Clinical trials: Botulinum Toxin
Fecal Incontinence
Mechanisms of Action on Rectal Motricity of Intrarectal Botulinum Toxin Injections
Previous studies have demonstrated the efficacy of this treatment in certain patients suffering from fecal incontinence, but it is not yet reimbursed in this indication as it is still in the evaluation phase.
- Trial name
- MECA-TOX (NCT05998187)
- Testing
- intra-rectal botulinum toxin injections
- Where
- France
- Volunteers
- 21 people
- Sponsor
- University Hospital, Rouen
Post-stroke Spasticity of the Lower Limb
Efficacy and Safety Study of Botulinum Toxin Type A Against Placebo to Treat Spasticity in the Leg After a Stroke
The purpose of this study is to determine whether injections of Botulinum toxin type A into muscles of the leg are effective in treating patients with increased muscle tension/uncontrollable muscle stiffness (spasticity) after a…
- Trial name
- PLUS (NCT01464307)
- Testing
- IncobotulinumtoxinA (400 Units)
- Where
- 53 sites in United States, Canada and 7 more
- Volunteers
- 290 people
- Sponsor
- Merz Pharmaceuticals GmbH
Premature Ejaculation
Safety and Efficacy of Botulinum Toxin-A Injection Into Ischiocavernosus Muscle for Premature Ejaculation
The aim of this work is to assess the efficacy and safety of Botulinum toxin - A injection into ischiocavernosus muscle in treatment of primary premature ejaculation.
- Trial name
- NCT06851598
- Testing
- 25 units botox, 50 units Botox, 75 units Botox
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Abdallah Mohamed Abdallah Mohamed Elgendy
Spastic Gait, Spastic
Exoskeleton Robotic Assisted Gait Training in Spastic Stroke Post Botulinum Toxin A Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A(BoNT-A) injection with exoskeleton Robotic assisted gait training (RABT) in patients with post-stroke…
- Trial name
- NCT06070987
- Testing
- BoNT-A injections, RF BoNT-A injection in first period and robot therapy, RF BoNT-A injection in second period and robot therapy
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Idiopathic Toe-walking
Botulinum Toxin A for Idiopathic Toe-walking
The purpose of this study is to determine whether botulinum toxin A (BTX) adds a favourable effect to treatment of idiopathic toe-walking with below knee walking casts.
- Trial name
- NCT01590693
- Testing
- Botulinum toxin A
- Where
- Sweden
- Volunteers
- 52 people
- Sponsor
- Karolinska Institutet
Post-Stroke Spasticity, Cerebrovascular Accident
Study Of GSK1358820 In Patients With Post-Stroke Upper Limb Spasticity
This is a study to confirm the superior efficacy of a single treatment of GSK1358820 over placebo in patients with post-stroke upper limb spasticity of both the wrist and finger flexors using the Modified Ashworth Scale (MAS)…
- Trial name
- NCT00460564
- Testing
- GSK1358820
- Where
- 18 sites in Japan
- Volunteers
- 109 people
- Sponsor
- GlaxoSmithKline
Cardiac Surgery
Prevention Atrial Fibrillation by BOTulinum Toxin Injections (BOTAF)
Over the past few years, research has focused on the prevention of atrial fibrillation (AF) after cardiac surgery, but highly effective interventions are still missing.
- Trial name
- BOTAF (NCT04075981)
- Testing
- Botulinum Toxin Type A Injection [Xeomin]
- Where
- 7 sites in France
- Volunteers
- 220 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Freezing of Gate, Parkinson Disease
Effectiveness of Botulinum Toxin in Freezing of Gate in Parkinson's Disease Walking in Parkinson's Disease.
Freezing of gait is a symptom of Parkinson's disease (PD) that becomes more evident with the evolution of the disease, and which presents an important difference compared to the other signs and symptoms: does not respond…
- Conditions
- Freezing of Gate, Parkinson Disease, Botulinum Toxin
- Trial name
- NCT06094309
- Testing
- Botulinum toxin type A injection
- Where
- Portugal
- Volunteers
- 20 people
- Sponsor
- Centro Hospitalar de Lisboa Central
Urinary Retention, Fowler's Syndrome
Botulinum Toxin A Injections in Patients With Fowler's Syndrome
Hypothesis / aims of study Urinary retention is uncommon in young women, and one cause is a primary disorder of urethral sphincter relaxation, characterised by an elevated urethral pressure profile and specific findings in the…
- Trial name
- NCT02428881
- Testing
- onabotulinumtoxinA
- Volunteers
- 10 people
- Sponsor
- University College, London
Interstitial Cystitis
Efficacy and Safety of Low Energy Shock Wave Plus BotulinumToxin A in Treating Patients With Interstitial Cystitis
Low energy shock wave (LESW) is known to facilitate tissue regeneration with analgesic and anti-inflammatory effects. LESW treatment has been demonstrated effective in treatment of nonbacterial prostatitis and chronic pelvic pain…
- Trial name
- NCT05275647
- Testing
- BOTOX 100U in normal saline, Normal saline
- Where
- Taiwan
- Volunteers
- 75 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Spasticity
MEDITOXIN® Versus BOTOX® in the Treatment of Post-stroke Spasticity of the Upper Limb Spasticity
This study is a randomized, double blind, multi-center, active drug controlled, phase III clinical trial to compare the efficacy and safety of MEDITOXIN® versus BOTOX® in treatment of post stroke upper limb(wrist, finger, thumb)…
- Trial name
- NCT01313767
- Testing
- Botulinum toxin type A
- Where
- South Korea
- Volunteers
- 196 people
- Sponsor
- Medy-Tox
Myofascial Pain Syndrome (MPS)
Botulinum Toxin Type A Versus Triamcinolone for Facial Myalgia
This single-blind randomized controlled trial aims to compare the therapeutic effects of Botulinum Toxin Type A and triamcinolone injections in adults with facial myofascial pain syndrome.
- Trial name
- NCT07867379
- Testing
- Botulinum Toxin A (Botox ), Triamcinolone Acetonide
- Where
- Saudi Arabia
- Volunteers
- 56 people
- Sponsor
- Riyadh Elm University
Contact Ulcer of Vocal Folds, Granuloma of Vocal Cords
Efficacy Study of Botulinum Toxin (BOTOX) Injections to Treat Vocal Fold Granulomas
Vocal process granulomas are inflammatory masses caused in part by vocal trauma that arise in the posterior aspect of the vocal folds and result in throat pain, difficulty swallowing, hoarseness, and globus sensation.
- Conditions
- Contact Ulcer of Vocal Folds, Granuloma of Vocal Cords, Granuloma, Laryngeal, Granuloma
- Trial name
- NCT01678053
- Testing
- onabotulinumtoxinA, omeprazole (proton pump inhibitor)
- Where
- United States
- Sponsor
- Phillip Song, MD
Vulvodynia
Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareuni and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT04057755
- Testing
- botulinum toxin A, NaCl
- Where
- Sweden
- Volunteers
- 90 people
- Sponsor
- Karolinska Institutet
Benign Prostatic Hyperplasia
A Study Evaluating the Effect of Botulinum Toxin Type A on Semen Quality in Patients With Benign Prostatic Hyperplasia
This is a 24 week study evaluating the effects of botulinum toxin Type A on semen quality in patients with signs and symptoms of Benign Prostatic Hyperplasia (BPH).
- Trial name
- NCT00894517
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- Allergan
Stroke, Hemiplegia, Spastic
Condensed and Distributed Robotic Therapy in Spastic Stroke Post Botulinum Toxin Injection
The purpose of this project is to examine and compare the immediate and long-term effects of combined Botulinum toxin type A (BoNT-A) injection between condensed and distributed robot-assisted training (RT) programs in patients…
- Trial name
- NCT03321097
- Testing
- condensed RT group, distributed RT group
- Where
- Taiwan
- Volunteers
- 36 people
- Sponsor
- Chang Gung Memorial Hospital
Glabellar Frown Lines
Study to Compare the Efficacy and Safety of ATGC-110 (Botulinum Toxin) With Xeomin® for the Treatment of Moderate to Severe Glabellar Frown Lines
Efficacy and safety of the investigational product, ATGC-110, was evaluated in comparison with Xeomin for a total of 16 weeks after the administration in treatment of glabellar frown lines.
- Trial name
- NCT05623410
- Testing
- ATGC-110, Xeomin®
- Where
- South Korea
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- ATGC Co., Ltd.
Spastic Neurogenic Bladder
The Efficacy of Botulinum Toxin in Spastic Neuropathic Bladder
To assess the efficacy of botulinum toxin in spastic neurogenic bladder.
- Trial name
- NCT03407183
- Testing
- intradetrusor injection of botulinumtoxinA (Botox)
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- AHMED FARAHAT HASSAN
Chronic Pain Due to Injury, Neuroma of Lower Limb
Botulinum Toxin Type A Versus Local Anesthetic Injection for Chronic Neuroma Pain After Combat-Related Amputation
Patients with combat-related amputations frequently experience persistent neuroma pain that may interfere with rehabilitation, prosthesis use, sleep, mobility, and quality of life.
- Conditions
- Chronic Pain Due to Injury, Neuroma of Lower Limb, Neural Injury, Neuroma of Upper Limb
- Trial name
- NEUROQUIET (NCT07626983)
- Testing
- Botulinum Toxin Type A (BoNT-A), Local Anesthetic Solution
- Where
- 2 sites in Ukraine
- Volunteers
- 100 people
- Sponsor
- Ukrainian Society of Regional Anesthesia and Pain Therapy
Localized Provoked Vulvodynia
Infiltration of the Vestibulum Vaginae With Botulin Toxin in Patients With Localized Provoked Vulvodynia
In this study we will investigate the efficacy and safety of infiltration of the vestibulum vaginae with botulin toxin in women who were diagnosed with localized provoked vulvodynia.
- Trial name
- VVS-01 (NCT01747161)
- Testing
- Botulin toxin, physiological water
- Where
- Belgium
- Volunteers
- 5 people
- Sponsor
- University Hospital, Ghent