Clinical trials: Botulinum Toxin
Cervical Dystonia
Zinc as an Adjunctive Therapy for Cervical Dystonia
The goal of this clinical trial is to evaluate if supplemental zinc can prolong the duration of benefit of botulinum toxin injections in cervical dystonia patients receiving care at the University of Florida.
- Trial name
- NCT07140874
- Testing
- Zinc citrate
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of Florida
Chronic Pain, Lower Extremity Wound
The Effect of Subcutaneous Injection of Botulinum Toxin A on Chronic Wound Pain in Lower Extremities
The aim of the study is to investigate the effect of subcutaneous administration of Botulinum toxin A on wound pain, wound healing and safety of treatment.
- Trial name
- NCT05426161
- Testing
- Botulinum Toxin A
- Where
- Denmark
- Volunteers
- 10 people
- Sponsor
- Bispebjerg Hospital
Spasticity
Study of Intramuscular Injections of OnabotulinumtoxinA to Assess Change in Disease Activity in Pediatric Participants With Spasticity Associated With Cerebral Palsy
Spasticity is often observed as muscle tightness and stiffness in the upper and/or lower limbs. Upper limb spasticity can interfere with joint movement and its severity can range from mild to severe.
- Trial name
- NCT06150729
- Where
- 8 sites in Mexico
- Volunteers
- 107 people
- Sponsor
- AbbVie
Overactive Bladder
The Efficacy of Botulinum Toxin in OVERACTIVE Bladder
To assess the efficacy of botulinum toxin injection in overactive bladder.
- Trial name
- NCT03888001
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pain, Haemorriodectomy
The Effect of Botulinum Toxin Injection After Hemorrhoidectomy in Pain Control.
Hemorrhoids are a common disease in the general population. Its prevalence is estimated to be 5-36 % and more prevalent in western countries .
- Conditions
- Pain, Haemorriodectomy, Anal Sphincterotomy
- Trial name
- NCT05891314
- Testing
- Botox Injectable Product, Internal sphincterotomy
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Cervical Dystonia
Dystonia Treatment With Injections Supplemented By Transcranial Magnetic Stimulation
We applied 16 sessions of rTMS over 4 consecutive days for adult patients suffering from cervical dystonia who received botulinum toxin (BoNT) injections on a regular basis.
- Trial name
- D-TWIST (NCT04916444)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Hyperhidrosis, Muscle Spasticity
Safety and Efficacy of BOTOX® (Botulinum Toxin Type A) in Korea
This post marketing surveillance study in Korea will evaluate the safety and efficacy of BOTOX (botulinum toxin Type A) in patients who receive treatment according to standard of care for primary axillary hyperhidrosis, focal…
- Conditions
- Hyperhidrosis, Muscle Spasticity, Glabellar Lines
- Trial name
- NCT02043145
- Testing
- botulinum toxin Type A
- Where
- South Korea
- Volunteers
- 727 people
- Sponsor
- Allergan
Facial Rhytides, Glabellar Rhytides
A Safety and Efficacy Study of OnabotulinumtoxinA in Upper Facial Rhytides
This is a safety and efficacy study of onabotulinumtoxinA in subjects with upper facial rhytides (forehead lines, glabellar lines, lateral canthal lines [crow's feet lines]).
- Trial name
- NCT02261493
- Testing
- OnabotulinumtoxinA, Normal Saline
- Where
- 24 sites in United States, Belgium and 2 more
- Volunteers
- 787 people
- Sponsor
- Allergan
Spasticity
Effectiveness of an Interprofessional Approach to the Treatment of Spasticity With Botulinum Toxin & Non-pharmacological Therapies
Many people with neurological conditions will experience spasticity, a nonvolitional and uncontrollable tightening and/or spasm of muscles.
- Trial name
- NCT07160699
- Testing
- Botulinum Neurotoxin Type A, Non-pharmacological therapies
- Where
- 2 sites in Switzerland, United Kingdom
- Volunteers
- 30 people
- Sponsor
- Technical University of Bern
Stroke, Spasticity
Early Injection of Botulinum Toxin on Motor Function and Gait Pattern in Stroke Patients
Spasticity, muscle weakness, abnormal gait pattern are co-morbidities commonly seen in stroke patients. They cause disabled condition of patients in activities of daily life and functional performance, and also accidental falls…
- Trial name
- NCT01817816
- Testing
- Botox_A, Botox_B
- Where
- Taiwan
- Volunteers
- 80 people
- Sponsor
- Changhua Christian Hospital
Dislocation of Temporomandibular Joint TMJ, Subluxation of Temporomandibular Joint
Assessment of Botulinum Toxin Injection for Treatment of Temporomandibular Joint Dislocation
Assessment of the effect of Botulinum toxin injection on the frequency of luxation and TMJ Pain in patients with TMJ dislocation either chronic recurrent dislocation or subluxation
- Trial name
- NCT05863286
- Testing
- Botulinum toxin type A
- Where
- Egypt
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Postherpetic Neuralgia
A Study Evaluating Botulinum Toxin Type A in Subjects With Postherpetic Neuralgia
4-month study including a 30-day baseline phase
- Trial name
- NCT00168441
- Testing
- Botulinum Toxin Type A
- Volunteers
- 117 people
- Sponsor
- Allergan
Parkinson's Disease, Neurogenic Bladder
Safety and Efficacy of botulinumA Toxin (BotoxA) for Treatment of Neurogenic Bladder of Parkinson's Disease
The basic nerve deficit of Parkinson's disease (PD) leads to lower urinary tract symptoms of frequency, urgency and urge urinary incontinence. Lower urinary tract symptoms tend to occur at more advanced stages of PD.
- Conditions
- Parkinson's Disease, Neurogenic Bladder, Urinary Incontinence, Clostridium Botulinum Toxin Adverse Reaction
- Trial name
- NCT01421719
- Testing
- Cystoscopic injection of Botox into the urinary bladder
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Stanford University
Symptomatic Ventricular Asystolia, Ventricular Tachycardia
Botulinum Toxin Injection to Prevent Ventricular Arrhythmias
The aim of this prospective non-randomized study was to assess the efficacy and safety of endomyocardial botulinum toxin injection in left ventricle for preventing ventricular arrhythmias.
- Trial name
- NCT02003001
- Testing
- Botulinum Toxin
- Where
- Russia
- Volunteers
- 30 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Strabismic Deviation, Strabismus
Botulinum Toxin for Strabismus Treatment
The bacterial species Clostridium botulinum produces a class of neurotoxins known as botulinum toxin. At the neuromuscular junction, botulinum toxin A prevents acetylcholine from being released.
- Trial name
- Botox Squint (NCT07180394)
- Testing
- Botox injection into extraocular muscles
- Where
- Pakistan
- Volunteers
- 127 people
- Sponsor
- Foundation University Islamabad
Piriformis Muscle Syndrome
Efficacy of Botulinum Toxin Versus Placebo on Pain and Health Related Quality of Life of Patients With Piriformis Muscle Syndrome
Piriformis muscle syndrome (PMS) is characterized by symptoms caused by compression or irritation of the sciatic nerve by the piriformis muscle as it exits the sciatic notch.
- Trial name
- PiriTox (NCT07624045)
- Testing
- Botulinum Toxin - A injections
- Where
- 7 sites in France
- Volunteers
- 108 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Excessive Gingival Display
Decision Regret Following Yonsei-Point Botulinum Toxin for Gummy Smile
This study evaluates patient-reported decision regret in adult patients who previously received standardized Botulinum Toxin Type A (BoNT-A) injection at the Yonsei Point for excessive gingival display (gummy smile).
- Trial name
- NCT07874022
- Testing
- Botulinum Toxin Type A injection at Yonsei Point
- Where
- 2 sites in Egypt
- Volunteers
- 32 people
- Sponsor
- Cairo University
Myofascial Pain Syndrome (MPS), Masticatory Muscle Pain
EMG-Based Evaluation of Occlusal Splint and Masseter Botox Effects on Head and Neck Muscles
This randomized controlled clinical trial aims to evaluate the individual and combined effects of occlusal splint therapy and botulinum toxin type A (BTX-A) injections into the masseter muscle on the activity of head and neck…
- Trial name
- NCT07082972
- Testing
- Botulinum toxin injection, Occlusal splint, Botulinum toxin + Occlusal splint combined
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people
- Sponsor
- Istanbul University
Myofascial Pelvic Pain
Botulinum Toxin Type A Versus Saline Trigger Point Injections for Myofascial Pelvic Pain
The purpose of this study is to determine whether there is a change in patient-reported pelvic pain following pelvic floor injections of 200 units of Botox compared with 20cc of normal saline.
- Trial name
- NCT01905137
- Testing
- Intervention-Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Urogynecology Associates
Parkinson Disease
Botulinum Toxin Type A (Botox) in the Management of Levodopa-Induced Peak-Dose Dyskinesias in Parkinson's Disease
The primary objective of this study is to determine whether intramuscular injections of botulinum toxin type A (Botox®) in selected cervical muscles at antidystonic dosages can reduce levodopa-induced peak-dose dyskinesias (LID)…
- Trial name
- NCT00477802
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Cincinnati