Clinical trials: Botulinum Toxins, Type A
Moderate to Severe Glabellar Lines
DWP450 for Treating Moderate to Severe Glabellar Lines
A multi-center, randomized, double-blind, positive drug-controlled clinical study to evaluate the safety and efficacy of Botulinum Toxin Type A for Injection in the treatment of moderate to severe glabellar lines
- Trial name
- NCT06354127
- Testing
- DWP450, Botox®
- Where
- China
- Volunteers
- 473 people
- Sponsor
- Daewoong Pharmaceutical Co. LTD.
Moderate to Severe Glabellar Lines
A Phase III Study to Evaluate the Efficacy and Safety of Recombinant Botulinum Toxin Type A for Injection in the Treatment of Moderate to Severe Glabellar Lines
This is a randomized, double-blind, placebo- and active-controlled parallel-group multi-center phase III study to evaluate the efficacy and safety of Rcombinant botulinum neurotoxin type A for injection (YY001)) in the treatment…
- Trial name
- NCT06499688
- Testing
- Rcombinant botulinum neurotoxin type A for injection (YY001), OnabotulinumtoxinA
- Where
- 16 sites in China
- Volunteers
- 529 people
- Sponsor
- Chongqing Claruvis Pharmaceutical Co., Ltd.
Wound; Abdomen, Abdominal Wall
The Biomechanical Effects of Flaccid Paralysis Induced by Botulinum Toxin a After Damage Control Laparotomy
Damage control laparotomy (DCL) is a life saving maneuver used with success in trauma and acute general surgery patients. The technique involves source control of sepsis and hemorrhage with an abbreviated laparotomy.
- Trial name
- NCT01495962
- Testing
- Botulinum Toxin Type A
- Where
- 2 sites in United States
- Volunteers
- 46 people
- Sponsor
- Mayo Clinic
Blepharospasm, Hemifacial Spasm
Pretarsal Versus Preseptal Botulinum Toxin for Patients With Eyelid Spasm
A triple-masked placebo-controlled trial assessing the efficacy and safety of pretarsal versus preseptal botulinum toxin for patients with eyelid spasm.
- Conditions
- Blepharospasm, Hemifacial Spasm, Botulinum Toxins, Type A
- Trial name
- NCT03508882
- Testing
- Botulinum Toxin Type A 100Unit/Vial (Product), Saline Solution for Injection
- Volunteers
- 100 people
- Sponsor
- The University of Hong Kong
Cervical Spasm, Radiotherapy Side Effect
Effect of Type-A Botulinum Toxin in the Post-radiosurgical Neck Contractures
The main objective of the study is to estimate the efficiency and to determine the optimal dose of Botulinum toxin A, administered by intramuscular way in cervical spasms after radiotherapy, as well as the optimal sites for these…
- Conditions
- Cervical Spasm, Radiotherapy Side Effect, Botulinum Toxin
- Trial name
- NCT02986880
- Testing
- Botulinum toxin A
- Where
- France
- Volunteers
- 14 people
- Sponsor
- Hopital Foch
Tennis Elbow
Effectiveness of Botulinum Toxin Injection in the Tennis Elbow Treatment
Some studies valued the effectiveness of botulinum toxin. Results are contradictory and we need more studies. The purpose of the study is to compare the effectiveness of botulinum toxin injection with placebo in the treatment of…
- Trial name
- TBA (NCT00437762)
- Testing
- Botulinum Toxin A Injection
- Where
- France
- Volunteers
- 61 people
- Sponsor
- University Hospital, Bordeaux
Migraine
(Botox) Mechanisms of Action in Altering the Molecular Environment in Which Pain Fibers Exist
To compare Botox-treated and Botox-untreated symptomatic tissues (defined as areas where the head hurts and the pain is felt) of chronic migraine (CM) patients using molecular studies.
- Trial name
- NCT03381261
- Testing
- Botulinum toxin type A
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- Massachusetts General Hospital
Glabellar Lines
Efficacy and Safety Assessment of Botulax® and BOTOX® for Improvement of Glabellar Lines.
This study is a phase 3 clinical trial of multi-center, random, blinded*, parallel control, and positive control to evaluate the efficacy and safety of Botulax® Injection compared to BOTOX® for improving moderate to severe…
- Trial name
- NCT05380154
- Testing
- Botulinum Toxin A type for injection (Botulax®), Botulinum Toxin A type for injection (BOTOX®, Bao Tuo Shi®)
- Where
- South Korea
- Volunteers
- 500 people
- Sponsor
- Hugel
Sexual Dysfunction, Erectile Dysfunction
Botulinum Toxin for Erectile Dysfunction
To evaluate the safety and efficacy of intra-cavernosal Botulinum toxin injection as an alternative line of treatment in patients with erectile dysfunction - not responding to oral PDE5i - through cavernosal smooth muscle…
- Trial name
- NCT03102762
- Testing
- Botulinum Toxin Type A, Normal saline
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Overactive Bladder, Incontinence, Daytime Urinary
Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB)
A non-intervention cohort study on the use of Botulinum Neurotoxin Type A (BoNT-A) in Paediatric Non-neurogenic Therapy Resistant Overactive Bladder (OAB). Primary endpoint was the reduction of urinary incontinence.
- Conditions
- Overactive Bladder, Incontinence, Daytime Urinary, Incontinence, Nighttime Urinary
- Trial name
- NCT06569342
- Testing
- Intradetrusor BoNT-A
- Where
- Denmark
- Volunteers
- 43 people
- Sponsor
- University of Aarhus
Migraine
Efficacy of OnabotulinumtoxinA in Migraine
Population studies estimate that patients who have episodic migraine transition to chronic migraine at a rate of about 2.5% per year. CM is a devastating disorder associated to severe disability.
- Trial name
- NCT04578782
- Testing
- OnabotulinumtoxinA
- Where
- Italy
- Volunteers
- 32 people
- Sponsor
- IRCCS National Neurological Institute "C. Mondino" Foundation
Pain
A Pilot Study of Needle Size and Pain Perception With Botulinum Toxin A Injections
The purpose of this study is to compare the levels of pain resulting from injections of Botox® for wrinkles on the forehead and between the eyes using two different sized needles (32 gauge and 30 gauge needles).
- Trial name
- NCT01981174
- Testing
- 30-gauge needle, 32-gauge needle
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Trigeminal Neuralgia
Safety and Efficacy of Botulinum Toxin A in Patients With Trigeminal Neuralgia
This is a double-blind randomized clinical trial comparing the pain reduction of individuals treated with BTX-A and placebo as well as evaluating possible changes in neuroinflammatory biomarkers.
- Trial name
- NCT06315790
- Testing
- Botulinum toxin A, Isotonic saline
- Where
- Denmark
- Volunteers
- 80 people
- Sponsor
- Henrik Schytz
Hypertrophic Scar
Botulinum Toxin Type a Iontophoresis for Postburn Hypertrophic Scar
The goal of this clinical trial study: is to determine the effect Botulinum toxin type A iontophoresis in hypertrophic scars for post burned patients.
- Trial name
- NCT05771623
- Testing
- Iontophoresis drug delivery device, Traditional physical therapy
- Where
- Egypt
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Cairo University
Urinary Incontinence, Overactive Bladder
Dysport® Treatment of Urinary Incontinence in Adults Subjects With Neurogenic Detrusor Overactivity (NDO) Due to Spinal Cord Injury or Multiple Sclerosis - Study 2
The purpose of this study is to provide confirmatory evidence of the safety and efficacy of two Dysport® doses (600 units [U] and 800 U), compared to placebo in reducing urinary incontinence (UI) in adult subjects treated for…
- Trial name
- CONTENT2 (NCT02660359)
- Testing
- Botulinum toxin type A
- Where
- 82 sites in Argentina, Australia and 14 more
- Volunteers
- 258 people
- Sponsor
- Ipsen
Vocal Tremor
False Vocal Fold vs EMG Guided Botox for Vocal Tremor
This is a prospective, non-randomized, two-arm comparative clinical trial evaluating outcomes of false vocal fold (FVF) botulinum toxin injections versus standard EMG-guided botulinum toxin injections in patients with essential…
- Trial name
- NCT07577310
- Testing
- False Vocal Fold (FVF) botulinum toxin injections, Electromyography (EMG)-Guided Injection
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- University of Alabama at Birmingham
Cleft Lip, Scarring
Botulinum Toxin to Improve Cosmesis of Primary Cleft Lip Repair
Objective: To determine if the use of botulinum toxin during primary cleft lip repair improves the cosmetic appearance of the cleft lip scar
- Conditions
- Cleft Lip, Scarring, Cleft Palate
- Trial name
- NCT02247193
- Testing
- Botulinum Toxin Type A, Normal Saline Injection
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Pain, Cerebral Palsy, Spastic
Botulinum Toxin-A as a Treatment for Chronic Muscle-Related Pain in Adults With Spastic Cerebral Palsy: a Randomized Controlled Trial
The purpose of this double-blinded, placebo-controlled study is to test if treatment with Botulinum toxin-A is effective in reducing chronic muscle-related pain in adults with spastic cerebral palsy.
- Trial name
- BATCP (NCT02434549)
- Testing
- Dysport®, Normal saline
- Where
- 2 sites in Sweden
- Volunteers
- 16 people
- Sponsor
- Kristina Tedroff
Obesity
Outcome of Combined Botulinum Toxin A Injection and Gastric Balloon Implantation in Obesity Treatment
Obesity, which is defined as the accumulation of fat in the body to a degree that impairs health, is defined as a serious public health problem and it is estimated that 13% (approximately 650 million) of the entire world…
- Trial name
- NCT05872932
- Testing
- gastric balloon implantation, botulinum toxin A injection
- Where
- Turkey (Türkiye)
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Sebahattin Celik MD
Neurogenic Bladder Dysfunction Nos, Spinal Cord Injury
Botox-A Injection to Improve Bladder Function in Early Spinal Cord Injury (#H-20344)
The purpose of this study is to see what the effect of Botox has on bladder function for those who have recently suffered spinal cord injury.
- Trial name
- NCT00711087
- Testing
- BOTOX-A, Saline injection
- Where
- 2 sites in United States
- Volunteers
- 1 people
- Sponsor
- Baylor College of Medicine
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