Clinical trials: Botulinum Toxin
Pain
Subcutaneous Botulinum Toxin for Cutaneous Allodynia - Enriched Responder Trial
Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions.
- Trial name
- NCT00822926
- Testing
- Botulinum Toxin Type A, Saline
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Stanford University
Bruxism, Occlusal Changes
Vertical Facial Morphology and Occlusal Force Changes After Masseter Botulinum Toxin Injection in Bruxism
This study investigated whether the shape of the face affects how jaw muscles respond to botulinum toxin injections in people who grind their teeth (bruxism).
- Trial name
- NCT07673471
- Testing
- Botulinum Toxin Type A (BOTOX) Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 34 people
- Sponsor
- Biruni University
Acne Vulgaris
Clinical Trial To Evaluate ANT-1207 In Subjects With Acne
The purpose of this study is to provide evidence of the safety, tolerance, and efficacy of ANT-1207 in the treatment of acne.
- Trial name
- NCT01293552
- Testing
- ANT-1207, Vehicle
- Where
- 15 sites in United States
- Volunteers
- 72 people
- Sponsor
- Anterios Inc.
Cerebral Palsy, Muscle Hypertonia
Evaluation of the Effect of the Presence Of Clowns on Pain and Anxiety Seen During Injections Botulinum Toxin in Child
In children requiring botulinum toxin injections, improving supervisory procedures of injection sessions to reduce pain and improve the experience of this invasive procedure is needed.
- Trial name
- CLOWN-TOX (NCT03149263)
- Testing
- distraction
- Where
- France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University Hospital, Brest
Cerebral Palsy
Improvement on GMFCS Level of Patients With Cerebral Palsy Treated by Repeated Botulinum Toxin-A
The aim of this retrospective, monocenter, observational study is to evaluate the changes in GMFCS levels of children with cerebral palsy (CP) who received repeated Botulinum Toxin-A (BoNT-A) injections in the lower limb(s) with…
- Trial name
- NCT03344952
- Testing
- Botulinum toxin type A, Physical therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 503 people
- Sponsor
- Kocaeli University
Chronic Pain, Chronic Pelvic Pain Syndrome
BTA vs Baclofen for Pelvic Myofascial Pain Syndrome
The aim of the study is to test the hypothesis that oral taking of baclofen in therapeutic dosage for 60 days is equally effective as injection of botulinum toxin type "A" in the area of trigger points of the pelvic muscles.
- Conditions
- Chronic Pain, Chronic Pelvic Pain Syndrome, Myofascial Pain Syndrome, Myofascial Trigger Point Pain
- Trial name
- BvsB (NCT05617118)
- Testing
- Baclofen 10mg, Botulinum toxin type A
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Saint Petersburg State University, Russia
Overactive Bladder
Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A in treating overactive bladder in spinal cord injury or multiple sclerosis patients.
- Trial name
- NCT00311376
- Testing
- botulinum toxin Type A (200U), botulinum toxin Type A (300U)
- Where
- 14 sites in United States, Australia and 12 more
- Volunteers
- 416 people
- Sponsor
- Allergan
Neuralgia, Chronic Pain
Botulinum Toxin for Chronic Neuropathic Pain
Treatment of peripheral neuropathic pain with Botulinum Toxin (BoNT) has showed promising results since the first study was released in 2001.
- Trial name
- NCT06036043
- Testing
- Botulinum toxin type A
- Where
- Denmark
- Volunteers
- 12 people
- Sponsor
- Region Zealand
Facial Rhytids
Botulinum Toxin A Single Blind Split-Face Randomized Pilot Study
A 16-week single-blind, split-face, randomized study. Each patient served as their own control, receiving onabotulinumtoxinA and abobotulinumtoxinA randomized to either the left or right side of the face.
- Trial name
- NCT02907268
- Testing
- onabotulinumtoxinA, abobotulinumtoxinA
- Volunteers
- 10 people
- Sponsor
- ICLS Dermatology & Plastic Surgery
Recalcitrant Alopecia Totalis, Recalcitrant Alopecia Universalis
The Randomized Double-blind Placebo-controlled Trial of Intralesional Botulinum Toxin A Injection for Recalcitrant Alopecia Totalis and Alopecia Universalis
The main purpose of this study is to determine the efficacy of intralesional botulinum toxin type A injection for recalcitrant alopecia totalis and alopecia universalis.
- Trial name
- NCT00997815
- Testing
- Botulinum toxin A, Normal saline injection
- Where
- Thailand
- Volunteers
- 20 people
- Sponsor
- Siriraj Hospital
Spasticity as Sequela of Stroke
Observational Longitudinal Study on the Outbreak and Management of Stroke Related Spasticity
Stroke is one of the leading cause of death and disability worldwide. Post-stroke spasticity (PSS) is outbreak after a stroke and is featured by disabling muscle stiffness.
- Trial name
- COLOSSEO (NCT05379413)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Italy
- Volunteers
- 960 people
- Sponsor
- Campus Bio-Medico University
Temporo-Myofascial Disorder
Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study
Temporomandibular disorders (TMD) are a group of conditions involving the temporomandibular joint (TMJ), masticatory muscles and associated structures.
- Trial name
- NCT02810015
- Testing
- Botulinum Toxin Type A
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Spasmodic Dysphonia, Quality of Life
Spasmodic Dysphonia Interviews
Previous research has shown that patients with voice disorders often have a lower quality of life and struggle with employment. Spasmodic Dysphonia (SD) is a voice disorder that causes abrupt and uncontrollable spasms of the…
- Trial name
- NCT06561334
- Testing
- Botulinum toxin injections
- Where
- United Kingdom
- Volunteers
- 22 people
- Sponsor
- Manchester University NHS Foundation Trust
Stroke, Brain Injuries
Comparative Efficacy of Three Preparations of Botox-A in Treating Spasticity
The study seeks to compare the effectiveness of three preparations of BOTOX-A® in treating muscle tightness and spasms in the feet and ankles of people with stroke.
- Conditions
- Stroke, Brain Injuries, Spasticity
- Trial name
- NCT00178646
- Testing
- Botox
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- The University of Texas Health Science Center, Houston
Thoracic Outlet Syndrome, Whiplash Injuries
Whiplash-induced Thoracic Outlet Syndrome Treated With Botulinum Toxin.
Whiplash injuries following car accident are common, it has been reported to affect 83% of individuals injured in traffic collisions (Yadla S, 2007).
- Trial name
- NCT05536570
- Testing
- IncobotulinumtoxinA 100 UNT
- Where
- Canada
- Volunteers
- 15 people
- Sponsor
- King, David, MD
Condylar Fractures, Subcondylar Fracture
The Effectiveness of Guided Botulinum Toxin "A" Injection to the Masticatory Muscles in the Management of Condylar and Subcondylar Fractures
The aim of this study, is to evaluate the effectiveness of ultrasound guided injection of botulinum toxin A into the muscles of mastication; the masseter, temporalis and the lateral pterygoid, in a closed reduction approach of…
- Trial name
- NCT07374341
- Testing
- BOTOX Cosmetic®, Closed reduction and intermaxillary fixation
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Pakinam Gheeta
COMPARISON BETWEEN GROUP TREATED WITH BOTULINUM TOXIN AND PLACEBO
Study of the Effect of Botulinum Toxin Injection in Rectus Femoris and Triceps on the Length and the Strength During Locomotion in Chronic Hemiparetic Patients
The aim of this randomized controlled study is to quantify the modification during locomotion of chronic hemiparetic patients of the strength and the length of Rectus Femoris and Triceps Surae induced by botulinum toxin injection…
- Trial name
- FOLOTOX (NCT01821573)
- Testing
- botulinum toxin type A, injection of NaCl 0.9%
- Where
- 3 sites in France
- Volunteers
- 36 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Blepharospasm, Hemifacial Spasm
Testing the Effect of Zinc Supplementation to Improve the Treatment Effect of Botulinum Toxin for Oculofacial Spasm
The purpose of this study is to determine whether zinc supplements are effective in enhancing the treatment of oculofacial spasm disorders with botulinum toxin.
- Trial name
- NCT01546805
- Testing
- Zinc Supplement, Sugar pill
- Where
- 2 sites in Canada
- Volunteers
- 40 people
- Sponsor
- St. Joseph's Healthcare Hamilton
Hernia, Ventral, Hernia Incisional
Compliance-Guided Abdominal Wall Closure Strategy in Large Ventral Hernia Repair
People undergoing repair of large ventral hernias can develop breathing problems after surgery, especially around the time when the abdominal wall is closed.
- Conditions
- Hernia, Ventral, Hernia Incisional, Postoperative Complications, Respiratory Insufficiency
- Trial name
- CLOSE-STAT (NCT07422441)
- Testing
- Compliance-Guided Abdominal Wall Closure Decision Strategy
- Where
- Poland
- Volunteers
- 50 people
- Sponsor
- Swissmed Hospital
Lateral Canthal Lines, Crow's Feet
Dose Finding Study In Subjects With Crow's Feet
The purpose of this study is to establish the therapeutic range of ANT-1401 in the treatment of Crow's Feet.
- Trial name
- NCT01951742
- Testing
- ANT-1401, Vehicle
- Where
- 10 sites in United States
- Volunteers
- 145 people, healthy volunteers welcome
- Sponsor
- Anterios Inc.