Clinical trials: Botulinum Toxin
Skin Aging
Safety and Efficacy of Botulinum Toxin Type A Topical Gel for Lateral Canthal Lines
This is a safety and efficacy study of botulinum toxin type A in subjects with lateral canthal lines.
- Trial name
- REALISE 1 (NCT02580370)
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 450 people
- Sponsor
- Revance Therapeutics, Inc.
Obesity
Effects of Gastric Antral Botulinum Toxin Injections in Obese Subjects
Obesity is an important public health problem in the United States. The investigators hypothesize that stomach injections of botulinum toxin A (BTA), delivered through an endoscope using endoscopic ultrasound (EUS), may cause…
- Trial name
- NCT00976443
- Testing
- BTA
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Forehead Rhytid Complex, Glabellar Rhytid Complex
Treatment of Forehead/Glabellar Rhytide Complex With Botulinum Toxin A Injection
This cross-over design study will evaluate the onset of action, efficacy, and duration of botulinum toxin A treatment on forehead/glabellar rhytid complexes with and without subsequent muscle contraction.
- Trial name
- NCT01688076
- Testing
- Botulinum Toxin A
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Cerebral Palsy
Sevoflurane and Propofol for Botulinum Toxin Injection
The investigators would like to compare clinical features (onset, duration, emergence time), efficacy of deep sedation (successful completion of procedure), safety (adverse events) and caregiver's satisfaction for sedation when…
- Trial name
- NCT05505123
- Testing
- Sevoflurane, Propofol
- Where
- South Korea
- Sponsor
- Yeungnam University College of Medicine
Cerebral Palsy
The Effects of Physiotherapy and Rehabilitation Programs Following Botulinum Toxin on Children With Cerebral Palsy
The purpose of this study was to investigate the effects of Physiotherapy and rehabilitation program on body functions and structures, activity and participation levels, personal and environmental factors following Multilevel…
- Trial name
- NCT03580174
- Testing
- Goal directed physiotherapy group, Routine physiotherapy group
- Where
- Turkey (Türkiye)
- Volunteers
- 24 people
- Sponsor
- Hacettepe University
Spasmodic Dysphonia
Dysphonia Pain Perception Following Botulinum Toxin Injections
Spasmodic dysphonia (SD) is a chronic voice disorder which can cause a significant decrease in voice related quality of life with no cure.
- Trial name
- NCT06767215
- Testing
- Ice Compress, No ice compress
- Where
- Canada
- Volunteers
- 116 people
- Sponsor
- University of British Columbia
Borderline Personality Disorder
Botulinum Toxin A for Emotional Stabilization in Borderline Personality Disorder (BPD)
The main objective of the trial is to test whether a single application of botulinum toxin A into the glabellar region will lead to emotional stabilization in borderline personality disorder through paralysis of facial…
- Trial name
- BTX-BPD (NCT02728778)
- Testing
- incobotulinumtoxin A, Acupuncture
- Where
- 2 sites in Germany
- Volunteers
- 54 people
- Sponsor
- Hannover Medical School
Overactive Bladder
Evaluation of Intradetrusor AbobotulinumtoxinA and IncobotulinumtoxinA in Women With Overactive Bladder
A randomized, single blind, non-inferiority clinical study was performed evaluating the efficacy and safety of AbobotulinumtoxinA vs.
- Trial name
- NCT06250543
- Testing
- AbobotulinumtoxinA 300 UNT, IncobotulinumtoxinA 100 UNT, Lidocain
- Where
- Slovenia
- Volunteers
- 64 people
- Sponsor
- Niko Kavcic
Chronic Plantar Fasciitis
Study to Assess the Efficacy and Safety of Dysport® in the Treatment of Chronic Plantar Fasciitis
This study will investigate the hypothesis that the analgesic effect of a single injection of Dysport (200 MU) induces a significant reduction of symptoms in chronic cases of plantar fasciitis.
- Trial name
- NCT00447876
- Testing
- Botulinum toxin type A
- Where
- 6 sites in Germany
- Volunteers
- 40 people
- Sponsor
- Ipsen
Retrograde Cricopharyngeus Dysfunction
Botulinum Toxin Injection in the UES for R-CPD
The aim of this study is to assess the effect of botulinum toxin injection into the upper esophageal sphincter in a double blind, placebo controlled study.
- Trial name
- BOTUS R-CPD (NCT06356025)
- Testing
- botulinum toxin type A, Sodium Chloride 0.9% Inj
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- AZ Delta
Carpal Tunnel Syndrome, Neurogenic Inflammation
BotulInum Toxin Type A for Peripheral Neuropathic Pain in subjEcts With Carpal Tunnel Syndrome
The main purpose of the study is to assess the safety and efficacy of repeated administrations of BoNT-A in subjects with NP attributable to carpal tunnel syndrome (CTS) through a randomized, double-blind, placebo-controlled…
- Conditions
- Carpal Tunnel Syndrome, Neurogenic Inflammation, Pain, Drug Use
- Trial name
- INjECT (NCT05411900)
- Testing
- BoNT-A
- Where
- Italy
- Volunteers
- 164 people
- Sponsor
- Francesco Bono
Botulism
Botulism Outbreak in Thailand (Episode II)
A second botulism outbreak in Northern Thailand was reported in 2006. 192 people were exposed to raw meat and the gut of deer, 83 suffered from diarrhea. Of these 5 developed respiratory failure, 1 impending respiratory failure.
- Trial name
- NCT00348426
- Testing
- Botulinum AntiToxin, neuro-electrophysiologic study, repetitive nerve stimulation, : Protocol early weaning ventilator after recovery of repetitive nerve stimulation and stable negative inspiratory pressure
- Where
- Thailand
- Volunteers
- 200 people
- Sponsor
- Department of Medical Services Ministry of Public Health of Thailand
Face Pain
Efficacy of Botulinum Toxin Versus Lidocaine in Treating Masticatory Myofascial Face Pain Using Ultrasound and EMG Guided Techniques
Botulinum toxin-A (BTX-A) prevents the release of acetylcholine in presynaptic terminals of the neuromuscular junction. It has been proposed to be effective in spastic conditions of the head and neck including oromandibular…
- Trial name
- NCT00992108
- Testing
- lidocaine, chemodenervation
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Urinary Bladder, Overactive, Spinal Cord Injury
Long-term Follow-up Study of Patients Who Received EG110A, a Non-replicative Herpes Simplex Virus 1-derived Gene Therapy
The aim of this study is to continue following participants who have received EG110A during five years to know how it is tolerated in humans, any side-effects it may cause and what might be an effective dose over five years.
- Trial name
- NCT07227285
- Testing
- Urodynamics, EG110A, Patient-reported Outcome
- Where
- 4 sites in United States
- Volunteers
- 16 people
- Sponsor
- Cyllene Therapeutics
Wrinkle
Injection Site Pain Botulinum Toxin Reconstituted in NS With and Without Sodium Bicarbonate
This study was designed to investigate the effects of botulinum toxin type A injections diluted with the mixture of sodium bicarbonate (SB) and normal saline (NS) on pain reduction, onset of action and duration of action.
- Trial name
- NCT04579419
- Testing
- Sodium Bicarbonate, Normal Saline
- Where
- Saudi Arabia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- King Abdulaziz Medical City
Myofascial Pain Syndrome, Myofascial Trigger Point Pain
Clinical Performance of Therapeutic Use of BTX for Bruxism
The goal of this clinical trial is to learn about the performance of botulinum toxin (BTX) injections for bruxism. Participants were divided into two groups according to the duration of the symptoms.
- Conditions
- Myofascial Pain Syndrome, Myofascial Trigger Point Pain, Bruxism, Pain
- Trial name
- BTX (NCT06258070)
- Testing
- Abobotulinumtoxin A injection for bruxism
- Where
- Tunisia
- Volunteers
- 67 people
- Sponsor
- Mohamed Tahar Maamouri University Hospital
Hypertrophic Scars
Treatment of Hypertrophic Scars Using Fractional CO2 Laser Alone in Comparison With Adding Botulinum Toxin Either Through Intralesional Injection or Assisted Drug Delivery
The current study aimed to evaluate the effectiveness of fractional laser treatment alone and fractional laser combined with botulinum toxin A, delivered either through injections or topical application fractional laser-assisted…
- Trial name
- BTX and LADD (NCT07360483)
- Testing
- Botulinum toxin type A (Botox®, Allergan)
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Cairo University
Cerebral Palsy
Integrated Management Enhances Functional Gains in Children With Cerebral Palsy Treated by BoNT-A
Evidence from literature support the use of Botulinum toxin A (BoNT-A) for upper limb spasticity management in children with cerebral palsy (CP).
- Trial name
- NCT03302871
- Testing
- Botulinum toxin type A, transcranial direct current stimulation, hybrid training model of CIMT and BIT
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Kocaeli University
Esophageal Achalasia, Esophageal Spasm, Diffuse
Peroral Endoscopic Myotomy Versus Botulinum Toxin Injection in Spastic Esophageal Disorders
To compare the efficacy of peroral endoscopic myotomy and Botulinum toxin injection in spastic esophageal disorders.
- Conditions
- Esophageal Achalasia, Esophageal Spasm, Diffuse, Esophageal Motility Disorders
- Trial name
- NCT02663206
- Testing
- peroral endoscopic myotomy, Botulinum toxin injection
- Where
- United States
- Sponsor
- Johns Hopkins University
Glabellar Frown Lines
The Efficacy and Safety Study of Protoxin Versus Botox® in Subjects With Moderate to Severe Glabellar Lines
This study will be conducted in Phase Ⅲ clinical trials. In Phase Ⅲ, subjects with moderate to severe glabellar lines are enrolled and those who are judged to be eligible for this study will be injected with the "PROTOXIN" at a…
- Trial name
- NCT05364580
- Testing
- PROTOXIN, Botox®
- Where
- 5 sites in South Korea
- Volunteers
- 269 people, healthy volunteers welcome
- Sponsor
- Protox Inc.