Clinical trials: Bowel Dysfunction
Crohn's Disease
A Study to Evaluate CC-5013 in the Treatment of Adolescents and Adults With Moderately Severe Crohn's Disease
A Multicenter, Randomized, Double-Blind, Placebo-Controlled,Parallel-Group Study to Evaluate the Safety and Efficacy of CC-5013 in the Treatment of Adolescents and Adults with Moderately Severe Crohn's Disease
- Trial name
- NCT00446433
- Testing
- CC-5013
- Where
- 20 sites in United States, France and 2 more
- Volunteers
- 90 people
- Sponsor
- Celgene Corporation
Colorectal Cancer
The Theranostic Value of STARD3 in Colorectal Cancer: The STAR Study
This study aims at verifying the overexpression of STARD3 in both early and advanced CRC patients derived tissues, to identify the pathways underpinning tumorigenesis and cancer progression in which STARD3 is involved.
- Trial name
- STAR (NCT06136949)
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Centro di Riferimento Oncologico - Aviano
Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC)
A Study to Evaluate Non-invasive Measurements of the Inflammatory Status in Patients with IBD
Patients with IBD, including both Crohn's disease and ulcerative colitis, require accurate monitoring of intestinal inflammation for optimal follow-up and treatment.
- Conditions
- Inflammatory Bowel Disease (IBD), Ulcerative Colitis (UC), Crohn Disease (CD)
- Trial name
- VERSATILE (NCT06900738)
- Testing
- Inflammometer
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Bowel Obstruction, Artificial Intelligence
Deep Learning-based Artificial Intelligence for the Diagnosis of Small Bowel Obstruction
The study will compare the diagnostic accuracy and time to diagnosis of computed tomography images of patients with suspected intestinal obstruction seen in the emergency room by residents and surgeons, with and without…
- Trial name
- NCT06481358
- Testing
- Artificial intelligence
- Where
- Japan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Small Bowel Diseases
Diagnostic and Therapeutic Efficacy and Safety of Enteroscopy in Pediatric Patients
The aim of our study was to compare the utility and safety of SBE and DBE in pediatric patients.
- Trial name
- NCT07410026
- Testing
- single-bollon enteroscopy, double-bollon enteroscopy
- Where
- China
- Volunteers
- 208 people
- Sponsor
- Shandong University
Cancer, Breast Cancer
Add-Aspirin: A Trial Assessing the Effects of Aspirin on Disease Recurrence and Survival After Primary Therapy in Common Non Metastatic Solid Tumours
Add-Aspirin aims to assess whether regular aspirin use after standard curative therapy can prevent recurrence and improve survival in individuals with non-metastatic common tumours.
- Conditions
- Cancer, Breast Cancer, Prostate Cancer, Colorectal Cancer
- Trial name
- NCT02804815
- Testing
- Aspirin 100mg, Aspirin 300mg
- Where
- 82 sites in Ireland, United Kingdom
- Volunteers
- 11,000 people
- Sponsor
- University College, London
Pancreatic Cancer, Periampullary Cancer
Tissue Adhesive Glue Modified Cyanoacrylate (Glubran® 2) in Soft Pancreas
This is a single-center, randomized controlled trial comparing the efficacy of pancreaticojejunostomy with modified N-butyl-2-cyanoacrylate(Glubran® 2) versus standard pancreaticojejunostomy without cyanoacrylate in preventing…
- Conditions
- Pancreatic Cancer, Periampullary Cancer, Duodenal Cancer, Cholangiocarcinoma
- Trial name
- NBCA-MS (NCT07155525)
- Testing
- Pancreaticojejunostomy with Modified N-Butyl-2-Cyanoacrylate (Glubran® 2), Standard(duct-to-mucosa) Pancreaticojejunostomy
- Where
- Egypt
- Volunteers
- 194 people
- Sponsor
- Minia University
Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer
Non-Operative Management and Following Immunotherapy for Colorectal Cancer and Other GI Cancers
This is a single-center, bidirectional (retrospective and prospective) registry study aimed at evaluating the safety and efficacy of Non-Operative Management (NOM) and Organ-Preserving Functional Surgery (OPFS) in patients with…
- Conditions
- Gastrointestinal Cancer, Colorectal (Colon or Rectal) Cancer, Stomach (Gastric) Cancer
- Trial name
- NOMIC (NCT07656740)
- Testing
- NOM, RO
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Peking University Cancer Hospital & Institute
Breast Cancer, Ovarian Cancer
Targeted Next-generation Sequencing Panel for Identification of Germline Mutations in Early Onset Cancers With Sporadic or Hereditary Presentation
Despite relevant clinical and/or familial presentations suggesting a hereditary predisposition (early-onset, multiple primary tumors, familial aggregation), targeted genomic analysis based on the phenotype are often non…
- Conditions
- Breast Cancer, Ovarian Cancer, Colorectal Cancer, Pediatric Cancers
- Trial name
- PANEL (NCT02664389)
- Testing
- Genetic analysis
- Where
- France
- Volunteers
- 289 people
- Sponsor
- University Hospital, Rouen
Colorectal Cancer
High-Dose Fluorouracil With or Without Leucovorin Compared With Standard Fluorouracil Plus Leucovorin Following Surgery in Treating Patients With Stage III Colon Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. It is not yet known which chemotherapy regimen is more effective for colon cancer.
- Trial name
- NCT00004150
- Testing
- fluorouracil, leucovorin calcium, adjuvant therapy
- Where
- 85 sites in Belgium, France and 4 more
- Sponsor
- Robert Roessle Klinik
Irritable Bowel Syndrome
Nursing Management of Irritable Bowel Syndrome (IBS) 2008
The aim of this study is test the efficacy of a comprehensive self-management therapy to decrease abdominal pain/discomfort and improve quality of life in patients with irritable bowel syndrome (IBS) compared to IBS patients…
- Trial name
- NCT00907790
- Testing
- Usual Care (Control Group), Comprehensive Self-Management (CSM)
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- University of Washington
Crohn Disease
Mother-to-Infant Transfer of Bacteriome, Fungome, Virome, and Metabolome in Health and Crohn's Disease
Inflammatory bowel diseases (IBD), including Crohn's disease (CD) and ulcerative colitis (UC), are caused by the loss of mucosal tolerance towards the commensal microbiota resulting in inflammatory responses.
- Trial name
- NCT05112497
- Testing
- No intervention procedure
- Where
- Hong Kong
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Outcome Assessment, Cancer of Colon
Textbook Outcome in Colon Carcinoma
BACKGROUND: Textbook outcome (TO) is a multidimensional quality management tool that uses a set of traditional surgical measures to reflect an "ideal" surgical result for a particular pathology.
- Trial name
- NCT05675904
- Testing
- Colon oncological resection
- Where
- Spain
- Volunteers
- 564 people
- Sponsor
- Hospital General Universitario de Alicante
Metastatic Colorectal Cancer
Regorafenib in Taiwan Metastatic Colorectal Cancer (mCRC) Patients
Regorafenib is currently the standard of care for refractory mCRC patients. Pivotal studies of regorafenib have proven the efficacy and safety, with a 28-day cycle (21 days on, 7 days off) and 160 mg dose given once daily.
- Trial name
- NCT03829852
- Testing
- Regorafenib
- Where
- Taiwan
- Volunteers
- 716 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Colorectal Cancer
A Study of ABT-751 in Patients With Colorectal Cancer
The purpose of the study is to determine if ABT-751 will decrease tumors, and determine how long the tumor shrinkage can be maintained in patients with colorectal cancer. Patients will receive ABT-751 by mouth daily for 21 days.
- Trial name
- NCT00073138
- Testing
- ABT-751
- Where
- 6 sites in United States
- Volunteers
- 40 people
- Sponsor
- Abbott
Ulcerative Colitis
CT-P13 (Infliximab) Subcutaneous Administration in Patients With Moderately to Severely Active Ulcerative Colitis (LIBERTY-UC)
This is Phase 3, Randomized, Placebo-controlled study to demonstrate superiority of CT-P13 SC over Placebo SC in Patients With Moderately to Severely Active Ulcerative Colitis
- Trial name
- NCT04205643
- Testing
- CT-P13 SC (Infliximab)
- Where
- Poland
- Volunteers
- 548 people
- Sponsor
- Celltrion
Colo-rectal Cancer
Early-Onset Colorectal Cancer: An Observational Retrospective and Prospective Multicenter Study
Observational, retrospective and prospective multicentric Italian study of patients diagnosed with colorectal cancer between age 18-40, aiming at underpinning the biology of vEO-CRC, including colibactin as well as a broader…
- Trial name
- HEBE (NCT06965335)
- Testing
- BIOLOGICAL STUDY aiming at describing clinicophatological features of EO-CRC vs SO-CRC
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- Niguarda Hospital
Colorectal Cancer
Azacitidine and CAPOX in Metastatic Colorectal Cancer
The goal of the Phase I portion of this study is to find the highest tolerable dose of azacitidine combined with capecitabine and oxaliplatin (CAPOX) that can be given to patients with metastatic colorectal cancer.
- Trial name
- NCT01193517
- Testing
- Azacitidine, Capecitabine, Oxaliplatin
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- M.D. Anderson Cancer Center
Colon Cancer, Physical Activity
Physical Activity and Its Impact on Colon Cancer Surgery
This is a prospective clinical study that studies how the physical activity level before operation of colon cancer affects the outcome of complication and histology.
- Trial name
- PACOS (NCT03947840)
- Testing
- Physical activity
- Where
- Sweden
- Volunteers
- 85 people
- Sponsor
- Umeå University
Fear of Cancer Recurrence, Colorectal Cancer
Reducing Fear of Cancer Recurrence in Danish Colorectal Cancer Survivors
Cognitive therapy has been shown to reduce fear of cancer recurrence (FCR), mainly in breast cancer survivors. The accessibility of cognitive behavioural interventions could be further improved by Internet delivery, but…
- Conditions
- Fear of Cancer Recurrence, Colorectal Cancer, Anxiety, Health Anxiety
- Trial name
- NCT04287218
- Testing
- TG-iConquerFear, aTAU
- Where
- Denmark
- Volunteers
- 95 people
- Sponsor
- Vejle Hospital