Clinical trials: Botulinum Toxin
Spasticity, Muscle, Spinal Cord Injuries
Long-term Efficacy of Spasticity-correcting Surgery and Botulinum Toxin Injections for Upper Limb Spasticity Treatment
Spasticity - a variety of motor over-activity and part of the upper motor neuron syndrome - is a common cause of impaired motor function after brain injuries of different etiologies.
- Conditions
- Spasticity, Muscle, Spinal Cord Injuries, Traumatic Brain Injury, Stroke
- Trial name
- NCT03910101
- Testing
- Hand surgery and intensive rehabilitation
- Where
- Sweden
- Volunteers
- 34 people
- Sponsor
- Vastra Gotaland Region
Overactive Bladder
Study of Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A (onabotulinumtoxinA) in treating patients with idiopathic overactive bladder with urinary incontinence.
- Trial name
- NCT00910845
- Testing
- onabotulinumtoxinA, normal saline
- Where
- 2 sites in United States, Canada
- Volunteers
- 557 people
- Sponsor
- Allergan
Knee Osteoarthritis
Intra-articular Botox Type A Versus Corticosteroids in Knee Osteoarthritis
Introduction: Osteoarthritis of the knee is a very common disease. However there are few treatment options for these patients. Botulinum toxin type A is an option for chronic pain.
- Trial name
- NCT02829281
- Testing
- Botulinum Toxin Type A, Triamcinolone hexacetonide, Saline
- Where
- Brazil
- Volunteers
- 105 people
- Sponsor
- Federal University of São Paulo
Myofascial Pain Syndromes, Myofascial Trigger Point Pain
Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain
This research study because is looking at woman with symptoms of chronic pelvic pain caused by short, tight, and tender pelvic floor muscles (Myofascial Pelvic Pain syndrome).
- Conditions
- Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Trigger Point Pain, Myofascial
- Trial name
- BotoxMPP (NCT02173405)
- Testing
- OnabotulinumtoxinA
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Episodic Migraine
Study of BOTOX Injections in Prevention of Migraine in Adult Participants With Episodic Migraine
Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound (International Classification of Headache Disorders, 2018).
- Trial name
- NCT05028569
- Testing
- BOTOX
- Where
- 133 sites in United States, Canada and 7 more
- Volunteers
- 775 people
- Sponsor
- AbbVie
Spastic Hemiplegia
Evaluation of Spasticity, Neuropathic Pain, and Gait Analysis in Stroke Patients Receiving Tolperison Therapy After Botulinum Toxin Injection
Tolperison is an antispastic agent used in the treatment of spasticity. Studies on tolperison are limited, and the literature on its effectiveness against spasticity and neuropathic pain is also limited.
- Trial name
- NCT07482618
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Ayse Guc
Hemorrhoids, Postoperative Pain
Botulinum Toxin A Before Hemorrhoidectomy to Prevent Postoperative Pain
Hemorrhoidectomy is an effective surgical treatment for advanced hemorrhoidal disease but is often associated with significant postoperative pain, which may delay recovery.
- Trial name
- BoTo-HEM (NCT07399860)
- Testing
- Botulinum toxin type A, Saline (0.9% NaCl)
- Where
- Russia
- Volunteers
- 292 people
- Sponsor
- Lomonosov Moscow State University Medical Research and Educational Center
Epicondylitis
A Phase III Study to Evaluate Efficacy of Botulinum Toxin for Treating Epicondylitis
The study aims to demonstrate that intramuscular injection of botulinum toxin with a paralyzing dose coupled with subcutaneous injection of corticoid has greater efficacy than corticoid injection only or toxin injection only for…
- Trial name
- EPITOX (NCT03380559)
- Testing
- Injection, botulinum toxin + corticoid
- Where
- France
- Volunteers
- 33 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Glabellar Frown Lines
Botulinum Toxin Treatment of Glabellar Lines: Efficacy and Safety Study III (BLESSIII)
The aim of this study is to assess the efficacy and safety of BoNT/A-DP in the treatment of glabellar lines in comparison with placebo, including efficacy after repeat treatments and long term safety.
- Trial name
- BLESSIII (NCT03985982)
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 410 people
- Sponsor
- Croma-Pharma GmbH
Cerebral Palsy
Improved Sitting Balance: Body Functions to Participation
The aim of this study is to evaluate the changes in activity and participation domains of International Classification of Functioning, Disability and Health (ICF) in children with cerebral palsy (CP) who received integrated…
- Trial name
- NCT03788317
- Testing
- Botulinum toxin type A
- Where
- Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Kocaeli University
Spinal Cord Injury, Spasticity
Extracorporeal Shockwave Therapy as an Additional Treatment for Spasticity Secondary to Spinal Cord Injury
Spasticity is a common consequence of spinal cord injury and can have a profound impact on quality of life. The goal of this study is to learn if an intervention called focused extracorporeal shockwave therapy can enhance the…
- Trial name
- NCT07894991
- Testing
- Focused extracorporeal shockwave therapy, Botulinum toxin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Kessler Foundation
Urinary Incontinence, Detrusor Overactivity
Refractory Urge Incontinence and Botox Injections
The purpose of this study is to see whether Botox A (injected into the bladder muscle) can improve symptoms of urge incontinence that has not improved with usual medical treatments.
- Conditions
- Urinary Incontinence, Detrusor Overactivity, Urinary Urgency, Urge Urinary Incontinence
- Trial name
- NCT00373789
- Testing
- Botulinum Toxin A, bladder detrusor muscle injection
- Where
- 8 sites in United States
- Volunteers
- 87 people
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Skin Aging
Efficacy and Safety of Botulinum Toxin Type A for Moderate to Severe Crow's Feet Lines
This study will confirm the efficacy and safety of a single topical administration of botulinum toxin type A compared to placebo control for the treatment of moderate to severe crow's feet lines
- Trial name
- NCT01940991
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 82 people
- Sponsor
- Revance Therapeutics, Inc.
Overactive Bladder (OAB), Botulinum Toxin Injection
Pretibial TENS for Pain and Anxiety During Intravesical OnabotulinumtoxinA Injection
Overactive bladder is a common condition that causes a frequent, urgent need to urinate and can significantly reduce quality of life.
- Conditions
- Overactive Bladder (OAB), Botulinum Toxin Injection, Procedural Pain Relief, Anxiety
- Trial name
- NCT07707791
- Testing
- Active Pretibial TENS
- Volunteers
- 68 people
- Sponsor
- Başakşehir Çam & Sakura City Hospital
Pain
Comparison of Botulinum Toxin and Sphincterotomy in the Treatment of Chronic Anal Fissure
Intra-sphincteric injection of botulinum toxin seems to be a reliable option causing temporary alleviation of sphincter spasm and allowing the fissure to heal.
- Trial name
- NCT01095900
- Testing
- conservative lateral internal sphincterotomy, Intra-sphincteric Botulinum-toxin injection
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Overactive Bladder
Botulinum Toxin Type A for the Treatment of Patients With Idiopathic Overactive Bladder With Urinary Incontinence
The purpose of this study is to assess the safety and effectiveness of botulinum toxin type A (onabotulinumtoxinA) in treating patients with idiopathic overactive bladder with urinary incontinence.
- Trial name
- NCT00910520
- Testing
- onabotulinumtoxinA, normal saline
- Where
- 7 sites in United States, Belgium and 5 more
- Volunteers
- 548 people
- Sponsor
- Allergan
Scar Keloid, Hypertrophic Scar
Botulinum Toxins Intralesional Injection for Scar Pain
Botulinum toxins has been approved by the FDA to treat chronic migraine. Botox had been shown to inhibiting the release of inflammatory mediators and peripheral neurotransmitters from sensory nerve to treat neuropathic pain.
- Trial name
- NCT03982862
- Testing
- Triamcinolone, Lidocaine, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 20 people
- Sponsor
- Kaohsiung Medical University
Raynaud Phenomenon Secondary to Systemic Sclerosis
Efficacy of Botulinum Toxin A in Adult Subjects With Raynaud Phenomenon Secondary to Systemic Sclerosis
This study aims to assess whether or not a single injection schedule of botulinum toxin A (BTX-A) in both hands improves Raynaud phenomenon (RP) secondary to systemic sclerosis (SSc) better than a placebo at 4, 12 and 24 weeks…
- Trial name
- BRASS (NCT03717961)
- Testing
- BOTOX® solution
- Where
- France
- Volunteers
- 91 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Cerebral Palsy
Botulinum Toxin Efficiency on Spasticity of Rectus Femoris and Semitendinosus Muscles as Functional Agonist and Antagonist Muscles
The aim of the study is to confirm the functional improvement obtained through treatment of spasticity on 2 agonist and antagonist muscles.
- Trial name
- NCT00133861
- Testing
- Botulinum toxin
- Where
- France
- Volunteers
- 23 people
- Sponsor
- Hospices Civils de Lyon
Upper Limb Spasticity
A Clinical Study on Recombinant Botulinum Toxin Type A (YY001) for Injection in The Treatment of Upper Limb Spasticity in Adults
This is a randomized, double-blind, multi-center phase II/III study to evaluate the efficacy and safety of Recombinant Botulinum Toxin Type A (YY001) for injection in the treatment of upper limb spasticity in adults
- Trial name
- NCT06783114
- Testing
- Recombinant Botulinum Toxin Type A for injection (YY001), BOTOX®
- Where
- 24 sites in China
- Volunteers
- 254 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.