Clinical trials: Botulinum Toxins, Type A
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Study of BOTOX Injections to Assess Change in Disease Activity and Adverse Events in Adult Female Participants With Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS)
Interstitial Cystitis/Bladder Pain Syndrome (IC/BPS) is a chronic and debilitating urological complex of disorders characterized by symptoms of bladder pain or discomfort, mostly upon bladder filling, and often accompanied by…
- Trial name
- IC/BPS POC (NCT05141006)
- Testing
- BOTOX
- Where
- 43 sites in United States, Canada
- Volunteers
- 83 people
- Sponsor
- AbbVie
Masseter Muscle Prominence
A Study to Assess the Effectiveness of BOTOX (Botulinum Toxin Type A) Injections for the Change of Masseter Muscle Prominence in Adult Participants
The masseter muscle is one of the muscles in the lower face used for chewing. Prominence of the masseter muscle can appear as a widened and square lower face shape, which is an aesthetic concern for individuals who prefer a…
- Trial name
- MMP EU P3 (NCT06068855)
- Testing
- BOTOX
- Where
- 27 sites in Belgium, Bulgaria and 5 more
- Volunteers
- 249 people
- Sponsor
- AbbVie
Overactive Bladder
OnabotulinumtoxinA (BOTOX®) Treatment for Urinary Incontinence in Patients With Overactive Bladder
This is a study to evaluate the efficacy and safety of onabotulinumtoxinA (BOTOX®) compared with placebo, in achieving a 100% reduction in urinary incontinence in patients with overactive bladder (OAB) not properly managed with…
- Trial name
- COMFORT (NCT01945489)
- Testing
- onabotulinumtoxinA, Normal saline
- Where
- 40 sites in United States
- Volunteers
- 254 people
- Sponsor
- Allergan
Scar
Botulinum Toxin to Improve Results in Cleft Lip Repair
Botulinum toxin type A (Botox; Allergan, Inc., Irvine, Calif) is widely used for facial rejuvenation and many other medical indications.
- Trial name
- NCT01429402
- Testing
- Botulinum Toxin Type A, Botulinum Type A, Normal Saline
- Where
- Taiwan
- Volunteers
- 120 people
- Sponsor
- Chang Gung Memorial Hospital
Myofascial Pelvic Pain
Botulinum Toxin Type A Versus Saline Trigger Point Injections for Myofascial Pelvic Pain
The purpose of this study is to determine whether there is a change in patient-reported pelvic pain following pelvic floor injections of 200 units of Botox compared with 20cc of normal saline.
- Trial name
- NCT01905137
- Testing
- Intervention-Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Boston Urogynecology Associates
Neurogenic Bladder, Lower Urinary Tract Symptoms
Optimization of OnabotulinumtoxinA (BTX-A) Injection for the Treatment of Neurogenic Lower Urinary Tract Dysfunction
The purpose of this study is to evaluate and standardize the way providers perform OnabotulinumtoxinA (BTX-A) injections into the bladder for the diagnosis of neurogenic lower urinary tract dysfunction (NLUTD)/overactive bladder…
- Conditions
- Neurogenic Bladder, Lower Urinary Tract Symptoms, Overactive Bladder, Neuro: Neurogenic Bladder
- Trial name
- BOND (NCT06059066)
- Testing
- Standard number of injection sites, Reduced number of injection sites
- Where
- United States
- Volunteers
- 78 people
- Sponsor
- The Methodist Hospital Research Institute
Epiphora
Determination of the Optimum Delivery Route for Botulinum Toxin A in Patients With Epiphora
Epiphora or excessive tearing is a significant disability for many affected patients diminishing their quality of life. There is a growing consensus that injection of Botulinum Toxin A (BTX-A) into the lacrimal gland provides…
- Trial name
- NCT01282541
- Testing
- Botulinum Toxin Type A
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Merbs, Shannath, M.D., Ph.D.
Complex Regional Pain Syndromes
Thoracic Sympathetic Ganglion Block With Botulinum Toxin Type A
Thoracic sympathetic ganglion block is a percutaneous procedure that paralyzes the action of sympathetic nerves transiently by injecting a local anesthetic around the ganglion.
- Trial name
- NCT06470581
- Testing
- Botulinum toxin A
- Volunteers
- 78 people
- Sponsor
- Seoul National University
Low Anterior Resection Syndrome, Rectal Cancer
The Value of Botox-A for Management of Low Anterior Resection Syndrome
Low anterior resection syndrome (LARS) is frequent after treatment for low rectal cancer. Increased bowel frequency and urgency with rectal spasms and incontinence have deleterious impacts on quality of life in a third of the…
- Trial name
- NCT01589471
- Testing
- intra-rectal Botulinum toxin A injection
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Overactive Bladder
Evaluation of Botulinum Toxin A Alone Versus Botulinum Toxin A With Hydrodistension for Treatment of Overactive Bladder
The specific aim of this trial is to determine if hydrodistention at the time of intradetrusor injection of botulinum toxin A has additional benefit in patients with refractory overactive bladder (OAB) and urgency symptoms…
- Trial name
- HydrA (NCT02995967)
- Testing
- Hydrodistention, Botulinum toxin-A
- Where
- United States
- Volunteers
- 3 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cervical Dystonia
Study to Assess the Efficacy and Safety of Dysport® in Cervical Dystonia
The aim is to demonstrate equivalent efficacy and safety in the treatment of the two most frequent forms of cervical dystonia (predominantly rotational torticollis and predominantly laterocollis) with the standard initial dose of…
- Trial name
- NCT00447772
- Testing
- Botulinum toxin type A
- Where
- 106 sites in Austria, Germany
- Volunteers
- 516 people
- Sponsor
- Ipsen
Spinal Cord Injury, Pain
Investigating Botulinum Toxin A to Treat Acute Neck/Upper Shoulder Pain Following a New Spinal Cord Injury.
As clinicians, it is often a struggle to find effective pain control for a certain subgroup of patients with tetraplegia. These patients often have severe upper back, neck, and shoulder pain, limiting rehabilitation productivity…
- Trial name
- NCT00320281
- Testing
- botulinum toxin A
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- Craig Hospital
Traumatic Brain Injury
Understanding and Treating Traumatic Brain Injury (TBI) Associated Photophobia With Botulinum Toxin Type A (BoNT-A)
The purpose of this research is to understand and treat Traumatic Brain Injury (TBI) associated photophobia (light sensitivity) and its impact on visual function.
- Trial name
- NCT06293300
- Testing
- BoNT A
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Miami
Migraine Disorders
A Study Using Botulinum Toxin Type A as Headache Prophylaxis for Migraine Patients With Frequent Headaches
This is a 60 week study including a double-blind phase followed by an open-label phase.
- Trial name
- NCT00168428
- Testing
- Botulinum Toxin Type A
- Where
- 6 sites in United States, Canada and 4 more
- Volunteers
- 705 people
- Sponsor
- Allergan
Thoracic Outlet Syndrome
Botulinum Toxin Injections for Thoracic Outlet Syndrome
Botulinum toxin type A injected into the anterior and middle scalene muscles will reduce the irritation on the neurovascular structures at the interscalene triangle in subjects with TOS.
- Trial name
- NCT01405482
- Testing
- Botulinum Toxin Type A, Normal Saline injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University of British Columbia
Rosacea, Botulinum Toxin
Clinical Observation of Botulinum Toxin A Treatment in the Treatment of Rosacea
the goal of this study is to study the clinical efficacy and safety of botox in the treatment of rosacea.
- Trial name
- NCT06282679
- Testing
- Botulinum Toxin Type A Injection [Botox]
- Where
- China
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nanjing First Hospital, Nanjing Medical University
Cerebral Palsy, Spastic
Effects of Botulinum Toxin Injection Combined with RESWT in Lower Extremity Spasticity in Children with Cerebral Palsy
This study aimed to check and compare the effects of botulinum toxin injection combined with shock wave therapy versus botulinum toxin injection only for lower extremity spasticity in children with cerebral palsy
- Trial name
- NCT06494618
- Testing
- Radial Extracorporeal Shockwave Therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people
- Sponsor
- Istanbul Medeniyet University
Sun-induced Wrinkles
Phase IV Study On Muscle Activity Of Two Commercial Preparations Of Botulinum
this study was proposed to provide more scientific and objective data on the clinical and aesthetic effects of these two toxins (Dysport and Xeomin).
- Trial name
- NCT01728337
- Testing
- Dysport, Xeomin
- Where
- Brazil
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
High Tone Pelvic Floor Dysfunction
EMG Guided Botulinum Toxin Type A Injections for Refractory High Tone Pelvic Floor Dysfunction
This is a prospective, pilot, longitudinal study to evaluate the use of EMG guidance for Botox A injection for chronic pelvic pain and HTPFD.
- Trial name
- BTXA EMG (NCT01323829)
- Testing
- EMG Guidance of Injection
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Pelvic and Sexual Health Institute
Vulvodynia
Placebo-controlled RCT of Botulinum Toxin A as a Treatment for Provoked Vestibulodynia
Women with provoked vestibulodynia (PVD) suffer from severe dyspareunia and often present a hyperactivity of the pelvic floor muscles (PFM) which maintain the dyspareunia.
- Trial name
- NCT02773641
- Testing
- Botulinum Toxin Type A, Sterile Saline Solution
- Where
- Sweden
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
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