Clinical trials: Bone and Joint Infection
Ankylosing Spondylitis, Work Productivity
Work Productivity and Social Activities In Patients With Ankylosing Spondylitis
The aim of this study is to evaluate the relationship between decrease in work productivity and social activities in patients with Ankylosing Spondylitis (AS) with disease activity, depression and quality of life together with…
- Trial name
- NCT04749537
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Bone Cancer, Articular Disease
18F-sodium Fluoride (NaF) PET to Replace Bone Scintigraphy: Safety and Efficacy Assessment
18F-sodium fluoride (18F-NaF) was already investigated numerous times in the last 40 years as a PET alternative to standard 99m-technetium-derived bone scintigraphy.
- Conditions
- Bone Cancer, Articular Disease, Infectious Disease
- Trial name
- NCT04842071
- Testing
- 18F-sodium fluoride
- Where
- 2 sites in Canada
- Volunteers
- 2,500 people
- Sponsor
- Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Spondyloarthritis
Risk of Tuberculous and Other Infections in Patients of Spondyloarthritis Treated With Tofacitinib in Bangladesh
Treatment failure of Spondyloarthropathies (SpA) leads to marked functional disability, higher rates of morbidity, mortality and poor quality of life.
- Trial name
- NCT03504072
- Testing
- Tofacitinib 5 mg,, Etanercept
- Where
- Bangladesh
- Volunteers
- 174 people
- Sponsor
- Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh
Knee Osteoarthritis, Bone; Deformity, Congenital
COREV 2.0 PMCF-Study on Manual and Navigated Revision Knee Patients
The Columbus® Revision endoprosthetic system is bearing the CE-mark. This means that within the scope of this observational study the patient will not be subjected to any additional stressful, study-related medical examinations…
- Conditions
- Knee Osteoarthritis, Bone; Deformity, Congenital, Prosthesis Failure, Prosthesis-Related Infections
- Trial name
- COREV (NCT05113303)
- Testing
- Navigated Revision Total Knee Arthroplasty, Manual Revision Total Knee Arthroplasty
- Where
- Spain
- Volunteers
- 100 people
- Sponsor
- Aesculap AG
Femoral Neck Fractures, Prosthetic Infection
Dual vs. Single-Antibiotic Impregnated Cement in Hemiarthroplasty for Femoral Neck Fracture
Rational for conducting the study: Periprosthetic joint infection (PJI) is the most feared complication following prosthetic replacement of the hip joint and is associated with increased mortality, morbidity and economic burden.
- Trial name
- DAICY (NCT05164081)
- Testing
- antibiotic loaded bone cement (gentamicin+clindamycin) COPAL G+C (Heraeus)., antibiotic loaded bone cement (gentamicin) Paladins R+G (Heraeus) or Refobacin (Biomet).
- Where
- Sweden
- Volunteers
- 7,000 people
- Sponsor
- Umeå University
Spondylitis, Ankylosing
A Study of the Safety and Efficacy of Golimumab in Subjects With Active Ankylosing Spondylitis
The purpose of this study is to evaluate the safety and efficacy of subcutaneous injections (under the skin) of golimumab for the treatment of active ankylosing spondylitis [AS(arthritis of the spine)].
- Trial name
- NCT00265083
- Testing
- golimumab
- Where
- 39 sites in United States, Belgium and 7 more
- Volunteers
- 356 people
- Sponsor
- Centocor, Inc.
Rheumatoid Arthritis, Ankylosing Spondylitis
PatientSpot Formerly Known as ArthritisPower
Patient Power is a patient research network and database (registry) to collect prospective information about demographics, self-reported diagnoses and medications, and willingness to participate in research from participants with…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Fibromyalgia, Gout
- Trial name
- NCT03840928
- Where
- United States
- Volunteers
- 40,000 people, healthy volunteers welcome
- Sponsor
- Global Healthy Living Foundation
Prosthetic Joint Infection, Osteomyelitis
Population Pharmacokinetic Model of Rifampicin in Staphylococcal Osteoarticular Infections
Staphylococcal osteoarticular infections (OAIs), including prosthetic joint infections and chronic osteomyelitis, represent a major cause of morbidity.
- Conditions
- Prosthetic Joint Infection, Osteomyelitis, Staphylococcal Infections
- Trial name
- Ciné-RIF (NCT07788404)
- Testing
- This study focuses on the pharmacokinetics of rifampicin and levofloxacin or ciprofloxacin, which are used in the treatment of osteoarticular infections caused by susceptible staphylococci as part of
- Where
- France
- Volunteers
- 40 people
- Sponsor
- Groupe Hospitalier Diaconesses Croix Saint-Simon
Arthritis, Rheumatoid, Spondyloarthritis
Pain Catastrophizing and Routine Assessment of Patient Index Data 3(RAPID3) in Ten Categories of Rheumatology Outpatients
Fulfilling by all patients consequently seen by 6 rheumatologists in a same outpatient rheumatology clinic (in at least one month period) of a set of 6 questionnaires, including RAPID3 and pain catastrophizing scales.
- Conditions
- Arthritis, Rheumatoid, Spondyloarthritis, Inflammatory Rheumatisms, Systemic Disorders
- Trial name
- NCT03306784
- Testing
- questionnaires
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Nantes University Hospital
Pharmacokinetics, Safety Issues
A Clinical Study With Adalimumab Biosimilar
The study aims to evaluate the pharmacokinetic profile, safety profile, and immunogenic potential of adalimumab of a new citrate-free formulation of adalimumab (Adalimumab Richmond) [Test Product] vs.
- Trial name
- NCT06291948
- Testing
- Humira® (adalimumab) AC Pen [Reference Product], Adalimumab Richmond [Test Product]
- Where
- Argentina
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Laboratorios Richmond S.A.C.I.F.
Inflammatory Disease, Crohn Disease
Monitoring of Inflammatory Conditions
People with inflammatory diseases treated with immune-suppressing medication are recommended to have regular blood-tests to monitor for potential side-effects of this treatment on their blood count, liver and kidneys.
- Conditions
- Inflammatory Disease, Crohn Disease, Ulcerative Colitis, Rheumatoid Arthritis
- Trial name
- NCT05458531
- Testing
- Questionnaire, Semi-structured interview
- Where
- United Kingdom
- Volunteers
- 664 people, healthy volunteers welcome
- Sponsor
- University of Nottingham
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Bone and Joint Infections
Clinical Evaluation of Daptomycin Bone Penetration
Bone and joint infections are commonly due to Gram-positive bacteria. Treatment of these infections is difficult because of the need of prolonged duration of antimicrobial agents in combination with surgical procedure.
- Trial name
- DAPTO-HUS (NCT01306825)
- Where
- 3 sites in France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Strasbourg, France
Rheumatic Disease, Rheumatic Disorder
Survey About Diet in Chronic Inflammatory Rheumatic Diseases
A French Survey on patients' practices, knowledge and beliefs about diet in chronic inflammatory rheumatic diseases (rheumatoid arthritis, psoriatic arthritis, spondylarthritis) Use of a questionnaire about what patients have…
- Conditions
- Rheumatic Disease, Rheumatic Disorder, Inflammatory Rheumatism, Rheumatoid Arthritis
- Trial name
- NCT05283096
- Testing
- Questionnaire
- Where
- France
- Volunteers
- 203 people
- Sponsor
- Poitiers University Hospital
Peridontal Disease, Rheumatic Arthritis
Nonsurgical Periodontal Treatment Combined With Anti-TNF-α in Patients With Rheumatoid Arthritis and Periodontitis
Periodontitis is a multifactorial disease of the periodontium that can lead to destruction of the alveolar bone and supporting connective tissue and subsequent tooth loss.
- Trial name
- NCT06818045
- Testing
- Non Surgical Periodontal Treatment, Periodontal measurements will be performed, biochemical measurements
- Where
- Turkey (Türkiye)
- Volunteers
- 46 people
- Sponsor
- Hatice Yemenoğlu
Bone Infection, Joint Infection
Subcutaneous Suppressive Antibiotic Therapy for Bone and Joint Infections
For patients having a bone or joint infections, with or without device, optimal surgical therapy could be sometimes non-feasible, especially in the elderly population.
- Trial name
- NCT03403608
- Where
- France
- Volunteers
- 10 people
- Sponsor
- Hospices Civils de Lyon
Open Fracture, Pseudarthrosis
Septic Management and Outcome of Open Fracture
The aim is the study of the management and outcome of the open fractures. Some open fractures will become pseudarthrosis. Thoses pseudarthrosis may be septic or not.
- Conditions
- Open Fracture, Pseudarthrosis, Bone and Joint Infection
- Trial name
- NCT04418882
- Testing
- management and follow up of all open fractures
- Where
- France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Bone and Joint Infection, Adherence, Medication
Adherence to Oral Antibiotics In Patients With Osteoarticular Infections
Bone and joint infection (BJI) are bacterial infections that can occur after surgery (nosocomial infections) or de novo. They constitute a public health problem in Western Countries .
- Trial name
- OBSAIO (NCT03311113)
- Testing
- Drug adherence questionnaire
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Allergic Rhinitis, Asthma
Integrating Targeted MedlinePlus Health Prescriptions Into Clinic Practice Workflow
The specific aim of this proposed project is to implement a standard process for integrating MedlinePlus health information prescriptions into the clinic workflow.
- Conditions
- Allergic Rhinitis, Asthma, Back Pain, Benign Prostatic Hypertrophy
- Trial name
- NCT00634608
- Testing
- Health Information Prescription
- Where
- United States
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Asthma, Atrial Fibrillation
The Living With a Long-Term Condition Study
Psychological distress (anxiety and depression) is common in and experienced differently by people living with long-term health conditions (LTCs).
- Conditions
- Asthma, Atrial Fibrillation, Cancer, Cerebrovascular Disorders
- Trial name
- LTC (NCT06072287)
- Testing
- Living with LTC Questionnaire
- Where
- United Kingdom
- Volunteers
- 600 people
- Sponsor
- King's College London