Clinical trials: Botulinum Toxin
Cleft Lip
Botulinum Toxin Injection in Reducing Lip Scar Following Cleft Lip Repair
A cleft lip is a congenital defect resulting from failing to merge developmental processes in the Orofacial region. One of the most common complications surgeons fear after cleft lip repair is a hypertrophic scar.
- Trial name
- NCT05559281
- Testing
- Botulinum, Fisher technique
- Where
- Egypt
- Volunteers
- 22 people
- Sponsor
- Hams Hamed Abdelrahman
Cerebral Palsy
Which is the Best Dose of Dysport in Helping With Hip Pain for Children With Cerebral Palsy?
The purpose of the study is to compare the effectiveness of 3 doses of Dysport (5, 10 or 15 Units/Kg/hip) in the management of chronic bilateral hip pain due to cerebral palsy in children/young people.
- Trial name
- NCT00455637
- Testing
- Botulinum toxin type A
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Ipsen
Hemifacial Microsomia, Facial Nerve Paralysis
Treatment for "Asymmetric Crying Facies"
This study focuses on children with hemifacial microsomia (HFM), a common congenital craniofacial deformity caused by abnormal development of the first and second branchial arches.
- Trial name
- NCT07802639
- Testing
- Botulinium toxin type A injection
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Xiaolei Jin
Hemorrhoids Third Degree
Open Hemorrohoidectomy Vs Transanal Hemorrhoidal Desarterialization in Hemorrhoids Grade III: The Effect on Symptoms
The goal of this clinical trial is to learn if open hemorroidectomy diminishes symptoms compared to transanal hemorrhoidal desarterialization (THD) in patients presenting with hemorrhoids grade III.
- Trial name
- NCT06420986
- Testing
- Open Hemorrhoidectomy, Transanal Hemorrhoidal Dearterialization
- Where
- Spain
- Volunteers
- 50 people
- Sponsor
- Hospital Son Llatzer
Temporomandibular Joint Disorder Bilateral
Efficacy of Botulinum Toxin in Temporomandibular Disorders
Temporomandibular disorders (TMDs) represent a multifactorial pathological group that gives rise to a varied and complex symptomatology that includes decreased jaw movement, muscle and joint pain, joint crepitation and limitation…
- Trial name
- TMD (NCT05651256)
- Testing
- Botulinum toxin type A injection
- Where
- Spain
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Salamanca
Sun-induced Wrinkles
Safety and Efficacy of the Full Face Applications of Variable Doses of a Commercial Botulinum Toxin Type a (Dysport®)
This is an open-label and phase IV study of full face injections of variable doses of botulinum toxin type A (BT-A). As it is an open-label and not blind study, both investigator and subjects will know the injection local and…
- Trial name
- NCT01032954
- Testing
- Botulinum toxin
- Where
- Brazil
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
High Tone Pelvic Floor Dysfunction
EMG Guided Botulinum Toxin Type A Injections for Refractory High Tone Pelvic Floor Dysfunction
This is a prospective, pilot, longitudinal study to evaluate the use of EMG guidance for Botox A injection for chronic pelvic pain and HTPFD.
- Trial name
- BTXA EMG (NCT01323829)
- Testing
- EMG Guidance of Injection
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Pelvic and Sexual Health Institute
Overactive Bladder, Incontinence, Daytime Urinary
Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB)
A non-intervention cohort study on the use of Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB). Primary endpoint was the reduction of urinary incontinence.
- Conditions
- Overactive Bladder, Incontinence, Daytime Urinary, Incontinence, Nighttime Urinary
- Trial name
- NCT06569342
- Testing
- Intradetrusor BoNT-A
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- University of Aarhus
Fissure in Ano
Complex Treatment of a Chronic Anal Fissure
This study is aimed at studying the efficacy and safety of treating chronic anal fissure with botulinum toxin versus lateral subcutaneous sphincterotomy.
- Trial name
- NCT03855046
- Testing
- IncobotulinumtoxinA 50 U Intramuscular Powder for Solution, Lateral subcutaneous sphincterotomy.
- Where
- 7 sites in Russia
- Volunteers
- 340 people
- Sponsor
- State Scientific Centre of Coloproctology, Russian Federation
Spinal Cord Injury, Neuropathic Pain
Neuropathic Pain Study With Botulinum Toxin A in Spinal Cord Injury Patients
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in spinal cord injury patients.
- Trial name
- NCT01579500
- Testing
- Botulinum toxin type A, normal saline
- Where
- South Korea
- Volunteers
- 40 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Spasticity, Cerebral Palsy
Shockwaves Therapy and Botulinum Toxin for the Treatment of Spasticity in Patients With Cerebral Palsy. A Cross Over RCT
Spasticity is a motor disorder that can affect the lower limbs in up to 75% patients with cerebral palsy, having a significantly effect on their mobility and quality of life.
- Trial name
- NCT02400619
- Testing
- shock waves, Botulinum Toxin Type A
- Where
- Spain
- Volunteers
- 70 people
- Sponsor
- Xavi Vidal Novellas
Bite Force, Botulinum Toxins, Type A
Muscle Weakness Duration After Single Botulinum Toxin Injection in Masseter
This study aimed to evaluate the duration of a reduced maximal voluntary bite force after a botulinum toxin intervention. Methods: In an intervention group, 25 units of Xeomin® (Merz Pharma GmbH \& Co KGaA, Frankfurt am Main…
- Trial name
- NCT05309564
- Testing
- Botulinum toxin type A
- Where
- Sweden
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Region Västerbotten
Focal Dystonia
fMRI Studies of Task Specificity in Focal Hand Dystonia
This study will examine how the brain makes involuntary spasms and contractions in patients with focal hand dystonia (FHD). Patients with dystonia have muscle spasms that cause uncontrolled twisting and repetitive movement or…
- Trial name
- NCT00310414
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Leg Length Inequality, Foot Deformities
Botox Clinical Trial
The surgery to correct leg \& foot deformities in children is a lengthy, \& sometimes, difficult procedure. Metal frames are attached to the leg and / or foot and over a period of time the frame is manipulated to obtain the…
- Trial name
- NCT00624299
- Testing
- Botox, Saline
- Where
- United Kingdom
- Sponsor
- Sheffield Children's NHS Foundation Trust
Stroke, Post-Stroke Spasticity
ESTIM-UL: FES for Upper Limb Recovery After Stroke
Stroke is a leading cause of long-term disability, frequently resulting in impaired upper limb motor function and spasticity. Although Botulinum Toxin Type A (BoNT-A) is effective in reducing focal spasticity, functional recovery…
- Conditions
- Stroke, Post-Stroke Spasticity, Post-Stroke Hemiparesis
- Trial name
- ESTIM-UL (NCT07513714)
- Testing
- Functional Electrical Stimulation (FES), Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Foggia
Blepharospasm
Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm
To evaluate the efficacy of different botulinum toxin A injection patterns in treating benign essential blepharospasm and to compare their influence on condition of eye surface .
- Trial name
- NCT02327728
- Testing
- Botulinum toxin A injection (5 sites: 12.5U), Botulinum toxin A injection (4 sites: 10U), Botulinum toxin A 12.5U
- Where
- China
- Volunteers
- 120 people
- Sponsor
- YangHui
Keratoconus
Botulinum Toxin A for the Treatment of Keratoconus
The purpose of this study is to associate the use of botulinum toxin type A for patients with keratoconus to demonstrate that tension eyelid has an important role in disease progression.
- Trial name
- NCT01691651
- Testing
- Subcutaneous injection of botulinum toxin type A, Botulinum Toxin Type A
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Upper Limb Spasticity Post-Stroke
Botulinum Toxin A Associated Costs in the Treatment of Upper Limb Spasticity Post Stroke
This study aims to estimate the costs of botulinum toxin A utilization in standard practice for the treatment of upper limb spasticity post-stroke in Portugal.
- Trial name
- P_Dysport_CS (NCT02384330)
- Where
- 3 sites in Portugal
- Volunteers
- 57 people
- Sponsor
- Ipsen
Browlift
Frontalis Botulinum Toxin
The botulinum toxin was first identified in the late 19th century(1). With its 40 different subtype this toxin is produced mainly by the gram positive anaerobic bacteria Clostridium Botulinum(2).
- Trial name
- NCT03186001
- Testing
- Abobotulinum toxin A
- Where
- Lebanon
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon
Cerebral Palsy
A Pilot Study of the Effect of Botulinum Toxin Type a (Dysport®, Abobotulinum Toxin A) Injection on Changes in Musculotendinous Length and Dynamics of Hamstring Muscles During Gait in Children With Spastic Cerebral Palsy Walking With Excessive Knee Flexion
This is a longitudinal, prospective, and open-label interventional study in a single center. We will investigate the effect of single injection in each patient.
- Trial name
- NCT02917967
- Testing
- Botulinum toxin injection
- Where
- South Korea
- Volunteers
- 31 people
- Sponsor
- Yonsei University