Clinical trials: Bone and Joint Infections
Bone and Joint Infection, Prosthetic Joint Infection
Phage Safety Retrospective Cohort Study
The aim of this study is to determine the imputability of adverse events in patients who have had phage therapy for the treatment of their bone or joint or implant infection, in order to find out whether these adverse effects are…
- Trial name
- PHASACO-retro (NCT04724603)
- Testing
- patients having had avderse event after phagotherapy for bone or joint or implant infection
- Where
- France
- Volunteers
- 25 people
- Sponsor
- Hospices Civils de Lyon
Rheumatoid Arthritis, Spondylarthritis
Quantiferon-TB Gold in the Assessment of Latent TB in Patients Candidate to Treatment or Treated With TNFα Antagonists
The purpose of this study is to evaluate the value of Quantiferon-TB Gold (QFT-G) assay in the screening for latent tuberculosis infection (LTBI) in rheumatologic patients due to start or on treatment with TNFα antagonists.
- Conditions
- Rheumatoid Arthritis, Spondylarthritis, Tuberculosis
- Trial name
- TNFTB (NCT00491933)
- Testing
- Quantiferon-TB Gold assay, Tuberculin skin test
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- ASST Fatebenefratelli Sacco
Prosthesis and Bone Infections, Cutibacterium Acnes
Cutibacterium Acnes in Bone and Joint Infections
Prosthetic Joint Infections (PJIs) are increasing with the use of orthopedic devices on an ageing population. Cutibacterium acnes is a commensal organism that plays an important role in the ecosystem healthy human skin, yet this…
- Trial name
- CaBJI (NCT03950063)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- CHU de Reims
Rheumatoid Arthritis, Inflammatory Bowel Disease
Incidence of Hospitalizations for Serious Infections in Patients Receiving Biologic Anti-Inflammatories for Rheumatologic, Psoriatic, and Gastrointestinal Conditions: A Descriptive Analysis
Purpose: With the existing biologic anti-inflammatory product patents expiring and the FDA approval of new biosimilar and innovator biologics, patients with rheumatologic (RA), psoriatic (PsO-PsA-AS), and gastrointestinal (GI)…
- Conditions
- Rheumatoid Arthritis, Inflammatory Bowel Disease, Psoriasis, Psoriatic Arthritis
- Trial name
- NCT02922192
- Testing
- TNF-α antagonists, non-TNFs, DMARD non-biologics
- Volunteers
- 90,360 people
- Sponsor
- Biologics & Biosimilars Collective Intelligence Consortium
Obesity
Antibiotic-related Serious Adverse Events in Obese Patients Treated for Bone and Joint Infection
It exists recommendations to get an optimal antibiotic treatment for bone and joint infection and prescription of antibiotics in the bone and joint infections on material meets certain obligations: the micro-organism must be…
- Trial name
- NCT02861092
- Where
- France
- Volunteers
- 76 people
- Sponsor
- Hospices Civils de Lyon
Osteoporosis, Inflammatory Rheumatism
Glucocorticoid-induced Osteoporosis in Patients With Chronic Inflammatory Rheumatic Diseases or Psoriasis
Glucocorticoids remain to be among the most important and most frequently used anti-inflammatory and immunosuppressive or immune-modulatory acting drugs to treat rheumatic (and other) diseases.
- Trial name
- Rh-GIOP (NCT02719314)
- Testing
- Glucocorticoid treatment
- Where
- Germany
- Volunteers
- 10,000 people
- Sponsor
- Prof Dr Frank Buttgereit
Bone and Joint Infection
Impact of Pharmaceutical Interviews Regarding the Management of Adverse Effects Related to the Antibiotic Therapy Used to Treat Osteoarticular Infections During Return Home
The primary objective is to evaluate the impact of Pharmaceutical Interviews in the patient self-management of non-severe side effects caused by antibiotics prescribed for the treatment of osteoarticular infections when the…
- Trial name
- EFIRAD (NCT05248490)
- Testing
- pharmaceutical interview
- Where
- France
- Volunteers
- 90 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint
Post-Market Clinical Follow-Up (PMCF) Study Evaluating the Safety and Efficacy of Tıpmed™ Revision Hip Prosthesis System
This is a multicenter, prospective, observational, post-market clinical follow-up (PMCF) study designed to evaluate the safety and clinical performance of the Tipmed™ Revision Hip Prosthesis System in adult participants…
- Conditions
- Revision Hip Arthroplasty, Aseptic Loosening of Prosthetic Joint, Prostheses-related Infections, Joint Instability
- Trial name
- NCT07653295
- Testing
- Tıpmed™ Revision Hip Prosthesis System
- Where
- 4 sites in Turkey (Türkiye)
- Volunteers
- 35 people
- Sponsor
- TIPMED Medical Device Manufacturing Ltd. Co.
Musculoskeletal Infection, Acute Hematogenous Osteomyelitis
Next-Generation Sequencing for Pathogen Detection and Quantification in Children With Musculoskeletal Infections
The purpose of this study is to evaluate the use of a blood test: Karius® plasma-based next-generation sequencing test (Karius Test), to see if we can detect and measure the infection causing agent in children with…
- Conditions
- Musculoskeletal Infection, Acute Hematogenous Osteomyelitis, Septic Arthritis, Osteomyelitis
- Trial name
- KDG-002 (NCT03846804)
- Testing
- Karius Test
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Indiana University
Fracture, Dislocation
Pre-drilling or Self Drilling External Fixation Pins
Hypothesis There is no difference in the incidence of pin tract infection and pin loosening in case of lower extremity external fixators when self-drilling schanz pins are used with or without pre-drilling.
- Trial name
- NCT01046747
- Testing
- Placement of external fixation pins
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Temple University
Infection, Bacterial
Stool Biobanking and Impact of Antimicrobials on the Gut Microbiota in Patients With Bone and Joint Infection
Bone and joint infections (BJI) is a public health issue in industrialized countries. Implant-associated BJI, are complex hospital-acquired infections and eradication of the pathogen is challenging in such patients.
- Trial name
- GUMIBONE (NCT03633188)
- Testing
- Patients treated by antibiotherapy
- Where
- 4 sites in France
- Volunteers
- 12 people
- Sponsor
- Hospices Civils de Lyon
Pain
A Pilot Study of Switching From One Pain Medication to Another (Opioid Rotation)
The purpose of this study is to see if changing from one pain medication like morphine or oxycodone to another pain medication, oxymorphone (OPANA®), will be helpful to patients.
- Trial name
- NCT00580294
- Testing
- Oxymorphone
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Bone and Joint Infection, Bacterial Infections
Microbiological Epidemiology in Patients Experiencing Microbiological or Clinical Failure Following Reimplantation After a 2-stage Exchange Strategy for Hip or Knee Prosthetic Joint Infection
This study concerns patients having had an infection on their prosthesis (hip, knee,..) and for whom a 2-step exchange of prosthesis has been done.
- Conditions
- Bone and Joint Infection, Bacterial Infections, EPIDEMIOLOGY
- Trial name
- NCT03627000
- Testing
- failure after reimplantation
- Volunteers
- 114 people
- Sponsor
- Hospices Civils de Lyon
Bone and Joint Infection, Osteomyelitis
Denosumab Related Osteonecrossi of the Jaw : : an Emergent and Potentially Complex Bone and Joint Infection
The aim of this study is to adescription of mandibular osteomylitis in patients having had a treatment by DENOSUMAB. Indeed, one of the adverse effect ot this molecule is to induce mandibular infection.
- Conditions
- Bone and Joint Infection, Osteomyelitis, Adverse Drug Event
- Trial name
- NCT03808285
- Testing
- mandibular osteomylitis
- Where
- France
- Volunteers
- 13 people
- Sponsor
- Hospices Civils de Lyon
Diabetes, Chronic Kidney Diseases
Benchtop NMR Spectroscopy for Assessment of Clinical Human Pathologies (BRANCH-P STUDY)
This research programme seeks to combine the resources of NHS primary care, with the leading spectroscopic work in low-magnetic fields of the Wilson Group (Nottingham Trent University) to demonstrate the potential for benchtop…
- Conditions
- Diabetes, Chronic Kidney Diseases, Cancer, Bowel Disease
- Trial name
- BRANCH-P (NCT05473325)
- Where
- United Kingdom
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Willows Health
SARS-CoV-2, Systemic Lupus Erythematosus
Association Between Long-term Hydroxychloroquine Treatment and Outcome of a History of Symptoms Suggestive of COVID-19 Infection During the Epidemic Period in France in Patients With Autoimmune Disease
This epidemiological, transversal, cohort study aims to determine the potential influence of an active long-term hydroxychloroquine intake over the prevalence of a history of symptoms evocative of a COVID-19 infection in patients…
- Conditions
- SARS-CoV-2, Systemic Lupus Erythematosus, Rheumatoid Arthritis, Sjogren's Syndrome
- Trial name
- COVCALL (NCT04345159)
- Testing
- Questionnaire by phone call
- Where
- France
- Volunteers
- 572 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Antibiotic Reaction, Bone and Joint Infection
Evaluation of the Use of Cefoxitin in Combination in Continuous Parenteral Administration in the Treatment of Bone and Joint Infections
Cephamycin related to 2nd generation cephalosporins, the use of cefoxitin has long been limited to antibiotic prophylaxis. Because of its spectrum (sensitive staphylococci, enterobacteria including ESBL, streptococci, anaerobes)…
- Trial name
- NCT03848104
- Testing
- bone and joint infection treated with cefoxitin
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Hospices Civils de Lyon
Campylobacter Infections
Campylobacter Spp. Bone and Joint Infection: a Retrospective Cohort Study
Campylobacter bacteria, a Gram-negative bacillus commensal in the digestive tract of many animals and mainly responsible for human infections with digestive origins, has been little studied in the field of osteoarticular…
- Trial name
- Campylo-BJI (NCT06425250)
- Testing
- Management, progression and risk factors for failure of BJI caused by Campylobacter spp., Description of the evolution and risk factors for failure of osteoarticular infections caused by Campylobacter spp.
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Hospices Civils de Lyon
Systemic Lupus, Rheumatoid Arthritis
Yellow Fever Vaccine in Patients With Rheumatic Diseases
According to World Health Organization (WHO), since December 2016, Brazil is showing a significant increase in cases of yellow fever in humans.
- Conditions
- Systemic Lupus, Rheumatoid Arthritis, Spondyloarthritis, Inflammatory Myopathy
- Trial name
- NCT03430388
- Testing
- Yellow Fever vaccine (17D)
- Where
- Brazil
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Degenerative Osteoarthritis, Rheumatic Arthritis
CoreHip - Post Market Clinical Follow-Up Study
The study is designed as a prospective, non-interventional multicentre cohort study. The product under Investigation will be used in Routine clinical practice and according to the authorized Instructions for Use (IfU).
- Conditions
- Degenerative Osteoarthritis, Rheumatic Arthritis, Fractures, Hip, Necrosis, Femur Head
- Trial name
- NCT03685110
- Testing
- CoreHip Total Hip Arthroplasty
- Where
- 6 sites in Germany, Switzerland
- Volunteers
- 248 people
- Sponsor
- Aesculap AG