Clinical trials: Botulinum Toxin
Post Stroke Seizure, Spastic Foot
Evaluation of Tibial Nerve Selective Neurotomy Compared to Botulinum Toxin Injections for Spastic Foot Treatment in Post-stroke Patients According to a Goal-centered Approach
In France, more than 110.000 patients are hospitalized for stroke per year. It is the leading cause of sudden disabilities in adults.
- Trial name
- FOOTNEUROTOX (NCT05874154)
- Testing
- Tibial nerve selective neurotomy, Botulinum toxin injection
- Where
- 4 sites in France
- Volunteers
- 60 people
- Sponsor
- Hospices Civils de Lyon
Nocturnal Bruxism
Botulinum Toxin A Injectable Solution in the Management of Bruxism: A Clinical Trial Study
A Clinical Trial Study to investigate the potential performance of BTXA on masseter muscle on patient with nocturnal bruxism and to check the pain scale and share this clinical experience.
- Trial name
- NCT03827122
- Testing
- onabotulinumtoxinA
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Colleges of Dentistry and Pharmacy
Multiple Sclerosis
Botulinum Toxin in Patients With Spastic Lower Limb Paresis Associated With Multiple Sclerosis
Spastic paraparesis is one of the most disabling functional deficits in the population with multiple sclerosis between 18 and 80 years of age and at any functional level.
- Trial name
- NCT04595045
- Testing
- Botulinum toxin type A infiltrations
- Where
- 2 sites in Spain
- Volunteers
- 84 people
- Sponsor
- Aránzazu Vázquez Doce
Cervical Dystonia
Assessment of Long-term Clinical Response to BoNT in Cervical Dystonia
The goal of this retrospective, international, multi-center chart abstraction is to learn about the long-term impact of product-specific immunogenicity-related factors in different botulinum neurotoxin type A formulations in…
- Trial name
- RELY-CD (NCT05884528)
- Testing
- CC BoNT/A, CF BoNT/A, CF to CC BoNT/A
- Where
- Germany
- Volunteers
- 270 people
- Sponsor
- Merz Therapeutics GmbH
Levator Ani Syndrome With Pain and/or Constipation Symptoms.
Comparison of Biofeedback vs. Botox Injection to Treat Levator Ani Syndrome
Purpose: To assess whether EMG directed biofeedback therapy or Botulinum toxin type A injection of the levator ani muscles has any effect on pain from the levator ani syndrome, and, in addition, to what extent either treatment is…
- Trial name
- NCT00564707
- Testing
- Biofeedback therapy, Botulinum Toxin Type A Injection
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Walter Reed Army Medical Center
Migraine Disorders, Headache
Safety and Efficacy of Botulinum Toxin Type A (BOTOX®) to Treat Chronic Migraine in Korea
This study is a Post-Marketing Surveillance study in Korea to evaluate the safety and efficacy of botulinum toxin Type A to treat Chronic Migraine in clinical practice.
- Trial name
- NCT01976611
- Testing
- botulinum toxin Type A
- Where
- South Korea
- Volunteers
- 402 people
- Sponsor
- Allergan
Glabella Line Severity
Efficacy and Safety Study of MT10109L in the Treatment of Glabella Line(Including a Preliminary Study to Evaluate Safety of MT10109L)
This study design is multi-center, randomized, double-blind, parallel group, active controlled, phase 3 clinical trial(Including randomized, double-blind, parallel group, active controlled, preliminary study).
- Trial name
- NCT03894748
- Testing
- Botulinum Toxin Type A
- Where
- 3 sites in South Korea
- Volunteers
- 168 people, healthy volunteers welcome
- Sponsor
- Medy-Tox
Psoriasis Vulgaris
Use of Botulinum Toxin to Treat Psoriasis
Psoriasis vulgaris is a chronic disease in which psoriatic plaques may appear on the knees, elbows, scalp and trunk. Evidence suggests the role of neurogenic inflammation in the pathogenesis of psoriasis.
- Trial name
- NCT00816517
- Testing
- injection of botulinum toxin type A.
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Minnesota
Endoscopy
Evaluation of the Role of Endoscopic Ultrasound Guided Gastric Botulinum Toxin Injection in the Treatment of Obesity.
Background: Gastric injections of Botulinum toxin A (BTA) may induce changes in gastric emptying and body weight, but results vary. BTA dose and depth of injection may affect efficacy.
- Trial name
- NCT03901040
- Testing
- endoscopic ultrasound
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Myofascial Pain Syndromes
Botulinum Toxin Type A (Dysport) Associated With Rehabilitation Treatment in Patients With Primary Myofascial Pain Syndrome
The main purpose of this study is to determine the effectiveness and safety of one dose of botulinum toxin type A (Dysport) associated with rehabilitation treatment on pain control in patients with a type of back pain called…
- Trial name
- NCT00149240
- Testing
- Botulinum toxin type A
- Where
- 4 sites in Spain
- Volunteers
- 24 people
- Sponsor
- Ipsen
Idiopathic Clubfoot (Talipes Equinovarus)
A Double-Blind, Randomized Control Trial Comparing Botulinum Toxin Type A (Botox) and Placebo in the Treatment of Idiopathic Clubfoot
The purpose of this study is to continue the work from the previous review study and determine the effectiveness of Botox in treating patients with idiopathic clubfoot by comparing outcomes of subjects treated with manipulation…
- Trial name
- NCT00152347
- Testing
- Botox
- Where
- Canada
- Volunteers
- 36 people
- Sponsor
- University of British Columbia
Cerebral Palsy
Rehabilitation and Treatment Utilization in Children With Cerebral Palsy: Analysis of the Korean Cerebral Palsy Registry
This cross-sectional observational study analyzed baseline data from 836 children with cerebral palsy enrolled in the Korean Cerebral Palsy Registry (KCPR), a nationwide multicenter prospective registry involving 42 institutions…
- Trial name
- NCT07862985
- Testing
- No Intervention
- Where
- South Korea
- Volunteers
- 836 people
- Sponsor
- Pusan National University Hospital
Moderate to Severe Glabellar Lines
Efficacy and Safety of Clostridium Botulinum Toxin Type A to Improve Appearance of Moderate to Severe Glabellar Lines
The purpose of this study was to demonstrate the safety and the efficacy of a single treatment of an injectable liquid form of Clostridium botulinum toxin type A haemagglutinin complex (BTX-A-HAC; hereafter referred to as…
- Trial name
- BTX-A-HAC NG (NCT02353871)
- Testing
- Botulinum toxin type A
- Where
- 9 sites in France, Germany
- Volunteers
- 185 people
- Sponsor
- Ipsen
Tears; Excess, Eyelid Spasm
Effect of Topical Botulinum Toxin Eyedrop on Palpebral Fissure
The purpose of this research study is to test if Topical (applied to the surface of the eye) Botulinum Toxin temporarily lowers the upper eyelid and makes the eyelid appear less open and thereby affects the eye surface and…
- Trial name
- NCT06080438
- Testing
- Botulinum toxin
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- University of Miami
Moderate to Severe Glabellar Lines
A Phase I/II, Randomized, Double-blind, Placebo, and Active Controlled Clinical Study to Evaluate the Safety, Tolerability, Immunogenicity, and Preliminary Efficacy of JHM03 in Subjects With Moderate to Severe Glabellar Lines
This is a phase 1/2, multicenter, randomized, double-blind, active-controlled and placebo-controlled study to evaluate safety, immunogenicity and efficacy of JHM03 for the treatment of moderate to severe glabellar lines in male…
- Trial name
- NCT06199336
- Testing
- JHM03, BOTOX®
- Where
- China
- Volunteers
- 190 people
- Sponsor
- JHM BioPharma (Tonghua) Co. , Ltd.
Excessive Gingival Display
The Effect Of Botox In Patients With Gummy Smile With And Without Zinc And Phytase Supplementation.
Participants with esthetic concern of excessive gingival display who meets the inclusion criteria, will be carried out including history taking, clinical examination and initial therapy.
- Trial name
- NCT06577285
- Testing
- zinc gluconate 50 mg with phytase supplement 176mg (800FTU), zinc gluconate 50 mg
- Where
- Egypt
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Cairo University
Esophageal Carcinoma
Botulinum Toxin Type A in Preventing Complications After Surgery in Patients With Esophageal Cancer
This randomized phase II trial studies how well botulinum toxin type A works in preventing complication after surgery in patients with esophageal cancer.
- Trial name
- NCT02965976
- Testing
- Botulinum Toxin Type A, Esophagectomy, Quality-of-Life Assessment
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Roswell Park Cancer Institute
Hemifacial Spasm
Botulinum Toxin A in the Treatment of Hemifacial Spasm
Hemifacial spasm patients who received botulinum toxin A injection were divided into two groups. Group A received unilateral injection while group B received bilateral injection.
- Trial name
- BTATHS (NCT03306940)
- Testing
- Botulinum Toxin Type A
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Tongji University
Facial Paralysis
Myofunctional Therapy in Facial Palsy
Objective: Quantify the benefits of myofunctional therapy associated to botulinum toxin injection in patients with long standing facial unilateral palsy.
- Trial name
- NCT00989209
- Testing
- Botulinum Toxin Type A, myofunctional therapy
- Where
- Brazil
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Trigeminal Neuralgia, Headache Disorders
Botulinum Toxin Type A Block of the Sphenopalatine Ganglion in Trigeminal Neuralgia. Safety Issues.
Trigeminal neuralgia is one of the strongest pains known to humans. Some patients do not have enough effect with the available pharmaceutical treatments and are offered surgery.
- Trial name
- NCT02662972
- Testing
- Botulinum Toxin Type A
- Where
- Norway
- Volunteers
- 10 people
- Sponsor
- Norwegian University of Science and Technology