Clinical trials: Botulinum Toxin, Type A
Chronic Pain, Post-thoracotomy Pain Syndrome
Botulinum Toxin A as Treatment for Chronic Postsurgical Pain Following Lung Cancer Surgery
Chronic postsurgical pain following lung cancer surgery is common with and 20-60 % develop chronic pain which persists more than six months after surgery. Causes and health impact of this pain have been comprehensively studied.
- Conditions
- Chronic Pain, Post-thoracotomy Pain Syndrome, Pain, Neuropathic, Pain, Postoperative
- Trial name
- NCT04585620
- Testing
- Onabotulinum Toxin A, Normal saline
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Allan Vestergaard Danielsen, MD
Hemifacial Spasm
Study of Abobotulinum Toxin Versus Neubotulinum Toxin Injection For Hemifacial Spasm in Thai Patients
A 50-Week Prospective, Double-Blinded, Randomized, Cross-over design in Multicenter Study of 100 unit of Abobotulinum Toxin Type A (Dysport®) versus 33.33 unit of Neubotulinum Toxin Type A (Neuronox®) Injection for Hemifacial…
- Trial name
- DNHFS (NCT04589364)
- Testing
- Injection botulinum toxin A ( Dysport 100 unit or Neuronox 33.33 unit)
- Where
- 4 sites in Thailand
- Volunteers
- 107 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Overactive Bladder
Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A in treating overactive bladder in spinal cord injury or multiple sclerosis patients.
- Trial name
- NCT00311376
- Testing
- botulinum toxin Type A (200U), botulinum toxin Type A (300U)
- Where
- 14 sites in United States, Australia and 12 more
- Volunteers
- 416 people
- Sponsor
- Allergan
Spasticity as Sequela of Stroke
Spasticity and Treatment Satisfaction Among Stroke Survivors
To investigate, through ethnography, changes in symptom burden and disability and their effects/interference on patient functioning, ability to perform activities of daily living (ADL) and quality of life (QoL) throughout the…
- Trial name
- REBOT (NCT03995524)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Ipsen
Overactive Bladder, Botulinum Toxin
Delivery of Intravesical Botulinum Toxin A Using Low Energy Shock Waves in Treatment of Overactive Bladder: A Feasibility Study
We hypothesize that LESWs might temporarily increase urothelial permeability and facilitate delivery of intravesical botulinum toxin without the need for injection.
- Conditions
- Overactive Bladder, Botulinum Toxin, Intravesical, ESWL
- Trial name
- NCT03385460
- Testing
- ESWL BOTOX
- Where
- Egypt
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hypertrophic Scar
Botulinum Toxin Type a Iontophoresis for Postburn Hypertrophic Scar
The goal of this clinical trial study: is to determine the effect Botulinum toxin type A iontophoresis in hypertrophic scars for post burned patients.
- Trial name
- NCT05771623
- Testing
- Iontophoresis drug delivery device, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Cairo University
Healthy
Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
NT 201 is a Botulinum toxin type A preparation free of complexing proteins. Injected into the muscle, NT 201 causes a reversible local relaxation of the injected muscle.
- Trial name
- NCT00694148
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Migraine Disorders
Botulinum Toxin Type A Blockade of the Sphenopalatine Ganglion in Treatment-refractory Chronic Migraine
This is a clinical trial to assess the efficacy of botox treatment of the sphenopalatine ganglion as an add-on treatment in drug resistant migraine.
- Trial name
- MiBlock (NCT04069897)
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Norway
- Volunteers
- 170 people
- Sponsor
- St. Olavs Hospital
Temporomandibular Disorder
Clinical Evaluation of Botulinum Toxin a in the Management of Temporomandibular Myofascial Pain
This study is a randomized, double-blind, placebo-controlled clinical trial designed to evaluate the effectiveness of botulinum toxin type A (BoNT-A) in patients with temporomandibular myofascial pain who have not improved after…
- Trial name
- NCT07847541
- Testing
- Botulinum Toxin Type A (BoNT-A)
- Where
- Pakistan
- Volunteers
- 118 people
- Sponsor
- Riphah International University
Glabellar Rhytides, Frown Lines Between the Eyebrows
Safety and Efficacy Study of Repeat Treatment With PurTox® Botulinum Toxin Type A for Frown Lines Between the Eyebrows
The overall purpose of this study is to evaluate the safety and effectiveness of repeat treatment of an intramuscular dose of Mentor Purified Toxin for the reduction of frown lines, compared with placebo.
- Trial name
- PT-03b (NCT00752050)
- Testing
- Mentor Purified Toxin Botulinum Toxin Type A, Preservative-free Saline
- Where
- United States
- Volunteers
- 699 people
- Sponsor
- Mentor Worldwide, LLC
Chronic Prostatitis With Chronic Pelvic Pain Syndrome, Prostatitis
Botulinum Toxin Type A for the Treatment of Male Chronic Pelvic Pain Syndrome
The aim of this randomized placebo-controlled study is to demonstrate the efficiency and safety of the injection of Botulinum Toxin Type A (200 Units) into the external urethral sphincter for the treatment of chronic…
- Trial name
- BTX-URO-01 (NCT00464373)
- Testing
- Botulinum Toxin Type A
- Where
- Switzerland
- Volunteers
- 11 people
- Sponsor
- Daniel Stephan Engeler
Plantar Fasciitis
The Efficacy of Botulinum Toxin vs. Corticosteroid for the Treatment of Refractory Plantar Fasciitis
This single-blinded, randomized-controlled trial compares the efficacy of ultrasound-guided onabotulinumtoxinA (BTX-A) injections to the flexor digitorum brevis with current standard of care corticosteroid injections to the…
- Trial name
- NCT05367271
- Testing
- Botulinum Toxin A, Dexamethasone
- Where
- United States
- Volunteers
- 62 people
- Sponsor
- Western Institute for Veterans Research
Magnesium, Botulinum Toxin Type A
Can Adjunctive Oral Magnesium Supplementation Prolong the Effect of Botulinum Toxin Type A in Excessive Gingival Display?
To evaluate and compare the effect of adjuvant oral magnesium supplementation combined with Botulinum Toxin Type A versus Botulinum Toxin Type A alone on the reduction of millimeter gingival display and the duration of clinical…
- Conditions
- Magnesium, Botulinum Toxin Type A, Excessive Gingival Display, Oral
- Trial name
- NCT07874009
- Testing
- Oral Magnesium Glycinate capsules, ● BoNT-A Injection Alone (Day 0)
- Where
- Egypt
- Volunteers
- 26 people
- Sponsor
- Cairo University
Chronic Migraine
A Study of Remote Electrical Neuromodulation for Acute Procedural Pain
The purpose of this study is to assess the effectiveness of using remote electrical neuromodulation, using the Nerivio ® device, to relieve pain associated with receiving onabotulinumtoxinA (Botox) injections for chronic migraine…
- Trial name
- NCT05730556
- Testing
- Nerivio ®
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Mayo Clinic
Arthritis, Pain
Intra-articularInjection of Botulinum Toxin Type
The purpose of this study is to determine whether intra-articular injection of botulinum toxin is effective in the treatment of chronic knee paindue to arthritis.
- Trial name
- NCT00211679
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Minneapolis Veterans Affairs Medical Center
Glabellar Frown Lines
Phase 2a Study of DaxibotulinumtoxinA-lanm for Injection in Dynamic Forehead Lines and Glabellar Lines
This is a Phase 2a open-label, single-arm study to evaluate the effects of DaxibotulinumtoxinA-lanm (DAXI) for Injection on the treatment of dynamic forehead lines (FHL) and glabellar lines (GL).
- Trial name
- NCT06411002
- Testing
- DAXXIFY
- Where
- United States
- Volunteers
- 27 people
- Sponsor
- Revance Therapeutics, Inc.
Male, Ultrasonography
Intraprostatic Injection of Botulinum Toxin A Versus Ethanol for Treatment of Patients With Benign Prostatic Hyperplasia
To compare safely and efficacy of intraprostatic injection of botulinum toxin A versus ethanol for treatment of benign prostatic hyperplasia (BPH).
- Conditions
- Male, Ultrasonography, Botulinum Toxins, Type A, Injection; Complications, Infection
- Trial name
- NCT03385161
- Testing
- Botulinum toxin A, Ethanol
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Cairo University
Glabellar Frown Lines
Efficacy and Safety of Botulinum Toxin at Moderate to Severe Glabellar Lines
Efficacy and safety of ATGC-100 are assessed in subjects with moderate to severe glabellar lines.
- Trial name
- NCT04830345
- Testing
- ATGC-100 100U, Botox 100U
- Where
- South Korea
- Volunteers
- 290 people, healthy volunteers welcome
- Sponsor
- EuBiologics Co.,Ltd
Upper Facial Lines (Glabellar Lines, Forehead Lines, & Lateral Canthal Lines)
Efficacy and Safety of DaxibotulinumtoxinA (DAXI) for Injection for Treatment of Upper Facial Lines
This is a Phase 2, multicenter, open-label, single-arm study to evaluate the efficacy and safety of DaxibotulinumtoxinA for injection (DAXI for injection) in the treatment of Glabellar Lines (GL), Dynamic Forehead Lines (FHL)…
- Trial name
- NCT04259086
- Testing
- DaxibotulinumtoxinA for injection
- Where
- 8 sites in United States, Canada
- Volunteers
- 48 people
- Sponsor
- Revance Therapeutics, Inc.
Nocturnal Bruxism
Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study
A Clinical Trial Study to investigate the potential performance of BTXA on masseter muscle on patient with nocturnal bruxism and to check the pain scale and share this clinical experience.
- Trial name
- NCT03827122
- Testing
- onabotulinumtoxinA
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy