Clinical trials: Bone and Bones
Hip Fractures, Elderly Patients
Comparison of Phenylephrine and Ephedrine in the Treatment of Hemodynamic Disorders After Spinal Anesthesia in the Elderly
Spinal anesthesia is often used for lower limb surgery in elderly. Hypotension is a side effect of spinal block. In this study, intravenous ephedrine and phenylephrine will be compared with each other to prevent spinal…
- Conditions
- Hip Fractures, Elderly Patients, Spinal Anesthesia, Lower Limb Surgery
- Trial name
- HypoGer (NCT03858465)
- Testing
- Ephedrine, Phenylephrine
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Medical University of Warsaw
Third Molars Extraction
A Comparison Between Conventional Surgery and Piezosurgery
Evaluation of the effect of conventional and piezo-surgery on the secretion of Heat Shock Protein (HSP70) and on the vial bone cells at the peripheral bone cut sides after the removal of impacted mandibular third molars on both…
- Trial name
- NCT02495207
- Testing
- Piezosurgery
- Where
- Syria
- Volunteers
- 15 people
- Sponsor
- Damascus University
FLT3 Gene Mutation Negative, FLT3 Internal Tandem Duplication Positive
Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome
This phase I/II trial studies the side effects and best dose of quizartinib when given in combination with azacitidine or cytarabine in treating patients with acute myeloid leukemia or myelodysplastic syndrome that have come back…
- Conditions
- FLT3 Gene Mutation Negative, FLT3 Internal Tandem Duplication Positive, Recurrent Acute Myeloid Leukemia, Recurrent Chronic Myelomonocytic Leukemia
- Trial name
- NCT01892371
- Testing
- Azacitidine, Cytarabine, Quizartinib
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- M.D. Anderson Cancer Center
Dental Implants
Comparing Pro-Inflammatory Cytokines and Bone Metabolism Mediators Around Laser-Lok and Machined Transmucosal Abutments
A pilot, prospective, randomized clinical trial is proposed. It is primarily aimed at assessing the expression of pro-inflammatory cytokine and bone metabolism mediators adjacent to Laser-Lok microgrooved (LL) or machined (M)…
- Trial name
- NCT03572244
- Testing
- Laser-Lok, Machined
- Volunteers
- 23 people
- Sponsor
- Christopher Barwacz
Myelodysplastic Syndromes
CPX-351 (Vyxeos™) for Transplant Eligible, Higher Risk Patients With Myelodysplastic Syndrome
This is a pilot and feasibility study of transplant eligible, higher risk myelodysplastic syndrome (MDS) patients to determine the safety and tolerability of a lower -dose and higher-dose CPX-351 regimen, with secondary…
- Trial name
- NCT03572764
- Testing
- CPX-351, Research skin biopsy, Research blood draw
- Where
- 3 sites in United States
- Volunteers
- 20 people
- Sponsor
- Washington University School of Medicine
Leukemia
Combination Chemotherapy in Treating Children With Relapsed Acute Lymphocytic Leukemia
RATIONALE: Drugs used in chemotherapy use different ways to stop cancer cells from dividing so they stop growing or die. Combining more than one drug may kill more cancer cells.
- Trial name
- NCT00002499
- Testing
- asparaginase, cytarabine, daunorubicin hydrochloride
- Where
- Argentina
- Sponsor
- Grupo Argentino de Tratamiento de la Leucemia Aguda
Myelodysplastic Syndrome
A Clinical Trial of Decitabine in Patients With Myelodysplastic Syndrome
The purpose of this study was to determine which of the doses of decitabine maximizes genomic demethylation in patients with Myelodysplastic Syndrome (MDS).
- Trial name
- NCT00282399
- Testing
- Subcutaneous Decitabine
- Where
- 3 sites in United States
- Volunteers
- 41 people
- Sponsor
- Eisai Inc.
Lumbar Herniated Disk
The Use of a Patient Decision Aid in the Choice of Surgery for Herniated Disc
Even though surgery due to lumbar disc herniation (LDH) shows a more rapid relief of pain and recovery, the evidence of surgery being superior to conservative treatment in the long term is inconclusive.
- Trial name
- NCT03884387
- Testing
- Patient Decision Aid
- Where
- Denmark
- Volunteers
- 142 people
- Sponsor
- Spine Centre of Southern Denmark
Open Fracture
Preventing Infections in Orthopaedic Patients
Determine if antibiotic prophylaxis with intravenous cephalosporin and aminoglycoside in patients with Type II and II open fractures is safe and effective.
- Trial name
- NCT02948387
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Olayemi Osiyemi MD
Anklyosing Spondylitis
16 Week Efficacy and 5 Year Long Term Efficacy, Safety and Tolerability of Secukinumab in Patients With Active Ankylosing Spondylitis
This study assessed the efficacy and safety of secukinumab in patients with active ankylosing spondylitis who were tolerant to or had an inadequate response to NSAIDs, DMARDs and / or TNFα inhibitor
- Trial name
- MEASURE2 (NCT01649375)
- Testing
- Secukinumab (75 mg), Secukinumab (150 mg)
- Where
- 53 sites in United States, Austria and 11 more
- Volunteers
- 219 people
- Sponsor
- Novartis Pharmaceuticals
Humerus, Proximal Humeral Fracture
Proximal Humerus Fractures: Randomized Study Between Locking Nails and Locking Plates for Neer 2 and 3 Parts
The hypothesis of this study is to determine whether the technique of intramedullary locking nail presents clinical results comparable to the technique of locking plates, based on the Constant Score.
- Conditions
- Humerus, Proximal Humeral Fracture, Fractures, Bone, Humeral Fractures
- Trial name
- NCT01984112
- Testing
- Locked plate, Intramedullary locked nail
- Where
- Brazil
- Volunteers
- 72 people
- Sponsor
- University of Sao Paulo
Acute Myeloid Leukemia, Myelodysplastic Syndromes
Phase II Trial in Elderly Patients With AML or MDS in Complete Remission Not Eligible for Allogenic Transplant
FLAT-Auto is a phase II trial. fludarabine and ARA-C will be combined with the alkylating agent treosulfan (FLAT), to investigate the feasibility and the efficacy of a new regimen, supported with autologous peripheral blood SCT…
- Conditions
- Acute Myeloid Leukemia, Myelodysplastic Syndromes, Transplant-Related Hematologic Malignancy
- Trial name
- FLAT-Auto (NCT03961919)
- Testing
- Fludarabine, ARA-C, Treosulfan
- Where
- Italy
- Volunteers
- 15 people
- Sponsor
- Ciceri Fabio
Prostate Cancer Metastatic
Trial of Cabozantinib (XL184) in Castrate-Resistant Prostate Cancer Metastatic to Bone
The purpose of this study is to look at the effects of cabozantinib on castrate-resistant prostate cancer metastatic (cancer that has spread to other parts of the body) to the bone and to learn about any side effects caused by…
- Trial name
- NCT01428219
- Testing
- Cabozantinib
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Michigan Rogel Cancer Center
Avascular Necrosis, Femoral Head Collapse
Avascular Necrosis (AVN) Long-Term Follow-up
Long-term follow-up of IDE patients for publication
- Trial name
- NCT00833430
- Where
- United States
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Fever, Sweats, and Hot Flashes, Infection
Levofloxacin Compared With Cefepime in Treating Cancer Patients With Fever and Neutropenia
RATIONALE: Levofloxacin may be effective in reducing fever and controlling other symptoms of neutropenia in patients who are being treated for cancer.
- Conditions
- Fever, Sweats, and Hot Flashes, Infection, Leukemia, Lymphoma
- Trial name
- NCT00020865
- Testing
- cefepime hydrochloride, levofloxacin
- Where
- United States
- Sponsor
- Jonsson Comprehensive Cancer Center
Osteoporosis, Postmenopausal
A Study in Indian Postmenopausal Women With Osteoporosis to Evaluate the Efficacy and Safety of Denosumab
The purpose of this study is to determine if denosumab is effective in increasing bone mineral density at the lumbar spine in Indian postmenopausal women with osteoporosis.
- Trial name
- NCT01495000
- Testing
- denosumab
- Where
- 11 sites in India
- Volunteers
- 250 people
- Sponsor
- GlaxoSmithKline
Traumatic Burst Fractures of the Thoracic or Lumbar Spine., Normal Neurological Function
Thoracic And Lumbar Burst Fracture: Correlation Between Structural Changes And Clinical Outcome Of Treatment
Evaluate the correlation between the structural changes of fractures of the thoracic and lumbar spine burst type with clinical outcome of the treatment.
- Trial name
- NCT02076607
- Testing
- Arthrodesis, Brace
- Where
- Brazil
- Volunteers
- 25 people
- Sponsor
- Hospital Ortopedico de Passo Fundo
Adrenal Gland Pheochromocytoma, Carcinoma In Situ
Project: Every Child for Younger Patients With Cancer
This study gathers health information for the Project: Every Child for younger patients with cancer. Gathering health information over time from younger patients with cancer may help doctors find better methods of treatment and…
- Conditions
- Adrenal Gland Pheochromocytoma, Carcinoma In Situ, Central Nervous System Neoplasm, Childhood Immature Teratoma
- Trial name
- NCT02402244
- Testing
- Cytology Specimen Collection Procedure, Medical Chart Review
- Where
- 279 sites in United States, Australia and 4 more
- Volunteers
- 75,000 people
- Sponsor
- Children's Oncology Group
Shoulder Fractures
Continuous vs Liposomal Bupivacaine Interscalene Block for Proximal Humeral Fracture (CLIP)
Restricted range of shoulder motion following ORIF is a potential complication that severely affects the patients' functional outcome and should be actively avoided by means of adequate pain control in addition to early…
- Trial name
- NCT04928664
- Testing
- Liposomal bupivacaine, Standard bupivacaine
- Where
- 2 sites in Hong Kong
- Volunteers
- 78 people
- Sponsor
- The University of Hong Kong
Rheumatoid Arthritis, Palindromic Arthritis
Rheumatology-based Adaptive Intervention for Social Determinants and Health Equity
Social determinants of health (SDoH), defined by the World Health Organization as "the conditions in which people are born, grow, work, live and age and the wider set of forces and systems shaping the conditions of daily life"…
- Conditions
- Rheumatoid Arthritis, Palindromic Arthritis, Juvenile Rheumatoid Arthritis, Ankylosing Spondylitis
- Trial name
- RAISE (NCT05715463)
- Testing
- Resource sheets, Community Resource Specialist, Nurse Navigator
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- Brigham and Women's Hospital
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