Clinical trials: Botulinum Toxin
Hemiplegic Patients Post-AVC
Central Effects of Botulinum Toxin: Neurophysiological Study in Stroke Patients With Spastic Lower Limb
Spasticity is a motor disorder characterized by a velocity-dependent increase in tonic stretch reflex with exaggerated tendon jerk (Lance 1980).
- Trial name
- NCT01829763
- Testing
- injection botox
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique Hopitaux De Marseille
Urge Urinary Incontinence
Intravesical Instillation of Botulinum Toxin Type A to Patients With Urge Urinary Incontinence
A pilot study to examine efficacy and safety of intravesical botulinum toxin type A.
- Trial name
- NCT00770406
- Testing
- botulinum toxin type A
- Where
- Denmark
- Volunteers
- 20 people
- Sponsor
- Glostrup University Hospital, Copenhagen
Stroke, Spasticity
Upper Extremity Rehabilitation Using Robot and Botulinum Toxin
Concomitant use of botulinum toxin and robot would make better results regarding upper extremity function compared to robot, botulinum toxin, or no intervention.
- Trial name
- NCT02228863
- Testing
- Early Inmotion and Botox, Botox, then Inmotion, Inmotion, then Botox
- Where
- South Korea
- Volunteers
- 348 people
- Sponsor
- National Rehabilitation Center, Seoul, Korea
Urinary Tract Disease
Antibiotic Strategy and Asymptomatic Bacteriuria in the Context of Intra-vesical Botulinum Toxin A Injections.
The study aims to demonstrate that the "thrifty antibiotic strategy" applied to MS or SCI patients with asymptomatic bacteriuria prior to BoNTA intravesical injections does not increase the rate of symptomatic post-injection UTIs…
- Trial name
- ANTIBIOBONTA (NCT05534399)
- Testing
- Intra-vesical BoNTA injections
- Where
- France
- Volunteers
- 526 people
- Sponsor
- University Hospital, Lille
Bruxism, Masseter Muscle Hypertrophy
Effect of Different Treatment Techniques on Masseter Muscle Thickness
This study aims to evaluate the effects of different treatment techniques on masseter muscle thickness, pain levels and maximum mouth opening in patients with bruxism.
- Trial name
- NCT06593821
- Testing
- Occlusal splint, preventive advice, Botulinum toxin
- Where
- Turkey (Türkiye)
- Volunteers
- 48 people
- Sponsor
- Zonguldak Bulent Ecevit University
Sleep Bruxism, Adult
Bruxism Xeomin® Intervention Trial
The purpose of this study is to test whether severe masticatory muscle spasms during sleep (e.g. teeth clenching and grinding, known as "bruxism" in technical jargon) demonstrably decrease after application of botulinum toxin…
- Trial name
- BRUX-XIT (NCT04792398)
- Testing
- Incobotulinumtoxin A (BTX A) Xeomin®
- Where
- Switzerland
- Volunteers
- 6 people
- Sponsor
- Dominik Ettlin
Facial Rhytides, Glabellar Rhytides
A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides
This is a safety and efficacy study of onabotulinumtoxinA in subjects with upper facial rhytides (forehead lines, glabellar lines, lateral canthal lines [crow's feet lines]).
- Trial name
- NCT02261493
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 24 sites in United States, Belgium and 2 more
- Volunteers
- 787 people
- Sponsor
- Allergan
Forward Head Posture With Associated Episodic Headache Disorder
Safety and Efficacy Study of Botox in the Treatment of Forward Head Posture With Associated Episodic Headache Disorder
This study will investigate the therapeutic utility of BOTOX in reducing the degree of Forward Head Posture (FHP) with associated headache and myofascial pain, decreasing the frequency of headache, and improving the overall…
- Trial name
- NCT01350375
- Testing
- Botox, Saline
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Research Center of Southern California
Upper Limb Spasticity After Stroke
A Prospective, Non-interventional Survey to Evaluate Injection Intervals and Treatment Modalities of Botulinum Toxin A (BoNT-A) in Adult Patients Suffering From Upper Limb Spasticity After Stroke
The purpose of the protocol is to evaluate injection intervals and treatment modalities up to 3 years follow-up of botulinum toxin A (BoNT-A) in adult patients suffering from upper limb spasticity after stroke.
- Trial name
- DECIDE (NCT01239628)
- Where
- 11 sites in Belgium
- Volunteers
- 45 people
- Sponsor
- Ipsen
Obesity
Endoscopic Ultrasound Guided Gastric Botulinum Toxin Injections Versus Glucagon Like Peptide 1 Receptor Agonist in Weight Loss
Background: Obesity is an important public health concern. Surgery is effective but invasive and expensive, and some obese persons are not good surgical candidates.
- Trial name
- NCT05268627
- Testing
- Liraglutide
- Where
- 2 sites in Egypt
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Hyperactive Masseter Muscle
Evaluation the Efficacy of Zinc on Botulinum Toxin A Injection
This clinical trial seeks to investigate a promising new approach to enhance the effectiveness and duration of Botulinum Toxin A (BTX-A) for the treatment of hyperactive masseter muscles.
- Trial name
- BTX-A (NCT07270042)
- Testing
- BOTOX 100U in normal saline with zinc
- Where
- Syria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Latakia University
Self Rehabilitation Combined With BTI on Upper Limb
Upper Limb Botulinum Toxin Injection Combined With Self Rehabilitation
To show that the addition of a self-rehabilitation program to standard treatment, involving repeated BTI and usual physiotherapy, improves impairment and activity limitation of the paretic upper limb more than the control…
- Trial name
- Armautotox (NCT02699762)
- Testing
- self rehabilitation of upper limb in experimental group
- Where
- France
- Volunteers
- 35 people
- Sponsor
- Centre d'Investigation Clinique et Technologique 805
Head Neck Cancer, Xerostomia Following Radiotherapy
Pretreatment Botulinum Toxin in Head and Neck Cancer Surgery
Head and neck cancer care, including tumors of the mouth, nose, throat and voice box, often requires radiation for cure to be achieved.
- Trial name
- NCT06530524
- Testing
- OnabotulinumtoxinA
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Chronic Anal Fissure
Postero-lateral Internal Sphincterotomy vs Botulinum Toxin Injection in the Treatment of Chronic Anal Fissure
We hypothesized that optimization of the dose of the Botulinum toxin injection (BT) and standardization of the technique of lateral internal sphincterotomy to posterolateral internal sphincterotomy (PIAS) could, in turn, report a…
- Trial name
- NCT03920449
- Testing
- Botulinum Toxins, Posterolateral internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Cerebrovascular Accident, Stroke
Spastic Cocontractions and Limitation of Active Movements Before and After Treatment During Injection of Botulinum Toxin
Following a stroke , 55% of the patients do not recover any traction of the upper limb and 30% a residual motricity not allowing a functional grip.
- Trial name
- NCT03453008
- Testing
- elbow extension, electromyography
- Where
- France
- Volunteers
- 14 people
- Sponsor
- University Hospital, Toulouse
Chronic Brain Injury, Cerebral Stroke
Qualitative Study Patient & Physician Experiences Botox COVID-19
During the COVID-19 pandemic and subsequent series of Lockdowns, clinic out-patient spasticity services were replaced with video based tele-consultation appointments, in order to reduce the potential risk of virus transmission…
- Conditions
- Chronic Brain Injury, Cerebral Stroke, MS (Multiple Sclerosis)
- Trial name
- QualBotoxCov (NCT05435404)
- Where
- United Kingdom
- Volunteers
- 11 people
- Sponsor
- East Kent Hospitals University NHS Foundation Trust
Overactive Bladder
Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Neurogenic Overactive Bladder
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A in treating overactive bladder in spinal cord injury or multiple sclerosis patients.
- Trial name
- NCT00311376
- Testing
- botulinum toxin Type A (200U), botulinum toxin Type A (300U)
- Where
- 14 sites in United States, Australia and 12 more
- Volunteers
- 416 people
- Sponsor
- Allergan
Chronic Anal Fissure
Low Versus High Dose OnabotulinumtoxinA for Chronic Anal Fissure
This prospective single-center cohort study describes short-term and one-year clinical outcomes of two routine doses of OnabotulinumtoxinA (20 units versus 50 units) for chronic anal fissure refractory to conservative therapy.
- Trial name
- NCT07543315
- Testing
- OnabotulinumtoxinA
- Where
- Egypt
- Volunteers
- 150 people
- Sponsor
- Tanta University
Anal Fissure
Comparison of Treatment Success of Botox Injection in the Internal Sphincter Versus Isosorbidedinitrate Ointment in Patients With an Anal Fissure
The standard treatment of anal fissure in the netherlands (ISDN ointment) is being compared to a relatively new treatment (injection of Botox in the internal anal sphincter).
- Trial name
- NCT00827736
- Testing
- Botox, ISDN ointment
- Where
- Netherlands
- Volunteers
- 73 people
- Sponsor
- Onze Lieve Vrouwe Gasthuis
Athletic Pubalgia
Intra-muscular Botulinum Toxin A in Chronic Athletic Pubalgia
Chronic athletic pubalgia is a frequent sport condition in which the effectiveness of medical treatment has not been proven. Intra-muscular injection of botulinum toxin A may have positive effects on pain in some chronic…
- Trial name
- PUBATOX (NCT05430893)
- Testing
- Botulinum Toxin A
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris