Clinical trials: Bone and Bones
Polycythemia, Polycythemia Vera (PV)
Potential Biological and Physiological Determinants for Exercice in Patients With Polycythemia Vera
Polycythemia vera (PV) is a rare haematological disorder characterized by an excessive production of red blood cells, associated with the somatic JAK2 V617F mutation.
- Trial name
- ACTIVAQ (NCT07341048)
- Testing
- Research samples blood viscosity and viscoelasticity:
- Where
- France
- Volunteers
- 54 people
- Sponsor
- Hospices Civils de Lyon
Mandibular Fractures
Tricalcium Phosphate and Chitosan as Bone Regenerator Versus Autologous Graft in Surgery for Mandibular Fracture
Introduction After a mandibular fracture where bone has been lost, a number of complications and challenges are presented in trying to solve them. These defects are mainly classified into two groups: functional and cosmetic.
- Trial name
- NCT02081885
- Testing
- Tricalcium Phosphate / Chitosan, Autologous Graft
- Where
- Mexico
- Volunteers
- 24 people
- Sponsor
- Instituto Mexicano del Seguro Social
Systemic Lupus Erthematosus, Sjogren's Syndrome
Mass Spectrometry-based Immune Profiling in Autoimmune Diseases
Based on mass spectrometry flow method, this study analyzed the typing of new T, B, NK and DC cell subsets in peripheral blood of common autoimmune diseases and their correlation with disease activity, aiming at establishing an…
- Conditions
- Systemic Lupus Erthematosus, Sjogren's Syndrome, Inflammatory Myopathies, Systemic Sclerosis (SSc)
- Trial name
- NCT07188285
- Where
- China
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Peking University People's Hospital
Postmenopausal Osteoporosis
Efficacy Of Clodronate 200 Mg/4 Ml I.M. Solution With 1% Lidocaine Every Other Week Vs Clodronate 100 Mg/3,3ml I.M. Solution With 1% Lidocaine Once-Week In A 1-Year Treatment Period Of Women With Postmenopausal Osteoporosis
Clodronic acid 100 mg/3,3 ml is used to prevent and treat postmenopausal osteoporosis. The intramuscular formulation, which is given at a dose of 100 mg every 7 o 14 days, is at least as effective as daily oral therapy and…
- Trial name
- NCT01348243
- Testing
- disodium clodronate 200 mg/4 ml with 1% lidocaine, Disodium clodronate 100 mg/3,3 ml with 1% lidocaine
- Where
- Italy
- Volunteers
- 260 people
- Sponsor
- Chiesi Farmaceutici S.p.A.
Neoplasm Metastasis, Neoplastic Processes
SUPR-3D: Simple Unplanned Palliative Radiotherapy Versus 3D Conformal Radiotherapy for Patients With Bone Metastases
The primary objective is to patient-reported Quality of Life related to complete control of Radiation Induced Nausea and Vomiting (RINV) between standard palliative radiotherapy and VMAT.
- Conditions
- Neoplasm Metastasis, Neoplastic Processes, Neoplasms, Pathologic Processes
- Trial name
- NCT03694015
- Testing
- SUPR, VMAT
- Where
- 5 sites in Canada
- Volunteers
- 160 people
- Sponsor
- British Columbia Cancer Agency
Chronic Myeloid Leukemia
Activity and Safety of Front-line Venetoclax and Rituximab in Young and Fit Patients With Chronic Lymphocytic Leukemia
Fludarabine, cyclophosphamide, and rituximab (FCR) is the gold treatment for fit and young patients with Chronic Lymphoid Leukemia (CLL).
- Trial name
- VeRitAs (NCT03455517)
- Testing
- Venetoclax, Rituximab
- Where
- 31 sites in Italy
- Volunteers
- 77 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Periprosthetic Joint Infection (PJI)
Is the EBJIS Definition of Prosthetic Joint Infection Meaningful in Our Clinical Practice?
This retrospective multi-center, multi-national cohort study is to validate the European Bone and Joint Infection Society (EBJIS) Definition of Prosthetic Joint Infection.
- Trial name
- NCT05117671
- Testing
- data collection to classify infection status
- Where
- 2 sites in Portugal, Switzerland
- Volunteers
- 1,554 people
- Sponsor
- University Hospital, Basel, Switzerland
Lead Exposure
Bone-Lead Level Associations With Brain and Mental Health
The goal of this study is to assess cumulative lead exposure among treatment-seeking patients in the MUSC hospital system receiving experimental transcranial magnetic stimulation (TMS), transcranial direct-current stimulation…
- Trial name
- NCT05887934
- Testing
- X-Ray Fluorescence Analyzer
- Where
- United States
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Orthopedic Disorder
Sclerotherapy and Bone Marrow Injection In Aneurysmal Bone Cyst
Aneurysmal bone cysts (ABCs) are benign, locally destructive growing bone tumors, which were first described in 1942 by Jaffé and Lichtenstein (1). They are most often diagnosed in childhood and early adulthood.
- Trial name
- NCT05696834
- Testing
- Sclerotherapy With Adjuvant Bone Marrow Injection In Management of Aneurysmal Bone Cyst
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Pituitary Diseases, Pituitary Neoplasms
Long Term Outcome Study in Patients With Pituitary Disorders
To determine the outcomes of patients with different pituitary disorders whether they are managed medically, surgically or expectantly.
- Trial name
- NCT03665064
- Volunteers
- 1,500 people
- Sponsor
- University of Alberta
Periodontal Disease
EMD and/or Bone Substitute for the Treatment of Class II Furcations
To clinically evaluate the treatment of mandibular class II furcation defects with enamel matrix derivative (EMD) and/or a bone substitute graft make of beta tricalcium phosphate/hydroxyapatite (βTCP/HA).
- Trial name
- NCT02474498
- Testing
- EMD, βTCP/HA, Flap access surgery
- Where
- Brazil
- Volunteers
- 41 people
- Sponsor
- University of Campinas, Brazil
Arthritis, Rheumatoid; Spondylitis, Ankylosing; Arthritis, Psoriatic; Colitis, Ulcerative
Tracking Biologics Along the Silk Road
The objective of this study is to explore and describe the disease characteristics, treatment and outcomes of participants with rheumatoid arthritis, ankylosing spondylitis, psoriatic arthritis, Crohn's Disease or ulcerative…
- Trial name
- HARIR (NCT03006198)
- Where
- 8 sites in Algeria, Egypt and 3 more
- Volunteers
- 140 people
- Sponsor
- Janssen Pharmaceutica N.V., Belgium
Low Back Pain
Safety And Efficacy Assessment of the zLock Facet Fusion System- A Pilot Study
ZygoFix has developed a system consisting of zLOCK Facet Fusion System. The zLOCK Facet Fusion System is intended for single level stabilization of a spinal motion segment to promote bonny fusion of the joint.
- Trial name
- NCT04229316
- Testing
- zLOCK Facet Stabilization System
- Where
- Hungary
- Volunteers
- 24 people
- Sponsor
- ZygoFix
Bone Defects, Dental Area
RETROSPECTIVE COLLECTION OF SAFETY AND PERFORMANCE DATA - 2023.02
This study, based on observations of clinical practice, aims to collect clinical data to update information on the performance and safety of the n-IBS® when used according to its intended purpose and current clinical…
- Trial name
- NCT07084506
- Where
- Belgium
- Volunteers
- 30 people
- Sponsor
- Bioceramed
Non Union Fracture
A Comparative Study of 2 Doses of BM Autologous H-MSC+Biomaterial vs Iliac Crest AutoGraft for Bone Healing in Non-Union
ORTHOUNION is a multi-centre, open, comparative, randomized, clinical trial with three parallel arms that aims to compare the efficacy of three treatments to enhance bone healing in patients with long bone non-union.
- Trial name
- ORTHOUNION (NCT03325504)
- Testing
- Cultured Mesenchymal Stem Cells, Autologous iliac crest graft
- Where
- 19 sites in France, Germany and 2 more
- Volunteers
- 46 people
- Sponsor
- Universidad Autonoma de Madrid
Osteoporosis
Efficacy and Safety of Brand Versus Generic Alendronate for Osteoporosis Treatment
Osteoporosis is a common disease defined as a decrease in bone mass and strength which increases risk of fragility fractures. This disorder may affecting health in many adults which causing disability, morbidity, and mortality.
- Trial name
- NCT02371252
- Testing
- Generic alendronate
- Where
- Thailand
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Mahidol University
Heart Failure
Congestive Heart Failure Cardiopoietic Regenerative Therapy (CHART-2) Trial - THE CHART-2 TRIAL
This study is designed to evaluate the efficacy and safety of the C3BS-CQR-1 in the treatment of patients with chronic heart failure secondary to ischemic cardiomyopathy.
- Trial name
- CHART-2 (NCT02317458)
- Testing
- Experimental
- Volunteers
- 400 people
- Sponsor
- Celyad Oncology SA
Atrophic Maxilla, Zygomatic Implants
Computer Guided Placement of Zygomatic Implants in Two Different Approaches
Evaluation of computer guided placement of Zygomatic implants utilizing intra sinus versus extra sinus surgical approach for the reconstruction of atrophic maxilla.
- Trial name
- NCT06129695
- Testing
- Zygomatic implants
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Cairo University
Fanconi Anemia, Severe Aplastic Anemia
Alpha/Beta TCD HCT in Patients With Inherited BMF Disorders
This is a phase II trial of T cell receptor alpha/beta depletion (α/β TCD) peripheral blood stem cell (PBSC) transplantation in patients with inherited bone marrow failure (BMF) disorders to eliminate the need for routine…
- Conditions
- Fanconi Anemia, Severe Aplastic Anemia, Myelodysplastic Syndromes, T Cell Receptor Alpha/Beta Depletion
- Trial name
- NCT03579875
- Testing
- Total Body Irradiation (TBI) (Plan 1), Cyclophosphamide (CY) (Plan 1), Fludarabine (FLU)
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Masonic Cancer Center, University of Minnesota
Osteosarcoma, Ewing's Sarcoma
Effects of Preoperative Physical Therapy in Patients With Lower Extremity Malignancy
This application proposes a prospective clinical trial to evaluate the impact of adding a focused physical therapy (PT) intervention to the preoperative regimen of individuals diagnosed with a malignancy of the lower extremity…
- Conditions
- Osteosarcoma, Ewing's Sarcoma, Rhabdomyosarcoma, Synovial Sarcoma
- Trial name
- NCT01674101
- Testing
- Endurance, Strengthening, Stretching
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- St. Jude Children's Research Hospital
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