Clinical trials: Botulinum Toxin
Myofascial Pain Syndrome, Myofascial Trigger Point Pain
Clinical Performance of Therapeutic Use of BTX for Bruxism
The goal of this clinical trial is to learn about the performance of botulinum toxin (BTX) injections for bruxism. Participants were divided into two groups according to the duration of the symptoms.
- Conditions
- Myofascial Pain Syndrome, Myofascial Trigger Point Pain, Bruxism, Pain
- Trial name
- BTX (NCT06258070)
- Testing
- Abobotulinumtoxin A injection for bruxism
- Where
- Tunisia
- Volunteers
- 67 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Healthy
Safety and Efficacy of NT 201, Free of Complexing Proteins, in the Treatment of Glabellar Frown Lines
NT 201 is a Botulinum toxin type A preparation free of complexing proteins. Injected into the muscle, NT 201 causes a reversible local relaxation of the injected muscle.
- Trial name
- NCT00694148
- Testing
- NT 201
- Where
- Germany
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Merz Pharmaceuticals GmbH
Epicondylitis, Lateral Humeral, Tennis Elbow
Botulinum Toxin Versus Active Strength Training in the Treatment of Lateral Epicondylitis
The purpose of this study is to compare efficacy, feasibility and cost effectiveness of botulinum toxin type A injections to active nine weeks strength training and stretching program in the treatment of the chronic lateral…
- Trial name
- BooST (NCT00930709)
- Testing
- Botulinum toxin type A (Botox®, Allergan), Active strength training and stretching
- Where
- Finland
- Volunteers
- 103 people
- Sponsor
- Seinajoki Central Hospital
PARKINSON DISEASE (Disorder)
Effect of Botulinum Toxin on Resting Tremor of the Refractory Upper Limb in Parkinsonians
Tremor is one of the most common symptoms in Parkinson Disease (PD), affecting almost 60% of patients. There is currently no specific treatment for tremor in PD, and 30% of patients develop drug-resistant tremor, making its…
- Trial name
- TOX PARK (NCT07822893)
- Where
- 2 sites in France
- Volunteers
- 39 people
- Sponsor
- University Hospital, Toulouse
Dyssynergic Defaecation, Evacuation Disorder
Infracoccygeal Botox for Dyssynergia
Background: Constipation is a common problem, affecting up to 20% of the population during their lifetime. Some patients respond poorly to standard treatments such as laxatives.
- Conditions
- Dyssynergic Defaecation, Evacuation Disorder, Anismus, Defecation Disorder
- Trial name
- NCT04879524
- Testing
- Percutaneous infracoccygeal Botulinum toxin injection to puborectalis
- Where
- United Kingdom
- Volunteers
- 8 people
- Sponsor
- Queen Mary University of London
Stroke, Multiple Sclerosis
Interest of a Musical Intervention on Stress Induced During Botulinum Toxin Injections in Spasticity (MUSIBOT)
Botulinum toxin (BT) injections are a painful treatment frequently used to treat spasticity following central neurological damage (stroke, multiple sclerosis, spinal cord injury, head trauma).
- Conditions
- Stroke, Multiple Sclerosis, Spinal Cord Injury, Head Trauma Injury
- Trial name
- MUSIBOT (NCT06920524)
- Testing
- Intervention group IM-IM
- Where
- France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Clermont-Ferrand
Lower Limb Spasticity
RELIEF Study: Lower Limb Pain Relief After Injection Cycles in Adults Suffering From Lower Limb Spasticity Following Stroke
The objective of this study is to demonstrate the effect of intramuscular BoNT-A injections in relieving pain, in a broad population of patients who suffer pain as the primary problem associated with spasticity.
- Trial name
- RELIEF (NCT02020980)
- Testing
- Botulinum toxin type A
- Where
- 28 sites in Spain
- Volunteers
- 186 people
- Sponsor
- Ipsen
Tennis Elbow
Dysport® Injection in the Treatment of Chronic Lateral Epicondylitis
The purpose of this study is to determine whether a single injection of Dysport with a new protocol at forearm is effective in the management of chronic lateral epicondylitis.
- Trial name
- DCLE (NCT00497913)
- Testing
- NaCl 0.9%, Botulinum Toxin A
- Where
- Iran
- Volunteers
- 52 people
- Sponsor
- Tehran University of Medical Sciences
Glabellar Frown Lines
The Safety and Efficacy Study of PROTOXIN in Subjects With Moderate to Severe Glabellar Lines
This study will be conducted in Phase I/II clinical trials. In Phase I, subjects with moderate to severe glabellar lines are enrolled and those who are judged to be eligible for this study will be injected with the "PROTOXIN" at…
- Trial name
- NCT04996810
- Testing
- PROTOXIN, Botox®
- Where
- 2 sites in South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Protox Inc.
Muscle Spasticity, Stroke
Botulinum Toxin A Adult Gastrocnemius Muscle Study
The study aims to compare the effectiveness of BOTOX-A® (botulinun toxin A) placed between two different injection sites, namely at the proximal portion of the gastrocnemius(GCM) versus at the midbelly of the GCM.
- Trial name
- BTX-A (NCT01278576)
- Testing
- BOTOX-A®
- Where
- 2 sites in South Korea
- Volunteers
- 40 people
- Sponsor
- The Catholic University of Korea
Condylar Fractures, Subcondylar Fracture
The Effectiveness of Guided Botulinum Toxin "A" Injection to the Masticatory Muscles in the Management of Condylar and Subcondylar Fractures
The aim of this study, is to evaluate the effectiveness of ultrasound guided injection of botulinum toxin A into the muscles of mastication; the masseter, temporalis and the lateral pterygoid, in a closed reduction approach of…
- Trial name
- NCT07374341
- Testing
- BOTOX Cosmetic®, Closed reduction and intermaxillary fixation
- Where
- Egypt
- Volunteers
- 16 people
- Sponsor
- Pakinam Gheeta
Overactive Bladder
Bladder Overactivity and Post-Botulinum Toxin Telemonitoring
Prospective, randomized, controlled, single-center study to compare the feasibility of home monitoring for patients receiving intradetrusor botulinum toxin injections with that of the usual hospital-based follow-up.
- Trial name
- VESIC@HOME (NCT07379372)
- Testing
- home care
- Volunteers
- 112 people
- Sponsor
- University Hospital, Grenoble
Herpes Labialis
Botulinum Toxin A for Herpes Labialis
The purpose of this study is to determine the efficacy and safety of Botulinum Toxin Type A as a preventative measure for Herpes Labialis.
- Trial name
- NCT01225341
- Testing
- onabotulinumtoxinA, Bacteriostatic normal saline
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- DeNova Research
Hyperhidrosis
Hyperhydrosis Treatment Using Botulinum Toxin
The purpose of this study is to describe two safe and reproducible techniques for the treatment of hyperhidrosis using botulinum toxin.
- Trial name
- NCT03816046
- Testing
- botulinum toxin A
- Where
- Lebanon
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- St Joseph University, Beirut, Lebanon
Migraine Disorders
BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Participants With Chronic Migraine
This study will evaluate the efficacy and safety of BOTOX® (Botulinum Toxin Type A) compared with placebo as headache prophylaxis in Chinese participants with chronic migraine.
- Trial name
- NCT03193346
- Testing
- botulinum toxin Type A
- Sponsor
- Allergan
Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment
Efficacy of 200 IU OnabotulinumtoxinA in Idiopathic Overactive Bladder Resistant to Anticholinergic Treatment
This study aimed to assess the efficacy and safety of onabotulinumtoxinA (botulinum toxin type A) in patients with idiopathic overactive bladder (OAB) and urinary incontinence who had previously failed to respond to…
- Trial name
- NCT06408051
- Testing
- Injection of onabotulinumtoxinA into the bladder wall
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hisar Intercontinental Hospital
Deglutition Disorders
Study of a Series of Patients Treated for Retrograde Cricopharyngeal Muscle Dysfunction Syndrome
R-CPD syndrome (Retrograde Cricopharyngeal Dysfunction syndrome) is an inability to burp. It is a syndrome whose diagnosis is clinical, and for which there is effective treatment.
- Trial name
- R-CPD-Syndrome (NCT06174831)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Strasbourg, France
Postherpetic Neuralgia, Nerve Trauma
Efficacy Study of Botox to Treat Neuropathic Pain
Objectives : to investigate the analgesic effects and safety of intradermal botulinum toxin A injection in the treatment of focal painful neuropathies (eg, postherpetic neuralgia, nerve trauma)
- Trial name
- NCT00527202
- Testing
- botulinum toxin A
- Where
- France
- Volunteers
- 29 people
- Sponsor
- Hospital Ambroise Paré Paris
Parkinson's Disease, Foot Dystonia
Foot Dystonia Treatment by Botulinum Toxin Injections in Parkinson Disease : Efficiency of Injections Made in Extrinsic Muscle (Flexor Digitorum Longus Muscle) Compared to Intrinsic Muscle (Flexor Digitorum Brevis or Quadratus Plantae Muscles)
Foot dystonia is frequently observed in patients suffering from Parkinson'disease. It is characterized by an abnormal involuntary movement which is very uncomfortable (difficult to walk) and painful for the patient.
- Trial name
- RBHP 2008 (NCT00909883)
- Testing
- Botulinum Toxin: Xeomin
- Where
- 4 sites in France
- Volunteers
- 45 people
- Sponsor
- University Hospital, Clermont-Ferrand
Upper Limb Spasticity
Attainment of Person-centred Goals After Botulinum Toxin Treatment for Upper Limb Spasticity in Real Life Practice
The primary purpose for this study is to understand the effect of botulinum toxin as a treatment integrated in the management of spasticity (stiffness) in the arm and/or hand, arising from any neurological condition.
- Trial name
- ULIS III (NCT02454803)
- Where
- 57 sites in United States, Australia and 12 more
- Volunteers
- 1,004 people
- Sponsor
- Ipsen