Clinical trials: Bowel Obstruction
Constipation
Comparison Trial of Enema vs. PEG 3350 for Constipation
The purpose of this study is to determine if milk and molasses enema or PEG 3350 works better for treatment of fecal impaction in children who are constipated.
- Trial name
- NCT00467350
- Testing
- PEG 3350, milk and molasses enema
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Children's Mercy Hospital Kansas City
Intestinal Obstruction
Effects of 500 mg Immediate Release and Extended Release Methylnaltrexone on Loperamide-induced Delay of the Oro-cecal and Whole-gut Transit Time in Healthy Subjects
The purpose of this study is to describe the effects of methylnaltrexone in preventing loperamide-induced delay of the oro-cecal and whole-gut transit time and measure pharmacokinetics of methylnaltrexone after subcutaneous and…
- Trial name
- LOP-MNTX-2009 (NCT01596777)
- Testing
- Loperamide, Methylnaltrexone 12 mg sc., Methylnaltrexone IR capsule
- Where
- Germany
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University Medicine Greifswald
Intussusception, Emergencies
Point-of-Care Ultrasonography for Intussusception
Pediatric emergency medicine (PEM) physicians are increasingly utilizing point-of-care ultrasound (POCUS). There is currently limited data regarding POCUS evaluation for intussusception in pediatric patients.
- Trial name
- NCT03360643
- Testing
- Point-of-care ultrasound prior to radiology ultrasound, Radiology-performed ultrasound
- Where
- United States
- Volunteers
- 256 people, healthy volunteers welcome
- Sponsor
- Children's Hospitals and Clinics of Minnesota
Postoperative Complications, Constipation
Study Evaluating the Safety of MOA-728 Administered Orally to Healthy Subjects
This is the first multiple-dose experience in humans with MOA-728 in an oral formulation. This study will provide an assessment of the safety, tolerability, and pharmacokinetics (PK) of MOA-728 following administration of…
- Trial name
- NCT00311350
- Testing
- MOA-728
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Bausch Health Americas, Inc.
Small Bowel Obstruction
REsectability Small Bowel Obstruction LAParoscopic (RESBOLAP) Score. Multicentric Data Registry
AIM OF THE STUDY The aim of the study is to develop a Resectability Laparoscopic Score as a helpful instrument during intraoperative decision-making in the setting of emergency laparoscopic surgery for small bowel obstruction…
- Trial name
- RESBOLAP (NCT05842135)
- Testing
- Laparoscopic approach to small bowel obstrcuction
- Where
- Italy
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- San Salvatore Hospital, AST Pesaro-Urbino
Colorectal Disorders, Regional Anesthesia Morbidity
Transversus Abdominis Plane Blocks With and Without Dexamethasone
Dexamethasone will be used as an adjunct to local anesthetics (bupivacaine) to prolong the duration of laparoscopically-placed transversus-abdominis plane blocks in elective colorectal resection.
- Conditions
- Colorectal Disorders, Regional Anesthesia Morbidity, Analgesia, Local Anesthetic Complication
- Trial name
- TAP-DEX (NCT05432934)
- Testing
- Dexamethasone
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Saskatchewan
Neurogenic Bladder, Neurogenic Bowel
The Role of Active Administration of Peristeen Bowel Evacuation for the Management of Urinary Tract Infection
This study investigates whether active use of transanal irrigation (Peristeen®) effectively manages urinary tract infection among patients with the diagnosis of neurogenic bladder.
- Conditions
- Neurogenic Bladder, Neurogenic Bowel, Spina Bifida, Fecal Incontinence
- Trial name
- NCT04815226
- Testing
- Peristeen Transanal Irrigation
- Where
- South Korea
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Seoul National University Hospital
Colo-rectal Cancer
Comparison of Ultrasound-guided Erector Spinae Plane Block and Transmuscular Quadratus Lumborum Block
The objective of this study is to compare the postoperative analgesic effect of bupivacaine injection via ultrasound-guided erector spinae block versus transmuscular quadratus lumborum block in patients undergoing abdominal…
- Trial name
- NCT05709899
- Testing
- nerve blocks
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- Assiut University
Paralytic Ileus
The Effects of Gum Chewing on Bowel Function Recovery Following Cesarean Section
Following all abdominal surgery, paralytic ileus commonly develops. Surgeons have traditionally withheld postoperative oral intake until the return of bowel function to prevent related complications.
- Trial name
- GUM01 (NCT01131416)
- Testing
- Gum chewing
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Chiang Mai University
Anorectal Disorder
Caudal Block,Saddle Block, Anorectal Surgery
Anorectal surgery includes pilonidal sinus, hemorrhoidectomy, anal fissure, and anal fistula operations. Various surgical and anesthetic techniques have been used to increase the level of analgesia in perioperative period and…
- Trial name
- NCT03498547
- Testing
- caudal block, saddle block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Kocaeli Derince Education and Research Hospital
Bowel Obstruction, Artificial Intelligence
Deep Learning-based Artificial Intelligence for the Diagnosis of Small Bowel Obstruction
The study will compare the diagnostic accuracy and time to diagnosis of computed tomography images of patients with suspected intestinal obstruction seen in the emergency room by residents and surgeons, with and without…
- Trial name
- NCT06481358
- Testing
- Artificial intelligence
- Where
- Japan
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Nagoya University
Children, Appendicitis
Quadratus Lumborum Block Versus Transversus Abdominis Plane Block in Children Undergoing Laparoscopic Appendicectomy
QL block has been recently described for chronic pain following abdominal hernia repair, and for postoperative analgesia following abdominal surgery as it leads to complete pain relief in the dermatomal area from (T6 - L1).
- Trial name
- NCT04031196
- Testing
- QLB, TAP block
- Where
- Egypt
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Endoscopic Surgical Procedure
Percutaneous Sigmoid Fixation For Management Of Recurrent Sigmoid Volvulus
The investigators included all patients who were presented to emergency department with recurrent sigmoid volvulus at Zagazig University hospital between (August 2024 to August 2025).
- Trial name
- NCT07155304
- Testing
- percutaneous sigmoid colon fixation
- Where
- Egypt
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Appendicitis
A Comparison of UGBRS Block and Local Infiltration
In this research study, the investigators are trying to find out which of the two methods of injecting local anesthetics (at the site of the belly button cut or by ultrasound guided rectus sheath block) will provide better pain…
- Trial name
- NCT02352519
- Testing
- UGBRSB, Local Infiltration
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Bowel Ileus, Flatus
Chewing Gum on Postoperative Ileus in Children
Traditional postoperative care has been challenged recently to improve and speedup recovery (including the return of bowel function) such that patients can be discharged to home more quickly.
- Trial name
- GUM_1 (NCT03666377)
- Testing
- Gum chewing
- Where
- Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Hemorrhoids, Anal Fissure and Fistula
Pudendal Nerve Block With Bupivacaine Alone and Bupivacaine With Methylene Blue for Postoperative Analgesia
Study Description: The goal of this clinical trial is to compare the duration of postoperative pain relief achieved with two different approaches to pudendal nerve block in patients undergoing elective perianal surgery.
- Conditions
- Hemorrhoids, Anal Fissure and Fistula, Perianal Abscess, Perianal Fistula
- Trial name
- NCT05990569
- Testing
- Ultrasound guided Pudendal nerve block
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Nepal Mediciti Hospital
Pain, Appendicitis
Laparoscopic Transversus Abdominis Plane Block (LTAP) for Appendicectomy Versus Standard Port Site Treatment
This study aims to compare Laparoscopic assisted LTAP (Transversus Abdominis Plane) to standard port-site infiltration in terms of post-operative visual analogue scores (VAS) for pain at 3, 6, 12 and 24 hours following…
- Conditions
- Pain, Appendicitis, Surgery, Analgesia
- Trial name
- TapBlock (NCT05427266)
- Testing
- Tap Block - Bupivacaine
- Volunteers
- 172 people, healthy volunteers welcome
- Sponsor
- Royal College of Surgeons, Ireland
Intussusception, Rotavirus Infections
Potential Mechanisms for Intussusception After Rotavirus Vaccine-Pilot Study
This is a prospective randomized clinical trial that aims to evaluate the potential effects of the first dose of rotavirus vaccines on gastrointestinal motility and anatomy and blood and stool cytokine responses.
- Trial name
- NCT02542462
- Testing
- Rotarix®,, Rotarix®, with other routine vaccines, RotaTeq®,
- Where
- United States
- Volunteers
- 144 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Medical Center, Cincinnati
Artificial Intelligence, Enteroscope
A Clinical Trial of the Effectiveness and Safety of Software Assisting Diagnose the Intestinal Polyp Digestive Endoscopy by Analysis of Colonoscopy Medical Images From Electronic Digestive Endoscopy Equipment
A clinical trial of the effectiveness and safety of intestinal polyp digestive endoscopy-assisted diagnosis software used in the analysis of colonoscopy medical images generated by electronic digestive endoscopy equipment.
- Conditions
- Artificial Intelligence, Enteroscope, Intestinal Polyposis, Adenomatous
- Trial name
- NCT05687318
- Testing
- DeFrame
- Where
- China
- Volunteers
- 337 people, healthy volunteers welcome
- Sponsor
- Peking Union Medical College Hospital
Colorectal Cancer
The Benefits of Deep Neuromuscular Block and Sugammadex in Laparoscopic Colorectal Surgery
Pneumoperitoneum, the use of carbon dioxide, presents some disadvantages, including a risk of hypercarbia and respiratory acidosis during surgery in the respiratory system, and of an increased mean arterial pressure and systemic…
- Trial name
- NCT02266056
- Testing
- Deep neuromuscular block using rocuronium and reversal with suggamadex, Moderate neuromuscular block using rocuronium and reversal with suggamadex
- Where
- South Korea
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Yonsei University