Clinical trials: Botulinum Toxin
Cerebral Palsy, Muscle Contraction
The Muscle in Children With Cerebral Palsy - Longitudinal Exploration of Microscopic Muscle Structure.
Cerebral palsy (CP) is a motor impairment due to a brain malformation or a brain lesion before the age of two. Spasticity, hypertonus in flexor muscles, dyscoordination and an impaired sensorimotor control are cardinal symptoms.
- Conditions
- Cerebral Palsy, Muscle Contraction, Muscle Spasticity
- Trial name
- CPBiopsyBTX (NCT05497609)
- Testing
- no intervention. Care as ususal
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Eva Ponten
Pain
Pain Perception of Children and Youth Receiving Non-sedated Botulinum Toxin-A Injections Using the Buzzy®
The use of Botulinum toxin injections (BoNT-A) has become a standard therapy for children and youth who suffer from stiffness of their muscles due to a neurological problem.
- Trial name
- NCT02273284
- Testing
- Buzzy
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Hamilton Health Sciences Corporation
Healthy Volunteers
Botulism Antitoxin Effects on Paralysis Induced by Botulinum Neurotoxins in the EDB Muscle
The primary purpose of this study is: 1. To evaluate the model determined by the ability of botulism antitoxin (bivalent, Aventis) to neutralize Botulinum toxin in the Extensor Digitorum Brevis model of muscle paralysis in Stage…
- Trial name
- NCT00636519
- Testing
- Botulism Antitoxin Bivalent (Equine) Types A and B, Botulism Antitoxin Heptavalent (Equine) Types A-G
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Emergent BioSolutions
Idiopathic Cervical Dystonia
UltraSound-Guided Versus Non-Ultrasound-Guided Botulinum Toxin Injections in Cervical Dystonia [CUSTODY]
Cervical dystonia is a condition that causes the neck muscles to tighten or spasm, leading to abnormal head positions and pain. The main questions it aims to answer are: Do ultrasound-guided BoNT injections improve quality of…
- Trial name
- CUSTODY (NCT07233993)
- Testing
- Ultrasound-guided botulinum toxin injection, Non-ultrasound-guided botulinum toxin injection
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Painful Bladder Syndrome (PBS)
Botulinum A Toxin in the Treatment of Patients With Painful Bladder Syndrome
Previous clinical observations showed that Botulinum A toxin (BoNT/A) has also an antinociceptive effect and can control the neuropathic pain.
- Trial name
- NCT01157507
- Testing
- Intravesical injection of Botulinum A Toxin, Bladder overdistension
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- University Of Perugia
Blepharospasm
Comparison of Different Botulinum Toxin A Injection Patterns in the Treatment of Blepharospasm
To evaluate the efficacy of different botulinum toxin A injection patterns in treating benign essential blepharospasm and to compare their influence on condition of eye surface .
- Trial name
- NCT02327728
- Testing
- Botulinum toxin A injection (5 sites: 12.5U), Botulinum toxin A injection (4 sites: 10U), Botulinum toxin A 12.5U
- Where
- China
- Volunteers
- 120 people
- Sponsor
- YangHui
Keratoconus
Botulinum Toxin A for the Treatment of Keratoconus
The purpose of this study is to associate the use of botulinum toxin type A for patients with keratoconus to demonstrate that tension eyelid has an important role in disease progression.
- Trial name
- NCT01691651
- Testing
- Subcutaneous injection of botulinum toxin type A, Botulinum Toxin Type A
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of São Paulo
Essential Vocal Tremor, Essential Voice Tremor
Propranolol and Botulinum Toxin for Essential Vocal Tremor
Essential tremor is the most common adult-onset movement disorder, and essential voice tremor is the vocal manifestation of essential tremor.
- Conditions
- Essential Vocal Tremor, Essential Voice Tremor, Essential Tremor, Voice Tremor
- Trial name
- NCT02111369
- Testing
- Propranolol, Botulinum Toxin
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Emory University
Cerebral Palsy
Which is the Best Dose of Dysport in Helping With Hip Pain for Children With Cerebral Palsy?
The purpose of the study is to compare the effectiveness of 3 doses of Dysport (5, 10 or 15 Units/Kg/hip) in the management of chronic bilateral hip pain due to cerebral palsy in children/young people.
- Trial name
- NCT00455637
- Testing
- Botulinum toxin type A
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- Ipsen
Raynaud's Disease
A Two-Part Study of BOTOX® Therapy for Ischemic Digits
Treating patients with Raynaud's phenomenon who have chronic pain and ulcerations is extremely challenging. Published reports and our previous work support our hypothesis that symptomatic patients experience relief of pain and…
- Trial name
- NCT01309802
- Testing
- onabotulinum toxin type-A
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Southern Illinois University
Degenerative Rotator Cuff Disease
DEgenerative ROtator Cuff Disease and Botulinum TOXin
The aim of the study is to assess the effectiveness of botulinum toxin in persistent shoulder pain due to degenerative rotator cuff disease.
- Trial name
- DEROTOX (NCT05327972)
- Testing
- The investigational medicinal product is incobotulinumtoxinA (XEOMIN®).
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Atrial Flutter
Radiofrequency Ablation Plus Botulinum Toxin Injection Versus Radiofrequency Ablation Only in Patients With Atrial Flutter
The aim of this randomized study was to assess the effectiveness of endomyocardial botulinum toxin injection for preventing post-procedural atrial fibrillation in patients undergoing the radiofrequency ablation of atrial flutter.
- Trial name
- NCT02002962
- Testing
- radiofrequency ablation, Botulinum Toxin Type A injection
- Where
- Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Fecal Incontinence
Intra-rectal Botulinum Toxin Injection for Intractable Non-retentive Fecal Incontinence in Children - an Open Label Pilot Study
Background: Fecal Incontinence (FI) is a frustrating and prevalent GI condition with profound social implications and a marked effect on quality of life.
- Trial name
- NCT06785844
- Testing
- Botulinum Toxin A (Botox )
- Where
- Israel
- Volunteers
- 14 people
- Sponsor
- Shaare Zedek Medical Center
Parkinson Disease
Botulinum Toxin Type A (Botox) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease
The primary objective of this study is to determine whether intramuscular injections of botulinum toxin type A (Botox®) in selected cervical muscles at antidystonic dosages can reduce levodopa-induced peak-dose dyskinesias (LID)…
- Trial name
- NCT00477802
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati
Cerebral Palsy
Augmented Reality to Reduce Pain During Botulinum Toxin Injections in Cerebral-palsied Children
Children with cerebral palsy may benefit from treatment with botulinum toxin injections to decrease spasticity for improve function and quality of life.
- Trial name
- MINIDOCS (NCT02596412)
- Testing
- use the module with augmented reality (Mini-Docs) on tablet during TB injection
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- Hospices Civils de Lyon
Rhizarthrosis
Assessment of Pain After Intra-articular Botulinum Toxin Injections in Carpometacarpal Osteoarthritis of the Thumb
Only 4 randomized controlled clinical trials have been published to date to assess the short-term effectiveness of intra-articular Botulinum Toxin injection on pain, function and quality of life in patients suffering from chronic…
- Trial name
- NCT04829565
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Temporomandibular Disorders
Peripheral TMD Pain Mechanisms and the Effect by Botulinum Toxin A
The goal of this clinical trial is to investigate the effect of botulinum toxin on neurons' plasticity in the masseter muscle in humans with and without painful myogenous temporomandibular disorders (TMDM).
- Trial name
- NCT05720065
- Testing
- Botulinum toxin type A, Isotonic saline 0,9%
- Where
- Sweden
- Volunteers
- 100 people
- Sponsor
- Karolinska Institutet
Cosmetic Treatment Wish
Quality of Life After Cosmetic Treatments
Prospective cohort study, investigating the pre-post treatment effect of cosmetic injectable and surgical treatments on quality of life (primary outcome measure: FACE-Q Psychological, secondary outcome measure: FACE-Q Social)…
- Trial name
- NCT07687030
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Chronic Disease, Nasal Polyposis
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Chronic Rhinosinusitis With Nasal Polyposis
Chronic rhinosinusitis (CRS) with nasal polyps is a particularly challenging form of chronic rhinosinusitis in several ways. Patients have significantly more severe symptom burden and worse quality of life than patients with…
- Conditions
- Chronic Disease, Nasal Polyposis, Rhinitis
- Trial name
- NCT02784262
- Testing
- botox injection Multiguide
- Where
- Norway
- Volunteers
- 11 people
- Sponsor
- Norwegian University of Science and Technology
Cerebral Palsy (CP), Cerebral Palsy, Hemiplegic
Effect of Whirlpool Therapy Combined With Botulinum Toxin in Children With Cerebral Palsy
This study aims to investigate the effects of adding whirlpool therapy to standard rehabilitation in children with cerebral palsy who recently received botulinum toxin-A injections.
- Trial name
- NCT07690722
- Testing
- Conventional Rehabilitation, Whirlpool Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- Ankara Etlik City Hospital