Clinical trials: Botulinum Toxin
Skin Wrinkling
Study to Determine If the Volume Used to Dilute BOTOX Cosmetic™ for Injection Affects Its Overall Effect and Duration.
It is thought that the amount of fluid used to dilute Botox for injection has an effect on the quality of the result and the duration of effect on the treatment of upper face rhytides, even though the dose remains the same.
- Trial name
- NCT00250952
- Testing
- Botox Cosmetic™
- Where
- 2 sites in United States, Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Carruthers Dermatology Centre
Change From Baseline House-Brackmann
Ultrasound-Guided Stellate Ganglion Block With Botulinum
the local stellate ganglion block with bupivacaine and corticosteroid treatment for acute peripheral facial nerve palsy in patients can induce hyperglycemia, and an alternative local therapy may be necessary and some time may ve…
- Trial name
- NCT05099835
- Testing
- Botox, triamcinolonacetonide
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Assiut University
Premature (Early) Ejaculation
Dual-Site Botulinum Toxin Type A Injection for Lifelong Premature Ejaculation
Premature ejaculation is a common sexual condition that can cause distress for men and their partners. Different treatments are available, but some men do not respond well to standard therapies.
- Trial name
- DUAL - PE (NCT07426640)
- Testing
- BoNT-A
- Where
- Saudi Arabia
- Volunteers
- 150 people
- Sponsor
- Al Mouwasat Hospital
Plantar Fascitis, Gastrocnemius Tightness
Treatment of Gastrocnemius Tightness and Subsequent Chronic Plantar Fasciitis with Botulinum Toxin a
This prospective clinical cohort study will follow 40 patients who recieve botulinum toxin A treatment for proximal medial gastrocnemius tightness with subsequent Chronic Plantar Fasciitis for two years.
- Trial name
- PLATOX (NCT05218785)
- Testing
- Botox
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- Oslo University Hospital
Urinary Bladder, Overactive, Urodynamics
Evaluation the Efficacy Between Botox Injection and Combination Pharmacotherapy in Patients With Detrusor Overactivity
To investigates the effects of botulinum toxin type A bladder injection compared to combined pharmacotherapy with Mirabegron and Solifenacin.
- Conditions
- Urinary Bladder, Overactive, Urodynamics, Effect of Drug
- Trial name
- NCT05968885
- Testing
- Intradetrusor Botox® (onabotulinumtoxinA) injection, Combine Mirabegron and Solifenacin.
- Where
- Taiwan
- Volunteers
- 300 people
- Sponsor
- Mackay Memorial Hospital
Spasticity as Sequela of Stroke
Phenol and Botulinum Toxin vs Botulinum Toxin Alone for Post-Stroke Upper-Limb Spasticity
This study aims to evaluate the efficacy of a combined treatment approach for post-stroke upper limb spasticity using phenol neurolysis and botulinum toxin (BoNT).
- Trial name
- NCT07440173
- Testing
- phenol neurolysis, Botulinum Toxin - A injections
- Volunteers
- 60 people
- Sponsor
- Assiut University
Peyronie's Disease
H-22411: BOTOX® for Peyronie's Disease
Peyronie's disease is a condition in which a plaque, or hard lump, forms on the penis. It causes hardened tissue, pain, and an abnormal bending in the penis. These symptoms are more severe during an erection.
- Trial name
- NCT00812838
- Testing
- 100 units of Botulinum Toxin Type A, Preservative free normal saline, 100 units Botulinum Toxin A
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Mohit Khera
Cerebral Palsy, Spastic
Effect of Video Game-assisted and BoNT-A Injection Therapy on Spasticity, Activity and Participation in CP Patients
Cerebral palsy (CP) is a non-progressive condition of the central nervous system caused by immature brain damage before, during or after birth. Persons affected by CP experience disability of various types.
- Trial name
- CPSpast (NCT04290169)
- Testing
- IncobotulinumtoxinA, Video game
- Volunteers
- 25 people
- Sponsor
- Sunnaas Rehabilitation Hospital
Spastic Cerebral Palsy
Short Term Follow-up of a Botulinum Toxin Intervention in Children With Spastic Cerebral Palsy
This study investigates the effect of integrated Botulinum Neurotoxin A (BoNT) treatment on morphologic muscle and tendon properties, spasticity, joint stiffness, joint range of motion, muscle strength, gait and gross motor…
- Trial name
- NCT05126693
- Testing
- Botulinum Toxin treatment combined with a post-BoNT intensive physical therapy period guided by individualized treatment goals.
- Where
- Belgium
- Volunteers
- 61 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Temporo-Myofascial Disorder
Treatment of Temporo-Myofascial Disorder of Muscular Origin Using Botulinum Toxin: A Prospective Study
Temporomandibular disorders (TMD) are a group of conditions involving the temporomandibular joint (TMJ), masticatory muscles and associated structures.
- Trial name
- NCT02810015
- Testing
- Botulinum Toxin Type A
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Chronic Low Back Pain
Botulinum Toxin A for the Treatment of Chronic Lumbar Back Pain
This study will assess the efficacy and the duration of efficacy of Botulinum toxin A (Botox®) injected into the lumbar paraspinal muscles for reducing pain and disability in subjects suffering from chronic low back pain of six…
- Trial name
- NCT00404417
- Testing
- Botulinum Toxin A / Botulinum Toxin A
- Where
- United States
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Spasticity, Brain Injuries
CLINICAL EFFECT OF BOTULINUM TOXIN TYPE A IN TREATMENT OF SPASTICITY
Spasticity has been defined as a disorder of the sensorimotor system characterized by a velocity-dependent increase in tonic stretch reflexes (muscle tone) with exaggerated tendon jerks, resulting from hyperexcitability of the…
- Conditions
- Spasticity, Brain Injuries, Spinal Cord Injuries, Multiple Sclerosis
- Trial name
- NCT04673240
- Testing
- Botulinum toxin type A injection
- Where
- Italy
- Volunteers
- 70 people
- Sponsor
- Università degli Studi del Piemonte Orientale Amedeo Avogadro
Aging
Comparative Study of the Effect of Dysport and Botox
The purpose of this study is to test the effect of Dysport and Botox on forehead wrinkles and EMG activity.
- Trial name
- NCT00434863
- Testing
- botulinum toxin type A
- Where
- Germany
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Laserklinik Karlsruhe
Enlarged Pores
Microneedle Patch With Botulinum Toxin in Management of Enlarged Facial Pores
The purpose of this study is to assess the efficacy and safety of microneedle patch with botulinum toxin for improving enlarged pores.
- Trial name
- NCT06293755
- Testing
- Microneedle patch, Intradermal injection
- Where
- Thailand
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Dhurakij Pundit University
Epicondylitis, Lateral Humeral, Tennis Elbow
Evaluation of Three Types of Injection for the Treatment of Lateral Epicondylalgia
The primary objective of this study is to compare the evolution of pain profiles among patients suffering from lateral epicondyalgia (tennis elbow) following three types of treatment: PRP-L injection versus type A botulinum toxin…
- Trial name
- LET (NCT02325063)
- Testing
- PRP-L Injection, Botox injection, Corticoid injection
- Where
- 2 sites in France
- Volunteers
- 13 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Major Depression
Efficacy Study of Botox for Depression
The objective of this proposed study is to obtain data on the efficacy of Botox in reducing symptoms of MDD in male and female patients between the ages of 18 and 65 years old.
- Trial name
- NCT01556971
- Testing
- Botox, Saline Solution
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Capital Clinical Research Associates, LLC
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to evaluate the safety and efficacy of RT001 to treat moderate to severe lateral canthal lines in adults and duration of effect.
- Trial name
- NCT00907387
- Testing
- RT001
- Where
- 9 sites in United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Pain Management, Pain
Silencing Neuroma Pain-Botulinum Toxin Versus Local Anesthetic Injection
Neuroma-related pain is a frequent and disabling condition after limb trauma and amputation. Available treatments often provide short-lasting or insufficient analgesia.
- Conditions
- Pain Management, Pain, Phantom Limb Pain, Phantom Limb Pain After Amputation
- Trial name
- SILENCE-NEUROM (NCT07431944)
- Testing
- Botulinium toxin type A injection, Local Anesthesia
- Where
- Ukraine
- Volunteers
- 100 people
- Sponsor
- Charitable Organisation Charitable Fund Superhumans (Co Cf Superhumans)
Glabellar Frown Lines
A Safety and Efficacy Study of Different Injections Volumes of Botulinum Toxin Type A, Azzalure, in the Glabellar Lines
A randomized, evaluator-blinded, comparative, study to evaluate the efficacy and safety of different injection volumes of botulinum toxin type A, Azzalure, in the glabellar lines.
- Trial name
- NCT02108158
- Testing
- Azzalure
- Where
- 2 sites in Sweden
- Volunteers
- 62 people
- Sponsor
- Galderma R&D
Psoriasis Vulgaris
Use of Botulinum Toxin to Treat Psoriasis
Psoriasis vulgaris is a chronic disease in which psoriatic plaques may appear on the knees, elbows, scalp and trunk. Evidence suggests the role of neurogenic inflammation in the pathogenesis of psoriasis.
- Trial name
- NCT00816517
- Testing
- injection of botulinum toxin type A.
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota