Clinical trials: Botulinum Toxin
Traumatic Brain Injury
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.
- Trial name
- NCT06293300
- Testing
- BoNT A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
Anal Fissure Chronic
The Efficacy of Botulinum Toxin Alone Versus Combined Botulinum Toxin and Topical Diltiazem in Chronic Anal Fissure
Anal fissure (AF) is a painful tear extending from the anal canal to the dentate line. Although the exact pathophysiology is not known, an increase in anal tonus, decreased ano-dermal blood flow and local ischemia are possible…
- Trial name
- NCT05797220
- Testing
- Botulinum Toxin Type A Injection [Botox], Botulinum Toxin Type A Injection [Botox] + Diltiazem Hydrochloride 20 Mg/G Rectal Gel
- Where
- Turkey (Türkiye)
- Volunteers
- 217 people
- Sponsor
- Istanbul Medipol University Hospital
Thoracic Outlet Syndrome
Botulinum Toxin Injections for Thoracic Outlet Syndrome
Botulinum toxin type A injected into the anterior and middle scalene muscles will reduce the irritation on the neurovascular structures at the interscalene triangle in subjects with TOS.
- Trial name
- NCT01405482
- Testing
- Botulinum Toxin Type A, Normal Saline injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Fissure in Ano
Comparison of Injections of Botulinum Toxin and Topical Nitroglycerin Ointment for the Treatment of Chronic Anal Fissure
Patients will be randomized to receive treatment with either a total of 20 U of botulinum toxin(diluted in saline to a concentration of 50 U per milliliter.
- Trial name
- NCT05590520
- Testing
- Botulinum injection, GTN OINTMENT
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Pak Emirates Military Hospital
Rosacea, Botulinum Toxin
Clinical Observation of Botulinum Toxin A Treatment in the Treatment of Rosacea
the goal of this study is to study the clinical efficacy and safety of botox in the treatment of rosacea.
- Trial name
- NCT06282679
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cerebral Palsy, Spastic
Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy
This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy
- Trial name
- NCT06494618
- Testing
- Radial Extracorporeal Shockwave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medeniyet University
Sun-induced Wrinkles
Phase IV Study On Muscle Activity Of Two Commercial Preparations Of Botulinum
this study was proposed to provide more scientific and objective data on the clinical and aesthetic effects of these two toxins (Dysport and Xeomin).
- Trial name
- NCT01728337
- Testing
- Dysport, Xeomin
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Pain
Subcutaneous Botulinum Toxin for Cutaneous Allodynia
Superficial injection of Botulinum toxin has been advocated for cosmetic purposes but has also been reported to be helpful for some pain conditions.
- Trial name
- NCT00725322
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Stanford University
Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction
Comparison of Three Botulinum Neuromodulators for Management of Facial Synkinesis
The purpose of this study is to compare the effectiveness of three commercially available botulinum toxin neuromodulators in the treatment of facial synkinesis using patient reported outcome measures.
- Conditions
- Facial Nerve Injuries, Facial Paresis Associated With Facial Nerve Dysfunction, Facial Asymmetry, Synkinesis
- Trial name
- NCT03048383
- Testing
- OnabotulinumtoxinA Injectable Product, AbobotulinumtoxinA Injectable Product, Incobotulinumtoxin A Injectable Product
- Volunteers
- 71 people
- Sponsor
- University of Utah
High Tone Pelvic Floor Dysfunction
EMG Guided Botulinum Toxin Type A Injections for Refractory High Tone Pelvic Floor Dysfunction
This is a prospective, pilot, longitudinal study to evaluate the use of EMG guidance for Botox A injection for chronic pelvic pain and HTPFD.
- Trial name
- BTXA EMG (NCT01323829)
- Testing
- EMG Guidance of Injection
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Pelvic and Sexual Health Institute
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
Moderate to Severe Glabellar Lines
DWP450 for Treating Moderate to Severe Glabellar Lines
A multi-center, randomized, double-blind, positive drug-controlled clinical study to evaluate the safety and efficacy of Botulinum Toxin Type A for Injection in the treatment of moderate to severe glabellar lines
- Trial name
- NCT06354127
- Testing
- DWP450, Botox®
- Where
- China
- Volunteers
- 473 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Cerebrovascular Accident
Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing
Claw toes deformity result in spasticity often seem in patients with central nerve disease. It also cause pressure sore in foot and pain during walking that didn't well improve under traditional treatment.
- Trial name
- NCT02586142
- Testing
- Botulinum Toxin Type A, Stretching exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Moderate to Severe Glabellar Lines
A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines
This is a randomized, double-blind, placebo- and active-controlled parallel-group multi-center phase III study to evaluate the efficacy and safety of Rcombinant botulinum neurotoxin type A for injection (YY001)) in the treatment…
- Trial name
- NCT06499688
- Testing
- Rcombinant botulinum neurotoxin type A for injection (YY001), OnabotulinumtoxinA
- Where
- 16 sites in China
- Volunteers
- 529 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Wound; Abdomen, Abdominal Wall
The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy
Damage control laparotomy (DCL) is a life saving maneuver used with success in trauma and acute general surgery patients. The technique involves source control of sepsis and hemorrhage with an abbreviated laparotomy.
- Trial name
- NCT01495962
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Blepharospasm, Hemifacial Spasm
Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm
A triple-masked placebo-controlled trial assessing the efficacy and safety of pretarsal versus preseptal botulinum toxin for patients with eyelid spasm.
- Conditions
- Blepharospasm, Hemifacial Spasm, Botulinum Toxins, Type A
- Trial name
- NCT03508882
- Testing
- Botulinum Toxin Type A 100Unit/Vial (Product), Saline Solution for Injection
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Cervical Spasm, Radiotherapy Side Effect
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
The main objective of the study is to estimate the efficiency and to determine the optimal dose of Botulinum toxin A, administered by intramuscular way in cervical spasms after radiotherapy, as well as the optimal sites for these…
- Conditions
- Cervical Spasm, Radiotherapy Side Effect, Botulinum Toxin
- Trial name
- NCT02986880
- Testing
- Botulinum toxin A
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hopital Foch
Tennis Elbow
Effectiveness of Botulinum Toxin Injection in the Tennis Elbow Treatment
Some studies valued the effectiveness of botulinum toxin. Results are contradictory and we need more studies. The purpose of the study is to compare the effectiveness of botulinum toxin injection with placebo in the treatment of…
- Trial name
- TBA (NCT00437762)
- Testing
- Botulinum Toxin A Injection
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Bordeaux
Glabellar Lines
Efficacy and Safety Assessment of Botulax® and BOTOX® for Improvement of Glabellar Lines.
This study is a phase 3 clinical trial of multi-center, random, blinded*, parallel control, and positive control to evaluate the efficacy and safety of Botulax® Injection compared to BOTOX® for improving moderate to severe…
- Trial name
- NCT05380154
- Testing
- Botulinum Toxin A type for injection (Botulax®), Botulinum Toxin A type for injection (BOTOX®, Bao Tuo Shi®)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Hugel