Clinical trials: Botulinum Toxin
Sialorrhea True Bulbar Palsy Medullary Injury
A Clinical Study of Ultrasound-guided Botulinum Toxin A Into Salivary Gland for Sialorrhea After True Bulbar Palsy
Sialorrhea refers to a group of syndromes characterized by excessive saliva secretion from the salivary glands or reduced clearance of oral saliva due to dysphagia, resulting in saliva overflowing from the corners of the mouth or…
- Trial name
- NCT07070817
- Testing
- Ultrasound-Guided Botulinum Toxin Type A (BoNT-A) Salivary Gland Injection, Control (Normal saline)
- Where
- China
- Sponsor
- houyajing
Diabetic Neuropathies
Botulinum Toxin Type A in Diabetic Peripheral Neuropathy
Background: Diabetes mellitus is commonly complicated by diabetic peripheral neuropathy. Due to common side effects and poor tolerance to medication, poor adherence to medication is common in diabetic peripheral neuropathy.
- Trial name
- NCT05296759
- Testing
- botulinum toxin A, Gabapentin, Duloxetine
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Alexandria University
Dysphonia, Spastic, Dysphonia
Reversal of Botulinum Neurotoxin Injection Related Dysphonia With Pyridostigmine
The purpose of this study is to evaluate the effects of pyridostigmine (Mestinon) on patient vocal outcomes after undergoing laryngeal botulinum neurotoxin (BoNT) injections, which is a standard treatment for spasmodic dysphonia.
- Conditions
- Dysphonia, Spastic, Dysphonia, Laryngeal Dystonia
- Trial name
- NCT05110417
- Testing
- Pyridostigmine Bromide 60 Milligrams (mg)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Eastern Virginia Medical School
Interstitial Cystitis
Intravesical Instillation of Liposome Encapsulated Botulinum Toxin A (Lipotoxin) in Treatment of Interstitial Cystitis
To evaluate the efficacy and safety of intravesical instillation of Lipotoxin for the treatment of IC/BPS
- Trial name
- NCT02247557
- Testing
- Liposome encapsulated BoNT-A, BOTOX 200U in normal saline, Normal saline
- Where
- Taiwan
- Volunteers
- 90 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Glabellar Frown Lines
Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study I
The aim of this study is to assess the efficacy and safety of BoNT/A-DP in the treatment of glabellar lines in comparison with placebo, including efficacy after repeat treatments and long term safety.
- Trial name
- BLESS I (NCT02677298)
- Testing
- Botulinum Toxin A
- Where
- 18 sites in United States, Germany and 1 more
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- Croma-Pharma GmbH
Nocturnal Bruxism
The Use of Low-Dose Botulinum Toxin Injection Into the Masseter Muscle to Treat Sleep Bruxism
Botulinum toxin (BOTOX®) injections into the masseter muscle are an effective treatment for nocturnal bruxism, with several trials using various dosages of botulinum toxin for this purpose.
- Trial name
- NCT05620316
- Testing
- BOTOX® Injection, Prick skin
- Where
- Syria
- Volunteers
- 22 people
- Sponsor
- Damascus University
Breast Neoplasms, Neoplasms by Site
The Use of Botulinum Toxin A in Two-Stage Tissue Expander/ Implant Breast Reconstruction
Breast reconstruction is a common procedure with over 86,000 breast reconstruction procedures performed in the United States in 2009. This is a 1.5-fold increase since 2007.
- Conditions
- Breast Neoplasms, Neoplasms by Site, Neoplasms, Breast Diseases
- Trial name
- Botox (NCT01427400)
- Testing
- Botulinum Toxin-A, Saline
- Where
- 2 sites in Canada
- Volunteers
- 128 people
- Sponsor
- University of British Columbia
Overactive Detrusor
Botulinum Toxin in the Treatment of Idiopathic Detrusor Overactivity
Overactive Bladder (OAB) is a chronic condition caused by instability of the detrusor or bladder muscle, which gives rise to symptoms of urinary urgency and often urinary incontinence.
- Trial name
- NCT02009540
- Testing
- Botulinum toxin injected to bladder body, Botulinum toxin injected into trigone
- Where
- Ireland
- Volunteers
- 60 people
- Sponsor
- Mr HD Flood
Lateral Canthal Lines, Crow's Feet
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the efficacy and safety of a single administration of RT001 compared to placebo gel for the treatment of moderate to severe lateral canthal lines.
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT00968825
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Cerebral Palsy
Music Therapy During Botulinum Injections
The primary objectives for this study are: 1. To demonstrate that music therapy can be an effective means of procedural support for children undergoing botox injections. 2.
- Trial name
- NCT00178217
- Testing
- Music Therapy
- Where
- United States
- Volunteers
- 101 people
- Sponsor
- University of Rochester
Hyperhidrosis
The Use of Microneedles With Topical Botulinum Toxin for Treatment of Palmar Hyperhidrosis
Hyperhidrosis or sweating of palms results from the overactivity of sweat glands and leads to psychosocial impairment with reduction in quality of life in those that are affected.
- Trial name
- NCT03203174
- Testing
- Microneedle, Botulinum Toxin Type A, Saline
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Lateral Canthal Lines, Crow's Feet
Efficacy and Safety Study of RT001 for the Treatment of Moderate to Severe Lateral Canthal Lines in Adults
The purpose of this study is to find out if an investigational drug, called RT001 Botulinum Toxin Type A Topical Gel, is safe and useful in minimizing the wrinkles between the eye and hairline called crow's feet, also known as…
- Conditions
- Lateral Canthal Lines, Crow's Feet, Facial Wrinkles
- Trial name
- NCT01064518
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Cervical Dystonia
Safety and Effectiveness of Valbenazine as Adjunct Therapy to Botulinum Toxin Injections in Cervical Dystonia
The most common form of idiopathic dystonia is adult-onset cervical dystonia (CD), a focal form of dystonia affecting the muscles of the neck.
- Trial name
- NCT06771323
- Testing
- Valbenazine
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Virginia Commonwealth University
Complex Regional Pain Syndrome
"Efficacy of Botulinum Toxin Injection in Reducing Limb Pain in Patients With Complex Regional Pain Syndrome"
Objective: The primary aim is to evaluate the efficacy of botulinum toxin A in reducing overall limb pain in patients with complex regional pain syndrome (CRPS).
- Trial name
- NCT03616262
- Testing
- Botox + Lidocaine, Lidocaine alone
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- VA Connecticut Healthcare System
Stomach Neoplasms
Botulinum Toxin for Stomach Cancer Treatment
Preclinical studies at our institution, using a genetic mouse model of gastric cancer, strongly suggest that innervation of the stomach wall is required not only for the development, but also for the progression of gastric…
- Trial name
- NCT01822210
- Testing
- Botox
- Where
- Norway
- Volunteers
- 7 people
- Sponsor
- St. Olavs Hospital
Glabellar Lines
Efficacy and Safety Assessment of Botulax® and BOTOX® for Improvement of Glabellar Lines.
This study is a phase 3 clinical trial of multi-center, random, blinded*, parallel control, and positive control to evaluate the efficacy and safety of Botulax® Injection compared to BOTOX® for improving moderate to severe…
- Trial name
- NCT05380154
- Testing
- Botulinum Toxin A type for injection (Botulax®), Botulinum Toxin A type for injection (BOTOX®, Bao Tuo Shi®)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Hugel
Overactive Bladder, Urinary Urge Incontinence
Intradetrusor Botulinum Toxin A for OAB Via 1 Versus 10 Injections: A Randomized Clinical Trial
Patients with either overactive bladder (OAB) or urgency urinary incontinence (UUI) with be randomized (like a flip of a coin) to receive 100 units of bladder Botox® at either one injection site or ten injection sites.
- Conditions
- Overactive Bladder, Urinary Urge Incontinence, Overactive Bladder Syndrome, Urinary Incontinence, Urge
- Trial name
- NCT05308979
- Testing
- OnabotulinumtoxinA 100 UNT [Botox]
- Where
- United States
- Volunteers
- 116 people, healthy volunteers welcome
- Sponsor
- University of California, Irvine
Ischemic Stroke, Hemorrhagic Stroke
Goal Attainment Scaling in Upper Limb Spasticity Treatment
Patients after stroke with upper limb spasticity treated with botulinum toxin-A (BTX-A) will be included in this two-part study.
- Trial name
- GASBTX (NCT04975646)
- Testing
- Prescribed exercise program
- Where
- Slovenia
- Volunteers
- 70 people
- Sponsor
- University Rehabilitation Institute, Republic of Slovenia
Post-Stroke Elbow Spasticity
Optimal Dose of Extracorporeal Shock Wave Therapy After Botulinum Toxin Type A Injection for Post-stroke Spasticity
Recently, It is known that the efficacy of botulinum toxin type A (BTX-A) with extracorporeal shock wave therapy (ESWT) is greater than that of BTX-A with electrical stimulation in the management of post-stroke spasticity of the…
- Trial name
- NCT02358005
- Testing
- Extracorporeal shock wave therapy 60mj, Extracorporeal shock wave therapy 120mj, non extracorporeal shock wave therapy
- Where
- South Korea
- Volunteers
- 60 people
- Sponsor
- Yonsei University
Glabellar Lines
Efficacy and Safety of Botulinum Toxin Type A Haemagglutinin Complex Next Generation (BTX-A-HAC NG) in Glabellar Lines
The purpose of the protocol is to demonstrate the safety and the efficacy of a single injection of a new formulation of Clostridium Botulinum toxin type A haemagglutinin complex (BTX A HAC NG) to improve the appearance of…
- Trial name
- NCT02493946
- Testing
- Botulinum toxin type A
- Where
- 24 sites in France, Germany and 1 more
- Volunteers
- 600 people
- Sponsor
- Ipsen