Clinical trials: Botulinum Toxin
Headache, Allodynia
Botulinum Toxin Type A in Treatment of Cranial Allodynia in Patients With Headache
The objective of this study is evaluated if the Botulinum Toxin Type A is superior to 0,9% saline in treatment of cranial Allodynia in patients with headache.
- Trial name
- NCT01357798
- Testing
- Botulinum toxin type A, 0,9% saline
- Where
- Brazil
- Volunteers
- 40 people
- Sponsor
- Federal University of Bahia
Moderate to Severe Glabellar Lines
Efficacy and Safety of Recombinant Botulinum Toxin Type A (Eveotox) for Injection to Treat Moderate to Severe Glabellar Lines
This is a Phase 3 clinical study to evaluate the efficacy, safety, and immunogenicity of single/repeated injections of Eveotox in the treatment of moderate to severe glabellar lines.
- Trial name
- NCT06937944
- Testing
- Rcombinant botulinum toxin type A for injection（Eveotox), OnabotulinumtoxinA (Botox)
- Where
- 15 sites in China
- Volunteers
- 669 people
- Sponsor
- JHM BioPharma (Tonghua) Co. , Ltd.
Androgenetic Alopecia
Use of Botulinum Toxin in the Treatment of Androgenic Alopecia
The purpose of this study is to evaluate the effect of using a purified botulinum toxin (Xeomin®, Merz, USA), the same injectable used to improve face wrinkles, to treat a specific type of hair loss seen in men and women not…
- Trial name
- NCT05456087
- Testing
- incobotulinumtoxin A
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Zel Skin and Laser Specialists
Obstructed Defaecation Syndrome, Anterior Rectocele
Rectocele Repair with or Without Internal Sphincter Botulinum Toxin Injection: a Prospective Randomized Trial
This is a single-centre, prospective randomized controlled trial on female patients with anterior rectocele associated with obstructed defecation syndrome
- Trial name
- NCT06804993
- Testing
- Transvaginal repair & botulinum toxin type A injection, Transvaginal repair & distilled water injection
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Mansoura University
Stroke, Post-Stroke Spasticity
ESTIM-UL: FES for Upper Limb Recovery After Stroke
Stroke is a leading cause of long-term disability, frequently resulting in impaired upper limb motor function and spasticity. Although Botulinum Toxin Type A (BoNT-A) is effective in reducing focal spasticity, functional recovery…
- Conditions
- Stroke, Post-Stroke Spasticity, Post-Stroke Hemiparesis
- Trial name
- ESTIM-UL (NCT07513714)
- Testing
- Functional Electrical Stimulation (FES), Conventional Rehabilitation
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Foggia
Pain
A Pilot Clinical Trial of Sympathetic Blockade With Botulinum Toxin Type A to Treat Complex Regional Pain Syndrome (CRPS): a Randomized, Double-Blind, Controlled, Crossover Trial.
Lumbar sympathetic blocks are part of the standard of care for treating patients with sympathetically-maintained pain (e.g. in complex regional pain syndrome or reflex sympathetic dystrophy- RSD).
- Trial name
- NCT00637533
- Testing
- Lumbar sympathetic block with Botulinum Toxin type A
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Stanford University
Moderate to Severe Glabellar Lines
A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines
This is a phase 1/2, multicenter, randomized, double-blind, active-controlled and placebo-controlled study to evaluate safety, immunogenicity and efficacy of JHM03 for the treatment of moderate to severe glabellar lines in male…
- Trial name
- NCT06199336
- Testing
- JHM03, BOTOX®
- Where
- China
- Volunteers
- 190 people
- Sponsor
- JHM BioPharma (Tonghua) Co. , Ltd.
Cerebrovascular Accident
Botulinim Toxin Type A Injections by Different Guidance in Stroke Patients With Spasticity on Lower Extremities
Stroke may result in lower extremity spasticity, which interfere with motor voluntary function and activities of daily living. Botulinum toxin type A (BTX-A) has been shown to improve lower extremity spasticity of stroke…
- Trial name
- NCT02469948
- Testing
- Botulinum toxin type A
- Where
- Taiwan
- Volunteers
- 40 people
- Sponsor
- Chang Gung Memorial Hospital
Cervical Dystonia
Long-term Outcome of DBS Versus Botulinum Toxin Treatment in Cervical Dystonia
Cervical dystonia (CD) is the most common isolated dystonia in adults. Cervical dystonia symptoms can in most patients be managed well by botulinum toxin (BTX) injections, and supporting treatment measures.
- Trial name
- NCT04432285
- Testing
- DBS-device, implanted in GPi bilaterally, Botulinum toxin
- Where
- Norway
- Volunteers
- 50 people
- Sponsor
- Oslo University Hospital
Wrinkles in Frontal Area
Field of Effects of Two Commercial Preparations of Botulinum Toxin Type A
The objective of this study is to compare the field of effects of the botulinum toxins (Dysport® and Botox®) using two equivalence-ratios and to gather supportive information, such as more detailed data on the effectiveness in…
- Trial name
- NCT00989768
- Testing
- Botulinum Toxin Type A (Dysport®), Botulinum Toxin Type A/Botox®, Botulinum Toxin Type A/Dysport®
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Drooling, Brain Injuries
Botulinum Toxin Injections Into the Salivary Glands of Cerebrospinal Children With Chronic Sialorrhea
French Health Authority describes sialorrhea (or drooling) as uncontrolled loss of saliva through the lips. Drooling is considered pathological after the age of three.
- Conditions
- Drooling, Brain Injuries, Chronic Sialorrhea, Children, Only
- Trial name
- SIALOBOT (NCT07067762)
- Where
- France
- Volunteers
- 5 people
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Upper Facial Lines
A Study to Evaluate Participant Satisfaction and Natural Outcomes Following Administration of BOTOX Cosmetic Injections in Adult Participants for Treatment of Upper Facial Lines
Facial lines that develop from repeated facial expression, such as glabellar lines (GL), lateral canthal lines (LCL), and forehead lines (FHL), are typically treated by selectively weakening specific muscles with small quantities…
- Trial name
- UFL BOND 974 (NCT06218251)
- Testing
- BOTOX
- Where
- 10 sites in United States, Canada
- Volunteers
- 100 people
- Sponsor
- AbbVie
Stroke
The Effects of Early and Late Injection of Botulinum Toxin Type A on Upper Limb Function in Patients With Stroke
The aim of this study is to determine whether early use of OnabotulinumtoxinA is more effective to improve functional outcomes of upper limb in patients with stroke.
- Trial name
- NCT02580838
- Testing
- OnabotulinumtoxinA
- Where
- Taiwan
- Volunteers
- 150 people
- Sponsor
- National Cheng-Kung University Hospital
Wrinkle, Glabellar Frown Lines
Head-to-Head Comparison of All Botulinum Neurotoxin Type A Products for Glabellar Rhytides
Study Type: This is a multicenter, triple-blind, randomized controlled trial. Purpose: The goal of this clinical trial is to compare the effectiveness and safety of all commercially available Botulinum Neurotoxin Type A (BoNT-A)…
- Conditions
- Wrinkle, Glabellar Frown Lines, Glabellar Furrowing
- Trial name
- NCT06448676
- Testing
- Botulinum toxin type A
- Where
- 3 sites in Netherlands
- Volunteers
- 325 people, healthy volunteers welcome
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Facial Rhytides, Crow's Feet Lines
Safety and Efficacy Study of Botulinum Toxin Type A for the Treatment of Crow's Feet Lines and Frown Lines
This study will evaluate the safety and efficacy of botulinum toxin type A compared to placebo for the treatment of Crow's Feet Lines and Frown Lines (Facial Rhytides) for patients who successfully completed Study 191622-099.
- Conditions
- Facial Rhytides, Crow's Feet Lines, Glabellar Lines
- Trial name
- NCT01224015
- Testing
- normal saline, onabotulinumtoxinA 44 U, onabotulinumtoxinA 24 U
- Where
- 4 sites in United States, Canada and 2 more
- Volunteers
- 684 people
- Sponsor
- Allergan
Overactive Bladder Syndrome, Refractory Overactive Bladder
Comparing Treatments for Refractory Overactive Bladder: Bladder Denervation vs Botulinum Toxin Injections
The goal of this clinical trial is to compare the effectiveness and safety of two treatments for refractory overactive bladder in adult women.
- Trial name
- SBD-BOT-OAB (NCT06796855)
- Testing
- Selective Bladder Denervation via Radiofrequency Ablation, Intravesical Onabotulinum Toxin A Injection
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bagcilar Training and Research Hospital
Catocholamine Induced Finger Necrosis
Botulinum Toxin A for Treatment of Catocholamine Induced Finger Necrosis
Patients in the intensive care unit (ICU) often require blood pressure support of vasoactive drugs such as amines. Finger necrosis (so called "blue toe syndrome") is a well documented phenomena with incidence reaching as high as…
- Trial name
- NCT01500668
- Testing
- Botox
- Where
- Israel
- Volunteers
- 20 people
- Sponsor
- Sheba Medical Center
Joint Diseases, Knee
Intra Articular Injection of Botulinum Toxin Versus Corticoids in Gonarthrosis
We believe we can demonstrate a link between the analgesic action of intra-articular injection of botulinum toxin and synovial inflammation by Dynamic Contrast Enhancement (DCE) perfusion Magnetic Resonance Imaging (MRI).
- Conditions
- Joint Diseases, Knee, Therapeutics, Magnetic Resonance Imaging
- Trial name
- TOXART (NCT03726788)
- Testing
- Botulinum Toxin Type A 100U, Botulinum Toxin Type A 200U, Triamcinolone Hexacetonide Inj Susp 20 MG/ML
- Where
- France
- Sponsor
- Lille Catholic University
Spasticity, Focal Dystonia
Compare Two Guidance Techniques for Botulinum Toxin Injections for the Treatment of Limb Spasticity and Focal Dystonia
This study seeks to compare the use of ultrasound and electrophysiologic techniques to target muscles for the treatment of spasticity and focal dystonia of the limbs.
- Conditions
- Spasticity, Focal Dystonia, Tremor, Limb
- Trial name
- NCT02334683
- Testing
- Electrical stimulation, Ultrasound
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Chronic Migraine
BOTOX® vs. XEOMIN® for Chronic Migraine
Chronic migraine (CM) is a disabling disorder that sidelines active duty personnel and diminishes their quality of life. It affects 1.3% to 2.4% of the general population.
- Trial name
- NCT05598723
- Testing
- IncobotulinumtoxinA (XEOMIN®), OnabotulinumtoxinA (BOTOX®)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- Naval Medical Center Camp Lejeune