Clinical trials: Botulinum Toxin
Bruxism, Myofascial Pain
Ultrasonographic Evaluation of Masseter Muscle Changes After Botulinum Toxin Injection in Bruxism Patients
This prospective pilot study aimed to evaluate short-term clinical and ultrasonographic changes in the masseter muscle following botulinum toxin injection in patients with bruxism.
- Conditions
- Bruxism, Myofascial Pain, Masseter Muscle Hypertrophy
- Trial name
- NCT07545200
- Testing
- Botulinum Toxin A (Botox )
- Where
- Turkey (Türkiye)
- Volunteers
- 17 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Cervicalgia, Low Back Pain
New Approaches in Evaluating Patients' Response to Botulinum Toxins in the Treatment of Chronic Neck Pain and Back Pain
This protocol is a prospective, open label, pilot study examining the utility of three established pain questionnaires (the Visual Analogue Scale (VAS), Neck Disability Index (NDI), the Oswestry Low Back Pain Questionnaire and…
- Trial name
- NCT02008136
- Testing
- Botulinum Toxins
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- VA Connecticut Healthcare System
Cervical Dystonia
Dystonia Treatment With Injections Supplemented By Transcranial Magnetic Stimulation
We applied 16 sessions of rTMS over 4 consecutive days for adult patients suffering from cervical dystonia who received botulinum toxin (BoNT) injections on a regular basis.
- Trial name
- D-TWIST (NCT04916444)
- Testing
- rTMS
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Florida
Glabellar Lines
Clinical Trial to Evaluate the Safety and Efficacy of JTM201 to Treat Moderate or Severe Glabellar Lines
This is Multicenter, Randomized, Double-blind, Placebo-controlled, Single-dose Study to evaluate Safety and Efficacy of JTM201 in patients with Moderate or Severe Glabellar Lines
- Trial name
- NCT06246552
- Testing
- JTM201
- Where
- United States
- Volunteers
- 480 people
- Sponsor
- Jetema USA Inc.
Essential Tremor
Kinematic-based BoNT-A Injections for Bilateral ET
The primary objective is to study the efficacy of botulinum toxin type A (Xeomin®) injected utilizing kinematically-based injection parameters for the treatment of upper extremity essential tremor (ET).
- Trial name
- NCT02551848
- Testing
- Botulinum toxin type A
- Where
- Canada
- Volunteers
- 25 people
- Sponsor
- Western University, Canada
Cluster Headache
Botulinum Toxin Type A Block of the Otic Ganglion in Chronic Cluster Headache: Safety Issues
Cluster headache (CH) is the most common of the trigeminal autonomic cephalalgias and one of the most severe pains known to man, having a large impact on the sufferer's quality of life.
- Trial name
- NCT03066635
- Testing
- Botulinum Toxin Type A 25 IU, Botulinum Toxin Type A 12.5 IU
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology
Cervical Dystonia,Primary
A Multimodal Approach to Cervical Dystonia Treatment With Association of Botulinum Toxin and Motor Learning Techniques
the aim of this study protocol is to describe, using a longitudinal study, a multimodal approach of treatment of cervical dystonia with botulinum toxin (BoNTA) and a new rehabilitation protocol named SPRInt (Sensory-motor…
- Trial name
- SPRInt (NCT03247868)
- Testing
- Botulinum Toxin+SPRInt
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Fondazione Don Carlo Gnocchi ETS
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Study of BOTOX Injections to Assess Change in Disease Activity and Adverse Events in Adult Female Participants With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic and debilitating urological complex of disorders characterized by symptoms of bladder pain or discomfort, mostly upon bladder filling, and often accompanied by…
- Trial name
- IC/BPS POC (NCT05141006)
- Testing
- BOTOX
- Where
- 43 sites in United States, Canada
- Volunteers
- 83 people
- Sponsor
- AbbVie
Masseter Muscle Prominence
A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants
The masseter muscle is one of the muscles in the lower face used for chewing. Prominence of the masseter muscle can appear as a widened and square lower face shape, which is an aesthetic concern for individuals who prefer a…
- Trial name
- MMP EU P3 (NCT06068855)
- Testing
- BOTOX
- Where
- 27 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 249 people
- Sponsor
- AbbVie
Trigeminal Neuralgia
Botulinum Toxin for Trigeminal Neuralgia
Trigeminal neuralgia (TN) is one of the most painful and common types of neuropathic pain encountered by clinicians. It is typically treated pharmacologically with anticonvulsants,but these can be ineffective, or can lose their…
- Trial name
- EASTERN (NCT03331913)
- Testing
- Botulinum Toxin type A (intradermal / submucosal injection at pain area), Botulinum Toxin type A (intra-masseter injection on the ipsilateral of pain involved)
- Where
- 5 sites in China
- Volunteers
- 150 people
- Sponsor
- The First Affiliated Hospital of Zhengzhou University
Paroxysmal Atrial Fibrillation, Indications for CABG
Botulinum Toxin Injection in Epicardial Fat Pads To Treat Atrial Fibrillation After Cardiac Surgery
The aim of this prospective randomized double-blind study was to compare the efficacy and safety of Botulinum toxin injection in epicardial fat pads for preventing recurrences (in early postoperative period) of atrial…
- Trial name
- NCT01842529
- Testing
- botulinum toxin injection, 0.9% normal saline injection, Implantable loop recorder
- Where
- 3 sites in United States, Russia
- Volunteers
- 60 people
- Sponsor
- Meshalkin Research Institute of Pathology of Circulation
Scar
Botulinum Toxin to Improve Results in Cleft Lip Repair
Botulinum toxin type A (Botox; Allergan, Inc., Irvine, Calif) is widely used for facial rejuvenation and many other medical indications.
- Trial name
- NCT01429402
- Testing
- Botulinum Toxin Type A, Botulinum Type A, Normal Saline
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Myofascial Pelvic Pain
Botulinum Toxin Type A Versus Saline Trigger Point Injections for Myofascial Pelvic Pain
The purpose of this study is to determine whether there is a change in patient-reported pelvic pain following pelvic floor injections of 200 units of Botox compared with 20cc of normal saline.
- Trial name
- NCT01905137
- Testing
- Intervention-Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Urogynecology Associates
Epiphora
Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora
Epiphora or excessive tearing is a significant disability for many affected patients diminishing their quality of life. There is a growing consensus that injection of Botulinum Toxin A (BTX-A) into the lacrimal gland provides…
- Trial name
- NCT01282541
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Merbs, Shannath, M.D., Ph.D.
Complex Regional Pain Syndromes
Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A
Thoracic sympathetic ganglion block is a percutaneous procedure that paralyzes the action of sympathetic nerves transiently by injecting a local anesthetic around the ganglion.
- Trial name
- NCT06470581
- Testing
- Botulinum toxin A
- Volunteers
- 78 people
- Sponsor
- Seoul National University
Low Anterior Resection Syndrome, Rectal Cancer
The Value of Botox-A for Management of Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is frequent after treatment for low rectal cancer. Increased bowel frequency and urgency with rectal spasms and incontinence have deleterious impacts on quality of life in a third of the…
- Trial name
- NCT01589471
- Testing
- intra-rectal Botulinum toxin A injection
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Cervical Dystonia, Blepharospasm
Efficacy and Safety of 10-Week or Shorter vs 12-Week or Longer Injection Intervals of Botulinum Toxin
Our hypothesis is that botulinum toxin injections (with onabotulinum toxin, incobotulinum toxin, and abobotulinum toxin) given at 10-week or shorter intervals for the indication of treatment of muscle spasms associated with…
- Conditions
- Cervical Dystonia, Blepharospasm, Limb Dystonia, Hemifacial Spasm
- Trial name
- NCT05103202
- Where
- United States
- Volunteers
- 105 people
- Sponsor
- University of Texas Southwestern Medical Center
Overactive Bladder
Evaluation of Botulinum Toxin A Alone Versus Botulinum Toxin A With Hydrodistension for Treatment of Overactive Bladder
The specific aim of this trial is to determine if hydrodistention at the time of intradetrusor injection of botulinum toxin A has additional benefit in patients with refractory overactive bladder (OAB) and urgency symptoms…
- Trial name
- HydrA (NCT02995967)
- Testing
- Hydrodistention, Botulinum toxin-A
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cervical Dystonia
Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia
The aim is to demonstrate equivalent efficacy and safety in the treatment of the two most frequent forms of cervical dystonia (predominantly rotational torticollis and predominantly laterocollis) with the standard initial dose of…
- Trial name
- NCT00447772
- Testing
- Botulinum toxin type A
- Where
- 106 sites in Austria, Germany
- Volunteers
- 516 people
- Sponsor
- Ipsen
Spinal Cord Injury, Pain
Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.
As clinicians, it is often a struggle to find effective pain control for a certain subgroup of patients with tetraplegia. These patients often have severe upper back, neck, and shoulder pain, limiting rehabilitation productivity…
- Trial name
- NCT00320281
- Testing
- botulinum toxin A
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Craig Hospital