported long-term outcome of SSRF hardware removal
- Where
- Switzerland
- Volunteers
- 28 people
- Sponsor
- University Hospital, Basel, Switzerland
Hip Fractures, Anesthesia Local
Suprasacral Parallel Shift - Ultrasound/MR Image Fusion Guided Lumbosacral Plexus Block
The main objective of the trial is to complete a double-blinded randomized controlled trial with crossover design of a lumbosacral plexus block with the Suprasacral Parallel Shift technique guided by ultrasound/magnetic resonance…
- Conditions
- Hip Fractures, Anesthesia Local, Pain, Perioperative
- Trial name
- NCT02593370
- Testing
- Lidocaine-epinephrine added gadoterate meglumine
- Where
- Denmark
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Thomas F. Bendtsen
Myelodysplastic Syndromes (MDS)
The National Myelodysplastic Syndromes (MDS) Study
Multi-center study enrolling patients suspected or newly diagnosed with myelodysplastic syndromes (MDS), myelodysplastic syndromes/myeloproliferative neoplasms (MDS/MPN) overlap disorder, or idiopathic cytopenia of undetermined…
- Trial name
- MDS (NCT02775383)
- Testing
- Therapeutic
- Where
- 281 sites in United States, Israel
- Volunteers
- 2,115 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Osteoporosis, Osteopenia
The Effect of Chymosin on the Intestinal Absorption of Calcium
An adequate calcium intake is important for bone turnover and the risk of developing osteoporosis. Yet many studies have documented that supplementation with calcium tablets are often associated with a poor compliance, therefore…
- Trial name
- Chymosin (NCT01370941)
- Testing
- Drug A Chymosin
- Where
- Denmark
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University of Aarhus
Retinal Disease, Age-Related Macular Degeneration
Stem Cell Ophthalmology Treatment Study II
This study will evaluate the use of autologous bone marrow derived stem cells (BMSC) for the treatment of retinal and optic nerve damage or disease.
- Conditions
- Retinal Disease, Age-Related Macular Degeneration, Retinitis Pigmentosa, Stargardt Disease
- Trial name
- SCOTS2 (NCT03011541)
- Testing
- Arm 1
- Where
- 4 sites in United States, Austria and 1 more
- Volunteers
- 500 people
- Sponsor
- MD Stem Cells
Aging, Physical Fitness
Myogenic and Osteogenic Responses to eXercise and Ibuprofen
The purpose of this study is to determine if the use of ibuprofen blocks the benefits of exercise to build bone and muscle mass.
- Trial name
- MOXI (NCT00462722)
- Testing
- Ibuprofen, musculoskeletal-loading exercise
- Where
- United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Chronic Myeloproliferative Disorders, Leukemia
Donor Bone Marrow Transplant in Treating Patients With Leukemia, Lymphoma, or Nonmalignant Hematologic Disorders
RATIONALE: Giving chemotherapy and total-body irradiation before a donor bone marrow transplant helps stop the growth of cancer cells. It also helps stop the patient's immune system from rejecting the donor's stem cells.
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Multiple Myeloma and Malignant Plasma Cell Neoplasms, Myelodysplastic Syndromes
- Trial name
- NCT00005622
- Testing
- cyclophosphamide, TBI
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Kyphosis, Vertebral Fracture
A Study of Effects of Age and Hyperkyphosis on Spine Motion and Loading
We are studying how spine movement changes with age, and when people have vertebral fractures (cracks in the bones of the spine) or hyperkyphosis (a forward stooped posture).
- Trial name
- NCT03008902
- Testing
- Near-infrared passive motion capture recording
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Beth Israel Deaconess Medical Center
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