Clinical trials: Botulinum Toxin
Stroke With Hemiparesis
Study of Botulinum Toxin and Recovery of Hand Function After Stroke
The purpose of this study is to determine whether injections of botulinum toxin (commonly known as BOTOX®) into the affected hand of Stroke patients, while targeting the muscles controlling the hand, will lead to improved use of…
- Trial name
- NCT01422161
- Testing
- Botulinum Toxin commonly known as BOTOX®
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- NYU Langone Health
Face Pain
Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques
Botulinum toxin-A (BTX-A) prevents the release of acetylcholine in presynaptic terminals of the neuromuscular junction. It has been proposed to be effective in spastic conditions of the head and neck including oromandibular…
- Trial name
- NCT00992108
- Testing
- lidocaine, chemodenervation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Scar
Botox in the Healing of Surgical Wounds of the Neck
The investigators hypothesize that Botox A will reduce scarring and improve healing of surgical neck wounds.
- Trial name
- NCT01177358
- Testing
- Botulinum Toxin Type A, Normal Saline
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Chronic Pain, Chronic Pelvic Pain Syndrome
BTA vs Baclofen for Pelvic Myofascial Pain Syndrome
The aim of the study is to test the hypothesis that oral taking of baclofen in therapeutic dosage for 60 days is equally effective as injection of botulinum toxin type "A" in the area of trigger points of the pelvic muscles.
- Conditions
- Chronic Pain, Chronic Pelvic Pain Syndrome, Myofascial Pain Syndrome, Myofascial Trigger Point Pain
- Trial name
- BvsB (NCT05617118)
- Testing
- Baclofen 10mg, Botulinum toxin type A
- Where
- Russia
- Volunteers
- 52 people
- Sponsor
- Saint Petersburg State University, Russia
Obesity
Effects of Gastric Antral Botulinum Toxin Injections in Obese Subjects
Obesity is an important public health problem in the United States. The investigators hypothesize that stomach injections of botulinum toxin A (BTA), delivered through an endoscope using endoscopic ultrasound (EUS), may cause…
- Trial name
- NCT00976443
- Testing
- BTA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Neuralgia
Botulinum Toxin Type A for Neuropathic Pain in Patients With Diabetic Peripheral Polyneuropathy
The purpose of this study is to determine whether botulinum toxin A is effective in the treatment of neuropathic pain in patients with diabetic peripheral polyneuropathy.
- Trial name
- BTXADMPPNP (NCT02460107)
- Testing
- Botulinum toxin type A, Normal saline
- Where
- South Korea
- Volunteers
- 9 people
- Sponsor
- Catholic University of Korea Saint Paul's Hospital
Multiple Sclerosis, Tremor
The Efficacy of Botulinum Toxin in Disabling Multiple Sclerosis (MS) Tremor
The incidence of tremor in Multiple Sclerosis (MS) has been estimated to affect up to 2/3rds of patients. Over half of the tremors involve the upper limb and frequently lead to further disability.
- Trial name
- NCT01018485
- Testing
- Botulinum Toxin Type A
- Where
- Australia
- Volunteers
- 30 people
- Sponsor
- Melbourne Health
Upper Esophageal Sphincter
Cricopharyngeal Dysfunction in Adults
The objective of the study, after reviewing the recent literature, is to corroborate the thesis of the authors considering the injection of botulinum toxin as a gesture that is both diagnostic and therapeutic in the disorders of…
- Trial name
- NCT03598933
- Where
- France
- Volunteers
- 28 people
- Sponsor
- University Hospital, Strasbourg, France
Cervicobrachial Neuralgia, Myofascial Pain Syndromes
Study to Evaluate the Efficacy of Botulinum Toxin Serotype A Injections for Cervicobrachial Myofascial Syndrome
Several studies have previously examined the use of botulinum toxin serotype A for myofascial pain of the neck and shoulders (cervicobrachial syndrome). These studies have suffered from: 1.
- Trial name
- NCT00241215
- Testing
- Botulinum toxin serotype A
- Where
- United States
- Volunteers
- 132 people
- Sponsor
- University of California, Los Angeles
Cerebral Palsy, Cerebral Palsy, Spastic
Physiotherapy After Botulinum Toxin Injection and Serial Casting
The effects of different physiotherapy programs on children with cerebral palsy who have been received botulinum toxin injection and serial casting application will be determined.
- Trial name
- NCT05312125
- Testing
- backward downhill walking, routine physiotherapy
- Where
- Turkey (Türkiye)
- Volunteers
- 19 people
- Sponsor
- Gazi University
Strabismus
Eye Muscle Needle Electromyogram (EMu) Study
In some cases, strabismus, or squint, is treated with injections of Botulinum toxin (BTX) to temporarily relax the eye muscle responsible for causing the eye to be pulled to one side.
- Trial name
- EMu (NCT03895632)
- Where
- United Kingdom
- Volunteers
- 25 people
- Sponsor
- Liverpool University Hospitals NHS Foundation Trust
Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy
Perineural Botulinum Toxin Injection Versus Oral Duloxetine in Relief of Foot Pain in Painful Peripheral Diabetic Neuropathy
Painful diabetic peripheral neuropathy (DPN) is a frequent and disabling complication of diabetes that commonly causes persistent foot pain, sleep impairment, and decreased quality of life.
- Conditions
- Diabetic Peripheral Neuropathy, Painful Diabetic Neuropathy, Diabetic Foot Pain, Neuralgia
- Trial name
- NCT07882238
- Testing
- Botulinum Toxin Type A, Duloxetine
- Volunteers
- 56 people
- Sponsor
- Assiut University
Sternotomy Closure,Open Heart Surgery
Botulinum Toxin Injection After Sternotomies to Improve Scar Aspect and Impact
Sternotomy scars, which are localized in a high-tension area are often dystrophic, hypertrophic or keloidal, and can be difficult to accept to patients who already endured a heavy intervention with high psychologic impact.
- Trial name
- BotuCiSter (NCT07013240)
- Testing
- Botulinum toxin injection
- Where
- France
- Volunteers
- 50 people
- Sponsor
- University Hospital, Bordeaux
Urinary Urge Incontinence
Efficacy of Botulinum Toxin Type A for the Treatment of Non-neurogenic Urinary Urge Incontinence
Non-neurogenic urinary urge incontinence (UUI) is a common quality of life disorder that causes people to feel an "urgent" need to urinate.
- Trial name
- NCT01226706
- Testing
- Botulinum Toxins, Type A
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Saskatchewan Health Authority - Regina Area
Restless Legs Syndrome
Restless Legs Syndrome Treatment With Botulinum Toxin
Restless Legs Syndrome (RLS) is a common sensori-motor disorder that causes sensory discomfort and motor restlessness, most often in the legs, which improves with movement.
- Trial name
- SOXIS (NCT00949806)
- Testing
- BNT (intradermal injection)
- Where
- France
- Volunteers
- 27 people
- Sponsor
- University Hospital, Bordeaux
Post Stroke Spasticity
Relation Between Dose and Time to Reinjection of Botulinum Toxin-A in Patient With Poststroke Spasticity From a Real-world Healthcare Insurance Database.
Determining the mean/median time between botulinum toxin-A injection within the treatment of patients with spasticity after stroke in relation to the botulinum toxin dose from a healthcare insurance database in the Netherlands.
- Trial name
- Relax (NCT04649632)
- Where
- Netherlands
- Volunteers
- 451 people
- Sponsor
- Ipsen
Overactive Bladder, Urinary Incontinence
Long Term Follow-up Study of Safety and Efficacy of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
The purpose of this study is to assess the long term safety and effectiveness of botulinum toxin type A in treating patients with idiopathic overactive bladder with urinary incontinence.
- Trial name
- NCT00915525
- Testing
- botulinum toxin Type A
- Where
- 8 sites in United States, Belgium and 6 more
- Volunteers
- 829 people
- Sponsor
- Allergan
Stroke, Spastic Hemiplegia
BTX-A and Mirror Therapy for Chronic Stroke Spasticity
Stroke is one of the leading causes of disability worldwide, particularly affecting the upper extremities and thus negatively impacting patients' activities of daily living and quality of life.
- Trial name
- NCT07331844
- Testing
- Botulinum toxin type A (Botox®, Allergan), Mirror Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Fatih Sultan Mehmet Training and Research Hospital
Wilson Disease
The Clinical Study of Botulinum Toxin Type A Injection in the Treatment of Wilson Disease
In order to expand the treatment of Wilson disease and improve the quality of life of patients with Wilson's disease, the clinical effect of botulinum toxin type A injection on Wilson's disease was discussed.
- Trial name
- WD (NCT06762509)
- Testing
- Botulinum toxin type A
- Where
- China
- Volunteers
- 60 people
- Sponsor
- The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine
Levator Ani Syndrome With Pain and/or Constipation Symptoms.
Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
Purpose: To assess whether EMG directed biofeedback therapy or Botulinum toxin type A injection of the levator ani muscles has any effect on pain from the levator ani syndrome, and, in addition, to what extent either treatment is…
- Trial name
- NCT00564707
- Testing
- Biofeedback therapy, Botulinum Toxin Type A Injection
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center