Clinical trials: Botulinum Toxin
Myofascial Pain Syndromes, Myofascial Trigger Point Pain
Injection With OnabotulinumtoxinA (Botox) for the Treatment of Chronic Pelvic Pain
This research study because is looking at woman with symptoms of chronic pelvic pain caused by short, tight, and tender pelvic floor muscles (Myofascial Pelvic Pain syndrome).
- Conditions
- Myofascial Pain Syndromes, Myofascial Trigger Point Pain, Trigger Point Pain, Myofascial
- Trial name
- BotoxMPP (NCT02173405)
- Testing
- OnabotulinumtoxinA
- Where
- 3 sites in United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Incisional Hernia Repair, Ventral Hernia Repair
Comparative Evaluation of Preoperative Preparation Methods in Patients With Large Incisional Hernias
Patients with large, complex, or giant incisional hernias often require advanced preoperative optimization to facilitate safe abdominal wall reconstruction and reduce postoperative complications.
- Trial name
- AWR-PREP (NCT07549113)
- Testing
- Botulinum Toxin A (Botox ), Progressive Preoperative Pneumoperitoneum, Combined Preoperative Preparation
- Where
- Russia
- Volunteers
- 120 people
- Sponsor
- State Budget Public Health Institution Scientific Research Institute - Ochapovsky Regional Clinical Hospital
Moderate to Severe Glabellar Lines
A Study on the Efficacy and Safety of Repeated Treatments With Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines
This is a Multi-center, Open-label Study on the Efficacy and Safety of Multiple Treatments with Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines.
- Trial name
- NCT06583486
- Testing
- Rcombinant botulinum neurotoxin type A for injection (YY001)
- Where
- 16 sites in China
- Volunteers
- 488 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Cerebrovascular Accident
Biomechanical and Neurophysiological Evaluation of the Effect of a Motor Block and an Injection of Botulinum Toxin on the Stiffness of the Paretic Sural Triceps Muscle
The research "Biomechanical and neurophysiological evaluation of the effects of a motor block and an injection of botulinum toxin on the stiffness of the paretic sural triceps muscle" will study the response to passive stretching…
- Trial name
- RAI PAR BLOC (NCT04717141)
- Testing
- Selective nerve block
- Where
- France
- Volunteers
- 27 people
- Sponsor
- Nantes University Hospital
Flu-like Symptoms
Flu-Like Symptoms as a Complication of Botulinum Toxin Therapy
Botulinum toxin (BoNT) has become a revolutionary treatment for many neurological, autonomic, gastrointestinal, genitourinary, and cosmetic disorders.
- Trial name
- NCT01337453
- Where
- United States
- Volunteers
- 247 people
- Sponsor
- Christine Hunter
Glabellar Frown Lines
The Efficacy and Safety of Protoxin in Subjects With Moderate to Severe Glabellar Lines
This clinical trial is an extended clinical trial for test subjects who participated in the phase 3 clinical trial of PT_BTA_P3_21 (clinical trial plan number) and completed follow-up observation up to 16 weeks after…
- Trial name
- NCT06124794
- Testing
- PROTOXIN
- Where
- 3 sites in South Korea
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Protox Inc.
Post-Stroke Spasticity, Spastic Equinovarus Foot
Efficacy of Focused Shock Wave Therapy Before and After Botulinum Toxin Injection in Patients With Post-Stroke Spastic Equinus/Equinovarus Foot: A Randomized Clinical Trial
Spastic equinovarus foot is the most common lower limb motor impairment after stroke and has a significant impact on gait, mobility, and quality of life.
- Trial name
- NCT07758322
- Testing
- Botulinum toxin type A, Focal Extracorporeal Shock Wave Therapy (ESWT)
- Where
- Spain
- Volunteers
- 69 people
- Sponsor
- María Belén Martínez Luna
Migraine Disorders
Open Label Study of BOTOX® (Botulinum Toxin Type A) as Headache Prophylaxis in Chinese Patients With Chronic Migraine
This study is an open-label extension study to evaluate the safety, tolerability and efficacy of BOTOX® as headache prophylaxis in Chinese patients with chronic migraine who have successfully completed the double-blind study…
- Trial name
- NCT03193359
- Testing
- botulinum toxin Type A
- Sponsor
- Allergan
Morbid Obesity
Laparoscopic Sleeve Gasterectomy With or Without Pyloric Botulinum Neurotoxin Injection
Leakage is the most common complication after laparoscopic sleeve gastrectomy which may amount to 20% in some studies. We hypothesize that Clostridium botulinum neurotoxin A (BTX-A) injection into the pyloric sphincter during the…
- Trial name
- NCT02325141
- Testing
- laparoscopic sleeve gastrectomy
- Volunteers
- 130 people
- Sponsor
- Mansoura University
Spinal Cord Injuries
Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients
To investigate the clinical effect of detrusor botulinum toxin A (BoNT-A) injection on neurogenic detrusor overactivity (NDO) and renal function and to compare the difference of expressions of sensory receptors and nerve growth…
- Trial name
- NCT01682603
- Testing
- Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 34 people
- Sponsor
- Buddhist Tzu Chi General Hospital
Glabellar Frown Lines
NT 201 (Xeomin®/Bocouture®) in Comparison With Clostridium Botulinum Toxin Type A in the Treatment of Glabellar Frown Lines
NT 201, also known as IncobotulinumtoxinA (Xeomin®/Bocouture®), is a Botulinum toxin type A preparation free of complexing proteins (150 kiloDalton).
- Trial name
- Head2Head (NCT00777803)
- Testing
- NT 201 (IncobotulinumtoxinA (Xeomin®/Bocouture®)), OnabotulinumtoxinA (Vistabel®)
- Where
- 17 sites in Austria, Germany and 1 more
- Volunteers
- 381 people
- Sponsor
- Merz Pharmaceuticals GmbH
Cerebrovascular Accident
Botulinum Toxin Injections by Ultrasounds Guidance and Stretching Exercise in Spastic Toe Clawing
Claw toes deformity result in spasticity often seem in patients with central nerve disease. It also cause pressure sore in foot and pain during walking that didn't well improve under traditional treatment.
- Trial name
- NCT02586142
- Testing
- Botulinum Toxin Type A, Stretching exercise
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Chang Gung Memorial Hospital
Blepharospasm, Hemi Facial Spasm
An RCT of a Patient-initiated Treatment Service for BEB and HFS
Blepharospasm and hemifacial spasm are debilitating conditions which significantly impact on patient quality of life. Cyclical treatment with botulinum toxin injections offers temporary relief but the duration of treatment…
- Trial name
- NCT02577224
- Testing
- Patient-initiated treatment
- Where
- United Kingdom
- Volunteers
- 130 people
- Sponsor
- Moorfields Eye Hospital NHS Foundation Trust
Hernia
Preoperative Botulinum Toxin A to Facilitate Midline Closure in Large Chronic Ventral Hernias
In patients with large hernias, chronic retraction of the lateral abdominal wall muscles, and visceral contents that are irreducible within the hernia sac, closure of the midline can be difficult or even impossible.
- Trial name
- Probhe (NCT07628205)
- Testing
- Posterior Component Separation (PCS) with TAR, Rives-Stoppa
- Where
- Italy
- Volunteers
- 44 people
- Sponsor
- Azienda Socio Sanitaria Territoriale Ovest Milanese, Ospedale di Legnano
Post-Stroke Upper Limb Spasticity
Comparing the Radial Extracorporeal Shock Waves and Botulinum Toxin Injection for Spasticity
Botulinum toxin type A (BoNT-A) is widely used in the clinics to reduce spasticity and improve upper limb function for post-stroke patients.
- Trial name
- NCT03131791
- Testing
- Shock Wave, Botulinum toxin A
- Where
- Taiwan
- Volunteers
- 42 people
- Sponsor
- Mackay Memorial Hospital
Spastic Equinovarus Foot, Stroke
Efficacy Study of Selective Tibial Neurotomy in the Treatment of the Spastic Equinovarus Foot Among Adult Hemiplegic Patients
Spastic equinovarus foot (SEF) is a major cause of disability in stroke patients. Treatments may include physical therapy, orthosis, botulinum toxin (BTX) injections and selective neurotomy.
- Trial name
- Neurotomy (NCT00825097)
- Testing
- Selective tibial neurotomy, Botulinum toxin injection
- Where
- Belgium
- Volunteers
- 16 people
- Sponsor
- Cliniques universitaires Saint-Luc- Université Catholique de Louvain
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label extension phase.
- Trial name
- NCT00156910
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States, Canada
- Volunteers
- 679 people
- Sponsor
- Allergan
Spasticity, Muscle
Effect of Treatment Dairy for Spasticity
1. Assessing whether the treatment diary can help optimize the overall treatment of patients. 2. To assess whether the patient finds the treatment diary useful and worth spending time on.
- Trial name
- NCT03384927
- Where
- Denmark
- Volunteers
- 96 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Ultrasound, Botulinum Toxin
Ultrasound-Guided Versus Anatomically Guided Botulinum Toxin Injection in Spasticity in Adults in Tanta University Hospitals
This study aimed to compare the safety and outcome of ultrasound (US)- guided botulinum toxin (BoNT) injection and anatomically guided injection in muscle spasticity of different causes in adults.
- Conditions
- Ultrasound, Botulinum Toxin, Spasticity, Adults
- Trial name
- NCT06941883
- Testing
- Botulinum toxin injection under anatomical landmark, Ultrasound-guided botulinum toxin injection
- Where
- Egypt
- Volunteers
- 68 people
- Sponsor
- Tanta University
Post Stroke Spastic Hemiplegia
Low or High Botox Dilution for the Hemiplegic Gait?
There is debate regarding the efficiency of different dilutions of Botulin toxin type A (BTX-A) injections. Some authors believe that highly diluted BTX-A injections achieve greater neuromuscular blockade resulting in higher…
- Trial name
- NCT04630873
- Testing
- Botulinum toxin, gait analysis
- Where
- Greece
- Volunteers
- 20 people
- Sponsor
- University of Ioannina