Clinical trials: Bowel Incontinence
Fecal Incontinence
Safety, Tolerability, Pharmacodynamic and Pharmacokinetics of a Single Rectal Application of 10 mg NRL001 in Elderly Subjects
A total of 26 healthy elderly male and female subjects will receive both 10 mg NRL001 in a 2 g rectal suppository and placebo in this double-blind, cross-over study.
- Trial name
- NCT01099683
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Norgine
Pelvic Organ Prolapse, Urinary Incontinence
Prospective Cohort Study of Robotic Assisted Laparoscopic Sacrocolpopexy Using MPATHY Restorelle Mesh
Robotic approach to sacral colpopexy is a relatively new procedure. The literature is scarce in regard to long term outcome. This advanced procedure is offered at Morristown Memorial.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Mesh Erosion
- Trial name
- MPATHY (NCT01320618)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Urinary Incontinence, Fecal Incontinence
Improving Women's Health by Using an Electronic Pelvic Floor Questionnaire
The overall goal of this study is to test whether an electronic pelvic floor questionnaire (e-PAQ-PF) will increase discussion rates of incontinence in a primary care setting.
- Conditions
- Urinary Incontinence, Fecal Incontinence, Pelvic Floor Disorders
- Trial name
- NCT00880880
- Testing
- e-PAQ-PF
- Where
- United States
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Fecal Incontinence
Effect of an Educational Program for Staff in Nursing Homes Concerning Patients Fecal Incontinence
Fecal incontinence (FI) has an increasing prevalence in the geriatric population which cannot be explained by co-morbidity or anatomical and psychological changes of aging alone.
- Trial name
- EPSPFI (NCT02183740)
- Testing
- Multifaceted educational program
- Where
- Norway
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Colorectal Cancer
Radiation Therapy on Pelvic Floor Disorders in Women
Investigators propose a retrospective cohort study to examine the impact of radiation therapy on the global pelvic floor function of women who have completed the immediate surveillance period for colorectal cancer
- Trial name
- RadPFD (NCT04623515)
- Testing
- REDCap Questionnaires
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Fecal Incontinence
Effect of Anorectal Biofeedback on Encopresis in School Aged Girls After Sexual Assault
Females who have been sexually abused anally, have a disturbed anorectal motility. They have an increased resting pressure at the lower part of the anal canal.
- Trial name
- NCT04652024
- Testing
- Anorectal manometry
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Badr University
Fecal Incontinence
Effect of Single Doses of 10 mg NRL001 Applied as a Suppository to the Anal Canal or Rectum
Study to assess the effects of 10mg NRL001 on mean anal resting pressure (MARP) when administered as a slow release suppository applied to the anal canal or rectum.
- Trial name
- NCT00893607
- Testing
- NRL001
- Where
- United Kingdom
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Norgine
Urinary Incontinence, Stress, Fecal Incontinence
Does Single Dose Imipramine Affect the Opening Pressure of the Urethral and Anal Sphincter?
A double-blinded, randomized, crossover study in healthy females with placebo and single dose imipramine 50 mg. Primary objective: Does imipramine increase the tone of the external urethral sphincter? Urethral Opening Pressure…
- Trial name
- NCT03102645
- Testing
- Imipramine Hydrochloride 25 MG
- Where
- Denmark
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Jonatan Kornholt
Encopresis
Internet-based Treatment of Early Childhood Fecal Incontinence
Encopresis, also known as fecal incontinence, is the voluntary or involuntary passage of stools causing soiling of clothes by a child over 4 years of age.
- Trial name
- NCT00067769
- Testing
- Internet-based intervention UCanPoopToo, treatment as usual
- Where
- United States
- Volunteers
- 91 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Pregnancy
Effect of Pilates and Kegel Exercises During Pregnancy
Urinary incontinence and fecal incontinence are common health problems in the postpartum period because of their effect on daily life and are likely to reduce quality of life.
- Trial name
- NCT06869538
- Testing
- Exercise
- Where
- Turkey (Türkiye)
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Hitit University
Colonic Neoplasms, Rectal Neoplasms
Endoscopically Assisted Colostomy With Colopexy for Critically Ill Patients Without General Anesthesia or Laparotomy
Indications for colostomy are rectal or anal cancer, diverticular disease, radiation enteritis, complex perirectal fistulas, anorectal trauma, severe incontinence, motility and functional disorders.
- Conditions
- Colonic Neoplasms, Rectal Neoplasms, Fecal Incontinence
- Trial name
- EACC (NCT02308631)
- Testing
- ENDOSCOPICALLY ASSISTED COLOSTOMY WITH COLOPEXY
- Where
- Brazil
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
MRI in Evaluation of Fecal Incontinence
Fecal Incontinence (FI) is a Debilitating Physical and Psychological Disorder Characterizedbytheinvoluntary Loss of Flatus or Liquid/Solid Stool.
Fecal incontinence (FI) is a debilitating physical and psychological disorder characterizedbytheinvoluntary loss of flatus or liquid/solid stool.
- Trial name
- NCT07898748
- Testing
- 3DendoanalultrasoundversusexternalphasedarrayMRI inevaluationoffecal Incontinence
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Assiut University
Pelvic Organ Prolapse, Urinary Incontinence
A Study of Robotic Assisted Laparoscopic Sacral Colpopexy Using Alyte Mesh
Robotic approach to sacral colpopexy is a relatively new procedure. The literature is scarce in regard to long term outcomes. This advanced procedure is offered at Morristown Memorial.
- Conditions
- Pelvic Organ Prolapse, Urinary Incontinence, Mesh Erosion
- Trial name
- ALYTE (NCT01320644)
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Atlantic Health System
Fecal Incontinence, Urinary Incontinence
First Time Mothers and Anal Incontinence Six Years Postpartum
Previous studies show that incontinence is relatively common during pregnancy and after delivery. Experiencing incontinence during pregnancy or in the first year after delivery increases the risk of long term incontinence.
- Conditions
- Fecal Incontinence, Urinary Incontinence, Quality of Life
- Trial name
- FiTMAI6 (NCT02792244)
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- Ostfold Hospital Trust
Fecal Incontinence, Constipation
Studies in Patients With Defecatory Disorders
Defecatory disorders like chronic constipation and faecal incontinence affect 25% of the population with rising incidence. Defecatory disorders pose a major health care burden and are poorly recognized and treated.
- Trial name
- NCT03317938
- Testing
- Fecobionics
- Where
- 2 sites in Hong Kong
- Volunteers
- 236 people, healthy volunteers welcome
- Sponsor
- Giome
Fecal Incontinence
Study of the Efficacy of 4 Treatments for Fecal Incontinence in Community-dwelling Women
This is a RCT aimed to assessing efficacy of kegel exercises,biofeedback, electrostimulation and transcutaneous neuromodulation on women with fecal incontinence, measuring its impact on anorectal physiology, cortical plasticity…
- Trial name
- NCT03394794
- Testing
- Pelvic floor rehabilitation
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Hospital de Mataró
Overactive Bladder, Urge Incontinence
Lidocaine Patches Prior to Percutaneous Nerve Evaluation
The study will be a double-blind randomized control trial comparing 4% lidocaine patch placed over the sacrum 3 minutes prior to a percutaneous nerve evaluation (PNE) procedure to a placebo patch in patients already scheduled to…
- Conditions
- Overactive Bladder, Urge Incontinence, Fecal Incontinence
- Trial name
- NCT05783219
- Testing
- Lidocaine patch
- Where
- 2 sites in United States
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Fecal Incontinence
Does Percutaneous Tibial Nerve Stimulation (PTNS) Improve Outcomes in Patients Presenting With Fecal Incontinence
The primary objective of this study is to determine whether Percutaneous Tibial Nerve Stimulation (PTNS), a minimally invasive, simple, cost effective, and outpatient treatment of patients with urinary incontinence, can also be…
- Trial name
- NCT01274585
- Testing
- Posterior tibial nerve stimulation (PTNS), Posterior tibial nerve stimulation
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Anal Sphincter Injury, Fecal Incontinence
Risk Factors for Anal Sphincter Damage During Vaginal Delivery
Vaginal delivery may cause various levels of damage to the anal sphincter. According to the literature, one third - two third of women diagnosed with 3rd degree rupture during vaginal delivery suffer from fecal incontinence.
- Trial name
- AnaSphRF (NCT01310426)
- Testing
- 3D transperineal Ultrasound
- Where
- Israel
- Volunteers
- 33 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Body Image, Urinary Incontinence
Pelvic Floor Dysfunction and Its Influence on Body Image and Sexual Function
The first objective to determinate the prevalence of pelvic floor dysfunction in pregnant women and in the first year postpartum.
- Conditions
- Body Image, Urinary Incontinence, Anal Incontinence, Anorectal Disorder
- Trial name
- PFD-BI (NCT03591393)
- Testing
- questionnaire
- Where
- Belgium
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Universitaire Ziekenhuizen KU Leuven