Clinical trials: Bone and Bones
Cystinosis, Native Kidney
Cystinosis and Mitochondrial Metabolism
Cystinosis is a monogenic autosomal recessive lysosomal storage disease with complete penetrance, caused by a biallelic mutation in the CTNS gene (17p13.2) encoding cystinosin, a ubiquitous membrane protein whose role is to clear…
- Trial name
- CYSTI-MITO (NCT07319091)
- Testing
- Mitochondrial metabolism
- Where
- 9 sites in France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Arteriosclerosis, Osteoporosis
An Open Clinical Trial to Assess the Influence of Newly Prescribed Aminobiphosphonates on Arterial Stiffness
The study tries to reveal if aminobisphosphonates influence aside the bone density also the vascular status in the typical elderly patient population
- Trial name
- NCT00180232
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Bone Demineralization
Alendronate for Prevention of AntiRetroviral Therapy-associated Bone Loss
Antiretroviral therapy (ART) initiation is associated with a significant loss of bone mineral density (BMD), characterised by increases in bone turnover, which is largely limited to the first 48 weeks of therapy.
- Trial name
- APART (NCT02322099)
- Testing
- Alendronate, calcium carbonate and colecalciferol, Tenofovir disoproxil
- Where
- 2 sites in Ireland
- Volunteers
- 53 people
- Sponsor
- University College Dublin
Gastric Adenocarcinoma
Derazantinib Alone or in Combination With Paclitaxel, Ramucirumab or Atezolizumab in Gastric Adenocarcinoma
The purpose of this study was to evaluate the efficacy of derazantinib monotherapy or derazantinib in combination with paclitaxel and ramucirumab in patients with gastric adenocarcinoma (GAC) i.e.
- Trial name
- FIDES-03 (NCT04604132)
- Testing
- Derazantinib, Derazantinib-paclitaxel-ramucirumab combination
- Where
- 81 sites in United States, Argentina and 13 more
- Volunteers
- 47 people
- Sponsor
- Basilea Pharmaceutica
Fractures Bone
ANKLE TRAUMA Diagnostic Value of Ultrasound Compared to Standard Radiography in the Detection of Fractures
To investigate the diagnostic value of ultrasound performed by a lay experimenter compared to standard radiographic imaging (or standard x-ray) in the detection of fractures in patients with closed acute ankle trauma and positive…
- Trial name
- NCT05528432
- Where
- Belgium
- Volunteers
- 150 people
- Sponsor
- Centre Hospitalier Universitaire Saint Pierre
Ankylosing Spondylitis
Study Of Celecoxib Or Diclofenac For Efficacy and Safety In Chinese Patients With Ankylosing Spondylitis
This is a local, multicenter, randomized, active comparator, double-blind, parallel group study with extension will be conducted to evaluate the efficacy and safety of celecoxib versus diclofenac SR in the treatment of Chinese…
- Trial name
- NCT00762463
- Testing
- Celecoxib, Diclofenac SR
- Where
- 5 sites in China
- Volunteers
- 240 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Myelofibrosis, Primary, Myelofibrosis, Post PV
Defining the Molecular Risk in Israeli Patients With Secondary Compared to Primary Myelofibrosis
The aim of the study is to determine the rate of HMR mutations in PMF and secondary MF (post PV/ET) subjects, and correlate the rate of mutations with clinical features as known prognostic scores.
- Conditions
- Myelofibrosis, Primary, Myelofibrosis, Post PV, Myelofibrosis, Post ET
- Trial name
- MRMF01 (NCT03402399)
- Testing
- Molecular analysis
- Where
- Israel
- Volunteers
- 222 people
- Sponsor
- Assaf-Harofeh Medical Center
Neuroblastoma, Neuroblastoma Recurrent
Anti-GD2 CAR T Cells in Pediatric Patients Affected by High Risk and/or Relapsed/Refractory Neuroblastoma or Other GD2-positive Solid Tumors
The purpose of this study is to test the safety and efficacy of GD2-CART01, a CAR T cell treatment targeting GD2 in paediatric or young adult patients with High Risk and/or relapsed/refractory Neuroblastoma.
- Conditions
- Neuroblastoma, Neuroblastoma Recurrent, GD2-positive Solid Tumors, Osteosarcoma
- Trial name
- NCT03373097
- Testing
- GD2-CART01
- Where
- Italy
- Volunteers
- 42 people
- Sponsor
- Bambino Gesù Hospital and Research Institute
Ankylosing Spondylitis
Efficacy and Safety of Loxoprofen Hydrogel Patch in Patients With Ankylosing Spondylitis
To assess the efficacy and safety of loxoprofen sodium hydrogel patch (LX-P) versus loxoprofen sodium tablet (LX-T) in patients with active ankylosing spondylitis(AS).
- Trial name
- NCT03800797
- Testing
- Loxoprofen sodium hydrogel patch, Loxoprofen sodium tablet
- Where
- China
- Volunteers
- 70 people
- Sponsor
- Sun Yat-sen University
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Rheumatoid Arthritis, Ankylosing Spondylitis
Impact of Air Pollution on the Course of Inflammatory Rheumatism
The objective of this study is to see if there is a link between air pollution and inflammatory rheumatism (rheumatoid arthritis and ankylosing spondylitis) To do this, the investigators are going to follow a cohort of about…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT05862584
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Ankylosing Spondylitis
Study Comparing Etanercept 50 mg Once Weekly to 25 mg Twice Weekly in Patients With Ankylosing Spondylitis
The purpose of this study is to compare efficacy, pharmacokinetics, and safety of investigational formulations of etanercept administered as 50 mg once weekly with 25 mg twice weekly and placebo in patients with ankylosing…
- Trial name
- NCT00418548
- Testing
- Etanercept
- Volunteers
- 350 people
- Sponsor
- Wyeth is now a wholly owned subsidiary of Pfizer
Ewing Sarcoma
SARC037: A Phase I/II Study to Evaluate the Safety of Trabectedin in Combination With Irinotecan in Ewing Sarcoma Patients
This study evaluates the trabectedin and irinotecan in the treatment of Ewings sarcoma, with a EWS-FLI1 mutation. Patients will also receive an infusion of 18F-FLT in combination with a Positron Emission Tomography (PET) scan to…
- Trial name
- U01CA236220 (NCT04067115)
- Testing
- Trabectedin 1 MG [Yondelis], Irinotecan, tumor biopsy
- Where
- 6 sites in United States
- Volunteers
- 37 people
- Sponsor
- Sarcoma Alliance for Research through Collaboration
Childhood Malignant Fibrous Histiocytoma of Bone, Sarcoma
Imatinib Mesylate in Treating Patients With Advanced Soft Tissue Sarcoma or Bone Sarcoma
RATIONALE: Imatinib mesylate may stop the growth of tumor cells by blocking the enzymes necessary for cancer cell growth. PURPOSE: Phase II trial to study the effectiveness of imatinib mesylate in treating patients who have…
- Trial name
- NCT00031915
- Testing
- imatinib mesylate
- Where
- 10 sites in United States
- Sponsor
- National Cancer Institute (NCI)
Fracture
Evaluation of Treatment of Fractures of the Humerus With a Plate.
The purpose of this study is to study with the use of clinical and radiological parameters the treatment of three-part and four-part fractures with the Winsta PH osteosynthesis device (Fischer Medical).
- Trial name
- NCT00408291
- Testing
- Winsta PH osteosynthesis device
- Where
- Denmark
- Volunteers
- 36 people
- Sponsor
- University of Aarhus
Rhizomelic Chondrodysplasia Punctata
RCDP Natural History Study
A prospective, longitudinal observational trial in patients with RCDP. Study participants will be evaluated at baseline and approximately every 6 months by the study team.
- Trial name
- NCT04031287
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- MED-LIFE DISCOVERIES LP
Odontogenic Cyst
Recurrence of Odontogenic Keratocyst
The aim of current cross over clinical trial is to evaluate the effect of topical 5-FU as adjunct therapy in reducing risk of the recurrence of OKCs
- Trial name
- NCT06071806
- Testing
- Topical Application of 5-Fluorouracil
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Tanta University
Sarcoma
Trastuzumab in Treating Patients With Recurrent Osteosarcoma
RATIONALE: Monoclonal antibodies, such as trastuzumab, can locate tumor cells and either kill them or deliver tumor-killing substances to them without harming normal cells.
- Trial name
- NCT00005033
- Testing
- trastuzumab, conventional surgery
- Where
- 4 sites in United States
- Sponsor
- Memorial Sloan Kettering Cancer Center
Pediatric Fracture Diagnosis by Ultrasound Compared to X-ray
Non-inferiority of Ultrasound for the Diagnosis of Upper Extremity Fractures in Children
This study evaluates the sensitivity of Ultrasound for Diagnostic of Fractures of the upper extremity compared to conventional x-ray in Children 0-18.
- Trial name
- FRUSKI (NCT04290247)
- Testing
- Ultrasound
- Where
- Switzerland
- Volunteers
- 428 people
- Sponsor
- University Children's Hospital Basel
Cancer
Cyproheptadine in Preventing Weight Loss in Children Receiving Chemotherapy for Cancer
RATIONALE: Cyproheptadine hydrochloride may prevent weight loss caused by cancer or cancer treatment. It is not yet known whether cyproheptadine is more effective than a placebo in preventing weight loss in young patients…
- Trial name
- NCT01132547
- Testing
- cyproheptadine hydrochloride
- Where
- 14 sites in United States
- Volunteers
- 22 people
- Sponsor
- University of South Florida
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