Clinical trials: Bowel Functions
Celiac Disease, Irritable Bowel Syndrome
Effect of FODMAP Restriction on Persistent GI-symptoms in Coeliac Patients
The first aim of the study is to investigate the prevalence of persistent gastrointestinal symptoms and compliance with gluten-free diet and the intake of FODMAP in adult celiac patients.
- Conditions
- Celiac Disease, Irritable Bowel Syndrome, Diet Modification, Gluten Sensitivity
- Trial name
- NCT03678935
- Testing
- Low FODMAP diet
- Where
- Norway
- Volunteers
- 80 people
- Sponsor
- Oslo University Hospital
Constipation
To Evaluate the Safety and Efficacy of Pediococcus Acidilactici PA53 in Relieving Constipation in Adults
To study the improvement of constipation symptoms, quality of life and mental state, intestinal function, intestinal hormones, inflammation and immunity, and intestinal flora of constipation subjects after 8-week intervention…
- Trial name
- NCT06761443
- Testing
- Probiotic, Maltodextrin
- Where
- China
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- Wecare Probiotics Co., Ltd.
Irritable Bowel Syndrome
Transplantation of Anaerobic Cultured Human Intestinal Microbiota in Irritable Bowel Syndrome
Patients with irritable bowel syndrome (IBS) are treated with microbiota from a human intestinal anaerobic sample cultured for decades. Patients are recruited consecutively with symptoms of IBS and serve as their own controls.
- Trial name
- ACHIM2 (NCT02857257)
- Testing
- ACHIM
- Where
- Sweden
- Volunteers
- 50 people
- Sponsor
- Uppsala University
Irritable Bowel Syndrome With Diarrhea
A Comparison of the Effects of ORP-101 Versus Placebo in Adult Patients With Irritable Bowel Syndrome With Diarrhea (IBS-D)
This study will evaluate the effects of ORP-101 versus placebo on stool consistency and abdominal pain in patients with Irritable Bowel Syndrome with Diarrhea (IBS-D).
- Trial name
- NCT04129619
- Testing
- ORP-101
- Where
- 74 sites in United States
- Volunteers
- 321 people
- Sponsor
- OrphoMed, Inc.
Solid Tumors With PTCH1 Loss-of-function Mutations
A Study Evaluating the Safety and Efficacy of ENV-101 (Taladegib) in Patients With Advanced Solid Tumors Harboring PTCH1 Loss of Function Mutations
This study employs a 2-stage design that aims to evaluate the efficacy and safety of ENV- 101, a potent Hedgehog (Hh) pathway inhibitor, in patients with refractory advanced solid tumors characterized by loss of function (LOF)…
- Trial name
- NCT05199584
- Testing
- ENV-101 (taladegib)
- Where
- 16 sites in United States
- Volunteers
- 20 people
- Sponsor
- Endeavor Biomedicines, Inc.
IBS - Irritable Bowel Syndrome
A Trial to Evaluate the Effects of Bifidobacterium Longum NCC3001 on Intestinal and Psychological Symptoms in Subjects With Irritable Bowel Syndrome
This is a prospective, randomized, placebo-controlled, double-blind, multi-center parallel- design study to evaluate the effect of BL NCC3001 in subjects with Irritable Bowel Syndrome.
- Trial name
- Mood-01 (NCT05054309)
- Testing
- Bifidobacterium longum
- Where
- 11 sites in Canada
- Volunteers
- 146 people
- Sponsor
- Société des Produits Nestlé (SPN)
Functional Gastrointestinal Disorders
GLP-1 Inhibits Prandial Antro-duodeno-jejunal Motility in Humans
The inhibitory effect of low dose GLP-1 is investigated on prandial motility of the stomach, duodenum and jejunum in vivo in humans.
- Trial name
- GLPMOT (NCT02731664)
- Testing
- GLP-1, Intravenous saline
- Where
- Sweden
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Uppsala University
Diarrhea- Irritable Bowel Syndrome
The Effect of Neu-P11 on Symptoms in Patients With D-IBS
Placebo controlled double-blind study with 40 patients who have an diarrhea-predominant IBS, 20 get Neu-P11, 20 get a placebo. Neu-P11 is a, Melatonin receptor-, Serotonin 5-HT- 1A and 5-HT- 1D - agonist and a serotonin 5-HT- 2B…
- Trial name
- Neu-P11 (NCT01558284)
- Testing
- Neu-P11
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Inflammatory Bowel Syndrome
Effect of Daily Consumption of Glycomacropeptide on Gut Microbiome and Blood Functional Proteome of Subjects With Irritable Bowel Syndrome
This study investigates the use of glycomacropeptide (GMP) as a means to manipulate the gut microbiome, metabolome and protein profile of subjects with irritable bowel syndrome (IBS).
- Trial name
- NCT05482464
- Testing
- Casein glycomacropeptide (CGMP)
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- Oregon State University
Irritable Bowel Syndrome, FODMAP
The Effect of a Low FODMAP Diet in Irritable Bowel Syndrome Patients
Tertiary care IBS patients will be recruited for a prospective low FODMAP intervention study, hereby focusing on the reintroduction phase of the diet, where patients are blindly challenged with different FODMAP groups…
- Trial name
- FIBS (NCT04373304)
- Testing
- low FODMAP diet
- Where
- Belgium
- Volunteers
- 45 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
IBS - Irritable Bowel Syndrome
Digital Treatment of Irritable Bowel Syndrome (IBS)
The aim of this work is to identify whether the digital treatment program Mage-tarmskolen has an effect on patients with IBS. Our secondary objectives is to address multiple aspects of digital treatmtent success of the different…
- Trial name
- DIGIBS (NCT06117865)
- Testing
- Module 1, Module 2, Module 3
- Where
- Norway
- Volunteers
- 728 people
- Sponsor
- Haukeland University Hospital
Rectal Cancer
The Impact of Probiotic Intervention on the Gut Microbiota and Bowel Function
This study aims to propose a novel, easy-to-operate intervention strategy that effectively improves defecation function after stoma reversal and to assess its impact on the gut microbiota.The efficacy and safety of antegrade…
- Trial name
- NCT07369830
- Testing
- Clostridium butyricum (live) Tablets(Meiya)
- Where
- China
- Volunteers
- 156 people
- Sponsor
- Huashan Hospital
Chronic Fatigue Syndrome
Giardia Induced Fatigue and Functional Gastrointestinal Diseases
A giardiasis outbreak in Bergen has given us the opportunity to approach two basic research questions of national and global importance: Studying the pathoimmunology of giardiasis in a natural setting, and following the genetic…
- Trial name
- GIFF (NCT00860236)
- Testing
- Psycoeducation/counseling, Cognitive behavioural therapy
- Where
- Norway
- Volunteers
- 40 people
- Sponsor
- University of Bergen
Functional Bloating (Disorder)
Pre-FIBRe Study: Predeterminants of Fibre Induced Bloating Response.
This study is an exploratory study aimed at gaining a greater understanding of the cause of abdominal bloating in response to two distinct fibre types.
- Trial name
- Pre-FIBRe (NCT04802798)
- Testing
- Fibre 1, Fibre 2
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- King's College London
Breast Cancer, Cognitive/Functional Effects
Study of Symptoms Caused by Cancer and Cancer Therapy in Patients With Invasive Breast, Lung, Prostate, or Colorectal Cancer
RATIONALE: Questionnaires that assess symptoms caused by cancer and cancer therapy may help improve the ability to plan treatment for patients with invasive cancer to help them live longer and more comfortably.
- Conditions
- Breast Cancer, Cognitive/Functional Effects, Colorectal Cancer, Lung Cancer
- Trial name
- NCT00303914
- Testing
- assessment of therapy complications, cognitive assessment, psychosocial assessment and care
- Where
- 32 sites in United States
- Volunteers
- 2,310 people
- Sponsor
- Eastern Cooperative Oncology Group
Hypertension
Salt Intake, Microbiota, Immune Response and Endothelial Function in Hypertension
Hypertension is a significant cardiovascular risk factor which affects 45% of the adult population. Salt intake is essential in the development and progression of hypertension.
- Trial name
- NCT04648592
- Testing
- Low salt diet plus sodium chloride supplements
- Where
- Spain
- Volunteers
- 25 people
- Sponsor
- Hospital Clínico Universitario de Valladolid
Irritable Bowel Syndrome
Trans-cutaneous Vagal Nerve Electrical Stimulation and Irritable Bowel Syndrome
This pilot study plan to investigate the sympathovagal balance in women affected by Irritable Bowel Syndrome (IBS), and to evaluate the effect of 6 months of trans-cutaneous vagal nerve electrical stimulation on digestive…
- Trial name
- StVSII (NCT02420158)
- Testing
- Trans-cutaneous vagal nerve electrical stimulation
- Where
- 2 sites in France
- Volunteers
- 18 people
- Sponsor
- Hospices Civils de Lyon
Microbial Composition, Immune Function
Gut Microbiome Response to Long-Haul Travel in Elite Football Players
The goal of this randomised control trial is to measure the gut microbiome response to long-haul travel alongside the demands of pre-season amongst elite football players.
- Trial name
- NCT07585474
- Testing
- Probiotic Capsule
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sheffield Hallam University
Gastroschisis
Evaluation of Glycerin Suppositories to Improve Bowel Function in Gastroschisis
Gastroschisis is a congenital defect of the abdominal wall that leads to evisceration of various amounts of the abdominal organs.
- Trial name
- NCT03355326
- Testing
- Glycerin Suppository
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Indiana University
Gut Microbiome, Inflammation
Targeted Metabolomics to Decipher Dietary Contributions to Pediatric Inflammatory Bowel Disease (IBD) - Main Study
The overall goal of the study is to investigate the dietary differences between children with well-controlled inflammatory bowel disease (IBD) and those with active disease by using targeted food metabolomics.
- Conditions
- Gut Microbiome, Inflammation, Irritable Bowel Syndrome
- Trial name
- TAMED IBD (NCT05014243)
- Volunteers
- 100 people
- Sponsor
- University of Colorado, Denver
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